The Current Landscape of mRNA Vaccines Against Viruses and Cancer–A Mini Review

Both infectious viral diseases and cancer have historically been some of the most common causes of death worldwide. The COVID-19 pandemic is a decidedly relevant example of the former. Despite progress having been made over past decades, new and improved techniques are still needed to address the li...
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Autor*in:	Reese Jalal Ladak [verfasserIn] Alexander J. He [verfasserIn] Yu-Hsun Huang [verfasserIn] Yu Ding [verfasserIn]

Format:	E-Artikel
Sprache:	Englisch

Erschienen:	2022

Schlagwörter:	cancer vaccination mRNA vaccine delivery viral vaccination mRNA vaccine developers clinical trials of mRNA vaccines mRNA vaccine mechanism

Übergeordnetes Werk:	In: Frontiers in Immunology - Frontiers Media S.A., 2011, 13(2022)
Übergeordnetes Werk:	volume:13 ; year:2022

Links:	Link aufrufen Link aufrufen Link aufrufen Journal toc

DOI / URN:	10.3389/fimmu.2022.885371

Katalog-ID:	DOAJ044825978

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spellingShingle	Reese Jalal Ladak misc RC581-607 misc cancer vaccination misc mRNA vaccine delivery misc viral vaccination misc mRNA vaccine developers misc clinical trials of mRNA vaccines misc mRNA vaccine mechanism misc Immunologic diseases. Allergy The Current Landscape of mRNA Vaccines Against Viruses and Cancer–A Mini Review
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topic_title	RC581-607 The Current Landscape of mRNA Vaccines Against Viruses and Cancer–A Mini Review cancer vaccination mRNA vaccine delivery viral vaccination mRNA vaccine developers clinical trials of mRNA vaccines mRNA vaccine mechanism
topic	misc RC581-607 misc cancer vaccination misc mRNA vaccine delivery misc viral vaccination misc mRNA vaccine developers misc clinical trials of mRNA vaccines misc mRNA vaccine mechanism misc Immunologic diseases. Allergy
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title	The Current Landscape of mRNA Vaccines Against Viruses and Cancer–A Mini Review
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title_sort	current landscape of mrna vaccines against viruses and cancer–a mini review
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title_auth	The Current Landscape of mRNA Vaccines Against Viruses and Cancer–A Mini Review
abstract	Both infectious viral diseases and cancer have historically been some of the most common causes of death worldwide. The COVID-19 pandemic is a decidedly relevant example of the former. Despite progress having been made over past decades, new and improved techniques are still needed to address the limitations faced by current treatment standards, with mRNA-based therapy emerging as a promising solution. Highly flexible, scalable and cost-effective, mRNA therapy is proving to be a compelling vaccine platform against viruses. Likewise, mRNA vaccines show similar promise against cancer as a platform capable of encoding multiple antigens for a diverse array of cancers, including those that are patient specific as a novel form of personalized medicine. In this review, the molecular mechanisms, biotechnological aspects, and clinical developments of mRNA vaccines against viral infections and cancer are discussed to provide an informative update on the current state of mRNA therapy research.
abstractGer	Both infectious viral diseases and cancer have historically been some of the most common causes of death worldwide. The COVID-19 pandemic is a decidedly relevant example of the former. Despite progress having been made over past decades, new and improved techniques are still needed to address the limitations faced by current treatment standards, with mRNA-based therapy emerging as a promising solution. Highly flexible, scalable and cost-effective, mRNA therapy is proving to be a compelling vaccine platform against viruses. Likewise, mRNA vaccines show similar promise against cancer as a platform capable of encoding multiple antigens for a diverse array of cancers, including those that are patient specific as a novel form of personalized medicine. In this review, the molecular mechanisms, biotechnological aspects, and clinical developments of mRNA vaccines against viral infections and cancer are discussed to provide an informative update on the current state of mRNA therapy research.
abstract_unstemmed	Both infectious viral diseases and cancer have historically been some of the most common causes of death worldwide. The COVID-19 pandemic is a decidedly relevant example of the former. Despite progress having been made over past decades, new and improved techniques are still needed to address the limitations faced by current treatment standards, with mRNA-based therapy emerging as a promising solution. Highly flexible, scalable and cost-effective, mRNA therapy is proving to be a compelling vaccine platform against viruses. Likewise, mRNA vaccines show similar promise against cancer as a platform capable of encoding multiple antigens for a diverse array of cancers, including those that are patient specific as a novel form of personalized medicine. In this review, the molecular mechanisms, biotechnological aspects, and clinical developments of mRNA vaccines against viral infections and cancer are discussed to provide an informative update on the current state of mRNA therapy research.
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title_short	The Current Landscape of mRNA Vaccines Against Viruses and Cancer–A Mini Review
url	https://doi.org/10.3389/fimmu.2022.885371 https://doaj.org/article/d8090fa0f8c641eebda01348de1d1e78 https://www.frontiersin.org/articles/10.3389/fimmu.2022.885371/full https://doaj.org/toc/1664-3224
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