The state of the duodenal villi in rats under epichlorohydrin and drugs influence
Introduction. The modern environment is polluted by xenobiotics which can cause the development of pathological processes. One of xenobiotics is epichlorohydrin (ECH). The impact of this xenobiotic causes changes in the state of various organs, including the organs of the digestive system. However,...
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Gespeichert in:
| Autor*in: |
A. S. Smirnov [verfasserIn] M. A. Mirzebasov [verfasserIn] S. M. Smirnov [verfasserIn] |
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| Format: |
E-Artikel |
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| Sprache: |
Englisch ; Russisch ; Ukrainisch |
| Erschienen: |
2019 |
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| Schlagwörter: |
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| Übergeordnetes Werk: |
In: Zaporožskij Medicinskij Žurnal - Zaporozhye State Medical University, 2016, 21(2019), 6, Seite 820-827 |
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| Übergeordnetes Werk: |
volume:21 ; year:2019 ; number:6 ; pages:820-827 |
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Link aufrufen |
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| DOI / URN: |
10.14739/2310-1210.2019.6.186643 |
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| Katalog-ID: |
DOAJ044928157 |
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| 520 | |a Introduction. The modern environment is polluted by xenobiotics which can cause the development of pathological processes. One of xenobiotics is epichlorohydrin (ECH). The impact of this xenobiotic causes changes in the state of various organs, including the organs of the digestive system. However, the effects of ECH on the duodenum have not been investigated. The aim of the study is to investigate the changes in the state of the duodenal villi in rats and changes in mitotic activity of mucous epithelial cells under ECH influence as well as to evaluate a possibility and effectiveness of Echinacea purpurea (EP) extract and thiotriazoline use for these changes correction. Material and methods. An experimental study was performed on male white rats. Six experimental groups were created. Six rats from each experimental group were removed from the experiment on the 1st, 7th, 15th, 30th, 60th days after the end of the two-month administration of ECH, EP extract and thiotriazoline. The height of the villi of the duodenal mucosa and changes in mitotic activity of mucous epithelial cells were estimated using a microscope of the MS 100 series of Micros (Austria). Results. Morphofunctional organization of duodenal mucosa in rats was changed after the long-term introduction of ECH. The height of villi and mitotic activity of mucous epithelial cells were reduced. Over time, the expressiveness of the changes diminished. Introduction of EP extract and thiotriazoline administration to rats which did not receive ECH was accompanied by an increase in the height of villi. In the case of thiotriazoline administration, this effect was longer. The use of EP extract as well as the use of thiotriazoline during ECH inhalations reduced the severity and duration of the decrease in the height of villi and mitotic activity of mucous epithelial cells caused by this chemical. The negative effects of ECH were corrected more effectivelly by thiotriazoline than by EP extract. Conclusions. Prolonged action of ECH is accompanied by negative changes in the state of duodenal mucosa. The negative effects of ECH were corrected more effectivelly by thiotriazoline than by EP extract. | ||
| 650 | 4 | |a duodenum | |
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10.14739/2310-1210.2019.6.186643 doi (DE-627)DOAJ044928157 (DE-599)DOAJa38a02fc321e4a929a846ef5bac52adf DE-627 ger DE-627 rakwb eng rus ukr A. S. Smirnov verfasserin aut The state of the duodenal villi in rats under epichlorohydrin and drugs influence 2019 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Introduction. The modern environment is polluted by xenobiotics which can cause the development of pathological processes. One of xenobiotics is epichlorohydrin (ECH). The impact of this xenobiotic causes changes in the state of various organs, including the organs of the digestive system. However, the effects of ECH on the duodenum have not been investigated. The aim of the study is to investigate the changes in the state of the duodenal villi in rats and changes in mitotic activity of mucous epithelial cells under ECH influence as well as to evaluate a possibility and effectiveness of Echinacea purpurea (EP) extract and thiotriazoline use for these changes correction. Material and methods. An experimental study was performed on male white rats. Six experimental groups were created. Six rats from each experimental group were removed from