ncHMR detector: a computational framework to systematically reveal non-classical functions of histone modification regulators

Abstract Recently, several non-classical functions of histone modification regulators (HMRs), independent of their known histone modification substrates and products, have been reported to be essential for specific cellular processes. However, there is no framework designed for identifying such func...
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Autor*in:	Shengen Hu [verfasserIn] Dawei Huo [verfasserIn] Zhaowei Yu [verfasserIn] Yujie Chen [verfasserIn] Jing Liu [verfasserIn] Lin Liu [verfasserIn] Xudong Wu [verfasserIn] Yong Zhang [verfasserIn]

Format:	E-Artikel
Sprache:	Englisch

Erschienen:	2020

Schlagwörter:	Histone modification regulator Non-classical function Computational framework Chromatin regulation

Übergeordnetes Werk:	In: Genome Biology - BMC, 2014, 21(2020), 1, Seite 16
Übergeordnetes Werk:	volume:21 ; year:2020 ; number:1 ; pages:16

Links:	Link aufrufen Link aufrufen Link aufrufen Journal toc

DOI / URN:	10.1186/s13059-020-01953-0

Katalog-ID:	DOAJ044363621

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520			\|a Abstract Recently, several non-classical functions of histone modification regulators (HMRs), independent of their known histone modification substrates and products, have been reported to be essential for specific cellular processes. However, there is no framework designed for identifying such functions systematically. Here, we develop ncHMR detector, the first computational framework to predict non-classical functions and cofactors of a given HMR, based on ChIP-seq data mining. We apply ncHMR detector in ChIP-seq data-rich cell types and predict non-classical functions of HMRs. Finally, we experimentally reveal that the predicted non-classical function of CBX7 is biologically significant for the maintenance of pluripotency.
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spelling	10.1186/s13059-020-01953-0 doi (DE-627)DOAJ044363621 (DE-599)DOAJ62bda084f283469d80b3e5bba375ba92 DE-627 ger DE-627 rakwb eng QH301-705.5 QH426-470 Shengen Hu verfasserin aut ncHMR detector: a computational framework to systematically reveal non-classical functions of histone modification regulators 2020 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Abstract Recently, several non-classical functions of histone modification regulators (HMRs), independent of their known histone modification substrates and products, have been reported to be essential for specific cellular processes. However, there is no framework designed for identifying such functions systematically. Here, we develop ncHMR detector, the first computational framework to predict non-classical functions and cofactors of a given HMR, based on ChIP-seq data mining. We apply ncHMR detector in ChIP-seq data-rich cell types and predict non-classical functions of HMRs. Finally, we experimentally reveal that the predicted non-classical function of CBX7 is biologically significant for the maintenance of pluripotency. Histone modification regulator Non-classical function Computational framework Chromatin regulation Biology (General) Genetics Dawei Huo verfasserin aut Zhaowei Yu verfasserin aut Yujie Chen verfasserin aut Jing Liu verfasserin aut Lin Liu verfasserin aut Xudong Wu verfasserin aut Yong Zhang verfasserin aut In Genome Biology BMC, 2014 21(2020), 1, Seite 16 (DE-627)326173617 (DE-600)2040529-7 1474760X nnns volume:21 year:2020 number:1 pages:16 https://doi.org/10.1186/s13059-020-01953-0 kostenfrei https://doaj.org/article/62bda084f283469d80b3e5bba375ba92 kostenfrei http://link.springer.com/article/10.1186/s13059-020-01953-0 kostenfrei https://doaj.org/toc/1474-760X Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2003 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 21 2020 1 16
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allfieldsSound	10.1186/s13059-020-01953-0 doi (DE-627)DOAJ044363621 (DE-599)DOAJ62bda084f283469d80b3e5bba375ba92 DE-627 ger DE-627 rakwb eng QH301-705.5 QH426-470 Shengen Hu verfasserin aut ncHMR detector: a computational framework to systematically reveal non-classical functions of histone modification regulators 2020 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Abstract Recently, several non-classical functions of histone modification regulators (HMRs), independent of their known histone modification substrates and products, have been reported to be essential for specific cellular processes. However, there is no framework designed for identifying such functions systematically. Here, we develop ncHMR detector, the first computational framework to predict non-classical functions and cofactors of a given HMR, based on ChIP-seq data mining. We apply ncHMR detector in ChIP-seq data-rich cell types and predict non-classical functions of HMRs. Finally, we experimentally reveal that the predicted non-classical function of CBX7 is biologically significant for the maintenance of pluripotency. Histone modification regulator Non-classical function Computational framework Chromatin regulation Biology (General) Genetics Dawei Huo verfasserin aut Zhaowei Yu verfasserin aut Yujie Chen verfasserin aut Jing Liu verfasserin aut Lin Liu verfasserin aut Xudong Wu verfasserin aut Yong Zhang verfasserin aut In Genome Biology BMC, 2014 21(2020), 1, Seite 16 (DE-627)326173617 (DE-600)2040529-7 1474760X nnns volume:21 year:2020 number:1 pages:16 https://doi.org/10.1186/s13059-020-01953-0 kostenfrei https://doaj.org/article/62bda084f283469d80b3e5bba375ba92 kostenfrei http://link.springer.com/article/10.1186/s13059-020-01953-0 kostenfrei https://doaj.org/toc/1474-760X Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2003 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 21 2020 1 16
