Risk factors for death in 632 patients with sickle cell disease in the United States and United Kingdom.

The role of pulmonary hypertension as a cause of mortality in sickle cell disease (SCD) is controversial.We evaluated the relationship between an elevated estimated pulmonary artery systolic pressure and mortality in patients with SCD. We followed patients from the walk-PHaSST screening cohort for a...
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Autor*in:	Mark T Gladwin [verfasserIn] Robyn J Barst [verfasserIn] J Simon R Gibbs [verfasserIn] Mariana Hildesheim [verfasserIn] Vandana Sachdev [verfasserIn] Mehdi Nouraie [verfasserIn] Kathryn L Hassell [verfasserIn] Jane A Little [verfasserIn] Dean E Schraufnagel [verfasserIn] Lakshmanan Krishnamurti [verfasserIn] Enrico Novelli [verfasserIn] Reda E Girgis [verfasserIn] Claudia R Morris [verfasserIn] Erika Berman Rosenzweig [verfasserIn] David B Badesch [verfasserIn] Sophie Lanzkron [verfasserIn] Oswaldo L Castro [verfasserIn] James G Taylor [verfasserIn] Jonathan C Goldsmith [verfasserIn] Gregory J Kato [verfasserIn] Victor R Gordeuk [verfasserIn] Roberto F Machado [verfasserIn] walk-PHaSST Investigators and Patients [verfasserIn]

Format:	E-Artikel
Sprache:	Englisch

Erschienen:	2014

Übergeordnetes Werk:	In: PLoS ONE - Public Library of Science (PLoS), 2007, 9(2014), 7, p e99489
Übergeordnetes Werk:	volume:9 ; year:2014 ; number:7, p e99489

Links:	Link aufrufen Link aufrufen Link aufrufen Journal toc

DOI / URN:	10.1371/journal.pone.0099489

Katalog-ID:	DOAJ044756348

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allfields	10.1371/journal.pone.0099489 doi (DE-627)DOAJ044756348 (DE-599)DOAJ36ede0ae221943d1887a84c560bea8cc DE-627 ger DE-627 rakwb eng Mark T Gladwin verfasserin aut Risk factors for death in 632 patients with sickle cell disease in the United States and United Kingdom. 2014 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier The role of pulmonary hypertension as a cause of mortality in sickle cell disease (SCD) is controversial.We evaluated the relationship between an elevated estimated pulmonary artery systolic pressure and mortality in patients with SCD. We followed patients from the walk-PHaSST screening cohort for a median of 29 months. A tricuspid regurgitation velocity (TRV)≥ 3.0 m/s cuttof, which has a 67-75% positive predictive value for mean pulmonary artery pressure ≥ 25 mm Hg was used. Among 572 subjects, 11.2% had TRV ≥ 3.0 m/sec. Among 582 with a measured NT-proBNP, 24.1% had values ≥ 160 pg/mL. Of 22 deaths during follow-up, 50% had a TRV ≥ 3.0 m/sec. At 24 months the cumulative survival was 83% with TRV ≥ 3.0 m/sec and 98% with TRV < 3.0 m/sec (p < 0.0001). The hazard ratios for death were 11.1 (95% CI 4.1-30.1; p < 0.0001) for TRV ≥ 3.0 m/sec, 4.6 (1.8-11.3; p = 0.001) for NT-proBNP ≥ 160 pg/mL, and 14.9 (5.5-39.9; p < 0.0001) for both TRV ≥ 3.0 m/sec and NT-proBNP ≥ 160 pg/mL. Age < 47 years, male gender, chronic transfusions, WHO class III-IV, increased hemolytic markers, ferritin and creatinine were also associated with increased risk of death.A TRV ≥ 3.0 m/sec occurs in approximately 10% of individuals and has the highest risk for death of any measured variable. The study is registered in ClinicalTrials.gov with identifier: NCT00492531. Medicine R Science Q Robyn J Barst verfasserin aut J Simon R Gibbs verfasserin aut Mariana Hildesheim verfasserin aut Vandana Sachdev verfasserin aut Mehdi Nouraie verfasserin aut Kathryn L Hassell verfasserin aut Jane A Little verfasserin aut Dean E Schraufnagel verfasserin aut Lakshmanan Krishnamurti verfasserin aut Enrico Novelli verfasserin aut Reda E Girgis verfasserin aut Claudia R Morris verfasserin aut Erika Berman Rosenzweig verfasserin aut David B Badesch verfasserin aut Sophie Lanzkron verfasserin aut Oswaldo L Castro verfasserin aut James G Taylor verfasserin aut Jonathan C Goldsmith verfasserin