Genomic and immunological profiles of small-cell lung cancer between East Asians and Caucasian

Abstract The characterization of immunological and genomic differences in small-cell lung cancer (SCLC) between East Asian (EA) and Caucasian patients can reveal important clinical therapies for EA patients with SCLC. By sequencing and analyzing a molecular and immunological dataset of 98-SCLC patie...
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Autor*in:	Anqi Lin [verfasserIn] Ningning Zhou [verfasserIn] Weiliang Zhu [verfasserIn] Jiexia Zhang [verfasserIn] Ting Wei [verfasserIn] Linlang Guo [verfasserIn] Peng Luo [verfasserIn] Jian Zhang [verfasserIn]

Format:	E-Artikel
Sprache:	Englisch

Erschienen:	2022

Schlagwörter:	SCLC East Asian Caucasian Genomic Immune-infiltrating

Übergeordnetes Werk:	In: Cancer Cell International - BMC, 2003, 22(2022), 1, Seite 16
Übergeordnetes Werk:	volume:22 ; year:2022 ; number:1 ; pages:16

Links:	Link aufrufen Link aufrufen Link aufrufen Journal toc

DOI / URN:	10.1186/s12935-022-02588-w

Katalog-ID:	DOAJ04469055X

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520			\|a Abstract The characterization of immunological and genomic differences in small-cell lung cancer (SCLC) between East Asian (EA) and Caucasian patients can reveal important clinical therapies for EA patients with SCLC. By sequencing and analyzing a molecular and immunological dataset of 98-SCLC patients of EA ancestry, immunogenicity, including DNA damage repair alterations and tumor mutation burden (TMB), was found to be significantly higher in the EA cohort than in the Caucasian cohort. The epithelial-mesenchymal transition (EMT) was the signaling signature with the predominant frequency of mutations across all patients in the EA cohort. Analysis of tumor-infiltrated immune cells revealed that resting lymphocytes were significantly enriched in the EA cohort. Compound-targeting analysis showed that topoisomerase inhibitors might be capable of targeting TP53 and RB1 comutations in EA SCLC patients. EA SCLC patients who harbored COL6A6 mutations had poor survival, while Caucasian SCLC patients with OTOF, ANKRD30B, and TECPR2 mutations were identified to have a shorter survival.
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spelling	10.1186/s12935-022-02588-w doi (DE-627)DOAJ04469055X (DE-599)DOAJa479861fe7c64f5daf01a52c0b10ae36 DE-627 ger DE-627 rakwb eng RC254-282 QH573-671 Anqi Lin verfasserin aut Genomic and immunological profiles of small-cell lung cancer between East Asians and Caucasian 2022 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Abstract The characterization of immunological and genomic differences in small-cell lung cancer (SCLC) between East Asian (EA) and Caucasian patients can reveal important clinical therapies for EA patients with SCLC. By sequencing and analyzing a molecular and immunological dataset of 98-SCLC patients of EA ancestry, immunogenicity, including DNA damage repair alterations and tumor mutation burden (TMB), was found to be significantly higher in the EA cohort than in the Caucasian cohort. The epithelial-mesenchymal transition (EMT) was the signaling signature with the predominant frequency of mutations across all patients in the EA cohort. Analysis of tumor-infiltrated immune cells revealed that resting lymphocytes were significantly enriched in the EA cohort. Compound-targeting analysis showed that topoisomerase inhibitors might be capable of targeting TP53 and RB1 comutations in EA SCLC patients. EA SCLC patients who harbored COL6A6 mutations had poor survival, while Caucasian SCLC patients with OTOF, ANKRD30B, and TECPR2 mutations were identified to have a shorter survival. SCLC East Asian Caucasian Genomic Immune-infiltrating Neoplasms. Tumors. Oncology. Including cancer and carcinogens Cytology Ningning Zhou verfasserin aut Weiliang Zhu verfasserin aut Jiexia Zhang verfasserin aut Ting Wei verfasserin aut Linlang Guo verfasserin aut Peng Luo verfasserin aut Jian Zhang verfasserin aut In Cancer Cell International BMC, 2003 22(2022), 1, Seite 16 (DE-627)355989204 (DE-600)2091573-1 14752867 nnns volume:22 year:2022 number:1 pages:16 https://doi.org/10.1186/s12935-022-02588-w kostenfrei https://doaj.org/article/a479861fe7c64f5daf01a52c0b10ae36 kostenfrei https://doi.org/10.1186/s12935-022-02588-w kostenfrei https://doaj.org/toc/1475-2867 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2009 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2055 GBV_ILN_2111 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 22 2022 1 16
