The efficacy and acceptability of exposure therapy for the treatment of post-traumatic stress disorder in children and adolescents: a systematic review and meta-analysis

Abstract Background Posttraumatic stress disorder (PTSD) is common among children and adolescents who have experienced traumatic events. Exposure therapy (ET) has been shown to be effective in treating PTSD in adults. However, its efficacy remains uncertain in children and adolescents. Aims To evaluate the efficacy and acceptability of ET in children and adolescents with PTSD. Method We searched PubMed, EMBASE, Cochrane, Web of Science, PsycINFO, CINAHL, ProQuest, LILACS, and international trial registries for randomized controlled trials (RCTs) assessed ET in children and adolescents (aged ≤18 years) with PTSD up to August 31, 2020. The primary outcomes were efficacy (the endpoint score from PTSD symptom severity rating scales) and acceptability (all-cause discontinuation), secondary outcomes included efficacy at follow-up (score from PTSD scales at the longest point of follow-up), depressive symptoms (end-point score on depressive symptom severity rating scales) and quality of life/social functioning (end-point score on quality of life/social functioning rating scales). This study was registered with PROSPERO (CRD42020150859). Result A total of 6 RCTs (278 patients) were included. The results showed that ET was statistically more efficacious than control groups (standardized mean differences [SMD]: − 0.47, 95% confidence interval [CI]: − 0.91 to − 0.03). In subgroup analysis, exposure therapy was more efficacious for patients with single type of trauma (SMD: − 1.04, 95%CI: − 1.43 to − 0.65). Patients with an average age of 14 years and older, ET was more effective than the control groups (SMD: − 1.04, 95%CI: − 1.43 to − 0.65), and the intervention using prolonged exposure therapy (PE) (SMD: − 1.04, 95%CI: − 1.43 to − 0.65) was superior than control groups. Results for secondary outcomes of efficacy at follow-up (SMD: − 0.64, 95%CI: − 1.17 to − 0.10) and depressive symptoms (SMD: − 0.58, 95%CI: − 0.93 to − 0.22) were similar to the previous findings for efficacy outcome. No statistically significant effects for acceptability and quality of life/social functioning were found. Conclusion ET showed superiority in efficacy at post-treatment/follow-up and depressive symptoms improvement in children and adolescents with PTSD. Patients with single type of trauma may benefit more from ET. And ET is more effective in patients 14 years or older. Moreover, PE could be a better choice. Ausführliche Beschreibung

Gespeichert in:

Autor*in:	Tengyue Huang [verfasserIn] Haomiao Li [verfasserIn] Shiyu Tan [verfasserIn] Siyu Xie [verfasserIn] Qisheng Cheng [verfasserIn] Yajie Xiang [verfasserIn] Xinyu Zhou [verfasserIn]

Format:	E-Artikel
Sprache:	Englisch

Erschienen:	2022

Schlagwörter:	Exposure therapy Post-traumatic stress disorder Children Adolescents Meta-analysis

Übergeordnetes Werk:	In: BMC Psychiatry - BMC, 2003, 22(2022), 1, Seite 12
Übergeordnetes Werk:	volume:22 ; year:2022 ; number:1 ; pages:12

Links:	Link aufrufen Link aufrufen Link aufrufen Journal toc

DOI / URN:	10.1186/s12888-022-03867-6

Katalog-ID:	DOAJ045021929

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520			\|a Abstract Background Posttraumatic stress disorder (PTSD) is common among children and adolescents who have experienced traumatic events. Exposure therapy (ET) has been shown to be effective in treating PTSD in adults. However, its efficacy remains uncertain in children and adolescents. Aims To evaluate the efficacy and acceptability of ET in children and adolescents with PTSD. Method We searched PubMed, EMBASE, Cochrane, Web of Science, PsycINFO, CINAHL, ProQuest, LILACS, and international trial registries for randomized controlled trials (RCTs) assessed ET in children and adolescents (aged ≤18 years) with PTSD up to August 31, 2020. The primary outcomes were efficacy (the endpoint score from PTSD symptom severity rating scales) and acceptability (all-cause discontinuation), secondary outcomes included efficacy at follow-up (score from PTSD scales at the longest point of follow-up), depressive symptoms (end-point score on depressive symptom severity rating scales) and quality of life/social functioning (end-point score on quality of life/social functioning rating scales). This study was registered with PROSPERO (CRD42020150859). Result A total of 6 RCTs (278 patients) were included. The results showed that ET was statistically more efficacious than control groups (standardized mean differences [SMD]: − 0.47, 95% confidence interval [CI]: − 0.91 to − 0.03). In subgroup analysis, exposure therapy was more efficacious for patients with single type of trauma (SMD: − 1.04, 95%CI: − 1.43 to − 0.65). Patients with an average age of 14 years and older, ET was more effective than the control groups (SMD: − 1.04, 95%CI: − 1.43 to − 0.65), and the intervention using prolonged exposure therapy (PE) (SMD: − 1.04, 95%CI: − 1.43 to − 0.65) was superior than control groups. Results for secondary outcomes of efficacy at follow-up (SMD: − 0.64, 95%CI: − 1.17 to − 0.10) and depressive symptoms (SMD: − 0.58, 95%CI: − 0.93 to − 0.22) were similar to the previous findings for efficacy outcome. No statistically significant effects for acceptability and quality of life/social functioning were found. Conclusion ET showed superiority in efficacy at post-treatment/follow-up and depressive symptoms improvement in children and adolescents with PTSD. Patients with single type of trauma may benefit more from ET. And ET is more effective in patients 14 years or older. Moreover, PE could be a better choice.