aut Gregory J Kato verfasserin aut Victor R Gordeuk verfasserin aut Roberto F Machado verfasserin aut walk-PHaSST Investigators and Patients verfasserin aut In PLoS ONE Public Library of Science (PLoS), 2007 9(2014), 7, p e99489 (DE-627)523574592 (DE-600)2267670-3 19326203 nnns volume:9 year:2014 number:7, p e99489 https://doi.org/10.1371/journal.pone.0099489 kostenfrei https://doaj.org/article/36ede0ae221943d1887a84c560bea8cc kostenfrei http://europepmc.org/articles/PMC4079316?pdf=render kostenfrei https://doaj.org/toc/1932-6203 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_34 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_206 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_235 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2031 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2057 GBV_ILN_2061 GBV_ILN_2111 GBV_ILN_2113 GBV_ILN_2190 GBV_ILN_2522 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4335 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 9 2014 7, p e99489
spelling	10.1371/journal.pone.0099489 doi (DE-627)DOAJ044756348 (DE-599)DOAJ36ede0ae221943d1887a84c560bea8cc DE-627 ger DE-627 rakwb eng Mark T Gladwin verfasserin aut Risk factors for death in 632 patients with sickle cell disease in the United States and United Kingdom. 2014 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier The role of pulmonary hypertension as a cause of mortality in sickle cell disease (SCD) is controversial.We evaluated the relationship between an elevated estimated pulmonary artery systolic pressure and mortality in patients with SCD. We followed patients from the walk-PHaSST screening cohort for a median of 29 months. A tricuspid regurgitation velocity (TRV)≥ 3.0 m/s cuttof, which has a 67-75% positive predictive value for mean pulmonary artery pressure ≥ 25 mm Hg was used. Among 572 subjects, 11.2% had TRV ≥ 3.0 m/sec. Among 582 with a measured NT-proBNP, 24.1% had values ≥ 160 pg/mL. Of 22 deaths during follow-up, 50% had a TRV ≥ 3.0 m/sec. At 24 months the cumulative survival was 83% with TRV ≥ 3.0 m/sec and 98% with TRV < 3.0 m/sec (p < 0.0001). The hazard ratios for death were 11.1 (95% CI 4.1-30.1; p < 0.0001) for TRV ≥ 3.0 m/sec, 4.6 (1.8-11.3; p = 0.001) for NT-proBNP ≥ 160 pg/mL, and 14.9 (5.5-39.9; p < 0.0001) for both TRV ≥ 3.0 m/sec and NT-proBNP ≥ 160 pg/mL. Age < 47 years, male gender, chronic transfusions, WHO class III-IV, increased hemolytic markers, ferritin and creatinine were also associated with increased risk of death.A TRV ≥ 3.0 m/sec occurs in approximately 10% of individuals and has the highest risk for death of any measured variable. The study is registered in ClinicalTrials.gov with identifier: NCT00492531. Medicine R Science Q Robyn J Barst verfasserin aut J Simon R Gibbs verfasserin aut Mariana Hildesheim verfasserin aut Vandana Sachdev verfasserin aut Mehdi Nouraie verfasserin aut Kathryn L Hassell verfasserin aut Jane A Little verfasserin aut Dean E Schraufnagel verfasserin aut Lakshmanan Krishnamurti verfasserin aut Enrico Novelli verfasserin aut Reda E Girgis verfasserin aut Claudia R Morris verfasserin aut Erika Berman Rosenzweig verfasserin aut David B Badesch verfasserin aut Sophie Lanzkron verfasserin aut Oswaldo L Castro verfasserin aut James G Taylor verfasserin aut Jonathan C Goldsmith verfasserin aut Gregory J Kato verfasserin aut Victor R Gordeuk verfasserin aut Roberto F Machado verfasserin aut walk-PHaSST Investigators and Patients verfasserin aut In PLoS ONE Public Library of Science (PLoS), 2007 9(2014), 7, p e99489 (DE-627)523574592 (DE-600)2267670-3 19326203 nnns volume:9 year:2014 number:7, p e99489 https://doi.org/10.1371/journal.pone.0099489 kostenfrei https://doaj.org/article/36ede0ae221943d1887a84c560bea8cc kostenfrei http://europepmc.org/articles/PMC4079316?pdf=render kostenfrei https://doaj.org/toc/1932-6203 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_34 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_206 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_235 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2031 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2057 GBV_ILN_2061 GBV_ILN_2111 GBV_ILN_2113 GBV_ILN_2190 GBV_ILN_2522 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4335 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 9 2014 7, p e99489
