The Role of Ribonuclease 1 and Ribonuclease Inhibitor 1 in Acute Kidney Injury after Open and Endovascular Thoracoabdominal Aortic Aneurysm Repair

Acute kidney injury (AKI) is one of the most common post-operative complications and is closely associated with increased mortality after open and endovascular thoracoabdominal aortic aneurysm (TAAA) repair. Ribonuclease (RNase) 1 belongs to the group of antimicrobial peptides elevated in septic pat...
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Autor*in:	Elisabeth Zechendorf [verfasserIn] Alexander Gombert [verfasserIn] Tanja Bülow [verfasserIn] Nadine Frank [verfasserIn] Christian Beckers [verfasserIn] Arne Peine [verfasserIn] Drosos Kotelis [verfasserIn] Michael J. Jacobs [verfasserIn] Gernot Marx [verfasserIn] Lukas Martin [verfasserIn]

Format:	E-Artikel
Sprache:	Englisch

Erschienen:	2020

Schlagwörter:	thoracoabdominal aortic aneurysm ribonuclease ribonuclease inhibitor 1 biomarker complex aortic surgery acute kidney injury

Übergeordnetes Werk:	In: Journal of Clinical Medicine - MDPI AG, 2013, 9(2020), 10, p 3292
Übergeordnetes Werk:	volume:9 ; year:2020 ; number:10, p 3292