the experiment on the 1st, 7th, 15th, 30th, 60th days after the end of the two-month administration of ECH, EP extract and thiotriazoline. The height of the villi of the duodenal mucosa and changes in mitotic activity of mucous epithelial cells were estimated using a microscope of the MS 100 series of Micros (Austria). Results. Morphofunctional organization of duodenal mucosa in rats was changed after the long-term introduction of ECH. The height of villi and mitotic activity of mucous epithelial cells were reduced. Over time, the expressiveness of the changes diminished. Introduction of EP extract and thiotriazoline administration to rats which did not receive ECH was accompanied by an increase in the height of villi. In the case of thiotriazoline administration, this effect was longer. The use of EP extract as well as the use of thiotriazoline during ECH inhalations reduced the severity and duration of the decrease in the height of villi and mitotic activity of mucous epithelial cells caused by this chemical. The negative effects of ECH were corrected more effectivelly by thiotriazoline than by EP extract. Conclusions. Prolonged action of ECH is accompanied by negative changes in the state of duodenal mucosa. The negative effects of ECH were corrected more effectivelly by thiotriazoline than by EP extract. duodenum villi mucosa epichlorohydrin rats Medicine R M. A. Mirzebasov verfasserin aut S. M. Smirnov verfasserin aut In Zaporožskij Medicinskij Žurnal Zaporozhye State Medical University, 2016 21(2019), 6, Seite 820-827 (DE-627)176064269X 23101210 nnns volume:21 year:2019 number:6 pages:820-827 https://doi.org/10.14739/2310-1210.2019.6.186643 kostenfrei https://doaj.org/article/a38a02fc321e4a929a846ef5bac52adf kostenfrei http://zmj.zsmu.edu.ua/article/view/186643/187029 kostenfrei https://doaj.org/toc/2306-4145 Journal toc kostenfrei https://doaj.org/toc/2310-1210 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ SSG-OLC-PHA AR 21 2019 6 820-827 |
| spelling |
10.14739/2310-1210.2019.6.186643 doi (DE-627)DOAJ044928157 (DE-599)DOAJa38a02fc321e4a929a846ef5bac52adf DE-627 ger DE-627 rakwb eng rus ukr A. S. Smirnov verfasserin aut The state of the duodenal villi in rats under epichlorohydrin and drugs influence 2019 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Introduction. The modern environment is polluted by xenobiotics which can cause the development of pathological processes. One of xenobiotics is epichlorohydrin (ECH). The impact of this xenobiotic causes changes in the state of various organs, including the organs of the digestive system. However, the effects of ECH on the duodenum have not been investigated. The aim of the study is to investigate the changes in the state of the duodenal villi in rats and changes in mitotic activity of mucous epithelial cells under ECH influence as well as to evaluate a possibility and effectiveness of Echinacea purpurea (EP) extract and thiotriazoline use for these changes correction. Material and methods. An experimental study was performed on male white rats. Six experimental groups were created. Six rats from each experimental group were removed from the experiment on the 1st, 7th, 15th, 30th, 60th days after the end of the two-month administration of ECH, EP extract and thiotriazoline. The height of the villi of the duodenal mucosa and changes in mitotic activity of mucous epithelial cells were estimated using a microscope of the MS 100 series of Micros (Austria). Results. Morphofunctional organization of duodenal mucosa in rats was changed after the long-term introduction of ECH. The height of villi and mitotic activity of mucous epithelial cells were reduced. Over time, the expressiveness of the changes diminished. Introduction of EP extract and thiotriazoline administration to rats which did not receive ECH was accompanied by an increase in the height of villi. In the case of thiotriazoline administration, this effect was longer. The use of EP extract as well as the use of thiotriazoline during ECH inhalations reduced the severity and duration of the decrease in the height of villi and mitotic activity of mucous epithelial cells caused by this chemical. The negative effects of ECH were corrected more effectivelly by thiotriazoline than by EP extract. Conclusions. Prolonged action of ECH is accompanied by negative changes in the state of duodenal mucosa. The negative effects of ECH were corrected more effectivelly by thiotriazoline than by EP extract. duodenum villi mucosa epichlorohydrin rats Medicine R M. A. Mirzebasov verfasserin aut S. M. Smirnov verfasserin aut In Zaporožskij Medicinskij Žurnal Zaporozhye State Medical University, 2016 21(2019), 6, Seite 820-827 (DE-627)176064269X 23101210 nnns volume:21 year:2019 number:6 pages:820-827 https://doi.org/10.14739/2310-1210.2019.6.186643 kostenfrei https://doaj.org/article/a38a02fc321e4a929a846ef5bac52adf kostenfrei http://zmj.zsmu.edu.ua/article/view/186643/187029 kostenfrei https://doaj.org/toc/2306-4145 Journal toc kostenfrei https://doaj.org/toc/2310-1210 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ SSG-OLC-PHA AR 21 2019 6 820-827 |
