Exercise ventilatory reserve predicts survival in adult congenital heart disease associated pulmonary arterial hypertension with Eisenmenger physiology

Impaired ventilatory responses during exercise significantly contribute to breathlessness in patients with pulmonary arterial hypertension (PAH). Breathing reserve (BR) at peak exercise during cardiopulmonary exercise testing (CPET), a measure of the reserve in the ventilatory capacity, and as a PAH...
Ausführliche Beschreibung

Gespeichert in:

Autor*in:	Chinthaka B. Samaranayake [verfasserIn] Ruth McNiven [verfasserIn] Aleksander Kempny [verfasserIn] Carl Harries [verfasserIn] Laura C. Price [verfasserIn] Michael Gatzoulis [verfasserIn] Konstantinos Dimopoulos [verfasserIn] Stephen J. Wort [verfasserIn] Colm McCabe [verfasserIn]

Format:	E-Artikel
Sprache:	Englisch

Erschienen:	2022

Schlagwörter:	Pulmonary arterial hypertension Eisenmenger syndrome Exercise Ventilatory responses breathing reserve Ventilation Prognosis

Übergeordnetes Werk:	In: International Journal of Cardiology Congenital Heart Disease - Elsevier, 2021, 7(2022), Seite 100331-
Übergeordnetes Werk:	volume:7 ; year:2022 ; pages:100331-

