Glucocorticoid-induced tumor necrosis factor receptor expression in patients with cervical human papillomavirus infection

Introduction The progression of human papillomavirus (HPV) infection in the anogenital tract has been associated with the involvement of cells with regulatory properties. Evidence has shown that glucocorticoid-induced tumor necrosis factor receptor (GITR) is an important surface molecule for the cha...
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Gespeichert in:

Autor*in:	Cacilda Tezelli Junqueira Padovani [verfasserIn] Camila Mareti Bonin [verfasserIn] Ines Aparecida Tozetti [verfasserIn] Alda Maria Teixeira Ferreira [verfasserIn] Carlos Eurico dos Santos Fernandes [verfasserIn] Izaias Pereira da Costa [verfasserIn]

Format:	E-Artikel
Sprache:	Englisch

Erschienen:	2013

Schlagwörter:	Human papillomavirus Immune response Immunohistochemistry

Übergeordnetes Werk:	In: Revista da Sociedade Brasileira de Medicina Tropical - Sociedade Brasileira de Medicina Tropical (SBMT), 2004, 46(2013), 3, Seite 288-292
Übergeordnetes Werk:	volume:46 ; year:2013 ; number:3 ; pages:288-292

Links:	Link aufrufen Link aufrufen Link aufrufen Journal toc

DOI / URN:	10.1590/0037-8682-0029-2013

Katalog-ID:	DOAJ044573790

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520			\|a Introduction The progression of human papillomavirus (HPV) infection in the anogenital tract has been associated with the involvement of cells with regulatory properties. Evidence has shown that glucocorticoid-induced tumor necrosis factor receptor (GITR) is an important surface molecule for the characterization of these cells and proposes that GITR ligand may constitute a rational treatment for many cancer types. We aimed to detect the presence of GITR and CD25 in cervical stroma cells with and without pathological changes or HPV infection to better understand the immune response in the infected tissue microenvironment. Methods We subjected 49 paraffin-embedded cervical tissue samples to HPV DNA detection and histopathological analysis, and subsequently immunohistochemistry to detect GITR and CD25 in lymphocytes. Results We observed that 76.9% of all samples with high GITR expression were HPV-positive regardless of histopathological findings. High GITR expression (77.8%) was predominant in samples with ≥1,000 RLU/PCB. Of the HPV-positive samples negative for intraepithelial lesion and malignancy, 62.5% had high GITR expression. High GITR expression was observed in both carcinoma and high-grade squamous intraepithelial lesion (HSIL) samples (p = 0.16). CD25 was present in great quantities in all samples. Conclusions The predominance of high GITR expression in samples with high viral load that were classified as HSIL and carcinoma suggests that GITR+ cells can exhibit regulatory properties and may contribute to the progression of HPV-induced cervical neoplasia, emphasizing the importance of GITR as a potential target for immune therapy of cervical cancer and as a disease evolution biomarker.