Links:	Link aufrufen Link aufrufen Link aufrufen Journal toc

DOI / URN:	10.3390/jcm9103292

Katalog-ID:	DOAJ044673531

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520			\|a Acute kidney injury (AKI) is one of the most common post-operative complications and is closely associated with increased mortality after open and endovascular thoracoabdominal aortic aneurysm (TAAA) repair. Ribonuclease (RNase) 1 belongs to the group of antimicrobial peptides elevated in septic patients and indicates the prediction of two or more organ failures. The role of RNase 1 and its antagonist RNase inhibitor 1 (RNH1) after TAAA repair is unknown. In this study, we analyzed RNase 1 and RNH1 serum levels in patients undergoing open (<i<n</i< = 14) or endovascular (<i<n</i< = 19) TAAA repair to determine their association with post-operative AKI and in-hospital mortality. Increased RNH1 serum levels after open TAAA repair as compared with endovascular TAAA repair immediately after surgery and 12, 48, and 72 h after surgery (all <i<p</i< < 0.05) were observed. Additionally, elevated RNase 1 and RNH1 serum levels 12, 24, and 48 h after surgery were shown to be significantly associated with AKI (all <i<p</i< < 0.05). RNH1 serum levels before and RNase 1 serum levels 12 h after TAAA repair were significantly correlated with in-hospital mortality (both <i<p</i< < 0.05). On the basis of these findings, RNase 1 and RNH1 may be therapeutically relevant and may represent biomarkers for post-operative AKI and in-hospital mortality.
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allfields	10.3390/jcm9103292 doi (DE-627)DOAJ044673531 (DE-599)DOAJbb62de05ec1845e98ed4d0c00dc7b686 DE-627 ger DE-627 rakwb eng Elisabeth Zechendorf verfasserin aut The Role of Ribonuclease 1 and Ribonuclease Inhibitor 1 in Acute Kidney Injury after Open and Endovascular Thoracoabdominal Aortic Aneurysm Repair 2020 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Acute kidney injury (AKI) is one of the most common post-operative complications and is closely associated with increased mortality after open and endovascular thoracoabdominal aortic aneurysm (TAAA) repair. Ribonuclease (RNase) 1 belongs to the group of antimicrobial peptides elevated in septic patients and indicates the prediction of two or more organ failures. The role of RNase 1 and its antagonist RNase inhibitor 1 (RNH1) after TAAA repair is unknown. In this study, we analyzed RNase 1 and RNH1 serum levels in patients undergoing open (<i<n</i< = 14) or endovascular (<i<n</i< = 19) TAAA repair to determine their association with post-operative AKI and in-hospital mortality. Increased RNH1 serum levels after open TAAA repair as compared with endovascular TAAA repair immediately after surgery and 12, 48, and 72 h after surgery (all <i<p</i< < 0.05) were observed. Additionally, elevated RNase 1 and RNH1 serum levels 12, 24, and 48 h after surgery were shown to be significantly associated with AKI (all <i<p</i< < 0.05). RNH1 serum levels before and RNase 1 serum levels 12 h after TAAA repair were significantly correlated with in-hospital mortality (both <i<p</i< < 0.05). On the basis of these findings, RNase 1 and RNH1 may be therapeutically relevant and may represent biomarkers for post-operative AKI and in-hospital mortality. thoracoabdominal aortic aneurysm ribonuclease ribonuclease inhibitor 1 biomarker complex aortic surgery acute kidney injury Medicine R Alexander Gombert verfasserin aut Tanja Bülow verfasserin aut Nadine Frank verfasserin aut Christian Beckers verfasserin aut Arne Peine verfasserin aut Drosos Kotelis verfasserin aut Michael J. Jacobs verfasserin aut Gernot Marx verfasserin aut Lukas Martin verfasserin aut In Journal of Clinical Medicine MDPI AG, 2013 9(2020), 10, p 3292 (DE-627)718632478 (DE-600)2662592-1 20770383 nnns volume:9 year:2020 number:10, p 3292 https://doi.org/10.3390/jcm9103292 kostenfrei https://doaj.org/article/bb62de05ec1845e98ed4d0c00dc7b686 kostenfrei https://www.mdpi.com/2077-0383/9/10/3292 kostenfrei https://doaj.org/toc/2077-0383 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2005 GBV_ILN_2009 GBV_ILN_2014 GBV_ILN_2055 GBV_ILN_2111 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 9 2020 10, p 3292
spelling	10.3390/jcm9103292 doi (DE-627)DOAJ044673531 (DE-599)DOAJbb62de05ec1845e98ed4d0c00dc7b686 DE-627 ger DE-627 rakwb eng Elisabeth Zechendorf verfasserin aut The Role of Ribonuclease 1 and Ribonuclease Inhibitor 1 in Acute Kidney Injury after Open and Endovascular Thoracoabdominal Aortic Aneurysm Repair 2020 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Acute kidney injury (AKI) is one of the most common post-operative complications and is closely associated with increased mortality after open and endovascular thoracoabdominal aortic aneurysm (TAAA) repair. Ribonuclease (RNase) 1 belongs to the group of antimicrobial peptides elevated in septic patients and indicates the prediction of two or more organ failures. The role of RNase 1 and its antagonist RNase inhibitor 1 (RNH1) after TAAA repair is unknown. In this study, we analyzed RNase 1 and RNH1 serum levels in patients undergoing open (<i<n</i< = 14) or endovascular (<i<n</i< = 19) TAAA repair to determine their association with post-operative AKI and in-hospital mortality. Increased RNH1 serum levels after open TAAA repair as compared with endovascular TAAA repair immediately after surgery and 12, 48, and 72 h after surgery (all <i<p</i< < 0.05) were observed. Additionally, elevated RNase 1 and RNH1 