| allfields_unstemmed |
10.14739/2310-1210.2019.6.186643 doi (DE-627)DOAJ044928157 (DE-599)DOAJa38a02fc321e4a929a846ef5bac52adf DE-627 ger DE-627 rakwb eng rus ukr A. S. Smirnov verfasserin aut The state of the duodenal villi in rats under epichlorohydrin and drugs influence 2019 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Introduction. The modern environment is polluted by xenobiotics which can cause the development of pathological processes. One of xenobiotics is epichlorohydrin (ECH). The impact of this xenobiotic causes changes in the state of various organs, including the organs of the digestive system. However, the effects of ECH on the duodenum have not been investigated. The aim of the study is to investigate the changes in the state of the duodenal villi in rats and changes in mitotic activity of mucous epithelial cells under ECH influence as well as to evaluate a possibility and effectiveness of Echinacea purpurea (EP) extract and thiotriazoline use for these changes correction. Material and methods. An experimental study was performed on male white rats. Six experimental groups were created. Six rats from each experimental group were removed from the experiment on the 1st, 7th, 15th, 30th, 60th days after the end of the two-month administration of ECH, EP extract and thiotriazoline. The height of the villi of the duodenal mucosa and changes in mitotic activity of mucous epithelial cells were estimated using a microscope of the MS 100 series of Micros (Austria). Results. Morphofunctional organization of duodenal mucosa in rats was changed after the long-term introduction of ECH. The height of villi and mitotic activity of mucous epithelial cells were reduced. Over time, the expressiveness of the changes diminished. Introduction of EP extract and thiotriazoline administration to rats which did not receive ECH was accompanied by an increase in the height of villi. In the case of thiotriazoline administration, this effect was longer. The use of EP extract as well as the use of thiotriazoline during ECH inhalations reduced the severity and duration of the decrease in the height of villi and mitotic activity of mucous epithelial cells caused by this chemical. The negative effects of ECH were corrected more effectivelly by thiotriazoline than by EP extract. Conclusions. Prolonged action of ECH is accompanied by negative changes in the state of duodenal mucosa. The negative effects of ECH were corrected more effectivelly by thiotriazoline than by EP extract. duodenum villi mucosa epichlorohydrin rats Medicine R M. A. Mirzebasov verfasserin aut S. M. Smirnov verfasserin aut In Zaporožskij Medicinskij Žurnal Zaporozhye State Medical University, 2016 21(2019), 6, Seite 820-827 (DE-627)176064269X 23101210 nnns volume:21 year:2019 number:6 pages:820-827 https://doi.org/10.14739/2310-1210.2019.6.186643 kostenfrei https://doaj.org/article/a38a02fc321e4a929a846ef5bac52adf kostenfrei http://zmj.zsmu.edu.ua/article/view/186643/187029 kostenfrei https://doaj.org/toc/2306-4145 Journal toc kostenfrei https://doaj.org/toc/2310-1210 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ SSG-OLC-PHA AR 21 2019 6 820-827 |
| allfieldsGer |
10.14739/2310-1210.2019.6.186643 doi (DE-627)DOAJ044928157 (DE-599)DOAJa38a02fc321e4a929a846ef5bac52adf DE-627 ger DE-627 rakwb eng rus ukr A. S. Smirnov verfasserin aut The state of the duodenal villi in rats under epichlorohydrin and drugs influence 2019 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Introduction. The modern environment is polluted by xenobiotics which can cause the development of pathological processes. One of xenobiotics is epichlorohydrin (ECH). The impact of this xenobiotic causes changes in the state of various organs, including the organs of the digestive system. However, the effects of ECH on the duodenum have not been investigated. The aim of the study is to investigate the changes in the state of the duodenal villi in rats and changes in mitotic activity of mucous epithelial cells under ECH influence as well as to evaluate a possibility and effectiveness of Echinacea purpurea (EP) extract and thiotriazoline use for these changes correction. Material and methods. An experimental study was performed on male white rats. Six experimental groups were created. Six rats from each experimental group were removed from the experiment on the 1st, 7th, 15th, 30th, 60th days after the end of the two-month administration of ECH, EP extract and thiotriazoline. The height of the villi of the duodenal mucosa and changes in mitotic activity of mucous epithelial cells were estimated using a microscope of the