The Role of Pre-existing Cross-Reactive Central Memory CD4 T-Cells in Vaccination With Previously Unseen Influenza Strains
Influenza vaccination is a common approach to prevent seasonal and pandemic influenza. Pre-existing antibodies against close viral strains might impair antibody formation against previously unseen strains–a process called original antigenic sin. The role of this pre-existing cellular immunity in thi...
Ausführliche Beschreibung
Autor*in: |
Mikalai Nienen [verfasserIn] Ulrik Stervbo [verfasserIn] Felix Mölder [verfasserIn] Sviatlana Kaliszczyk [verfasserIn] Leon Kuchenbecker [verfasserIn] Ludmila Gayova [verfasserIn] Brunhilde Schweiger [verfasserIn] Karsten Jürchott [verfasserIn] Jochen Hecht [verfasserIn] Avidan U. Neumann [verfasserIn] Sven Rahmann [verfasserIn] Timm Westhoff [verfasserIn] Petra Reinke [verfasserIn] Andreas Thiel [verfasserIn] Nina Babel [verfasserIn] |
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Format: |
E-Artikel |
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Sprache: |
Englisch |
Erschienen: |
2019 |
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Übergeordnetes Werk: |
In: Frontiers in Immunology - Frontiers Media S.A., 2011, 10(2019) |
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Übergeordnetes Werk: |
volume:10 ; year:2019 |
Links: |
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DOI / URN: |
10.3389/fimmu.2019.00593 |
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Katalog-ID: |
DOAJ044769822 |
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10.3389/fimmu.2019.00593 doi (DE-627)DOAJ044769822 (DE-599)DOAJaa40b8fd1e7141a2895cefcebf19319e DE-627 ger DE-627 rakwb eng RC581-607 Mikalai Nienen verfasserin aut The Role of Pre-existing Cross-Reactive Central Memory CD4 T-Cells in Vaccination With Previously Unseen Influenza Strains 2019 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Influenza vaccination is a common approach to prevent seasonal and pandemic influenza. Pre-existing antibodies against close viral strains might impair antibody formation against previously unseen strains–a process called original antigenic sin. The role of this pre-existing cellular immunity in this process is, despite some hints from animal models, not clear. Here, we analyzed cellular and humoral immunity in healthy individuals before and after vaccination with seasonal influenza vaccine. Based on influenza-specific hemagglutination inhibiting (HI) titers, vaccinees were grouped into HI-negative and -positive cohorts followed by in-depth cytometric and TCR repertoire analysis. Both serological groups revealed cross-reactive T-cell memory to the vaccine strains at baseline that gave rise to the majority of vaccine-specific T-cells post vaccination. On the contrary, very limited number of vaccine-specific T-cell clones was recruited from the naive pool. Furthermore, baseline quantity of vaccine-specific central memory helper T-cells and clonotype richness of this population directly correlated with the vaccination efficacy. Our findings suggest that the deliberate recruitment of pre-existing cross-reactive cellular memory might help to improve vaccination outcome. influenza vaccination vaccination efficacy pre-existing cross-reactive T-cells central memory T-cell clonotype diversity Immunologic diseases. Allergy Mikalai Nienen verfasserin aut Mikalai Nienen verfasserin aut Ulrik Stervbo verfasserin aut Felix Mölder verfasserin aut Sviatlana Kaliszczyk verfasserin aut Leon Kuchenbecker verfasserin aut Ludmila Gayova verfasserin aut Brunhilde Schweiger verfasserin aut Karsten Jürchott verfasserin aut Jochen Hecht verfasserin aut Jochen Hecht verfasserin aut Avidan U. Neumann verfasserin aut Sven Rahmann verfasserin aut Timm Westhoff verfasserin aut Petra Reinke verfasserin aut Petra Reinke verfasserin aut Andreas Thiel verfasserin aut Nina Babel verfasserin aut Nina Babel verfasserin aut Nina Babel verfasserin aut In Frontiers in Immunology Frontiers Media S.A., 2011 10(2019) (DE-627)657998354 (DE-600)2606827-8 16643224 nnns volume:10 year:2019 https://doi.org/10.3389/fimmu.2019.00593 kostenfrei https://doaj.org/article/aa40b8fd1e7141a2895cefcebf19319e kostenfrei https://www.frontiersin.org/article/10.3389/fimmu.2019.00593/full kostenfrei https://doaj.org/toc/1664-3224 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2003 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 10 2019 |
spelling |