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allfields	10.1186/s12888-022-03867-6 doi (DE-627)DOAJ045021929 (DE-599)DOAJ43703c26a968486bb69d92a98e976afb DE-627 ger DE-627 rakwb eng RC435-571 Tengyue Huang verfasserin aut The efficacy and acceptability of exposure therapy for the treatment of post-traumatic stress disorder in children and adolescents: a systematic review and meta-analysis 2022 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Abstract Background Posttraumatic stress disorder (PTSD) is common among children and adolescents who have experienced traumatic events. Exposure therapy (ET) has been shown to be effective in treating PTSD in adults. However, its efficacy remains uncertain in children and adolescents. Aims To evaluate the efficacy and acceptability of ET in children and adolescents with PTSD. Method We searched PubMed, EMBASE, Cochrane, Web of Science, PsycINFO, CINAHL, ProQuest, LILACS, and international trial registries for randomized controlled trials (RCTs) assessed ET in children and adolescents (aged ≤18 years) with PTSD up to August 31, 2020. The primary outcomes were efficacy (the endpoint score from PTSD symptom severity rating scales) and acceptability (all-cause discontinuation), secondary outcomes included efficacy at follow-up (score from PTSD scales at the longest point of follow-up), depressive symptoms (end-point score on depressive symptom severity rating scales) and quality of life/social functioning (end-point score on quality of life/social functioning rating scales). This study was registered with PROSPERO (CRD42020150859). Result A total of 6 RCTs (278 patients) were included. The results showed that ET was statistically more efficacious than control groups (standardized mean differences [SMD]: − 0.47, 95% confidence interval [CI]: − 0.91 to − 0.03). In subgroup analysis, exposure therapy was more efficacious for patients with single type of trauma (SMD: − 1.04, 95%CI: − 1.43 to − 0.65). Patients with an average age of 14 years and older, ET was more effective than the control groups (SMD: − 1.04, 95%CI: − 1.43 to − 0.65), and the intervention using prolonged exposure therapy (PE) (SMD: − 1.04, 95%CI: − 1.43 to − 0.65) was superior than control groups. Results for secondary outcomes of efficacy at follow-up (SMD: − 0.64, 95%CI: − 1.17 to − 0.10) and depressive symptoms (SMD: − 0.58, 95%CI: − 0.93 to − 0.22) were similar to the previous findings for efficacy outcome. No statistically significant effects for acceptability and quality of life/social functioning were found. Conclusion ET showed superiority in efficacy at post-treatment/follow-up and depressive symptoms improvement in children and adolescents with PTSD. Patients with single type of trauma may benefit more from ET. And ET is more effective in patients 14 years or older. Moreover, PE could be a better choice. Exposure therapy Post-traumatic stress disorder Children Adolescents Meta-analysis Psychiatry Haomiao Li verfasserin aut Shiyu Tan verfasserin aut Siyu Xie verfasserin aut Qisheng Cheng verfasserin aut Yajie Xiang verfasserin aut Xinyu Zhou verfasserin aut In BMC Psychiatry BMC, 2003 22(2022), 1, Seite 12 (DE-627)331018799 (DE-600)2050438-X 1471244X nnns volume:22 year:2022 number:1 pages:12 https://doi.org/10.1186/s12888-022-03867-6 kostenfrei https://doaj.org/article/43703c26a968486bb69d92a98e976afb kostenfrei https://doi.org/10.1186/s12888-022-03867-6 kostenfrei https://doaj.org/toc/1471-244X Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2031 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2057 GBV_ILN_2061 GBV_ILN_2111 GBV_ILN_2113 GBV_ILN_2190 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 22 2022 1 12
spelling	10.1186/s12888-022-03867-6 doi (DE-627)DOAJ045021929 (DE-599)DOAJ43703c26a968486bb69d92a98e976afb DE-627 ger DE-627 rakwb eng RC435-571 Tengyue Huang verfasserin aut The efficacy and acceptability of exposure therapy for the treatment of post-traumatic stress disorder in children and adolescents: a systematic review and meta-analysis 2022 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Abstract Background Posttraumatic stress disorder (PTSD) is common among children and adolescents who have experienced traumatic events. Exposure therapy (ET) has been shown to be effective in treating PTSD in adults. However, its efficacy remains uncertain in children and adolescents. Aims To evaluate the efficacy and acceptability of ET in children and adolescents with PTSD. Method We searched PubMed, EMBASE, Cochrane, Web of Science, PsycINFO, CINAHL, ProQuest, LILACS, and international trial registries for randomized controlled trials (RCTs) assessed ET in children and adolescents (aged ≤18 years) with PTSD up to August 31, 2020. The primary outcomes were efficacy (the endpoint score from PTSD symptom severity rating scales) and acceptability (all-cause discontinuation), secondary outcomes included efficacy at follow-up (score from PTSD scales at the longest point of follow-up), depressive symptoms (end-point score on depressive symptom severity rating scales) and quality of life/social functioning (end-point score on quality of life/social functioning rating scales). This study was registered with PROSPERO (CRD42020150859). Result A total of 6 RCTs (278 patients) were included. The results showed that ET was statistically more efficacious than control groups (standardized mean differences [SMD]: − 0.47, 95% confidence interval [CI]: − 0.91 to − 0.03). In subgroup analysis, exposure therapy was more efficacious for patients with single type of trauma (SMD: − 1.04, 95%CI: − 1.43 to − 0.65). Patients with an average age of 14 years and older, ET was more effective than the control groups (SMD: − 1.04, 95%CI: − 1.43 to − 0.65), and the intervention using prolonged exposure therapy (PE) (SMD: − 1.04, 95%CI: − 1.43 to − 0.65) was superior than control groups. Results for secondary outcomes of efficacy at follow-up (SMD: − 0.64, 95%CI: − 1.17 to − 0.10) and depressive symptoms (SMD: − 0.58, 95%CI: − 0.93 to − 0.22) were similar to the previous findings for efficacy outcome. No statistically significant effects for acceptability and quality of life/social functioning were found. Conclusion ET showed superiority in efficacy at post-treatment/follow-up and depressive symptoms improvement in children and adolescents with PTSD. Patients with single type of trauma may benefit more from ET. And ET is more effective in patients 14 years or older. Moreover, PE could be a better choice. Exposure therapy Post-traumatic stress disorder Children Adolescents Meta-analysis Psychiatry Haomiao Li verfasserin aut Shiyu Tan verfasserin aut Siyu Xie verfasserin aut Qisheng Cheng verfasserin aut Yajie Xiang verfasserin aut Xinyu Zhou verfasserin aut In BMC Psychiatry BMC, 2003 22(2022), 1, Seite 12 (DE-627)331018799 (DE-600)2050438-X 1471244X nnns volume:22 year:2022 number:1 pages:12 https://doi.org/10.1186/s12888-022-03867-6 kostenfrei https://doaj.org/article/43703c26a968486bb69d92a98e976afb kostenfrei https://doi.org/10.1186/s12888-022-03867-6 kostenfrei https://doaj.org/toc/1471-244X Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2031 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2057 GBV_ILN_2061 GBV_ILN_2111 GBV_ILN_2113 GBV_ILN_2190 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 22 2022 1 12
allfields_unstemmed	10.1186/s12888-022-03867-6 doi (DE-627)DOAJ045021929 (DE-599)DOAJ43703c26a968486bb69d92a98e976afb DE-627 ger DE-627 rakwb eng RC435-571 Tengyue Huang verfasserin aut The efficacy and acceptability of exposure therapy for the treatment of post-traumatic stress disorder in children and adolescents: a systematic review and meta-analysis 2022 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Abstract Background Posttraumatic stress disorder (PTSD) is common among children and adolescents who have experienced traumatic events. Exposure therapy (ET) has been shown to be effective in treating PTSD in adults. However, its efficacy remains uncertain in children and adolescents. Aims To evaluate the efficacy and acceptability of ET in children and adolescents with PTSD. Method We searched PubMed, EMBASE, Cochrane, Web of Science, PsycINFO, CINAHL, ProQuest, LILACS, and international trial registries for randomized controlled trials (RCTs) assessed ET in children and adolescents (aged ≤18 years) with PTSD up to August 31, 2020. The primary outcomes were efficacy (the endpoint score from PTSD symptom severity rating scales) and acceptability (all-cause discontinuation), secondary outcomes included efficacy at follow-up (score from PTSD scales at the longest point of follow-up), depressive symptoms (end-point score on depressive symptom severity rating scales) and quality of life/social functioning (end-point score on quality of life/social functioning rating scales). This study was registered with PROSPERO (CRD42020150859). Result A total of 6 RCTs (278 patients) were included. The results showed that ET was statistically more efficacious than control groups (standardized mean differences [SMD]: − 0.47, 95% confidence interval [CI]: − 0.91 to − 0.03). In subgroup analysis, exposure therapy was more efficacious for patients with single type of trauma (SMD: − 1.04, 95%CI: − 1.43 to − 0.65). Patients with an average age of 14 years and older, ET was more effective than the control groups (SMD: − 1.04, 95%CI: − 1.43 to − 0.65), and the intervention using prolonged exposure therapy (PE) (SMD: − 1.04, 95%CI: − 1.43 to − 0.65) was superior than control groups. Results for secondary outcomes of efficacy at follow-up (SMD: − 0.64, 95%CI: − 1.17 to − 0.10) and depressive symptoms (SMD: − 0.58, 95%CI: − 0.93 to − 0.22) were similar to the previous findings for efficacy outcome. No statistically significant effects for acceptability and quality of life/social functioning were found. Conclusion ET showed superiority in efficacy at post-treatment/follow-up and depressive symptoms improvement in children and adolescents with PTSD. Patients with single type of trauma may benefit more from ET. And ET is more effective in patients 14 years or older. Moreover, PE could be a better choice. Exposure therapy Post-traumatic stress disorder Children Adolescents Meta-analysis Psychiatry Haomiao Li verfasserin aut Shiyu Tan verfasserin aut Siyu Xie verfasserin aut Qisheng Cheng verfasserin aut Yajie Xiang verfasserin aut Xinyu Zhou verfasserin aut In BMC Psychiatry BMC, 2003 22(2022), 1, Seite 12 (DE-627)331018799 (DE-600)2050438-X 1471244X nnns volume:22 year:2022 number:1 pages:12 https://doi.org/10.1186/s12888-022-03867-6 kostenfrei https://doaj.org/article/43703c26a968486bb69d92a98e976afb kostenfrei https://doi.org/10.1186/s12888-022-03867-6 kostenfrei https://doaj.org/toc/1471-244X Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2031 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2057 GBV_ILN_2061 GBV_ILN_2111 GBV_ILN_2113 GBV_ILN_2190 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 22 2022 1 12