allfields_unstemmed	10.1371/journal.pone.0099489 doi (DE-627)DOAJ044756348 (DE-599)DOAJ36ede0ae221943d1887a84c560bea8cc DE-627 ger DE-627 rakwb eng Mark T Gladwin verfasserin aut Risk factors for death in 632 patients with sickle cell disease in the United States and United Kingdom. 2014 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier The role of pulmonary hypertension as a cause of mortality in sickle cell disease (SCD) is controversial.We evaluated the relationship between an elevated estimated pulmonary artery systolic pressure and mortality in patients with SCD. We followed patients from the walk-PHaSST screening cohort for a median of 29 months. A tricuspid regurgitation velocity (TRV)≥ 3.0 m/s cuttof, which has a 67-75% positive predictive value for mean pulmonary artery pressure ≥ 25 mm Hg was used. Among 572 subjects, 11.2% had TRV ≥ 3.0 m/sec. Among 582 with a measured NT-proBNP, 24.1% had values ≥ 160 pg/mL. Of 22 deaths during follow-up, 50% had a TRV ≥ 3.0 m/sec. At 24 months the cumulative survival was 83% with TRV ≥ 3.0 m/sec and 98% with TRV < 3.0 m/sec (p < 0.0001). The hazard ratios for death were 11.1 (95% CI 4.1-30.1; p < 0.0001) for TRV ≥ 3.0 m/sec, 4.6 (1.8-11.3; p = 0.001) for NT-proBNP ≥ 160 pg/mL, and 14.9 (5.5-39.9; p < 0.0001) for both TRV ≥ 3.0 m/sec and NT-proBNP ≥ 160 pg/mL. Age < 47 years, male gender, chronic transfusions, WHO class III-IV, increased hemolytic markers, ferritin and creatinine were also associated with increased risk of death.A TRV ≥ 3.0 m/sec occurs in approximately 10% of individuals and has the highest risk for death of any measured variable. The study is registered in ClinicalTrials.gov with identifier: NCT00492531. Medicine R Science Q Robyn J Barst verfasserin aut J Simon R Gibbs verfasserin aut Mariana Hildesheim verfasserin aut Vandana Sachdev verfasserin aut Mehdi Nouraie verfasserin aut Kathryn L Hassell verfasserin aut Jane A Little verfasserin aut Dean E Schraufnagel verfasserin aut Lakshmanan Krishnamurti verfasserin aut Enrico Novelli verfasserin aut Reda E Girgis verfasserin aut Claudia R Morris verfasserin aut Erika Berman Rosenzweig verfasserin aut David B Badesch verfasserin aut Sophie Lanzkron verfasserin aut Oswaldo L Castro verfasserin aut James G Taylor verfasserin aut Jonathan C Goldsmith verfasserin aut Gregory J Kato verfasserin aut Victor R Gordeuk verfasserin aut Roberto F Machado verfasserin aut walk-PHaSST Investigators and Patients verfasserin aut In PLoS ONE Public Library of Science (PLoS), 2007 9(2014), 7, p e99489 (DE-627)523574592 (DE-600)2267670-3 19326203 nnns volume:9 year:2014 number:7, p e99489 https://doi.org/10.1371/journal.pone.0099489 kostenfrei https://doaj.org/article/36ede0ae221943d1887a84c560bea8cc kostenfrei http://europepmc.org/articles/PMC4079316?pdf=render kostenfrei https://doaj.org/toc/1932-6203 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_34 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_206 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_235 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2031 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2057 GBV_ILN_2061 GBV_ILN_2111 GBV_ILN_2113 GBV_ILN_2190 GBV_ILN_2522 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4335 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 9 2014 7, p e99489