10.3389/fimmu.2019.00593 doi (DE-627)DOAJ044769822 (DE-599)DOAJaa40b8fd1e7141a2895cefcebf19319e DE-627 ger DE-627 rakwb eng RC581-607 Mikalai Nienen verfasserin aut The Role of Pre-existing Cross-Reactive Central Memory CD4 T-Cells in Vaccination With Previously Unseen Influenza Strains 2019 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Influenza vaccination is a common approach to prevent seasonal and pandemic influenza. Pre-existing antibodies against close viral strains might impair antibody formation against previously unseen strains–a process called original antigenic sin. The role of this pre-existing cellular immunity in this process is, despite some hints from animal models, not clear. Here, we analyzed cellular and humoral immunity in healthy individuals before and after vaccination with seasonal influenza vaccine. Based on influenza-specific hemagglutination inhibiting (HI) titers, vaccinees were grouped into HI-negative and -positive cohorts followed by in-depth cytometric and TCR repertoire analysis. Both serological groups revealed cross-reactive T-cell memory to the vaccine strains at baseline that gave rise to the majority of vaccine-specific T-cells post vaccination. On the contrary, very limited number of vaccine-specific T-cell clones was recruited from the naive pool. Furthermore, baseline quantity of vaccine-specific central memory helper T-cells and clonotype richness of this population directly correlated with the vaccination efficacy. Our findings suggest that the deliberate recruitment of pre-existing cross-reactive cellular memory might help to improve vaccination outcome. influenza vaccination vaccination efficacy pre-existing cross-reactive T-cells central memory T-cell clonotype diversity Immunologic diseases. Allergy Mikalai Nienen verfasserin aut Mikalai Nienen verfasserin aut Ulrik Stervbo verfasserin aut Felix Mölder verfasserin aut Sviatlana Kaliszczyk verfasserin aut Leon Kuchenbecker verfasserin aut Ludmila Gayova verfasserin aut Brunhilde Schweiger verfasserin aut Karsten Jürchott verfasserin aut Jochen Hecht verfasserin aut Jochen Hecht verfasserin aut Avidan U. Neumann verfasserin aut Sven Rahmann verfasserin aut Timm Westhoff verfasserin aut Petra Reinke verfasserin aut Petra Reinke verfasserin aut Andreas Thiel verfasserin aut Nina Babel verfasserin aut Nina Babel verfasserin aut Nina Babel verfasserin aut In Frontiers in Immunology Frontiers Media S.A., 2011 10(2019) (DE-627)657998354 (DE-600)2606827-8 16643224 nnns volume:10 year:2019 https://doi.org/10.3389/fimmu.2019.00593 kostenfrei https://doaj.org/article/aa40b8fd1e7141a2895cefcebf19319e kostenfrei https://www.frontiersin.org/article/10.3389/fimmu.2019.00593/full kostenfrei https://doaj.org/toc/1664-3224 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2003 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 10 2019 |
allfields_unstemmed |
10.3389/fimmu.2019.00593 doi (DE-627)DOAJ044769822 (DE-599)DOAJaa40b8fd1e7141a2895cefcebf19319e DE-627 ger DE-627 rakwb eng RC581-607 Mikalai Nienen verfasserin aut The Role of Pre-existing Cross-Reactive Central Memory CD4 T-Cells in Vaccination With Previously Unseen Influenza Strains 2019 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Influenza vaccination is a common approach to prevent seasonal and pandemic influenza. Pre-existing antibodies against close viral strains might impair antibody formation against previously unseen strains–a process called original antigenic sin. The role of this pre-existing cellular immunity in this process is, despite some hints from animal models, not clear. Here, we analyzed cellular and humoral immunity in healthy individuals before and after vaccination with seasonal influenza vaccine. Based on influenza-specific hemagglutination inhibiting (HI) titers, vaccinees were grouped into HI-negative and -positive cohorts followed by in-depth cytometric and TCR repertoire analysis. Both serological groups revealed cross-reactive T-cell memory to the vaccine strains at baseline that gave rise to the majority of vaccine-specific T-cells post vaccination. On the contrary, very limited number of vaccine-specific T-cell clones was recruited from the naive pool. Furthermore, baseline quantity of vaccine-specific central memory helper T-cells and clonotype richness of this population directly correlated with the vaccination efficacy. Our findings suggest that the deliberate recruitment of pre-existing cross-reactive cellular memory might help to improve vaccination outcome. influenza vaccination vaccination efficacy pre-existing cross-reactive T-cells central memory T-cell clonotype diversity Immunologic diseases. Allergy Mikalai Nienen verfasserin aut Mikalai Nienen verfasserin aut Ulrik Stervbo verfasserin aut Felix Mölder verfasserin aut Sviatlana Kaliszczyk verfasserin aut Leon Kuchenbecker verfasserin aut Ludmila