allfieldsGer	10.1186/s12888-022-03867-6 doi (DE-627)DOAJ045021929 (DE-599)DOAJ43703c26a968486bb69d92a98e976afb DE-627 ger DE-627 rakwb eng RC435-571 Tengyue Huang verfasserin aut The efficacy and acceptability of exposure therapy for the treatment of post-traumatic stress disorder in children and adolescents: a systematic review and meta-analysis 2022 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Abstract Background Posttraumatic stress disorder (PTSD) is common among children and adolescents who have experienced traumatic events. Exposure therapy (ET) has been shown to be effective in treating PTSD in adults. However, its efficacy remains uncertain in children and adolescents. Aims To evaluate the efficacy and acceptability of ET in children and adolescents with PTSD. Method We searched PubMed, EMBASE, Cochrane, Web of Science, PsycINFO, CINAHL, ProQuest, LILACS, and international trial registries for randomized controlled trials (RCTs) assessed ET in children and adolescents (aged ≤18 years) with PTSD up to August 31, 2020. The primary outcomes were efficacy (the endpoint score from PTSD symptom severity rating scales) and acceptability (all-cause discontinuation), secondary outcomes included efficacy at follow-up (score from PTSD scales at the longest point of follow-up), depressive symptoms (end-point score on depressive symptom severity rating scales) and quality of life/social functioning (end-point score on quality of life/social functioning rating scales). This study was registered with PROSPERO (CRD42020150859). Result A total of 6 RCTs (278 patients) were included. The results showed that ET was statistically more efficacious than control groups (standardized mean differences [SMD]: − 0.47, 95% confidence interval [CI]: − 0.91 to − 0.03). In subgroup analysis, exposure therapy was more efficacious for patients with single type of trauma (SMD: − 1.04, 95%CI: − 1.43 to − 0.65). Patients with an average age of 14 years and older, ET was more effective than the control groups (SMD: − 1.04, 95%CI: − 1.43 to − 0.65), and the intervention using prolonged exposure therapy (PE) (SMD: − 1.04, 95%CI: − 1.43 to − 0.65) was superior than control groups. Results for secondary outcomes of efficacy at follow-up (SMD: − 0.64, 95%CI: − 1.17 to − 0.10) and depressive symptoms (SMD: − 0.58, 95%CI: − 0.93 to − 0.22) were similar to the previous findings for efficacy outcome. No statistically significant effects for acceptability and quality of life/social functioning were found. Conclusion ET showed superiority in efficacy at post-treatment/follow-up and depressive symptoms improvement in children and adolescents with PTSD. Patients with single type of trauma may benefit more from ET. And ET is more effective in patients 14 years or older. Moreover, PE could be a better choice. Exposure therapy Post-traumatic stress disorder Children Adolescents Meta-analysis Psychiatry Haomiao Li verfasserin aut Shiyu Tan verfasserin aut Siyu Xie verfasserin aut Qisheng Cheng verfasserin aut Yajie Xiang verfasserin aut Xinyu Zhou verfasserin aut In BMC Psychiatry BMC, 2003 22(2022), 1, Seite 12 (DE-627)331018799 (DE-600)2050438-X 1471244X nnns volume:22 year:2022 number:1 pages:12 https://doi.org/10.1186/s12888-022-03867-6 kostenfrei https://doaj.org/article/43703c26a968486bb69d92a98e976afb kostenfrei https://doi.org/10.1186/s12888-022-03867-6 kostenfrei https://doaj.org/toc/1471-244X Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2031 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2057 GBV_ILN_2061 GBV_ILN_2111 GBV_ILN_2113 GBV_ILN_2190 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 22 2022 1 12
allfieldsSound	10.1186/s12888-022-03867-6 doi (DE-627)DOAJ045021929 (DE-599)DOAJ43703c26a968486bb69d92a98e976afb DE-627 ger DE-627 rakwb eng RC435-571 Tengyue Huang verfasserin aut The efficacy and acceptability of exposure therapy for the treatment of post-traumatic stress disorder in children and adolescents: a systematic review and meta-analysis 2022 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Abstract Background Posttraumatic stress disorder (PTSD) is common among children and adolescents who have experienced traumatic events. Exposure therapy (ET) has been shown to be effective in treating PTSD in adults. However, its efficacy remains uncertain in children and adolescents. Aims To evaluate the efficacy and acceptability of ET in children and adolescents with PTSD. Method We searched PubMed, EMBASE, Cochrane, Web of Science, PsycINFO, CINAHL, ProQuest, LILACS, and international trial registries for randomized controlled trials (RCTs) assessed ET in children and adolescents (aged ≤18 years) with PTSD up to August 31, 2020. The primary outcomes were efficacy (the endpoint score from PTSD symptom severity rating scales) and acceptability (all-cause discontinuation), secondary outcomes included efficacy at follow-up (score from PTSD scales at the longest point of follow-up), depressive symptoms (end-point score on depressive symptom severity rating scales) and quality of life/social functioning (end-point score on quality of life/social functioning rating scales). This study was registered with PROSPERO (CRD42020150859). Result A total of 6 RCTs (278 patients) were included. The results showed that ET was statistically more efficacious than control groups (standardized mean differences [SMD]: − 0.47, 95% confidence interval [CI]: − 0.91 to − 0.03). In subgroup analysis, exposure therapy was more efficacious for patients with single type of trauma (SMD: − 1.04, 95%CI: − 1.43 to − 0.65). Patients with an average age of 14 years and older, ET was more effective than the control groups (SMD: − 1.04, 95%CI: − 1.43 to − 0.65), and the intervention