Links:	Link aufrufen Link aufrufen Link aufrufen Journal toc

DOI / URN:	10.1016/j.ijcchd.2022.100331

Katalog-ID:	DOAJ045049238

Internformat


LEADER	01000caa a22002652 4500
001	DOAJ045049238
003	DE-627
005	20230308090110.0
007	cr uuu---uuuuu
008	230227s2022 xx \|\|\|\|\|o 00\| \|\|eng c
024	7		\|a 10.1016/j.ijcchd.2022.100331 \|2 doi
035			\|a (DE-627)DOAJ045049238
035			\|a (DE-599)DOAJb1769b65a4984df2a8d685b8f79d9b49
040			\|a DE-627 \|b ger \|c DE-627 \|e rakwb
041			\|a eng
050		0	\|a RC666-701
100	0		\|a Chinthaka B. Samaranayake \|e verfasserin \|4 aut
245	1	0	\|a Exercise ventilatory reserve predicts survival in adult congenital heart disease associated pulmonary arterial hypertension with Eisenmenger physiology
264		1	\|c 2022
336			\|a Text \|b txt \|2 rdacontent
337			\|a Computermedien \|b c \|2 rdamedia
338			\|a Online-Ressource \|b cr \|2 rdacarrier
520			\|a Impaired ventilatory responses during exercise significantly contribute to breathlessness in patients with pulmonary arterial hypertension (PAH). Breathing reserve (BR) at peak exercise during cardiopulmonary exercise testing (CPET), a measure of the reserve in the ventilatory capacity, and as a PAH prognostic marker has not received wide attention. We assessed the prognostic value of a reduced BR (≤30% predicted) on survival in patients with two forms of PAH: congenital heart disease-associated PAH and Eisenmenger physiology (EIS) and idiopathic PAH (IPAH). Propensity score matched cohorts of 50 EIS and 50 IPAH patients who underwent CPET in our institution were included. Overall transplant-free survival at 5 and 10 years was assessed. Twenty-five (50.0%) EIS and 15 (33.3%) IPAH patients had a BR ≤ 30% at peak exercise (p = 0.047). Independent predictors of a BR ≤ 30% across all patients included cardiothoracic ratio on chest radiograph (HR 2.2, 95% CI 1.6–3.0, p = 0.01) and moderate to severe restriction on resting spirometry (HR 1.9, 95% CI 1.1–2.8, p = 0.03). A BR ≤ 30% was associated with a significantly higher risk of mortality in the EIS group at 10 years follow-up (HR 3.4, 95% CI 1.1 to 11.4, p = 0.045). Neither a BR ≤ 30% or <30% offered prognostic discrimination in IPAH. In summary, a BR <30% at peak exercise is associated with better survival in patients with EIS. Lung parenchymal restriction inferred from larger cardiothoracic ratios may contribute to reduced BR along with increased ventilatory drive.
650		4	\|a Pulmonary arterial hypertension
650		4	\|a Eisenmenger syndrome
650		4	\|a Exercise
650		4	\|a Ventilatory responses breathing reserve
650		4	\|a Ventilation
650		4	\|a Prognosis
653		0	\|a Diseases of the circulatory (Cardiovascular) system
700	0		\|a Ruth McNiven \|e verfasserin \|4 aut
700	0		\|a Aleksander Kempny \|e verfasserin \|4 aut
700	0		\|a Carl Harries \|e verfasserin \|4 aut
700	0		\|a Laura C. Price \|e verfasserin \|4 aut
700	0		\|a Michael Gatzoulis \|e verfasserin \|4 aut