Gayova verfasserin aut Brunhilde Schweiger verfasserin aut Karsten Jürchott verfasserin aut Jochen Hecht verfasserin aut Jochen Hecht verfasserin aut Avidan U. Neumann verfasserin aut Sven Rahmann verfasserin aut Timm Westhoff verfasserin aut Petra Reinke verfasserin aut Petra Reinke verfasserin aut Andreas Thiel verfasserin aut Nina Babel verfasserin aut Nina Babel verfasserin aut Nina Babel verfasserin aut In Frontiers in Immunology Frontiers Media S.A., 2011 10(2019) (DE-627)657998354 (DE-600)2606827-8 16643224 nnns volume:10 year:2019 https://doi.org/10.3389/fimmu.2019.00593 kostenfrei https://doaj.org/article/aa40b8fd1e7141a2895cefcebf19319e kostenfrei https://www.frontiersin.org/article/10.3389/fimmu.2019.00593/full kostenfrei https://doaj.org/toc/1664-3224 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2003 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 10 2019 |
allfieldsGer |
10.3389/fimmu.2019.00593 doi (DE-627)DOAJ044769822 (DE-599)DOAJaa40b8fd1e7141a2895cefcebf19319e DE-627 ger DE-627 rakwb eng RC581-607 Mikalai Nienen verfasserin aut The Role of Pre-existing Cross-Reactive Central Memory CD4 T-Cells in Vaccination With Previously Unseen Influenza Strains 2019 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Influenza vaccination is a common approach to prevent seasonal and pandemic influenza. Pre-existing antibodies against close viral strains might impair antibody formation against previously unseen strains–a process called original antigenic sin. The role of this pre-existing cellular immunity in this process is, despite some hints from animal models, not clear. Here, we analyzed cellular and humoral immunity in healthy individuals before and after vaccination with seasonal influenza vaccine. Based on influenza-specific hemagglutination inhibiting (HI) titers, vaccinees were grouped into HI-negative and -positive cohorts followed by in-depth cytometric and TCR repertoire analysis. Both serological groups revealed cross-reactive T-cell memory to the vaccine strains at baseline that gave rise to the majority of vaccine-specific T-cells post vaccination. On the contrary, very limited number of vaccine-specific T-cell clones was recruited from the naive pool. Furthermore, baseline quantity of vaccine-specific central memory helper T-cells and clonotype richness of this population directly correlated with the vaccination efficacy. Our findings suggest that the deliberate recruitment of pre-existing cross-reactive cellular memory might help to improve vaccination outcome. influenza vaccination vaccination efficacy pre-existing cross-reactive T-cells central memory T-cell clonotype diversity Immunologic diseases. Allergy Mikalai Nienen verfasserin aut Mikalai Nienen verfasserin aut Ulrik Stervbo verfasserin aut Felix Mölder verfasserin aut Sviatlana Kaliszczyk verfasserin aut Leon Kuchenbecker verfasserin aut Ludmila Gayova verfasserin aut Brunhilde Schweiger verfasserin aut Karsten Jürchott verfasserin aut Jochen Hecht verfasserin aut Jochen Hecht verfasserin aut Avidan U. Neumann verfasserin aut Sven Rahmann verfasserin aut Timm Westhoff verfasserin aut Petra Reinke verfasserin aut Petra Reinke verfasserin aut Andreas Thiel verfasserin aut Nina Babel verfasserin aut Nina Babel verfasserin aut Nina Babel verfasserin aut In Frontiers in Immunology Frontiers Media S.A., 2011 10(2019) (DE-627)657998354 (DE-600)2606827-8 16643224 nnns volume:10 year:2019 https://doi.org/10.3389/fimmu.2019.00593 kostenfrei https://doaj.org/article/aa40b8fd1e7141a2895cefcebf19319e kostenfrei https://www.frontiersin.org/article/10.3389/fimmu.2019.00593/full kostenfrei https://doaj.org/toc/1664-3224 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2003 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 10 2019 |
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role of pre-existing cross-reactive central memory cd4 t-cells in vaccination with previously unseen influenza strains |
callnumber |
RC581-607 |
title_auth |
The Role of Pre-existing Cross-Reactive Central Memory CD4 T-Cells in Vaccination With Previously Unseen Influenza Strains |
abstract |