using prolonged exposure therapy (PE) (SMD: − 1.04, 95%CI: − 1.43 to − 0.65) was superior than control groups. Results for secondary outcomes of efficacy at follow-up (SMD: − 0.64, 95%CI: − 1.17 to − 0.10) and depressive symptoms (SMD: − 0.58, 95%CI: − 0.93 to − 0.22) were similar to the previous findings for efficacy outcome. No statistically significant effects for acceptability and quality of life/social functioning were found. Conclusion ET showed superiority in efficacy at post-treatment/follow-up and depressive symptoms improvement in children and adolescents with PTSD. Patients with single type of trauma may benefit more from ET. And ET is more effective in patients 14 years or older. Moreover, PE could be a better choice. Exposure therapy Post-traumatic stress disorder Children Adolescents Meta-analysis Psychiatry Haomiao Li verfasserin aut Shiyu Tan verfasserin aut Siyu Xie verfasserin aut Qisheng Cheng verfasserin aut Yajie Xiang verfasserin aut Xinyu Zhou verfasserin aut In BMC Psychiatry BMC, 2003 22(2022), 1, Seite 12 (DE-627)331018799 (DE-600)2050438-X 1471244X nnns volume:22 year:2022 number:1 pages:12 https://doi.org/10.1186/s12888-022-03867-6 kostenfrei https://doaj.org/article/43703c26a968486bb69d92a98e976afb kostenfrei https://doi.org/10.1186/s12888-022-03867-6 kostenfrei https://doaj.org/toc/1471-244X Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2031 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2057 GBV_ILN_2061 GBV_ILN_2111 GBV_ILN_2113 GBV_ILN_2190 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 22 2022 1 12
language	English
source	In BMC Psychiatry 22(2022), 1, Seite 12 volume:22 year:2022 number:1 pages:12
sourceStr	In BMC Psychiatry 22(2022), 1, Seite 12 volume:22 year:2022 number:1 pages:12
format_phy_str_mv	Article
institution	findex.gbv.de
topic_facet	Exposure therapy Post-traumatic stress disorder Children Adolescents Meta-analysis Psychiatry
isfreeaccess_bool	true
container_title	BMC Psychiatry
authorswithroles_txt_mv	Tengyue Huang @@aut@@ Haomiao Li @@aut@@ Shiyu Tan @@aut@@ Siyu Xie @@aut@@ Qisheng Cheng @@aut@@ Yajie Xiang @@aut@@ Xinyu Zhou @@aut@@
publishDateDaySort_date	2022-01-01T00:00:00Z
hierarchy_top_id	331018799
id	DOAJ045021929
language_de	englisch
fullrecord	<?xml version="1.0" encoding="UTF-8"?><collection xmlns="http://www.loc.gov/MARC21/slim"><record><leader>01000caa a22002652 4500</leader><controlfield tag="001">DOAJ045021929</controlfield><controlfield tag="003">DE-627</controlfield><controlfield tag="005">20230308085854.0</controlfield><controlfield tag="007">cr uuu---uuuuu</controlfield><controlfield tag="008">230227s2022 xx \|\|\|\|\|o 00\| \|\|eng c</controlfield><datafield tag="024" ind1="7" ind2=" "><subfield code="a">10.1186/s12888-022-03867-6</subfield><subfield code="2">doi</subfield></datafield><datafield tag="035" ind1=" " ind2=" "><subfield code="a">(DE-627)DOAJ045021929</subfield></datafield><datafield tag="035" ind1=" " ind2=" "><subfield code="a">(DE-599)DOAJ43703c26a968486bb69d92a98e976afb</subfield></datafield><datafield tag="040" ind1=" " ind2=" "><subfield code="a">DE-627</subfield><subfield code="b">ger</subfield><subfield code="c">DE-627</subfield><subfield code="e">rakwb</subfield></datafield><datafield tag="041" ind1=" " ind2=" "><subfield code="a">eng</subfield></datafield><datafield tag="050" ind1=" " ind2="0"><subfield code="a">RC435-571</subfield></datafield><datafield tag="100" ind1="0" ind2=" "><subfield code="a">Tengyue Huang</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="245" ind1="1" ind2="4"><subfield code="a">The efficacy and acceptability of exposure therapy for the treatment of post-traumatic stress disorder in children and adolescents: a systematic review and meta-analysis</subfield></datafield><datafield tag="264" ind1=" " ind2="1"><subfield code="c">2022</subfield></datafield><datafield tag="336" ind1=" " ind2=" "><subfield code="a">Text</subfield><subfield code="b">txt</subfield><subfield code="2">rdacontent</subfield></datafield><datafield tag="337" ind1=" " ind2=" "><subfield code="a">Computermedien</subfield><subfield code="b">c</subfield><subfield code="2">rdamedia</subfield></datafield><datafield tag="338" ind1=" " ind2=" "><subfield code="a">Online-Ressource</subfield><subfield code="b">cr</subfield><subfield code="2">rdacarrier</subfield></datafield><datafield tag="520" ind1=" " ind2=" "><subfield code="a">Abstract Background Posttraumatic stress disorder (PTSD) is common among children and adolescents who have experienced traumatic events. Exposure therapy (ET) has been shown to be effective in treating PTSD in adults. However, its efficacy remains uncertain in children and adolescents. Aims To evaluate the efficacy and acceptability of ET in children and adolescents with PTSD. Method We searched PubMed, EMBASE, Cochrane, Web of Science, PsycINFO, CINAHL, ProQuest, LILACS, and international trial registries for randomized controlled trials (RCTs) assessed ET in children and adolescents (aged ≤18 years) with PTSD up to August 31, 2020. The primary outcomes were efficacy (the endpoint score from PTSD symptom severity rating scales) and acceptability (all-cause discontinuation), secondary outcomes included efficacy at follow-up (score from PTSD scales at the longest point of follow-up), depressive symptoms (end-point score on depressive symptom severity rating scales) and quality of life/social functioning (end-point score on quality of life/social functioning rating scales). This study was registered with PROSPERO (CRD42020150859). Result A total of 6 RCTs (278 