700	0		\|a Konstantinos Dimopoulos \|e verfasserin \|4 aut
700	0		\|a Stephen J. Wort \|e verfasserin \|4 aut
700	0		\|a Colm McCabe \|e verfasserin \|4 aut
773	0	8	\|i In \|t International Journal of Cardiology Congenital Heart Disease \|d Elsevier, 2021 \|g 7(2022), Seite 100331- \|w (DE-627)1759387916 \|x 26666685 \|7 nnns
773	1	8	\|g volume:7 \|g year:2022 \|g pages:100331-
856	4	0	\|u https://doi.org/10.1016/j.ijcchd.2022.100331 \|z kostenfrei
856	4	0	\|u https://doaj.org/article/b1769b65a4984df2a8d685b8f79d9b49 \|z kostenfrei
856	4	0	\|u http://www.sciencedirect.com/science/article/pii/S2666668522000143 \|z kostenfrei
856	4	2	\|u https://doaj.org/toc/2666-6685 \|y Journal toc \|z kostenfrei
912			\|a GBV_USEFLAG_A
912			\|a SYSFLAG_A
912			\|a GBV_DOAJ
912			\|a GBV_ILN_20
912			\|a GBV_ILN_22
912			\|a GBV_ILN_23
912			\|a GBV_ILN_24
912			\|a GBV_ILN_31
912			\|a GBV_ILN_39
912			\|a GBV_ILN_40
912			\|a GBV_ILN_60
912			\|a GBV_ILN_62
912			\|a GBV_ILN_63
912			\|a GBV_ILN_65
912			\|a GBV_ILN_69
912			\|a GBV_ILN_73
912			\|a GBV_ILN_74
912			\|a GBV_ILN_95
912			\|a GBV_ILN_105
912			\|a GBV_ILN_110
912			\|a GBV_ILN_151
912			\|a GBV_ILN_161
912			\|a GBV_ILN_170
912			\|a GBV_ILN_206
912			\|a GBV_ILN_213
912			\|a GBV_ILN_224
912			\|a GBV_ILN_230
912			\|a GBV_ILN_285
912			\|a GBV_ILN_293
912			\|a GBV_ILN_602
912			\|a GBV_ILN_2001
912			\|a GBV_ILN_2003
912			\|a GBV_ILN_2005
912			\|a GBV_ILN_2006
912			\|a GBV_ILN_2007
912			\|a GBV_ILN_2008
912			\|a GBV_ILN_2009
912			\|a GBV_ILN_2010
912			\|a GBV_ILN_2011
912			\|a GBV_ILN_2014
912			\|a GBV_ILN_2015
912			\|a GBV_ILN_2020
912			\|a GBV_ILN_2021
912			\|a GBV_ILN_2025
912			\|a GBV_ILN_2026
912			\|a GBV_ILN_2027
912			\|a GBV_ILN_2034
912			\|a GBV_ILN_2038
912			\|a GBV_ILN_2044
912			\|a GBV_ILN_2048
912			\|a GBV_ILN_2049
912			\|a GBV_ILN_2050
912			\|a GBV_ILN_2055
912			\|a GBV_ILN_2056
912			\|a GBV_ILN_2059
912			\|a GBV_ILN_2061
912			\|a GBV_ILN_2064
912			\|a GBV_ILN_2088
912			\|a GBV_ILN_2106
912			\|a GBV_ILN_2110
912			\|a GBV_ILN_2112
912			\|a GBV_ILN_2122
912			\|a GBV_ILN_2129
912			\|a GBV_ILN_2143
912			\|a GBV_ILN_2152
912			\|a GBV_ILN_2153
912			\|a GBV_ILN_2190
912			\|a GBV_ILN_2232
912			\|a GBV_ILN_2336
912			\|a GBV_ILN_2470
912			\|a GBV_ILN_2507
912			\|a GBV_ILN_4012
912			\|a GBV_ILN_4035
912			\|a GBV_ILN_4037
912			\|a GBV_ILN_4112
912			\|a GBV_ILN_4125
912			\|a GBV_ILN_4126
912			\|a GBV_ILN_4242
912			\|a GBV_ILN_4249
912			\|a GBV_ILN_4251
912			\|a GBV_ILN_4305
912			\|a GBV_ILN_4306
912			\|a GBV_ILN_4307
912			\|a GBV_ILN_4313
912			\|a GBV_ILN_4322
912			\|a GBV_ILN_4323
912			\|a GBV_ILN_4324
912			\|a GBV_ILN_4325
912			\|a GBV_ILN_4326
912			\|a GBV_ILN_4333
912			\|a GBV_ILN_4334
912			\|a GBV_ILN_4338
912			\|a GBV_ILN_4367
912			\|a GBV_ILN_4393
912			\|a GBV_ILN_4700
951			\|a AR
952			\|d 7 \|j 2022 \|h 100331-