allfieldsGer	10.1371/journal.pone.0099489 doi (DE-627)DOAJ044756348 (DE-599)DOAJ36ede0ae221943d1887a84c560bea8cc DE-627 ger DE-627 rakwb eng Mark T Gladwin verfasserin aut Risk factors for death in 632 patients with sickle cell disease in the United States and United Kingdom. 2014 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier The role of pulmonary hypertension as a cause of mortality in sickle cell disease (SCD) is controversial.We evaluated the relationship between an elevated estimated pulmonary artery systolic pressure and mortality in patients with SCD. We followed patients from the walk-PHaSST screening cohort for a median of 29 months. A tricuspid regurgitation velocity (TRV)≥ 3.0 m/s cuttof, which has a 67-75% positive predictive value for mean pulmonary artery pressure ≥ 25 mm Hg was used. Among 572 subjects, 11.2% had TRV ≥ 3.0 m/sec. Among 582 with a measured NT-proBNP, 24.1% had values ≥ 160 pg/mL. Of 22 deaths during follow-up, 50% had a TRV ≥ 3.0 m/sec. At 24 months the cumulative survival was 83% with TRV ≥ 3.0 m/sec and 98% with TRV < 3.0 m/sec (p < 0.0001). The hazard ratios for death were 11.1 (95% CI 4.1-30.1; p < 0.0001) for TRV ≥ 3.0 m/sec, 4.6 (1.8-11.3; p = 0.001) for NT-proBNP ≥ 160 pg/mL, and 14.9 (5.5-39.9; p < 0.0001) for both TRV ≥ 3.0 m/sec and NT-proBNP ≥ 160 pg/mL. Age < 47 years, male gender, chronic transfusions, WHO class III-IV, increased hemolytic markers, ferritin and creatinine were also associated with increased risk of death.A TRV ≥ 3.0 m/sec occurs in approximately 10% of individuals and has the highest risk for death of any measured variable. The study is registered in ClinicalTrials.gov with identifier: NCT00492531. Medicine R Science Q Robyn J Barst verfasserin aut J Simon R Gibbs verfasserin aut Mariana Hildesheim verfasserin aut Vandana Sachdev verfasserin aut Mehdi Nouraie verfasserin aut Kathryn L Hassell verfasserin aut Jane A Little verfasserin aut Dean E Schraufnagel verfasserin aut Lakshmanan Krishnamurti verfasserin aut Enrico Novelli verfasserin aut Reda E Girgis verfasserin aut Claudia R Morris verfasserin aut Erika Berman Rosenzweig verfasserin aut David B Badesch verfasserin aut Sophie Lanzkron verfasserin aut Oswaldo L Castro verfasserin aut James G Taylor verfasserin aut Jonathan C Goldsmith verfasserin aut Gregory J Kato verfasserin aut Victor R Gordeuk verfasserin aut Roberto F Machado verfasserin aut walk-PHaSST Investigators and Patients verfasserin aut In PLoS ONE Public Library of Science (PLoS), 2007 9(2014), 7, p e99489 (DE-627)523574592 (DE-600)2267670-3 19326203 nnns volume:9 year:2014 number:7, p e99489 https://doi.org/10.1371/journal.pone.0099489 kostenfrei https://doaj.org/article/36ede0ae221943d1887a84c560bea8cc kostenfrei http://europepmc.org/articles/PMC4079316?pdf=render kostenfrei https://doaj.org/toc/1932-6203 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_34 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_206 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_235 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2031 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2057 GBV_ILN_2061 GBV_ILN_2111 GBV_ILN_2113 GBV_ILN_2190 GBV_ILN_2522 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4335 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 9 2014 7, p e99489
allfieldsSound	10.1371/journal.pone.0099489 doi (DE-627)DOAJ044756348 (DE-599)DOAJ36ede0ae221943d1887a84c560bea8cc DE-627 ger DE-627 rakwb eng Mark T Gladwin verfasserin aut Risk factors for death in 632 patients with sickle cell disease in the United States and United Kingdom. 