serum levels 12, 24, and 48 h after surgery were shown to be significantly associated with AKI (all <i<p</i< < 0.05). RNH1 serum levels before and RNase 1 serum levels 12 h after TAAA repair were significantly correlated with in-hospital mortality (both <i<p</i< < 0.05). On the basis of these findings, RNase 1 and RNH1 may be therapeutically relevant and may represent biomarkers for post-operative AKI and in-hospital mortality. thoracoabdominal aortic aneurysm ribonuclease ribonuclease inhibitor 1 biomarker complex aortic surgery acute kidney injury Medicine R Alexander Gombert verfasserin aut Tanja Bülow verfasserin aut Nadine Frank verfasserin aut Christian Beckers verfasserin aut Arne Peine verfasserin aut Drosos Kotelis verfasserin aut Michael J. Jacobs verfasserin aut Gernot Marx verfasserin aut Lukas Martin verfasserin aut In Journal of Clinical Medicine MDPI AG, 2013 9(2020), 10, p 3292 (DE-627)718632478 (DE-600)2662592-1 20770383 nnns volume:9 year:2020 number:10, p 3292 https://doi.org/10.3390/jcm9103292 kostenfrei https://doaj.org/article/bb62de05ec1845e98ed4d0c00dc7b686 kostenfrei https://www.mdpi.com/2077-0383/9/10/3292 kostenfrei https://doaj.org/toc/2077-0383 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2005 GBV_ILN_2009 GBV_ILN_2014 GBV_ILN_2055 GBV_ILN_2111 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 9 2020 10, p 3292
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allfieldsSound	10.3390/jcm9103292 doi (DE-627)DOAJ044673531 (DE-599)DOAJbb62de05ec1845e98ed4d0c00dc7b686 DE-627 ger DE-627 rakwb eng Elisabeth Zechendorf verfasserin aut The Role of Ribonuclease 1 and Ribonuclease Inhibitor 1 in Acute Kidney Injury after Open and Endovascular Thoracoabdominal Aortic Aneurysm Repair 2020 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Acute kidney injury (AKI) is one of the most common post-operative complications and is closely associated with increased mortality after open and endovascular thoracoabdominal aortic aneurysm (TAAA) repair. Ribonuclease (RNase) 1 belongs to the group of antimicrobial peptides elevated in septic patients and indicates the prediction of two or more organ failures. The role of RNase 1 and its antagonist RNase inhibitor 1 (RNH1) after TAAA repair is unknown. In this study, we analyzed RNase 1 and RNH1 serum levels in patients undergoing open (<i<n</i< = 14) or endovascular (<i<n</i< = 19) TAAA repair to determine their association with post-operative AKI and in-hospital mortality. Increased RNH1 serum levels after open TAAA repair as compared with endovascular TAAA repair immediately after surgery and 12, 48, and 72 h after surgery (all <i<p</i< < 0.05) were observed. Additionally, elevated RNase 1 and RNH1 serum levels 12, 24, and 48 h after surgery were shown to be significantly associated with AKI (all <i<p</i< < 0.05). RNH1 serum levels before and RNase 1 serum levels 12 h after TAAA repair were significantly correlated with in-hospital mortality (both <i<p</i< < 0.05). On the basis of these findings, RNase 1 and RNH1 may be therapeutically relevant and may represent biomarkers for post-operative AKI and in-hospital mortality. thoracoabdominal aortic aneurysm ribonuclease ribonuclease inhibitor 1 biomarker complex aortic surgery acute kidney injury Medicine R Alexander Gombert verfasserin aut Tanja Bülow verfasserin aut Nadine Frank verfasserin aut Christian Beckers verfasserin aut Arne Peine verfasserin aut Drosos Kotelis verfasserin aut Michael J. Jacobs verfasserin aut Gernot Marx verfasserin aut Lukas Martin verfasserin aut In Journal of Clinical Medicine MDPI AG, 2013 9(2020), 10, p 3292 (DE-627)718632478 (DE-600)2662592-1 20770383 nnns volume:9 year:2020 number:10, p 3292 https://doi.org/10.3390/jcm9103292 kostenfrei https://doaj.org/article/bb62de05ec1845e98ed4d0c00dc7b686 kostenfrei https://www.mdpi.com/2077-0383/9/10/3292 kostenfrei https://doaj.org/toc/2077-0383 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2005 GBV_ILN_2009 GBV_ILN_2014 GBV_ILN_2055 GBV_ILN_2111 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 9 2020 10, p 3292
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author	Elisabeth Zechendorf
spellingShingle	Elisabeth Zechendorf misc thoracoabdominal aortic aneurysm misc ribonuclease misc ribonuclease inhibitor 1 misc biomarker misc complex aortic surgery misc acute kidney injury misc Medicine misc R The Role of Ribonuclease 1 and Ribonuclease Inhibitor 1 in Acute Kidney Injury after Open and Endovascular Thoracoabdominal Aortic Aneurysm Repair
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topic_title	The Role of Ribonuclease 1 and Ribonuclease Inhibitor 1 in Acute Kidney Injury after Open and Endovascular Thoracoabdominal Aortic Aneurysm Repair thoracoabdominal aortic aneurysm ribonuclease ribonuclease inhibitor 1 biomarker complex aortic surgery acute kidney injury
topic	misc thoracoabdominal aortic aneurysm misc ribonuclease misc ribonuclease inhibitor 1 misc biomarker misc complex aortic surgery misc acute kidney injury misc Medicine misc R
topic_unstemmed	misc thoracoabdominal aortic aneurysm misc ribonuclease misc ribonuclease inhibitor 1 misc biomarker misc complex aortic surgery misc acute kidney injury misc Medicine misc R
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title	The Role of Ribonuclease 1 and Ribonuclease Inhibitor 1 in Acute Kidney Injury after Open and Endovascular Thoracoabdominal Aortic Aneurysm Repair