Indexfelder

author_variant	c b s cbs r m rm a k ak c h ch l c p lcp m g mg k d kd s j w sjw c m cm
matchkey_str	article:26666685:2022----::xrieetltrrsrerdcsuvvlndlcneiahatiesascaeploayreil
hierarchy_sort_str	2022
callnumber-subject-code	RC
publishDate	2022
allfields	10.1016/j.ijcchd.2022.100331 doi (DE-627)DOAJ045049238 (DE-599)DOAJb1769b65a4984df2a8d685b8f79d9b49 DE-627 ger DE-627 rakwb eng RC666-701 Chinthaka B. Samaranayake verfasserin aut Exercise ventilatory reserve predicts survival in adult congenital heart disease associated pulmonary arterial hypertension with Eisenmenger physiology 2022 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Impaired ventilatory responses during exercise significantly contribute to breathlessness in patients with pulmonary arterial hypertension (PAH). Breathing reserve (BR) at peak exercise during cardiopulmonary exercise testing (CPET), a measure of the reserve in the ventilatory capacity, and as a PAH prognostic marker has not received wide attention. We assessed the prognostic value of a reduced BR (≤30% predicted) on survival in patients with two forms of PAH: congenital heart disease-associated PAH and Eisenmenger physiology (EIS) and idiopathic PAH (IPAH). Propensity score matched cohorts of 50 EIS and 50 IPAH patients who underwent CPET in our institution were included. Overall transplant-free survival at 5 and 10 years was assessed. Twenty-five (50.0%) EIS and 15 (33.3%) IPAH patients had a BR ≤ 30% at peak exercise (p = 0.047). Independent predictors of a BR ≤ 30% across all patients included cardiothoracic ratio on chest radiograph (HR 2.2, 95% CI 1.6–3.0, p = 0.01) and moderate to severe restriction on resting spirometry (HR 1.9, 95% CI 1.1–2.8, p = 0.03). A BR ≤ 30% was associated with a significantly higher risk of mortality in the EIS group at 10 years follow-up (HR 3.4, 95% CI 1.1 to 11.4, p = 0.045). Neither a BR ≤ 30% or <30% offered prognostic discrimination in IPAH. In summary, a BR <30% at peak exercise is associated with better survival in patients with EIS. Lung parenchymal restriction inferred from larger cardiothoracic ratios may contribute to reduced BR along with increased ventilatory drive. Pulmonary arterial hypertension Eisenmenger syndrome Exercise Ventilatory responses breathing reserve Ventilation Prognosis Diseases of the circulatory (Cardiovascular) system Ruth McNiven verfasserin aut Aleksander Kempny verfasserin aut Carl Harries verfasserin aut Laura C. Price verfasserin aut Michael Gatzoulis verfasserin aut Konstantinos Dimopoulos verfasserin aut Stephen J. Wort verfasserin aut Colm McCabe verfasserin aut In International Journal of Cardiology Congenital Heart Disease Elsevier, 2021 7(2022), Seite 100331- (DE-627)1759387916 26666685 nnns volume:7 year:2022 pages:100331- https://doi.org/10.1016/j.ijcchd.2022.100331 kostenfrei https://doaj.org/article/b1769b65a4984df2a8d685b8f79d9b49 kostenfrei http://www.sciencedirect.com/science/article/pii/S2666668522000143 kostenfrei https://doaj.org/toc/2666-6685 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2034 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2088 GBV_ILN_2106 GBV_ILN_2110 GBV_ILN_2112 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2470 GBV_ILN_2507 GBV_ILN_4012 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4393 GBV_ILN_4700 AR 7 2022 100331-
spelling	10.1016/j.ijcchd.2022.100331 doi (DE-627)DOAJ045049238 (DE-599)DOAJb1769b65a4984df2a8d685b8f79d9b49 DE-627 ger DE-627 rakwb eng RC666-701 Chinthaka B. Samaranayake verfasserin aut Exercise ventilatory reserve predicts survival in adult congenital heart disease associated pulmonary arterial hypertension with Eisenmenger physiology 2022 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Impaired ventilatory responses during exercise significantly contribute to breathlessness in patients with pulmonary arterial hypertension (PAH). Breathing reserve (BR) at peak exercise during cardiopulmonary exercise testing (CPET), a measure of the reserve in the ventilatory capacity, and as a PAH prognostic marker has not received wide attention. We assessed the prognostic value of a reduced BR (≤30% predicted) on survival in patients with two forms of PAH: congenital heart disease-associated PAH