patients) were included. The results showed that ET was statistically more efficacious than control groups (standardized mean differences [SMD]: − 0.47, 95% confidence interval [CI]: − 0.91 to − 0.03). In subgroup analysis, exposure therapy was more efficacious for patients with single type of trauma (SMD: − 1.04, 95%CI: − 1.43 to − 0.65). Patients with an average age of 14 years and older, ET was more effective than the control groups (SMD: − 1.04, 95%CI: − 1.43 to − 0.65), and the intervention using prolonged exposure therapy (PE) (SMD: − 1.04, 95%CI: − 1.43 to − 0.65) was superior than control groups. Results for secondary outcomes of efficacy at follow-up (SMD: − 0.64, 95%CI: − 1.17 to − 0.10) and depressive symptoms (SMD: − 0.58, 95%CI: − 0.93 to − 0.22) were similar to the previous findings for efficacy outcome. No statistically significant effects for acceptability and quality of life/social functioning were found. Conclusion ET showed superiority in efficacy at post-treatment/follow-up and depressive symptoms improvement in children and adolescents with PTSD. Patients with single type of trauma may benefit more from ET. And ET is more effective in patients 14 years or older. 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callnumber-first	R - Medicine
author	Tengyue Huang
spellingShingle	Tengyue Huang misc RC435-571 misc Exposure therapy misc Post-traumatic stress disorder misc Children misc Adolescents misc Meta-analysis misc Psychiatry The efficacy and acceptability of exposure therapy for the treatment of post-traumatic stress disorder in children and adolescents: a systematic review and meta-analysis
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topic_title	RC435-571 The efficacy and acceptability of exposure therapy for the treatment of post-traumatic stress disorder in children and adolescents: a systematic review and meta-analysis Exposure therapy Post-traumatic stress disorder Children Adolescents Meta-analysis
topic	misc RC435-571 misc Exposure therapy misc Post-traumatic stress disorder misc Children misc Adolescents misc Meta-analysis misc Psychiatry
topic_unstemmed	misc RC435-571 misc Exposure therapy misc Post-traumatic stress disorder misc Children misc Adolescents misc Meta-analysis misc Psychiatry
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title	The efficacy and acceptability of exposure therapy for the treatment of post-traumatic stress disorder in children and adolescents: a systematic review and meta-analysis
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title_full	The efficacy and acceptability of exposure therapy for the treatment of post-traumatic stress disorder in children and adolescents: a systematic review and meta-analysis
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title_sort	efficacy and acceptability of exposure therapy for the treatment of post-traumatic stress disorder in children and adolescents: a systematic review and meta-analysis
callnumber	RC435-571
title_auth	The efficacy and acceptability of exposure therapy for the treatment of post-traumatic stress disorder in children and adolescents: a systematic review and meta-analysis
abstract	Abstract Background Posttraumatic stress disorder (PTSD) is common among children and adolescents who have experienced traumatic events. Exposure therapy (ET) has been shown to be effective in treating PTSD in adults. However, its efficacy remains uncertain in children and adolescents. Aims To evaluate the efficacy and acceptability of ET in children and adolescents with PTSD. Method We searched PubMed, EMBASE, Cochrane, Web of Science, PsycINFO, CINAHL, ProQuest, LILACS, and international trial registries for randomized controlled trials (RCTs) assessed ET in children and adolescents (aged ≤18 years) with PTSD up to August 31, 2020. The primary outcomes were efficacy (the endpoint score from PTSD symptom severity rating scales) and acceptability (all-cause discontinuation), secondary outcomes included efficacy at follow-up (score from PTSD scales at the longest point of follow-up), depressive symptoms (end-point score on depressive symptom severity rating scales) and quality of life/social functioning (end-point score on quality of life/social functioning rating scales). This study was registered with PROSPERO (CRD42020150859). Result A total of 6 RCTs (278 patients) were included. The results showed that ET was statistically more efficacious than control groups (standardized mean differences [SMD]: − 0.47, 95% confidence interval [CI]: − 0.91 to − 0.03). In subgroup analysis, exposure therapy was more efficacious for patients with single type of trauma (SMD: − 1.04, 95%CI: − 1.43 to − 0.65). Patients with an average age of 14 years and older, ET was more effective than the control groups (SMD: − 1.04, 95%CI: − 1.43 to − 0.65), and the intervention using prolonged exposure therapy (PE) (SMD: − 1.04, 95%CI: − 1.43 to − 0.65) was superior than control groups. Results for secondary outcomes of efficacy at follow-up (SMD: − 0.64, 95%CI: − 1.17 to − 0.10) and depressive symptoms (SMD: − 0.58, 95%CI: − 0.93 to − 0.22) were similar to the previous findings for efficacy outcome. No statistically significant effects for acceptability and quality of life/social functioning were found. Conclusion ET showed superiority in efficacy at post-treatment/follow-up and depressive symptoms improvement in children and adolescents with PTSD. Patients with single type of trauma may benefit more from ET. And ET is more effective in patients 14 years or older. Moreover, PE could be a better choice.