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title_full	The Role of Ribonuclease 1 and Ribonuclease Inhibitor 1 in Acute Kidney Injury after Open and Endovascular Thoracoabdominal Aortic Aneurysm Repair
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author_browse	Elisabeth Zechendorf Alexander Gombert Tanja Bülow Nadine Frank Christian Beckers Arne Peine Drosos Kotelis Michael J. Jacobs Gernot Marx Lukas Martin
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title_sort	role of ribonuclease 1 and ribonuclease inhibitor 1 in acute kidney injury after open and endovascular thoracoabdominal aortic aneurysm repair
title_auth	The Role of Ribonuclease 1 and Ribonuclease Inhibitor 1 in Acute Kidney Injury after Open and Endovascular Thoracoabdominal Aortic Aneurysm Repair
abstract	Acute kidney injury (AKI) is one of the most common post-operative complications and is closely associated with increased mortality after open and endovascular thoracoabdominal aortic aneurysm (TAAA) repair. Ribonuclease (RNase) 1 belongs to the group of antimicrobial peptides elevated in septic patients and indicates the prediction of two or more organ failures. The role of RNase 1 and its antagonist RNase inhibitor 1 (RNH1) after TAAA repair is unknown. In this study, we analyzed RNase 1 and RNH1 serum levels in patients undergoing open (<i<n</i< = 14) or endovascular (<i<n</i< = 19) TAAA repair to determine their association with post-operative AKI and in-hospital mortality. Increased RNH1 serum levels after open TAAA repair as compared with endovascular TAAA repair immediately after surgery and 12, 48, and 72 h after surgery (all <i<p</i< < 0.05) were observed. Additionally, elevated RNase 1 and RNH1 serum levels 12, 24, and 48 h after surgery were shown to be significantly associated with AKI (all <i<p</i< < 0.05). RNH1 serum levels before and RNase 1 serum levels 12 h after TAAA repair were significantly correlated with in-hospital mortality (both <i<p</i< < 0.05). On the basis of these findings, RNase 1 and RNH1 may be therapeutically relevant and may represent biomarkers for post-operative AKI and in-hospital mortality.
abstractGer	Acute kidney injury (AKI) is one of the most common post-operative complications and is closely associated with increased mortality after open and endovascular thoracoabdominal aortic aneurysm (TAAA) repair. Ribonuclease (RNase) 1 belongs to the group of antimicrobial peptides elevated in septic patients and indicates the prediction of two or more organ failures. The role of RNase 1 and its antagonist RNase inhibitor 1 (RNH1) after TAAA repair is unknown. In this study, we analyzed RNase 1 and RNH1 serum levels in patients undergoing open (<i<n</i< = 14) or endovascular (<i<n</i< = 19) TAAA repair to determine their association with post-operative AKI and in-hospital mortality. Increased RNH1 serum levels after open TAAA repair as compared with endovascular TAAA repair immediately after surgery and 12, 48, and 72 h after surgery (all <i<p</i< < 0.05) were observed. Additionally, elevated RNase 1 and RNH1 serum levels 12, 24, and 48 h after surgery were shown to be significantly associated with AKI (all <i<p</i< < 0.05). RNH1 serum levels before and RNase 1 serum levels 12 h after TAAA repair were significantly correlated with in-hospital mortality (both <i<p</i< < 0.05). On the basis of these findings, RNase 1 and RNH1 may be therapeutically relevant and may represent biomarkers for post-operative AKI and in-hospital mortality.
abstract_unstemmed	Acute kidney injury (AKI) is one of the most common post-operative complications and is closely associated with increased mortality after open and endovascular thoracoabdominal aortic aneurysm (TAAA) repair. Ribonuclease (RNase) 1 belongs to the group of antimicrobial peptides elevated in septic patients and indicates the prediction of two or more organ failures. The role of RNase 1 and its antagonist RNase inhibitor 1 (RNH1) after TAAA repair is unknown. In this study, we analyzed RNase 1 and RNH1 serum levels in patients undergoing open (<i<n</i< = 14) or endovascular (<i<n</i< = 19) TAAA repair to determine their association with post-operative AKI and in-hospital mortality. Increased RNH1 serum levels after open TAAA repair as compared with endovascular TAAA repair immediately after surgery and 12, 48, and 72 h after surgery (all <i<p</i< < 0.05) were observed. Additionally, elevated RNase 1 and RNH1 serum levels 12, 24, and 48 h after surgery were shown to be significantly associated with AKI (all <i<p</i< < 0.05). RNH1 serum levels before and RNase 1 serum levels 12 h after TAAA repair were significantly correlated with in-hospital mortality (both <i<p</i< < 0.05). On the basis of these findings, RNase 1 and RNH1 may be therapeutically relevant and may represent biomarkers for post-operative AKI and in-hospital mortality.
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title_short	The Role of Ribonuclease 1 and Ribonuclease Inhibitor 1 in Acute Kidney Injury after Open and Endovascular Thoracoabdominal Aortic Aneurysm Repair
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author2	Alexander Gombert Tanja Bülow Nadine Frank Christian Beckers Arne Peine Drosos Kotelis Michael J. Jacobs Gernot Marx Lukas Martin
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up_date	2024-07-04T00:02:29.762Z
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The Role of Ribonuclease 1 and Ribonuclease Inhibitor 1 in Acute Kidney Injury after Open and Endovascular Thoracoabdominal Aortic Aneurysm Repair

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