MS 100 series of Micros (Austria). Results. Morphofunctional organization of duodenal mucosa in rats was changed after the long-term introduction of ECH. The height of villi and mitotic activity of mucous epithelial cells were reduced. Over time, the expressiveness of the changes diminished. Introduction of EP extract and thiotriazoline administration to rats which did not receive ECH was accompanied by an increase in the height of villi. In the case of thiotriazoline administration, this effect was longer. The use of EP extract as well as the use of thiotriazoline during ECH inhalations reduced the severity and duration of the decrease in the height of villi and mitotic activity of mucous epithelial cells caused by this chemical. The negative effects of ECH were corrected more effectivelly by thiotriazoline than by EP extract. Conclusions. Prolonged action of ECH is accompanied by negative changes in the state of duodenal mucosa. The negative effects of ECH were corrected more effectivelly by thiotriazoline than by EP extract. duodenum villi mucosa epichlorohydrin rats Medicine R M. A. Mirzebasov verfasserin aut S. M. Smirnov verfasserin aut In Zaporožskij Medicinskij Žurnal Zaporozhye State Medical University, 2016 21(2019), 6, Seite 820-827 (DE-627)176064269X 23101210 nnns volume:21 year:2019 number:6 pages:820-827 https://doi.org/10.14739/2310-1210.2019.6.186643 kostenfrei https://doaj.org/article/a38a02fc321e4a929a846ef5bac52adf kostenfrei http://zmj.zsmu.edu.ua/article/view/186643/187029 kostenfrei https://doaj.org/toc/2306-4145 Journal toc kostenfrei https://doaj.org/toc/2310-1210 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ SSG-OLC-PHA AR 21 2019 6 820-827 |
| allfieldsSound |
10.14739/2310-1210.2019.6.186643 doi (DE-627)DOAJ044928157 (DE-599)DOAJa38a02fc321e4a929a846ef5bac52adf DE-627 ger DE-627 rakwb eng rus ukr A. S. Smirnov verfasserin aut The state of the duodenal villi in rats under epichlorohydrin and drugs influence 2019 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Introduction. The modern environment is polluted by xenobiotics which can cause the development of pathological processes. One of xenobiotics is epichlorohydrin (ECH). The impact of this xenobiotic causes changes in the state of various organs, including the organs of the digestive system. However, the effects of ECH on the duodenum have not been investigated. The aim of the study is to investigate the changes in the state of the duodenal villi in rats and changes in mitotic activity of mucous epithelial cells under ECH influence as well as to evaluate a possibility and effectiveness of Echinacea purpurea (EP) extract and thiotriazoline use for these changes correction. Material and methods. An experimental study was performed on male white rats. Six experimental groups were created. Six rats from each experimental group were removed from the experiment on the 1st, 7th, 15th, 30th, 60th days after the end of the two-month administration of ECH, EP extract and thiotriazoline. The height of the villi of the duodenal mucosa and changes in mitotic activity of mucous epithelial cells were estimated using a microscope of the MS 100 series of Micros (Austria). Results. Morphofunctional organization of duodenal mucosa in rats was changed after the long-term introduction of ECH. The height of villi and mitotic activity of mucous epithelial cells were reduced. Over time, the expressiveness of the changes diminished. Introduction of EP extract and thiotriazoline administration to rats which did not receive ECH was accompanied by an increase in the height of villi. In the case of thiotriazoline administration, this effect was longer. The use of EP extract as well as the use of thiotriazoline during ECH inhalations reduced the severity and duration of the decrease in the height of villi and mitotic activity of mucous epithelial cells caused by this chemical. The negative effects of ECH were corrected more effectivelly by thiotriazoline than by EP extract. Conclusions. Prolonged action of ECH is accompanied by negative changes in the state of duodenal mucosa. The negative effects of ECH were corrected more effectivelly by thiotriazoline than by EP extract. duodenum villi mucosa epichlorohydrin rats Medicine R M. A. Mirzebasov verfasserin aut S. M. Smirnov verfasserin aut In Zaporožskij Medicinskij Žurnal Zaporozhye State Medical University, 2016 21(2019), 6, Seite 820-827 (DE-627)176064269X 23101210 nnns volume:21 year:2019 number:6 pages:820-827 https://doi.org/10.14739/2310-1210.2019.6.186643 kostenfrei https://doaj.org/article/a38a02fc321e4a929a846ef5bac52adf kostenfrei http://zmj.zsmu.edu.ua/article/view/186643/187029 kostenfrei https://doaj.org/toc/2306-4145 Journal toc kostenfrei https://doaj.org/toc/2310-1210 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ SSG-OLC-PHA AR 21 2019 6 820-827 |