abstractGer	Abstract Background Posttraumatic stress disorder (PTSD) is common among children and adolescents who have experienced traumatic events. Exposure therapy (ET) has been shown to be effective in treating PTSD in adults. However, its efficacy remains uncertain in children and adolescents. Aims To evaluate the efficacy and acceptability of ET in children and adolescents with PTSD. Method We searched PubMed, EMBASE, Cochrane, Web of Science, PsycINFO, CINAHL, ProQuest, LILACS, and international trial registries for randomized controlled trials (RCTs) assessed ET in children and adolescents (aged ≤18 years) with PTSD up to August 31, 2020. The primary outcomes were efficacy (the endpoint score from PTSD symptom severity rating scales) and acceptability (all-cause discontinuation), secondary outcomes included efficacy at follow-up (score from PTSD scales at the longest point of follow-up), depressive symptoms (end-point score on depressive symptom severity rating scales) and quality of life/social functioning (end-point score on quality of life/social functioning rating scales). This study was registered with PROSPERO (CRD42020150859). Result A total of 6 RCTs (278 patients) were included. The results showed that ET was statistically more efficacious than control groups (standardized mean differences [SMD]: − 0.47, 95% confidence interval [CI]: − 0.91 to − 0.03). In subgroup analysis, exposure therapy was more efficacious for patients with single type of trauma (SMD: − 1.04, 95%CI: − 1.43 to − 0.65). Patients with an average age of 14 years and older, ET was more effective than the control groups (SMD: − 1.04, 95%CI: − 1.43 to − 0.65), and the intervention using prolonged exposure therapy (PE) (SMD: − 1.04, 95%CI: − 1.43 to − 0.65) was superior than control groups. Results for secondary outcomes of efficacy at follow-up (SMD: − 0.64, 95%CI: − 1.17 to − 0.10) and depressive symptoms (SMD: − 0.58, 95%CI: − 0.93 to − 0.22) were similar to the previous findings for efficacy outcome. No statistically significant effects for acceptability and quality of life/social functioning were found. Conclusion ET showed superiority in efficacy at post-treatment/follow-up and depressive symptoms improvement in children and adolescents with PTSD. Patients with single type of trauma may benefit more from ET. And ET is more effective in patients 14 years or older. Moreover, PE could be a better choice.
abstract_unstemmed	Abstract Background Posttraumatic stress disorder (PTSD) is common among children and adolescents who have experienced traumatic events. Exposure therapy (ET) has been shown to be effective in treating PTSD in adults. However, its efficacy remains uncertain in children and adolescents. Aims To evaluate the efficacy and acceptability of ET in children and adolescents with PTSD. Method We searched PubMed, EMBASE, Cochrane, Web of Science, PsycINFO, CINAHL, ProQuest, LILACS, and international trial registries for randomized controlled trials (RCTs) assessed ET in children and adolescents (aged ≤18 years) with PTSD up to August 31, 2020. The primary outcomes were efficacy (the endpoint score from PTSD symptom severity rating scales) and acceptability (all-cause discontinuation), secondary outcomes included efficacy at follow-up (score from PTSD scales at the longest point of follow-up), depressive symptoms (end-point score on depressive symptom severity rating scales) and quality of life/social functioning (end-point score on quality of life/social functioning rating scales). This study was registered with PROSPERO (CRD42020150859). Result A total of 6 RCTs (278 patients) were included. The results showed that ET was statistically more efficacious than control groups (standardized mean differences [SMD]: − 0.47, 95% confidence interval [CI]: − 0.91 to − 0.03). In subgroup analysis, exposure therapy was more efficacious for patients with single type of trauma (SMD: − 1.04, 95%CI: − 1.43 to − 0.65). Patients with an average age of 14 years and older, ET was more effective than the control groups (SMD: − 1.04, 95%CI: − 1.43 to − 0.65), and the intervention using prolonged exposure therapy (PE) (SMD: − 1.04, 95%CI: − 1.43 to − 0.65) was superior than control groups. Results for secondary outcomes of efficacy at follow-up (SMD: − 0.64, 95%CI: − 1.17 to − 0.10) and depressive symptoms (SMD: − 0.58, 95%CI: − 0.93 to − 0.22) were similar to the previous findings for efficacy outcome. No statistically significant effects for acceptability and quality of life/social functioning were found. Conclusion ET showed superiority in efficacy at post-treatment/follow-up and depressive symptoms improvement in children and adolescents with PTSD. Patients with single type of trauma may benefit more from ET. And ET is more effective in patients 14 years or older. Moreover, PE could be a better choice.