language	English
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authorswithroles_txt_mv	Shengen Hu @@aut@@ Dawei Huo @@aut@@ Zhaowei Yu @@aut@@ Yujie Chen @@aut@@ Jing Liu @@aut@@ Lin Liu @@aut@@ Xudong Wu @@aut@@ Yong Zhang @@aut@@
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callnumber-first	Q - Science
author	Shengen Hu
spellingShingle	Shengen Hu misc QH301-705.5 misc QH426-470 misc Histone modification regulator misc Non-classical function misc Computational framework misc Chromatin regulation misc Biology (General) misc Genetics ncHMR detector: a computational framework to systematically reveal non-classical functions of histone modification regulators
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topic_title	QH301-705.5 QH426-470 ncHMR detector: a computational framework to systematically reveal non-classical functions of histone modification regulators Histone modification regulator Non-classical function Computational framework Chromatin regulation
topic	misc QH301-705.5 misc QH426-470 misc Histone modification regulator misc Non-classical function misc Computational framework misc Chromatin regulation misc Biology (General) misc Genetics
topic_unstemmed	misc QH301-705.5 misc QH426-470 misc Histone modification regulator misc Non-classical function misc Computational framework misc Chromatin regulation misc Biology (General) misc Genetics
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title	ncHMR detector: a computational framework to systematically reveal non-classical functions of histone modification regulators
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title_sort	nchmr detector: a computational framework to systematically reveal non-classical functions of histone modification regulators
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title_auth	ncHMR detector: a computational framework to systematically reveal non-classical functions of histone modification regulators
abstract	Abstract Recently, several non-classical functions of histone modification regulators (HMRs), independent of their known histone modification substrates and products, have been reported to be essential for specific cellular processes. However, there is no framework designed for identifying such functions systematically. Here, we develop ncHMR detector, the first computational framework to predict non-classical functions and cofactors of a given HMR, based on ChIP-seq data mining. We apply ncHMR detector in ChIP-seq data-rich cell types and predict non-classical functions of HMRs. Finally, we experimentally reveal that the predicted non-classical function of CBX7 is biologically significant for the maintenance of pluripotency.
abstractGer	Abstract Recently, several non-classical functions of histone modification regulators (HMRs), independent of their known histone modification substrates and products, have been reported to be essential for specific cellular processes. However, there is no framework designed for identifying such functions systematically. Here, we develop ncHMR detector, the first computational framework to predict non-classical functions and cofactors of a given HMR, based on ChIP-seq data mining. We apply ncHMR detector in ChIP-seq data-rich cell types and predict non-classical functions of HMRs. Finally, we experimentally reveal that the predicted non-classical function of CBX7 is biologically significant for the maintenance of pluripotency.
abstract_unstemmed	Abstract Recently, several non-classical functions of histone modification regulators (HMRs), independent of their known histone modification substrates and products, have been reported to be essential for specific cellular processes. However, there is no framework designed for identifying such functions systematically. Here, we develop ncHMR detector, the first computational framework to predict non-classical functions and cofactors of a given HMR, based on ChIP-seq data mining. We apply ncHMR detector in ChIP-seq data-rich cell types and predict non-classical functions of HMRs. Finally, we experimentally reveal that the predicted non-classical function of CBX7 is biologically significant for the maintenance of pluripotency.
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title_short	ncHMR detector: a computational framework to systematically reveal non-classical functions of histone modification regulators
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ncHMR detector: a computational framework to systematically reveal non-classical functions of histone modification regulators

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