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S. Smirnov</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="245" ind1="1" ind2="4"><subfield code="a">The state of the duodenal villi in rats under epichlorohydrin and drugs influence</subfield></datafield><datafield tag="264" ind1=" " ind2="1"><subfield code="c">2019</subfield></datafield><datafield tag="336" ind1=" " ind2=" "><subfield code="a">Text</subfield><subfield code="b">txt</subfield><subfield code="2">rdacontent</subfield></datafield><datafield tag="337" ind1=" " ind2=" "><subfield code="a">Computermedien</subfield><subfield code="b">c</subfield><subfield code="2">rdamedia</subfield></datafield><datafield tag="338" ind1=" " ind2=" "><subfield code="a">Online-Ressource</subfield><subfield code="b">cr</subfield><subfield code="2">rdacarrier</subfield></datafield><datafield tag="520" ind1=" " ind2=" "><subfield code="a">Introduction. The modern environment is polluted by xenobiotics which can cause the development of pathological processes. One of xenobiotics is epichlorohydrin (ECH). The impact of this xenobiotic causes changes in the state of various organs, including the organs of the digestive system. However, the effects of ECH on the duodenum have not been investigated. The aim of the study is to investigate the changes in the state of the duodenal villi in rats and changes in mitotic activity of mucous epithelial cells under ECH influence as well as to evaluate a possibility and effectiveness of Echinacea purpurea (EP) extract and thiotriazoline use for these changes correction. Material and methods. An experimental study was performed on male white rats. Six experimental groups were created. Six rats from each experimental group were removed from the experiment on the 1st, 7th, 15th, 30th, 60th days after the end of the two-month administration of ECH, EP extract and thiotriazoline. The height of the villi of the duodenal mucosa and changes in mitotic activity of mucous epithelial cells were estimated using a microscope of the MS 100 series of Micros (Austria). Results. Morphofunctional organization of duodenal mucosa in rats was changed after the long-term introduction of ECH. The height of villi and mitotic activity of mucous epithelial cells were reduced. Over time, the expressiveness of the changes diminished. Introduction of EP extract and thiotriazoline administration to rats which did not receive ECH was accompanied by an increase in the height of villi. In the case of thiotriazoline administration, this effect was longer. The use of EP extract as well as the use of thiotriazoline during ECH inhalations reduced the severity and duration of the decrease in the height of villi and mitotic activity of mucous epithelial cells caused by this chemical. The negative effects of ECH were corrected more effectivelly by thiotriazoline than by EP extract. Conclusions. 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state of the duodenal villi in rats under epichlorohydrin and drugs influence |
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The state of the duodenal villi in rats under epichlorohydrin and drugs influence |
| abstract |
Introduction. The modern environment is polluted by xenobiotics which can cause the development of pathological processes. One of xenobiotics is epichlorohydrin (ECH). The impact of this xenobiotic causes changes in the state of various organs, including the organs of the digestive system. However, the effects of ECH on the duodenum have not been investigated. The aim of the study is to investigate the changes in the state of the duodenal villi in rats and changes in mitotic activity of mucous epithelial cells under ECH influence as well as to evaluate a possibility and effectiveness of Echinacea purpurea (EP) extract and thiotriazoline use for these changes correction. Material and methods. An experimental study was performed on male white rats. Six experimental groups were created. Six rats from each experimental group were removed from the experiment on the 1st, 7th, 15th, 30th, 60th days after the end of the two-month administration of ECH, EP extract and thiotriazoline. The height of the villi of the duodenal mucosa and changes in mitotic activity of mucous epithelial cells were estimated using a microscope of the MS 100 series of Micros (Austria). Results. Morphofunctional organization of duodenal mucosa in rats was changed after the long-term introduction of ECH. The height of villi and mitotic activity of mucous epithelial cells were reduced. Over time, the expressiveness of the changes diminished. Introduction of EP extract and thiotriazoline administration to rats which did not receive ECH was accompanied by an increase in the height of villi. In the case of thiotriazoline administration, this effect was longer. The use of EP extract as well as the use of thiotriazoline during ECH inhalations reduced the severity and duration of the decrease in the height of villi and mitotic activity of mucous epithelial cells caused by this chemical. The negative effects of ECH were corrected more effectivelly by thiotriazoline than by EP extract. Conclusions. Prolonged action of ECH is accompanied by negative changes in the state of duodenal mucosa. The negative effects of ECH were corrected more effectivelly by thiotriazoline than by EP extract. |