2014 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier The role of pulmonary hypertension as a cause of mortality in sickle cell disease (SCD) is controversial.We evaluated the relationship between an elevated estimated pulmonary artery systolic pressure and mortality in patients with SCD. We followed patients from the walk-PHaSST screening cohort for a median of 29 months. A tricuspid regurgitation velocity (TRV)≥ 3.0 m/s cuttof, which has a 67-75% positive predictive value for mean pulmonary artery pressure ≥ 25 mm Hg was used. Among 572 subjects, 11.2% had TRV ≥ 3.0 m/sec. Among 582 with a measured NT-proBNP, 24.1% had values ≥ 160 pg/mL. Of 22 deaths during follow-up, 50% had a TRV ≥ 3.0 m/sec. At 24 months the cumulative survival was 83% with TRV ≥ 3.0 m/sec and 98% with TRV < 3.0 m/sec (p < 0.0001). The hazard ratios for death were 11.1 (95% CI 4.1-30.1; p < 0.0001) for TRV ≥ 3.0 m/sec, 4.6 (1.8-11.3; p = 0.001) for NT-proBNP ≥ 160 pg/mL, and 14.9 (5.5-39.9; p < 0.0001) for both TRV ≥ 3.0 m/sec and NT-proBNP ≥ 160 pg/mL. Age < 47 years, male gender, chronic transfusions, WHO class III-IV, increased hemolytic markers, ferritin and creatinine were also associated with increased risk of death.A TRV ≥ 3.0 m/sec occurs in approximately 10% of individuals and has the highest risk for death of any measured variable. The study is registered in ClinicalTrials.gov with identifier: NCT00492531. Medicine R Science Q Robyn J Barst verfasserin aut J Simon R Gibbs verfasserin aut Mariana Hildesheim verfasserin aut Vandana Sachdev verfasserin aut Mehdi Nouraie verfasserin aut Kathryn L Hassell verfasserin aut Jane A Little verfasserin aut Dean E Schraufnagel verfasserin aut Lakshmanan Krishnamurti verfasserin aut Enrico Novelli verfasserin aut Reda E Girgis verfasserin aut Claudia R Morris verfasserin aut Erika Berman Rosenzweig verfasserin aut David B Badesch verfasserin aut Sophie Lanzkron verfasserin aut Oswaldo L Castro verfasserin aut James G Taylor verfasserin aut Jonathan C Goldsmith verfasserin aut Gregory J Kato verfasserin aut Victor R Gordeuk verfasserin aut Roberto F Machado verfasserin aut walk-PHaSST Investigators and Patients verfasserin aut In PLoS ONE Public Library of Science (PLoS), 2007 9(2014), 7, p e99489 (DE-627)523574592 (DE-600)2267670-3 19326203 nnns volume:9 year:2014 number:7, p e99489 https://doi.org/10.1371/journal.pone.0099489 kostenfrei https://doaj.org/article/36ede0ae221943d1887a84c560bea8cc kostenfrei http://europepmc.org/articles/PMC4079316?pdf=render kostenfrei https://doaj.org/toc/1932-6203 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_34 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_206 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_235 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2031 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2057 GBV_ILN_2061 GBV_ILN_2111 GBV_ILN_2113 GBV_ILN_2190 GBV_ILN_2522 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4335 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 9 2014 7, p e99489
language	English
source	In PLoS ONE 9(2014), 7, p e99489 volume:9 year:2014 number:7, p e99489
sourceStr	In PLoS ONE 9(2014), 7, p e99489 volume:9 year:2014 number:7, p e99489
format_phy_str_mv	Article
institution	findex.gbv.de
topic_facet	Medicine R Science Q
isfreeaccess_bool	true
container_title	PLoS ONE
authorswithroles_txt_mv	Mark T Gladwin @@aut@@ Robyn J Barst @@aut@@ J Simon R Gibbs @@aut@@ Mariana Hildesheim @@aut@@ Vandana Sachdev @@aut@@ Mehdi Nouraie @@aut@@ Kathryn L Hassell @@aut@@ Jane A Little @@aut@@ Dean E Schraufnagel @@aut@@ Lakshmanan Krishnamurti @@aut@@ Enrico Novelli @@aut@@ Reda E Girgis @@aut@@ Claudia R Morris @@aut@@ Erika Berman Rosenzweig @@aut@@ David B Badesch @@aut@@ Sophie Lanzkron @@aut@@ Oswaldo L Castro @@aut@@ James G Taylor @@aut@@ Jonathan C Goldsmith @@aut@@ Gregory J Kato @@aut@@ Victor R Gordeuk @@aut@@ Roberto F Machado @@aut@@ walk-PHaSST Investigators and Patients @@aut@@
publishDateDaySort_date	2014-01-01T00:00:00Z
hierarchy_top_id	523574592
id	DOAJ044756348
language_de	englisch
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author	Mark T Gladwin
spellingShingle	Mark T Gladwin misc Medicine misc R misc Science misc Q Risk factors for death in 632 patients with sickle cell disease in the United States and United Kingdom.