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allfields	10.1590/0037-8682-0029-2013 doi (DE-627)DOAJ044573790 (DE-599)DOAJ01db04438d0d4e1ebf74c177ce8cfa4f DE-627 ger DE-627 rakwb eng RC955-962 Cacilda Tezelli Junqueira Padovani verfasserin aut Glucocorticoid-induced tumor necrosis factor receptor expression in patients with cervical human papillomavirus infection 2013 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Introduction The progression of human papillomavirus (HPV) infection in the anogenital tract has been associated with the involvement of cells with regulatory properties. Evidence has shown that glucocorticoid-induced tumor necrosis factor receptor (GITR) is an important surface molecule for the characterization of these cells and proposes that GITR ligand may constitute a rational treatment for many cancer types. We aimed to detect the presence of GITR and CD25 in cervical stroma cells with and without pathological changes or HPV infection to better understand the immune response in the infected tissue microenvironment. Methods We subjected 49 paraffin-embedded cervical tissue samples to HPV DNA detection and histopathological analysis, and subsequently immunohistochemistry to detect GITR and CD25 in lymphocytes. Results We observed that 76.9% of all samples with high GITR expression were HPV-positive regardless of histopathological findings. High GITR expression (77.8%) was predominant in samples with ≥1,000 RLU/PCB. Of the HPV-positive samples negative for intraepithelial lesion and malignancy, 62.5% had high GITR expression. High GITR expression was observed in both carcinoma and high-grade squamous intraepithelial lesion (HSIL) samples (p = 0.16). CD25 was present in great quantities in all samples. Conclusions The predominance of high GITR expression in samples with high viral load that were classified as HSIL and carcinoma suggests that GITR+ cells can exhibit regulatory properties and may contribute to the progression of HPV-induced cervical neoplasia, emphasizing the importance of GITR as a potential target for immune therapy of cervical cancer and as a disease evolution biomarker. Human papillomavirus Immune response Immunohistochemistry Arctic medicine. Tropical medicine Camila Mareti Bonin verfasserin aut Ines Aparecida Tozetti verfasserin aut Alda Maria Teixeira Ferreira verfasserin aut Carlos Eurico dos Santos Fernandes verfasserin aut Izaias Pereira da Costa verfasserin aut In Revista da Sociedade Brasileira de Medicina Tropical Sociedade Brasileira de Medicina Tropical (SBMT), 2004 46(2013), 3, Seite 288-292 (DE-627)324614918 (DE-600)2028921-2 16789849 nnns volume:46 year:2013 number:3 pages:288-292 https://doi.org/10.1590/0037-8682-0029-2013 kostenfrei https://doaj.org/article/01db04438d0d4e1ebf74c177ce8cfa4f kostenfrei http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0037-86822013000300288&lng=en&tlng=en kostenfrei https://doaj.org/toc/1678-9849 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 46 2013 3 288-292
spelling	10.1590/0037-8682-0029-2013 doi (DE-627)DOAJ044573790 (DE-599)DOAJ01db04438d0d4e1ebf74c177ce8cfa4f DE-627 ger DE-627 rakwb eng RC955-962 Cacilda Tezelli Junqueira Padovani verfasserin aut Glucocorticoid-induced tumor necrosis factor receptor expression in patients with cervical human papillomavirus infection 2013 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Introduction The progression of human papillomavirus (HPV) infection in the anogenital tract has been associated with the involvement of cells with regulatory properties. Evidence has shown that glucocorticoid-induced tumor necrosis factor receptor (GITR) is an important surface molecule for the characterization of these cells and proposes that GITR ligand may constitute a rational treatment for many cancer types. We aimed to detect the presence of GITR and CD25 in cervical stroma cells with and without pathological changes or HPV infection to better understand the immune response in the infected tissue microenvironment. Methods We subjected 49 paraffin-embedded cervical tissue samples to HPV DNA detection and histopathological analysis, and subsequently immunohistochemistry to detect GITR and CD25 in lymphocytes. Results We observed that 76.9% of all samples with high GITR expression were HPV-positive regardless of histopathological findings. High GITR expression (77.8%) was predominant in samples with ≥1,000 RLU/PCB. Of the HPV-positive samples negative for intraepithelial lesion and malignancy, 62.5% had high GITR expression. High GITR expression was observed in both carcinoma and high-grade squamous intraepithelial lesion (HSIL) samples (p = 0.16). CD25 was present in great quantities in all samples. Conclusions The predominance of high GITR expression in samples with high viral load that were classified as HSIL and carcinoma suggests that GITR+ cells can exhibit regulatory properties and may contribute to the progression of HPV-induced cervical neoplasia, emphasizing the importance of GITR as a potential target for immune therapy of cervical cancer and as a disease evolution biomarker. Human papillomavirus Immune response Immunohistochemistry Arctic medicine. Tropical medicine Camila Mareti Bonin verfasserin aut Ines Aparecida Tozetti verfasserin aut Alda Maria Teixeira Ferreira verfasserin aut Carlos Eurico dos Santos Fernandes verfasserin aut Izaias Pereira da Costa verfasserin aut In Revista da Sociedade Brasileira de Medicina Tropical Sociedade Brasileira de Medicina Tropical (SBMT), 2004 46(2013), 3, Seite 288-292 (DE-627)324614918 (DE-600)2028921-2 16789849 nnns volume:46 year:2013 number:3 pages:288-292 https://doi.org/10.1590/0037-8682-0029-2013 kostenfrei https://doaj.org/article/01db04438d0d4e1ebf74c177ce8cfa4f kostenfrei http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0037-86822013000300288&lng=en&tlng=en kostenfrei https://doaj.org/toc/1678-9849 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 46 2013 3 288-292
allfields_unstemmed	10.1590/0037-8682-0029-2013 doi (DE-627)DOAJ044573790 (DE-599)DOAJ01db04438d0d4e1ebf74c177ce8cfa4f DE-627 ger DE-627 rakwb eng RC955-962 Cacilda Tezelli Junqueira Padovani verfasserin aut Glucocorticoid-induced tumor necrosis factor receptor expression in patients with cervical human papillomavirus infection 2013 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Introduction The progression of human papillomavirus (HPV) infection in the anogenital tract has been associated with the involvement of cells with regulatory properties. Evidence has shown that glucocorticoid-induced tumor necrosis factor receptor (GITR) is an important surface molecule for the characterization of these cells and proposes that GITR ligand may constitute a rational treatment for many cancer types. We aimed to detect the presence of GITR and CD25 in cervical stroma cells with and without pathological changes or HPV infection to better understand the immune response in the infected tissue microenvironment. Methods We subjected 49 paraffin-embedded cervical tissue samples to HPV DNA detection and histopathological analysis, and subsequently immunohistochemistry to detect GITR and CD25 in lymphocytes. Results We observed that 76.9% of all samples with high GITR expression were HPV-positive regardless of histopathological findings. High GITR expression (77.8%) was predominant in samples with ≥1,000 RLU/PCB. Of the HPV-positive samples negative for intraepithelial lesion and malignancy, 62.5% had high GITR expression. High GITR expression was observed in both carcinoma and high-grade squamous intraepithelial lesion (HSIL) samples (p = 0.16). CD25 was present in great quantities in all samples. Conclusions The predominance of high GITR expression in samples with high viral load that were classified as HSIL and carcinoma suggests that GITR+ cells can exhibit regulatory properties and may contribute to the progression of HPV-induced cervical neoplasia, emphasizing the importance of GITR as a potential target for immune therapy of cervical cancer and as a disease evolution biomarker. Human papillomavirus Immune response Immunohistochemistry Arctic medicine. Tropical medicine Camila Mareti Bonin verfasserin aut Ines Aparecida Tozetti verfasserin aut Alda Maria Teixeira Ferreira verfasserin aut Carlos Eurico dos Santos Fernandes verfasserin aut Izaias Pereira da Costa verfasserin aut In Revista da Sociedade Brasileira de Medicina Tropical Sociedade Brasileira de Medicina Tropical (SBMT), 2004 46(2013), 3, Seite 288-292 (DE-627)324614918 (DE-600)2028921-2 16789849 nnns volume:46 year:2013 number:3 pages:288-292 https://doi.org/10.1590/0037-8682-0029-2013 kostenfrei https://doaj.org/article/01db04438d0d4e1ebf74c177ce8cfa4f kostenfrei http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0037-86822013000300288&lng=en&tlng=en kostenfrei https://doaj.org/toc/1678-9849 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 46 2013 3 288-292