and Eisenmenger physiology (EIS) and idiopathic PAH (IPAH). Propensity score matched cohorts of 50 EIS and 50 IPAH patients who underwent CPET in our institution were included. Overall transplant-free survival at 5 and 10 years was assessed. Twenty-five (50.0%) EIS and 15 (33.3%) IPAH patients had a BR ≤ 30% at peak exercise (p = 0.047). Independent predictors of a BR ≤ 30% across all patients included cardiothoracic ratio on chest radiograph (HR 2.2, 95% CI 1.6–3.0, p = 0.01) and moderate to severe restriction on resting spirometry (HR 1.9, 95% CI 1.1–2.8, p = 0.03). A BR ≤ 30% was associated with a significantly higher risk of mortality in the EIS group at 10 years follow-up (HR 3.4, 95% CI 1.1 to 11.4, p = 0.045). Neither a BR ≤ 30% or <30% offered prognostic discrimination in IPAH. In summary, a BR <30% at peak exercise is associated with better survival in patients with EIS. Lung parenchymal restriction inferred from larger cardiothoracic ratios may contribute to reduced BR along with increased ventilatory drive. Pulmonary arterial hypertension Eisenmenger syndrome Exercise Ventilatory responses breathing reserve Ventilation Prognosis Diseases of the circulatory (Cardiovascular) system Ruth McNiven verfasserin aut Aleksander Kempny verfasserin aut Carl Harries verfasserin aut Laura C. Price verfasserin aut Michael Gatzoulis verfasserin aut Konstantinos Dimopoulos verfasserin aut Stephen J. Wort verfasserin aut Colm McCabe verfasserin aut In International Journal of Cardiology Congenital Heart Disease Elsevier, 2021 7(2022), Seite 100331- (DE-627)1759387916 26666685 nnns volume:7 year:2022 pages:100331- https://doi.org/10.1016/j.ijcchd.2022.100331 kostenfrei https://doaj.org/article/b1769b65a4984df2a8d685b8f79d9b49 kostenfrei http://www.sciencedirect.com/science/article/pii/S2666668522000143 kostenfrei https://doaj.org/toc/2666-6685 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2034 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2088 GBV_ILN_2106 GBV_ILN_2110 GBV_ILN_2112 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2470 GBV_ILN_2507 GBV_ILN_4012 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4393 GBV_ILN_4700 AR 7 2022 100331-
allfields_unstemmed	10.1016/j.ijcchd.2022.100331 doi (DE-627)DOAJ045049238 (DE-599)DOAJb1769b65a4984df2a8d685b8f79d9b49 DE-627 ger DE-627 rakwb eng RC666-701 Chinthaka B. Samaranayake verfasserin aut Exercise ventilatory reserve predicts survival in adult congenital heart disease associated pulmonary arterial hypertension with Eisenmenger physiology 2022 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Impaired ventilatory responses during exercise significantly contribute to breathlessness in patients with pulmonary arterial hypertension (PAH). Breathing reserve (BR) at peak exercise during cardiopulmonary exercise testing (CPET), a measure of the reserve in the ventilatory capacity, and as a PAH prognostic marker has not received wide attention. We assessed the prognostic value of a reduced BR (≤30% predicted) on survival in patients with two forms of PAH: congenital heart disease-associated PAH and Eisenmenger physiology (EIS) and idiopathic PAH (IPAH). Propensity score matched cohorts of 50 EIS and 50 IPAH patients who underwent CPET in our institution were included. Overall transplant-free survival at 5 and 10 years was assessed. Twenty-five (50.0%) EIS and 15 (33.3%) IPAH patients had a BR ≤ 30% at peak exercise (p = 0.047). Independent predictors of a BR ≤ 30% across all patients included cardiothoracic ratio on chest radiograph (HR 2.2, 95% CI 1.6–3.0, p = 0.01) and moderate to severe restriction on resting spirometry (HR 1.9, 95% CI 1.1–2.8, p = 0.03). A BR ≤ 30% was associated with a significantly higher risk of mortality in the EIS group at 10 years follow-up (HR 3.4, 95% CI 1.1 to 11.4, p = 0.045). Neither a BR ≤ 30% or <30% offered prognostic discrimination in IPAH. In summary, a BR <30% at peak exercise is associated with better survival in patients with EIS. Lung parenchymal restriction inferred from larger cardiothoracic ratios may contribute to reduced BR along with increased ventilatory drive. Pulmonary arterial hypertension Eisenmenger syndrome Exercise Ventilatory responses breathing reserve Ventilation Prognosis