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allfieldsSound	10.1186/s12935-022-02588-w doi (DE-627)DOAJ04469055X (DE-599)DOAJa479861fe7c64f5daf01a52c0b10ae36 DE-627 ger DE-627 rakwb eng RC254-282 QH573-671 Anqi Lin verfasserin aut Genomic and immunological profiles of small-cell lung cancer between East Asians and Caucasian 2022 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Abstract The characterization of immunological and genomic differences in small-cell lung cancer (SCLC) between East Asian (EA) and Caucasian patients can reveal important clinical therapies for EA patients with SCLC. By sequencing and analyzing a molecular and immunological dataset of 98-SCLC patients of EA ancestry, immunogenicity, including DNA damage repair alterations and tumor mutation burden (TMB), was found to be significantly higher in the EA cohort than in the Caucasian cohort. The epithelial-mesenchymal transition (EMT) was the signaling signature with the predominant frequency of mutations across all patients in the EA cohort. Analysis of tumor-infiltrated immune cells revealed that resting lymphocytes were significantly enriched in the EA cohort. Compound-targeting analysis showed that topoisomerase inhibitors might be capable of targeting TP53 and RB1 comutations in EA SCLC patients. EA SCLC patients who harbored COL6A6 mutations had poor survival, while Caucasian SCLC patients with OTOF, ANKRD30B, and TECPR2 mutations were identified to have a shorter survival. SCLC East Asian Caucasian Genomic Immune-infiltrating Neoplasms. Tumors. Oncology. Including cancer and carcinogens Cytology Ningning Zhou verfasserin aut Weiliang Zhu verfasserin aut Jiexia Zhang verfasserin aut Ting Wei verfasserin aut Linlang Guo verfasserin aut Peng Luo verfasserin aut Jian Zhang verfasserin aut In Cancer Cell International BMC, 2003 22(2022), 1, Seite 16 (DE-627)355989204 (DE-600)2091573-1 14752867 nnns volume:22 year:2022 number:1 pages:16 https://doi.org/10.1186/s12935-022-02588-w kostenfrei https://doaj.org/article/a479861fe7c64f5daf01a52c0b10ae36 kostenfrei https://doi.org/10.1186/s12935-022-02588-w kostenfrei https://doaj.org/toc/1475-2867 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2009 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2055 GBV_ILN_2111 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 22 2022 1 16
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topic_facet	SCLC East Asian Caucasian Genomic Immune-infiltrating Neoplasms. Tumors. Oncology. Including cancer and carcinogens Cytology
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container_title	Cancer Cell International
authorswithroles_txt_mv	Anqi Lin @@aut@@ Ningning Zhou @@aut@@ Weiliang Zhu @@aut@@ Jiexia Zhang @@aut@@ Ting Wei @@aut@@ Linlang Guo @@aut@@ Peng Luo @@aut@@ Jian Zhang @@aut@@
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callnumber-first	R - Medicine
author	Anqi Lin
spellingShingle	Anqi Lin misc RC254-282 misc QH573-671 misc SCLC misc East Asian misc Caucasian misc Genomic misc Immune-infiltrating misc Neoplasms. Tumors. Oncology. Including cancer and carcinogens misc Cytology Genomic and immunological profiles of small-cell lung cancer between East Asians and Caucasian
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topic_title	RC254-282 QH573-671 Genomic and immunological profiles of small-cell lung cancer between East Asians and Caucasian SCLC East Asian Caucasian Genomic Immune-infiltrating
topic	misc RC254-282 misc QH573-671 misc SCLC misc East Asian misc Caucasian misc Genomic misc Immune-infiltrating misc Neoplasms. Tumors. Oncology. Including cancer and carcinogens misc Cytology
topic_unstemmed	misc RC254-282 misc QH573-671 misc SCLC misc East Asian misc Caucasian misc Genomic misc Immune-infiltrating misc Neoplasms. Tumors. Oncology. Including cancer and carcinogens misc Cytology
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title	Genomic and immunological profiles of small-cell lung cancer between East Asians and Caucasian