| abstractGer |
Introduction. The modern environment is polluted by xenobiotics which can cause the development of pathological processes. One of xenobiotics is epichlorohydrin (ECH). The impact of this xenobiotic causes changes in the state of various organs, including the organs of the digestive system. However, the effects of ECH on the duodenum have not been investigated. The aim of the study is to investigate the changes in the state of the duodenal villi in rats and changes in mitotic activity of mucous epithelial cells under ECH influence as well as to evaluate a possibility and effectiveness of Echinacea purpurea (EP) extract and thiotriazoline use for these changes correction. Material and methods. An experimental study was performed on male white rats. Six experimental groups were created. Six rats from each experimental group were removed from the experiment on the 1st, 7th, 15th, 30th, 60th days after the end of the two-month administration of ECH, EP extract and thiotriazoline. The height of the villi of the duodenal mucosa and changes in mitotic activity of mucous epithelial cells were estimated using a microscope of the MS 100 series of Micros (Austria). Results. Morphofunctional organization of duodenal mucosa in rats was changed after the long-term introduction of ECH. The height of villi and mitotic activity of mucous epithelial cells were reduced. Over time, the expressiveness of the changes diminished. Introduction of EP extract and thiotriazoline administration to rats which did not receive ECH was accompanied by an increase in the height of villi. In the case of thiotriazoline administration, this effect was longer. The use of EP extract as well as the use of thiotriazoline during ECH inhalations reduced the severity and duration of the decrease in the height of villi and mitotic activity of mucous epithelial cells caused by this chemical. The negative effects of ECH were corrected more effectivelly by thiotriazoline than by EP extract. Conclusions. Prolonged action of ECH is accompanied by negative changes in the state of duodenal mucosa. The negative effects of ECH were corrected more effectivelly by thiotriazoline than by EP extract. |
| abstract_unstemmed |
Introduction. The modern environment is polluted by xenobiotics which can cause the development of pathological processes. One of xenobiotics is epichlorohydrin (ECH). The impact of this xenobiotic causes changes in the state of various organs, including the organs of the digestive system. However, the effects of ECH on the duodenum have not been investigated. The aim of the study is to investigate the changes in the state of the duodenal villi in rats and changes in mitotic activity of mucous epithelial cells under ECH influence as well as to evaluate a possibility and effectiveness of Echinacea purpurea (EP) extract and thiotriazoline use for these changes correction. Material and methods. An experimental study was performed on male white rats. Six experimental groups were created. Six rats from each experimental group were removed from the experiment on the 1st, 7th, 15th, 30th, 60th days after the end of the two-month administration of ECH, EP extract and thiotriazoline. The height of the villi of the duodenal mucosa and changes in mitotic activity of mucous epithelial cells were estimated using a microscope of the MS 100 series of Micros (Austria). Results. Morphofunctional organization of duodenal mucosa in rats was changed after the long-term introduction of ECH. The height of villi and mitotic activity of mucous epithelial cells were reduced. Over time, the expressiveness of the changes diminished. Introduction of EP extract and thiotriazoline administration to rats which did not receive ECH was accompanied by an increase in the height of villi. In the case of thiotriazoline administration, this effect was longer. The use of EP extract as well as the use of thiotriazoline during ECH inhalations reduced the severity and duration of the decrease in the height of villi and mitotic activity of mucous epithelial cells caused by this chemical. The negative effects of ECH were corrected more effectivelly by thiotriazoline than by EP extract. Conclusions. Prolonged action of ECH is accompanied by negative changes in the state of duodenal mucosa. The negative effects of ECH were corrected more effectivelly by thiotriazoline than by EP extract. |
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