Diseases of the circulatory (Cardiovascular) system Ruth McNiven verfasserin aut Aleksander Kempny verfasserin aut Carl Harries verfasserin aut Laura C. Price verfasserin aut Michael Gatzoulis verfasserin aut Konstantinos Dimopoulos verfasserin aut Stephen J. Wort verfasserin aut Colm McCabe verfasserin aut In International Journal of Cardiology Congenital Heart Disease Elsevier, 2021 7(2022), Seite 100331- (DE-627)1759387916 26666685 nnns volume:7 year:2022 pages:100331- https://doi.org/10.1016/j.ijcchd.2022.100331 kostenfrei https://doaj.org/article/b1769b65a4984df2a8d685b8f79d9b49 kostenfrei http://www.sciencedirect.com/science/article/pii/S2666668522000143 kostenfrei https://doaj.org/toc/2666-6685 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2034 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2088 GBV_ILN_2106 GBV_ILN_2110 GBV_ILN_2112 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2470 GBV_ILN_2507 GBV_ILN_4012 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4393 GBV_ILN_4700 AR 7 2022 100331-
allfieldsGer	10.1016/j.ijcchd.2022.100331 doi (DE-627)DOAJ045049238 (DE-599)DOAJb1769b65a4984df2a8d685b8f79d9b49 DE-627 ger DE-627 rakwb eng RC666-701 Chinthaka B. Samaranayake verfasserin aut Exercise ventilatory reserve predicts survival in adult congenital heart disease associated pulmonary arterial hypertension with Eisenmenger physiology 2022 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Impaired ventilatory responses during exercise significantly contribute to breathlessness in patients with pulmonary arterial hypertension (PAH). Breathing reserve (BR) at peak exercise during cardiopulmonary exercise testing (CPET), a measure of the reserve in the ventilatory capacity, and as a PAH prognostic marker has not received wide attention. We assessed the prognostic value of a reduced BR (≤30% predicted) on survival in patients with two forms of PAH: congenital heart disease-associated PAH and Eisenmenger physiology (EIS) and idiopathic PAH (IPAH). Propensity score matched cohorts of 50 EIS and 50 IPAH patients who underwent CPET in our institution were included. Overall transplant-free survival at 5 and 10 years was assessed. Twenty-five (50.0%) EIS and 15 (33.3%) IPAH patients had a BR ≤ 30% at peak exercise (p = 0.047). Independent predictors of a BR ≤ 30% across all patients included cardiothoracic ratio on chest radiograph (HR 2.2, 95% CI 1.6–3.0, p = 0.01) and moderate to severe restriction on resting spirometry (HR 1.9, 95% CI 1.1–2.8, p = 0.03). A BR ≤ 30% was associated with a significantly higher risk of mortality in the EIS group at 10 years follow-up (HR 3.4, 95% CI 1.1 to 11.4, p = 0.045). Neither a BR ≤ 30% or <30% offered prognostic discrimination in IPAH. In summary, a BR <30% at peak exercise is associated with better survival in patients with EIS. Lung parenchymal restriction inferred from larger cardiothoracic ratios may contribute to reduced BR along with increased ventilatory drive. Pulmonary arterial hypertension Eisenmenger syndrome Exercise Ventilatory responses breathing reserve Ventilation Prognosis Diseases of the circulatory (Cardiovascular) system Ruth McNiven verfasserin aut Aleksander Kempny verfasserin aut Carl Harries verfasserin aut Laura C. Price verfasserin aut Michael Gatzoulis verfasserin aut Konstantinos Dimopoulos verfasserin aut Stephen J. Wort verfasserin aut Colm McCabe verfasserin aut In International Journal of Cardiology Congenital Heart Disease Elsevier, 2021 7(2022), Seite 100331- (DE-627)1759387916 26666685 nnns volume:7 year:2022 pages:100331- https://doi.org/10.1016/j.ijcchd.2022.100331 kostenfrei https://doaj.org/article/b1769b65a4984df2a8d685b8f79d9b49 kostenfrei http://www.sciencedirect.com/science/article/pii/S2666668522000143 kostenfrei https://doaj.org/toc/2666-6685 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2034 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2088 GBV_ILN_2106 GBV_ILN_2110 GBV_ILN_2112 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2470 GBV_ILN_2507 GBV_ILN_4012 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4393 GBV_ILN_4700 AR 7 2022 100331-