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title_full	Genomic and immunological profiles of small-cell lung cancer between East Asians and Caucasian
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title_sort	genomic and immunological profiles of small-cell lung cancer between east asians and caucasian
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title_auth	Genomic and immunological profiles of small-cell lung cancer between East Asians and Caucasian
abstract	Abstract The characterization of immunological and genomic differences in small-cell lung cancer (SCLC) between East Asian (EA) and Caucasian patients can reveal important clinical therapies for EA patients with SCLC. By sequencing and analyzing a molecular and immunological dataset of 98-SCLC patients of EA ancestry, immunogenicity, including DNA damage repair alterations and tumor mutation burden (TMB), was found to be significantly higher in the EA cohort than in the Caucasian cohort. The epithelial-mesenchymal transition (EMT) was the signaling signature with the predominant frequency of mutations across all patients in the EA cohort. Analysis of tumor-infiltrated immune cells revealed that resting lymphocytes were significantly enriched in the EA cohort. Compound-targeting analysis showed that topoisomerase inhibitors might be capable of targeting TP53 and RB1 comutations in EA SCLC patients. EA SCLC patients who harbored COL6A6 mutations had poor survival, while Caucasian SCLC patients with OTOF, ANKRD30B, and TECPR2 mutations were identified to have a shorter survival.
abstractGer	Abstract The characterization of immunological and genomic differences in small-cell lung cancer (SCLC) between East Asian (EA) and Caucasian patients can reveal important clinical therapies for EA patients with SCLC. By sequencing and analyzing a molecular and immunological dataset of 98-SCLC patients of EA ancestry, immunogenicity, including DNA damage repair alterations and tumor mutation burden (TMB), was found to be significantly higher in the EA cohort than in the Caucasian cohort. The epithelial-mesenchymal transition (EMT) was the signaling signature with the predominant frequency of mutations across all patients in the EA cohort. Analysis of tumor-infiltrated immune cells revealed that resting lymphocytes were significantly enriched in the EA cohort. Compound-targeting analysis showed that topoisomerase inhibitors might be capable of targeting TP53 and RB1 comutations in EA SCLC patients. EA SCLC patients who harbored COL6A6 mutations had poor survival, while Caucasian SCLC patients with OTOF, ANKRD30B, and TECPR2 mutations were identified to have a shorter survival.
abstract_unstemmed	Abstract The characterization of immunological and genomic differences in small-cell lung cancer (SCLC) between East Asian (EA) and Caucasian patients can reveal important clinical therapies for EA patients with SCLC. By sequencing and analyzing a molecular and immunological dataset of 98-SCLC patients of EA ancestry, immunogenicity, including DNA damage repair alterations and tumor mutation burden (TMB), was found to be significantly higher in the EA cohort than in the Caucasian cohort. The epithelial-mesenchymal transition (EMT) was the signaling signature with the predominant frequency of mutations across all patients in the EA cohort. Analysis of tumor-infiltrated immune cells revealed that resting lymphocytes were significantly enriched in the EA cohort. Compound-targeting analysis showed that topoisomerase inhibitors might be capable of targeting TP53 and RB1 comutations in EA SCLC patients. EA SCLC patients who harbored COL6A6 mutations had poor survival, while Caucasian SCLC patients with OTOF, ANKRD30B, and TECPR2 mutations were identified to have a shorter survival.
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title_short	Genomic and immunological profiles of small-cell lung cancer between East Asians and Caucasian
url	https://doi.org/10.1186/s12935-022-02588-w https://doaj.org/article/a479861fe7c64f5daf01a52c0b10ae36 https://doaj.org/toc/1475-2867
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Genomic and immunological profiles of small-cell lung cancer between East Asians and Caucasian

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