Influenza vaccination is a common approach to prevent seasonal and pandemic influenza. Pre-existing antibodies against close viral strains might impair antibody formation against previously unseen strains–a process called original antigenic sin. The role of this pre-existing cellular immunity in this process is, despite some hints from animal models, not clear. Here, we analyzed cellular and humoral immunity in healthy individuals before and after vaccination with seasonal influenza vaccine. Based on influenza-specific hemagglutination inhibiting (HI) titers, vaccinees were grouped into HI-negative and -positive cohorts followed by in-depth cytometric and TCR repertoire analysis. Both serological groups revealed cross-reactive T-cell memory to the vaccine strains at baseline that gave rise to the majority of vaccine-specific T-cells post vaccination. On the contrary, very limited number of vaccine-specific T-cell clones was recruited from the naive pool. Furthermore, baseline quantity of vaccine-specific central memory helper T-cells and clonotype richness of this population directly correlated with the vaccination efficacy. Our findings suggest that the deliberate recruitment of pre-existing cross-reactive cellular memory might help to improve vaccination outcome. |
abstractGer |
Influenza vaccination is a common approach to prevent seasonal and pandemic influenza. Pre-existing antibodies against close viral strains might impair antibody formation against previously unseen strains–a process called original antigenic sin. The role of this pre-existing cellular immunity in this process is, despite some hints from animal models, not clear. Here, we analyzed cellular and humoral immunity in healthy individuals before and after vaccination with seasonal influenza vaccine. Based on influenza-specific hemagglutination inhibiting (HI) titers, vaccinees were grouped into HI-negative and -positive cohorts followed by in-depth cytometric and TCR repertoire analysis. Both serological groups revealed cross-reactive T-cell memory to the vaccine strains at baseline that gave rise to the majority of vaccine-specific T-cells post vaccination. On the contrary, very limited number of vaccine-specific T-cell clones was recruited from the naive pool. Furthermore, baseline quantity of vaccine-specific central memory helper T-cells and clonotype richness of this population directly correlated with the vaccination efficacy. Our findings suggest that the deliberate recruitment of pre-existing cross-reactive cellular memory might help to improve vaccination outcome. |
abstract_unstemmed |
Influenza vaccination is a common approach to prevent seasonal and pandemic influenza. Pre-existing antibodies against close viral strains might impair antibody formation against previously unseen strains–a process called original antigenic sin. The role of this pre-existing cellular immunity in this process is, despite some hints from animal models, not clear. Here, we analyzed cellular and humoral immunity in healthy individuals before and after vaccination with seasonal influenza vaccine. Based on influenza-specific hemagglutination inhibiting (HI) titers, vaccinees were grouped into HI-negative and -positive cohorts followed by in-depth cytometric and TCR repertoire analysis. Both serological groups revealed cross-reactive T-cell memory to the vaccine strains at baseline that gave rise to the majority of vaccine-specific T-cells post vaccination. On the contrary, very limited number of vaccine-specific T-cell clones was recruited from the naive pool. Furthermore, baseline quantity of vaccine-specific central memory helper T-cells and clonotype richness of this population directly correlated with the vaccination efficacy. Our findings suggest that the deliberate recruitment of pre-existing cross-reactive cellular memory might help to improve vaccination outcome. |
collection_details |
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title_short |
The Role of Pre-existing Cross-Reactive Central Memory CD4 T-Cells in Vaccination With Previously Unseen Influenza Strains |
url |
https://doi.org/10.3389/fimmu.2019.00593 https://doaj.org/article/aa40b8fd1e7141a2895cefcebf19319e https://www.frontiersin.org/article/10.3389/fimmu.2019.00593/full https://doaj.org/toc/1664-3224 |
remote_bool |
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author2 |
Mikalai Nienen Ulrik Stervbo Felix Mölder Sviatlana Kaliszczyk Leon Kuchenbecker Ludmila Gayova Brunhilde Schweiger Karsten Jürchott Jochen Hecht Avidan U. Neumann Sven Rahmann Timm Westhoff Petra Reinke Andreas Thiel Nina Babel |
author2Str |
Mikalai Nienen Ulrik Stervbo Felix Mölder Sviatlana Kaliszczyk Leon Kuchenbecker Ludmila Gayova Brunhilde Schweiger Karsten Jürchott Jochen Hecht Avidan U. Neumann Sven Rahmann Timm Westhoff Petra Reinke Andreas Thiel Nina Babel |
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RC - Internal Medicine |
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doi_str |
10.3389/fimmu.2019.00593 |
callnumber-a |
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up_date |
2024-07-04T00:24:47.379Z |
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