allfieldsGer	10.1590/0037-8682-0029-2013 doi (DE-627)DOAJ044573790 (DE-599)DOAJ01db04438d0d4e1ebf74c177ce8cfa4f DE-627 ger DE-627 rakwb eng RC955-962 Cacilda Tezelli Junqueira Padovani verfasserin aut Glucocorticoid-induced tumor necrosis factor receptor expression in patients with cervical human papillomavirus infection 2013 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Introduction The progression of human papillomavirus (HPV) infection in the anogenital tract has been associated with the involvement of cells with regulatory properties. Evidence has shown that glucocorticoid-induced tumor necrosis factor receptor (GITR) is an important surface molecule for the characterization of these cells and proposes that GITR ligand may constitute a rational treatment for many cancer types. We aimed to detect the presence of GITR and CD25 in cervical stroma cells with and without pathological changes or HPV infection to better understand the immune response in the infected tissue microenvironment. Methods We subjected 49 paraffin-embedded cervical tissue samples to HPV DNA detection and histopathological analysis, and subsequently immunohistochemistry to detect GITR and CD25 in lymphocytes. Results We observed that 76.9% of all samples with high GITR expression were HPV-positive regardless of histopathological findings. High GITR expression (77.8%) was predominant in samples with ≥1,000 RLU/PCB. Of the HPV-positive samples negative for intraepithelial lesion and malignancy, 62.5% had high GITR expression. High GITR expression was observed in both carcinoma and high-grade squamous intraepithelial lesion (HSIL) samples (p = 0.16). CD25 was present in great quantities in all samples. Conclusions The predominance of high GITR expression in samples with high viral load that were classified as HSIL and carcinoma suggests that GITR+ cells can exhibit regulatory properties and may contribute to the progression of HPV-induced cervical neoplasia, emphasizing the importance of GITR as a potential target for immune therapy of cervical cancer and as a disease evolution biomarker. Human papillomavirus Immune response Immunohistochemistry Arctic medicine. Tropical medicine Camila Mareti Bonin verfasserin aut Ines Aparecida Tozetti verfasserin aut Alda Maria Teixeira Ferreira verfasserin aut Carlos Eurico dos Santos Fernandes verfasserin aut Izaias Pereira da Costa verfasserin aut In Revista da Sociedade Brasileira de Medicina Tropical Sociedade Brasileira de Medicina Tropical (SBMT), 2004 46(2013), 3, Seite 288-292 (DE-627)324614918 (DE-600)2028921-2 16789849 nnns volume:46 year:2013 number:3 pages:288-292 https://doi.org/10.1590/0037-8682-0029-2013 kostenfrei https://doaj.org/article/01db04438d0d4e1ebf74c177ce8cfa4f kostenfrei http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0037-86822013000300288&lng=en&tlng=en kostenfrei https://doaj.org/toc/1678-9849 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 46 2013 3 288-292
allfieldsSound	10.1590/0037-8682-0029-2013 doi (DE-627)DOAJ044573790 (DE-599)DOAJ01db04438d0d4e1ebf74c177ce8cfa4f DE-627 ger DE-627 rakwb eng RC955-962 Cacilda Tezelli Junqueira Padovani verfasserin aut Glucocorticoid-induced tumor necrosis factor receptor expression in patients with cervical human papillomavirus infection 2013 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Introduction The progression of human papillomavirus (HPV) infection in the anogenital tract has been associated with the involvement of cells with regulatory properties. Evidence has shown that glucocorticoid-induced tumor necrosis factor receptor (GITR) is an important surface molecule for the characterization of these cells and proposes that GITR ligand may constitute a rational treatment for many cancer types. We aimed to detect the presence of GITR and CD25 in cervical stroma cells with and without pathological changes or HPV infection to better understand the immune response in the infected tissue microenvironment. Methods We subjected 49 paraffin-embedded cervical tissue samples to HPV DNA detection and histopathological analysis, and subsequently immunohistochemistry to detect GITR and CD25 in lymphocytes. Results We observed that 76.9% of all samples with high GITR expression were HPV-positive regardless of histopathological findings. High GITR expression (77.8%) was predominant in samples with ≥1,000 RLU/PCB. Of the HPV-positive samples negative for intraepithelial lesion and malignancy, 62.5% had high GITR expression. High GITR expression was observed in both carcinoma and high-grade squamous intraepithelial lesion (HSIL) samples (p = 0.16). CD25 was present in great quantities in all samples. Conclusions The predominance of high GITR expression in samples with high viral load that were classified as HSIL and carcinoma suggests that GITR+ cells can exhibit regulatory properties and may contribute to the progression of HPV-induced cervical neoplasia, emphasizing the importance of GITR as a potential target