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title_short	The efficacy and acceptability of exposure therapy for the treatment of post-traumatic stress disorder in children and adolescents: a systematic review and meta-analysis
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fullrecord_marcxml	<?xml version="1.0" encoding="UTF-8"?><collection xmlns="http://www.loc.gov/MARC21/slim"><record><leader>01000caa a22002652 4500</leader><controlfield tag="001">DOAJ045021929</controlfield><controlfield tag="003">DE-627</controlfield><controlfield tag="005">20230308085854.0</controlfield><controlfield tag="007">cr uuu---uuuuu</controlfield><controlfield tag="008">230227s2022 xx \|\|\|\|\|o 00\| \|\|eng c</controlfield><datafield tag="024" ind1="7" ind2=" "><subfield code="a">10.1186/s12888-022-03867-6</subfield><subfield code="2">doi</subfield></datafield><datafield tag="035" ind1=" " ind2=" "><subfield code="a">(DE-627)DOAJ045021929</subfield></datafield><datafield tag="035" ind1=" " ind2=" "><subfield code="a">(DE-599)DOAJ43703c26a968486bb69d92a98e976afb</subfield></datafield><datafield tag="040" ind1=" " ind2=" "><subfield code="a">DE-627</subfield><subfield code="b">ger</subfield><subfield code="c">DE-627</subfield><subfield code="e">rakwb</subfield></datafield><datafield tag="041" ind1=" " ind2=" "><subfield code="a">eng</subfield></datafield><datafield tag="050" ind1=" " ind2="0"><subfield code="a">RC435-571</subfield></datafield><datafield tag="100" ind1="0" ind2=" "><subfield code="a">Tengyue Huang</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="245" ind1="1" ind2="4"><subfield code="a">The efficacy and acceptability of exposure therapy for the treatment of post-traumatic stress disorder in children and adolescents: a systematic review and meta-analysis</subfield></datafield><datafield tag="264" ind1=" " ind2="1"><subfield code="c">2022</subfield></datafield><datafield tag="336" ind1=" " ind2=" "><subfield code="a">Text</subfield><subfield code="b">txt</subfield><subfield code="2">rdacontent</subfield></datafield><datafield tag="337" ind1=" " ind2=" "><subfield code="a">Computermedien</subfield><subfield code="b">c</subfield><subfield code="2">rdamedia</subfield></datafield><datafield tag="338" ind1=" " ind2=" "><subfield code="a">Online-Ressource</subfield><subfield code="b">cr</subfield><subfield code="2">rdacarrier</subfield></datafield><datafield tag="520" ind1=" " ind2=" "><subfield code="a">Abstract Background Posttraumatic stress disorder (PTSD) is common among children and adolescents who have experienced traumatic events. Exposure therapy (ET) has been shown to be effective in treating PTSD in adults. However, its efficacy remains uncertain in children and adolescents. Aims To evaluate the efficacy and acceptability of ET in children and adolescents with PTSD. Method We searched PubMed, EMBASE, Cochrane, Web of Science, PsycINFO, CINAHL, ProQuest, LILACS, and international trial registries for randomized controlled trials (RCTs) assessed ET in children and adolescents (aged ≤18 years) with PTSD up to August 31, 2020. The primary outcomes were efficacy (the endpoint score from PTSD symptom severity rating scales) and acceptability (all-cause discontinuation), secondary outcomes included efficacy at follow-up (score from PTSD scales at the longest point of follow-up), depressive symptoms (end-point score on depressive symptom severity rating scales) and quality of life/social functioning (end-point score on quality of life/social functioning rating scales). This study was registered with PROSPERO (CRD42020150859). Result A total of 6 RCTs (278 patients) were included. The results showed that ET was statistically more efficacious than control groups (standardized mean differences [SMD]: − 0.47, 95% confidence interval [CI]: − 0.91 to − 0.03). In subgroup analysis, exposure therapy was more efficacious for patients with single type of trauma (SMD: − 1.04, 95%CI: − 1.43 to − 0.65). Patients with an average age of 14 years and older, ET was more effective than the control groups (SMD: − 1.04, 95%CI: − 1.43 to − 0.65), and the intervention using prolonged exposure therapy (PE) (SMD: − 1.04, 95%CI: − 1.43 to − 0.65) was superior than control groups. Results for secondary outcomes of efficacy at follow-up (SMD: − 0.64, 95%CI: − 1.17 to − 0.10) and depressive symptoms (SMD: − 0.58, 95%CI: − 0.93 to − 0.22) were similar to the previous findings for efficacy outcome. No statistically significant effects for acceptability and quality of life/social functioning were found. Conclusion ET showed superiority in efficacy at post-treatment/follow-up and depressive symptoms improvement in children and adolescents with PTSD. Patients with single type of trauma may benefit more from ET. And ET is more effective in patients 14 years or older. 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The efficacy and acceptability of exposure therapy for the treatment of post-traumatic stress disorder in children and adolescents: a systematic review and meta-analysis

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