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topic_title	Risk factors for death in 632 patients with sickle cell disease in the United States and United Kingdom
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title	Risk factors for death in 632 patients with sickle cell disease in the United States and United Kingdom.
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title_full	Risk factors for death in 632 patients with sickle cell disease in the United States and United Kingdom
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title_sort	risk factors for death in 632 patients with sickle cell disease in the united states and united kingdom
title_auth	Risk factors for death in 632 patients with sickle cell disease in the United States and United Kingdom.
abstract	The role of pulmonary hypertension as a cause of mortality in sickle cell disease (SCD) is controversial.We evaluated the relationship between an elevated estimated pulmonary artery systolic pressure and mortality in patients with SCD. We followed patients from the walk-PHaSST screening cohort for a median of 29 months. A tricuspid regurgitation velocity (TRV)≥ 3.0 m/s cuttof, which has a 67-75% positive predictive value for mean pulmonary artery pressure ≥ 25 mm Hg was used. Among 572 subjects, 11.2% had TRV ≥ 3.0 m/sec. Among 582 with a measured NT-proBNP, 24.1% had values ≥ 160 pg/mL. Of 22 deaths during follow-up, 50% had a TRV ≥ 3.0 m/sec. At 24 months the cumulative survival was 83% with TRV ≥ 3.0 m/sec and 98% with TRV < 3.0 m/sec (p < 0.0001). The hazard ratios for death were 11.1 (95% CI 4.1-30.1; p < 0.0001) for TRV ≥ 3.0 m/sec, 4.6 (1.8-11.3; p = 0.001) for NT-proBNP ≥ 160 pg/mL, and 14.9 (5.5-39.9; p < 0.0001) for both TRV ≥ 3.0 m/sec and NT-proBNP ≥ 160 pg/mL. Age < 47 years, male gender, chronic transfusions, WHO class III-IV, increased hemolytic markers, ferritin and creatinine were also associated with increased risk of death.A TRV ≥ 3.0 m/sec occurs in approximately 10% of individuals and has the highest risk for death of any measured variable. The study is registered in ClinicalTrials.gov with identifier: NCT00492531.
abstractGer	The role of pulmonary hypertension as a cause of mortality in sickle cell disease (SCD) is controversial.We evaluated the relationship between an elevated estimated pulmonary artery systolic pressure and mortality in patients with SCD. We followed patients from the walk-PHaSST screening cohort for a median of 29 months. A tricuspid regurgitation velocity (TRV)≥ 3.0 m/s cuttof, which has a 67-75% positive predictive value for mean pulmonary artery pressure ≥ 25 mm Hg was used. Among 572 subjects, 11.2% had TRV ≥ 3.0 m/sec. Among 582 with a measured NT-proBNP, 24.1% had values ≥ 160 pg/mL. Of 22 deaths during follow-up, 50% had a TRV ≥ 3.0 m/sec. At 24 months the cumulative survival was 83% with TRV ≥ 3.0 m/sec and 98% with TRV < 3.0 m/sec (p < 0.0001). The hazard ratios for death were 11.1 (95% CI 4.1-30.1; p < 0.0001) for TRV ≥ 3.0 m/sec, 4.6 (1.8-11.3; p = 0.001) for NT-proBNP ≥ 160 pg/mL, and 14.9 (5.5-39.9; p < 0.0001) for both TRV ≥ 3.0 m/sec and NT-proBNP ≥ 160 pg/mL. Age < 47 years, male gender, chronic transfusions, WHO class III-IV, increased hemolytic markers, ferritin and creatinine were also associated with increased risk of death.A TRV ≥ 3.0 m/sec occurs in approximately 10% of individuals and has the highest risk for death of any measured variable. The study is registered in ClinicalTrials.gov with identifier: NCT00492531.