for immune therapy of cervical cancer and as a disease evolution biomarker. Human papillomavirus Immune response Immunohistochemistry Arctic medicine. Tropical medicine Camila Mareti Bonin verfasserin aut Ines Aparecida Tozetti verfasserin aut Alda Maria Teixeira Ferreira verfasserin aut Carlos Eurico dos Santos Fernandes verfasserin aut Izaias Pereira da Costa verfasserin aut In Revista da Sociedade Brasileira de Medicina Tropical Sociedade Brasileira de Medicina Tropical (SBMT), 2004 46(2013), 3, Seite 288-292 (DE-627)324614918 (DE-600)2028921-2 16789849 nnns volume:46 year:2013 number:3 pages:288-292 https://doi.org/10.1590/0037-8682-0029-2013 kostenfrei https://doaj.org/article/01db04438d0d4e1ebf74c177ce8cfa4f kostenfrei http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0037-86822013000300288&lng=en&tlng=en kostenfrei https://doaj.org/toc/1678-9849 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 46 2013 3 288-292
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callnumber-first	R - Medicine
author	Cacilda Tezelli Junqueira Padovani
spellingShingle	Cacilda Tezelli Junqueira Padovani misc RC955-962 misc Human papillomavirus misc Immune response misc Immunohistochemistry misc Arctic medicine. Tropical medicine Glucocorticoid-induced tumor necrosis factor receptor expression in patients with cervical human papillomavirus infection
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topic_title	RC955-962 Glucocorticoid-induced tumor necrosis factor receptor expression in patients with cervical human papillomavirus infection Human papillomavirus Immune response Immunohistochemistry
topic	misc RC955-962 misc Human papillomavirus misc Immune response misc Immunohistochemistry misc Arctic medicine. Tropical medicine
topic_unstemmed	misc RC955-962 misc Human papillomavirus misc Immune response misc Immunohistochemistry misc Arctic medicine. Tropical medicine
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title	Glucocorticoid-induced tumor necrosis factor receptor expression in patients with cervical human papillomavirus infection
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title_full	Glucocorticoid-induced tumor necrosis factor receptor expression in patients with cervical human papillomavirus infection
author_sort	Cacilda Tezelli Junqueira Padovani
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author_browse	Cacilda Tezelli Junqueira Padovani Camila Mareti Bonin Ines Aparecida Tozetti Alda Maria Teixeira Ferreira Carlos Eurico dos Santos Fernandes Izaias Pereira da Costa
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title_sort	glucocorticoid-induced tumor necrosis factor receptor expression in patients with cervical human papillomavirus infection
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title_auth	Glucocorticoid-induced tumor necrosis factor receptor expression in patients with cervical human papillomavirus infection
abstract	Introduction The progression of human papillomavirus (HPV) infection in the anogenital tract has been associated with the involvement of cells with regulatory properties. Evidence has shown that glucocorticoid-induced tumor necrosis factor receptor (GITR) is an important surface molecule for the characterization of these cells and proposes that GITR ligand may constitute a rational treatment for many cancer types. We aimed to detect the presence of GITR and CD25 in cervical stroma cells with and without pathological changes or HPV infection to better understand the immune response in the infected tissue microenvironment. Methods We subjected 49 paraffin-embedded cervical tissue samples to HPV DNA detection and histopathological analysis, and subsequently immunohistochemistry to detect GITR and CD25 in lymphocytes. Results We observed that 76.9% of all samples with high GITR expression were HPV-positive regardless of histopathological findings. High GITR expression (77.8%) was predominant in samples with ≥1,000 RLU/PCB. Of the HPV-positive samples negative for intraepithelial lesion and malignancy, 62.5% had high GITR expression. High GITR expression was observed in both carcinoma and high-grade squamous intraepithelial lesion (HSIL) samples (p = 0.16). CD25 was present in great quantities in all samples. Conclusions The predominance of high GITR expression in samples with high viral load that were classified as HSIL and carcinoma suggests that GITR+ cells can exhibit regulatory properties and may contribute to the progression of HPV-induced cervical neoplasia, emphasizing the importance of GITR as a potential target for immune therapy of cervical cancer and as a disease evolution biomarker.