abstract_unstemmed	The role of pulmonary hypertension as a cause of mortality in sickle cell disease (SCD) is controversial.We evaluated the relationship between an elevated estimated pulmonary artery systolic pressure and mortality in patients with SCD. We followed patients from the walk-PHaSST screening cohort for a median of 29 months. A tricuspid regurgitation velocity (TRV)≥ 3.0 m/s cuttof, which has a 67-75% positive predictive value for mean pulmonary artery pressure ≥ 25 mm Hg was used. Among 572 subjects, 11.2% had TRV ≥ 3.0 m/sec. Among 582 with a measured NT-proBNP, 24.1% had values ≥ 160 pg/mL. Of 22 deaths during follow-up, 50% had a TRV ≥ 3.0 m/sec. At 24 months the cumulative survival was 83% with TRV ≥ 3.0 m/sec and 98% with TRV < 3.0 m/sec (p < 0.0001). The hazard ratios for death were 11.1 (95% CI 4.1-30.1; p < 0.0001) for TRV ≥ 3.0 m/sec, 4.6 (1.8-11.3; p = 0.001) for NT-proBNP ≥ 160 pg/mL, and 14.9 (5.5-39.9; p < 0.0001) for both TRV ≥ 3.0 m/sec and NT-proBNP ≥ 160 pg/mL. Age < 47 years, male gender, chronic transfusions, WHO class III-IV, increased hemolytic markers, ferritin and creatinine were also associated with increased risk of death.A TRV ≥ 3.0 m/sec occurs in approximately 10% of individuals and has the highest risk for death of any measured variable. The study is registered in ClinicalTrials.gov with identifier: NCT00492531.
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title_short	Risk factors for death in 632 patients with sickle cell disease in the United States and United Kingdom.
url	https://doi.org/10.1371/journal.pone.0099489 https://doaj.org/article/36ede0ae221943d1887a84c560bea8cc http://europepmc.org/articles/PMC4079316?pdf=render https://doaj.org/toc/1932-6203
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up_date	2024-07-04T00:21:44.191Z
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We followed patients from the walk-PHaSST screening cohort for a median of 29 months. A tricuspid regurgitation velocity (TRV)≥ 3.0 m/s cuttof, which has a 67-75% positive predictive value for mean pulmonary artery pressure ≥ 25 mm Hg was used. Among 572 subjects, 11.2% had TRV ≥ 3.0 m/sec. Among 582 with a measured NT-proBNP, 24.1% had values ≥ 160 pg/mL. Of 22 deaths during follow-up, 50% had a TRV ≥ 3.0 m/sec. At 24 months the cumulative survival was 83% with TRV ≥ 3.0 m/sec and 98% with TRV < 3.0 m/sec (p < 0.0001). The hazard ratios for death were 11.1 (95% CI 4.1-30.1; p < 0.0001) for TRV ≥ 3.0 m/sec, 4.6 (1.8-11.3; p = 0.001) for NT-proBNP ≥ 160 pg/mL, and 14.9 (5.5-39.9; p < 0.0001) for both TRV ≥ 3.0 m/sec and NT-proBNP ≥ 160 pg/mL. Age < 47 years, male gender, chronic transfusions, WHO class III-IV, increased hemolytic markers, ferritin and creatinine were also associated with increased risk of death.A TRV ≥ 3.0 m/sec occurs in approximately 10% of individuals and has the highest risk for death of any measured variable. 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Risk factors for death in 632 patients with sickle cell disease in the United States and United Kingdom.

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