abstractGer	Introduction The progression of human papillomavirus (HPV) infection in the anogenital tract has been associated with the involvement of cells with regulatory properties. Evidence has shown that glucocorticoid-induced tumor necrosis factor receptor (GITR) is an important surface molecule for the characterization of these cells and proposes that GITR ligand may constitute a rational treatment for many cancer types. We aimed to detect the presence of GITR and CD25 in cervical stroma cells with and without pathological changes or HPV infection to better understand the immune response in the infected tissue microenvironment. Methods We subjected 49 paraffin-embedded cervical tissue samples to HPV DNA detection and histopathological analysis, and subsequently immunohistochemistry to detect GITR and CD25 in lymphocytes. Results We observed that 76.9% of all samples with high GITR expression were HPV-positive regardless of histopathological findings. High GITR expression (77.8%) was predominant in samples with ≥1,000 RLU/PCB. Of the HPV-positive samples negative for intraepithelial lesion and malignancy, 62.5% had high GITR expression. High GITR expression was observed in both carcinoma and high-grade squamous intraepithelial lesion (HSIL) samples (p = 0.16). CD25 was present in great quantities in all samples. Conclusions The predominance of high GITR expression in samples with high viral load that were classified as HSIL and carcinoma suggests that GITR+ cells can exhibit regulatory properties and may contribute to the progression of HPV-induced cervical neoplasia, emphasizing the importance of GITR as a potential target for immune therapy of cervical cancer and as a disease evolution biomarker.
abstract_unstemmed	Introduction The progression of human papillomavirus (HPV) infection in the anogenital tract has been associated with the involvement of cells with regulatory properties. Evidence has shown that glucocorticoid-induced tumor necrosis factor receptor (GITR) is an important surface molecule for the characterization of these cells and proposes that GITR ligand may constitute a rational treatment for many cancer types. We aimed to detect the presence of GITR and CD25 in cervical stroma cells with and without pathological changes or HPV infection to better understand the immune response in the infected tissue microenvironment. Methods We subjected 49 paraffin-embedded cervical tissue samples to HPV DNA detection and histopathological analysis, and subsequently immunohistochemistry to detect GITR and CD25 in lymphocytes. Results We observed that 76.9% of all samples with high GITR expression were HPV-positive regardless of histopathological findings. High GITR expression (77.8%) was predominant in samples with ≥1,000 RLU/PCB. Of the HPV-positive samples negative for intraepithelial lesion and malignancy, 62.5% had high GITR expression. High GITR expression was observed in both carcinoma and high-grade squamous intraepithelial lesion (HSIL) samples (p = 0.16). CD25 was present in great quantities in all samples. Conclusions The predominance of high GITR expression in samples with high viral load that were classified as HSIL and carcinoma suggests that GITR+ cells can exhibit regulatory properties and may contribute to the progression of HPV-induced cervical neoplasia, emphasizing the importance of GITR as a potential target for immune therapy of cervical cancer and as a disease evolution biomarker.
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title_short	Glucocorticoid-induced tumor necrosis factor receptor expression in patients with cervical human papillomavirus infection
url	https://doi.org/10.1590/0037-8682-0029-2013 https://doaj.org/article/01db04438d0d4e1ebf74c177ce8cfa4f http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0037-86822013000300288&lng=en&tlng=en https://doaj.org/toc/1678-9849
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up_date	2024-07-03T23:38:01.874Z
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High GITR expression was observed in both carcinoma and high-grade squamous intraepithelial lesion (HSIL) samples (p = 0.16). CD25 was present in great quantities in all samples. Conclusions The predominance of high GITR expression in samples with high viral load that were classified as HSIL and carcinoma suggests that GITR+ cells can exhibit regulatory properties and may contribute to the progression of HPV-induced cervical neoplasia, emphasizing the importance of GITR as a potential target for immune therapy of cervical cancer and as a disease evolution biomarker.</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a">Human papillomavirus</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a">Immune response</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a">Immunohistochemistry</subfield></datafield><datafield tag="653" ind1=" " ind2="0"><subfield code="a">Arctic medicine. 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