allfieldsSound	10.1016/j.ijcchd.2022.100331 doi (DE-627)DOAJ045049238 (DE-599)DOAJb1769b65a4984df2a8d685b8f79d9b49 DE-627 ger DE-627 rakwb eng RC666-701 Chinthaka B. Samaranayake verfasserin aut Exercise ventilatory reserve predicts survival in adult congenital heart disease associated pulmonary arterial hypertension with Eisenmenger physiology 2022 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Impaired ventilatory responses during exercise significantly contribute to breathlessness in patients with pulmonary arterial hypertension (PAH). Breathing reserve (BR) at peak exercise during cardiopulmonary exercise testing (CPET), a measure of the reserve in the ventilatory capacity, and as a PAH prognostic marker has not received wide attention. We assessed the prognostic value of a reduced BR (≤30% predicted) on survival in patients with two forms of PAH: congenital heart disease-associated PAH and Eisenmenger physiology (EIS) and idiopathic PAH (IPAH). Propensity score matched cohorts of 50 EIS and 50 IPAH patients who underwent CPET in our institution were included. Overall transplant-free survival at 5 and 10 years was assessed. Twenty-five (50.0%) EIS and 15 (33.3%) IPAH patients had a BR ≤ 30% at peak exercise (p = 0.047). Independent predictors of a BR ≤ 30% across all patients included cardiothoracic ratio on chest radiograph (HR 2.2, 95% CI 1.6–3.0, p = 0.01) and moderate to severe restriction on resting spirometry (HR 1.9, 95% CI 1.1–2.8, p = 0.03). A BR ≤ 30% was associated with a significantly higher risk of mortality in the EIS group at 10 years follow-up (HR 3.4, 95% CI 1.1 to 11.4, p = 0.045). Neither a BR ≤ 30% or <30% offered prognostic discrimination in IPAH. In summary, a BR <30% at peak exercise is associated with better survival in patients with EIS. Lung parenchymal restriction inferred from larger cardiothoracic ratios may contribute to reduced BR along with increased ventilatory drive. Pulmonary arterial hypertension Eisenmenger syndrome Exercise Ventilatory responses breathing reserve Ventilation Prognosis Diseases of the circulatory (Cardiovascular) system Ruth McNiven verfasserin aut Aleksander Kempny verfasserin aut Carl Harries verfasserin aut Laura C. Price verfasserin aut Michael Gatzoulis verfasserin aut Konstantinos Dimopoulos verfasserin aut Stephen J. Wort verfasserin aut Colm McCabe verfasserin aut In International Journal of Cardiology Congenital Heart Disease Elsevier, 2021 7(2022), Seite 100331- (DE-627)1759387916 26666685 nnns volume:7 year:2022 pages:100331- https://doi.org/10.1016/j.ijcchd.2022.100331 kostenfrei https://doaj.org/article/b1769b65a4984df2a8d685b8f79d9b49 kostenfrei http://www.sciencedirect.com/science/article/pii/S2666668522000143 kostenfrei https://doaj.org/toc/2666-6685 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2034 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2088 GBV_ILN_2106 GBV_ILN_2110 GBV_ILN_2112 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2470 GBV_ILN_2507 GBV_ILN_4012 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4393 GBV_ILN_4700 AR 7 2022 100331-
language	English
source	In International Journal of Cardiology Congenital Heart Disease 7(2022), Seite 100331- volume:7 year:2022 pages:100331-
sourceStr	In International Journal of Cardiology Congenital Heart Disease 7(2022), Seite 100331- volume:7 year:2022 pages:100331-
format_phy_str_mv	Article
institution	findex.gbv.de
topic_facet	Pulmonary arterial hypertension Eisenmenger syndrome Exercise Ventilatory responses breathing reserve Ventilation Prognosis Diseases of the circulatory (Cardiovascular) system
isfreeaccess_bool	true
container_title	International Journal of Cardiology Congenital Heart Disease
authorswithroles_txt_mv	Chinthaka B. Samaranayake @@aut@@ Ruth McNiven @@aut@@ Aleksander Kempny @@aut@@ Carl Harries @@aut@@ Laura C. Price @@aut@@ Michael Gatzoulis @@aut@@ Konstantinos Dimopoulos @@aut@@ Stephen J. Wort @@aut@@ Colm McCabe @@aut@@
publishDateDaySort_date	2022-01-01T00:00:00Z
hierarchy_top_id	1759387916
id	DOAJ045049238
language_de	englisch
fullrecord	<?xml version="1.0" encoding="UTF-8"?><collection xmlns="http://www.loc.gov/MARC21/slim"><record><leader>01000caa a22002652 4500</leader><controlfield tag="001">DOAJ045049238</controlfield><controlfield tag="003">DE-627</controlfield><controlfield tag="005">20230308090110.0</controlfield><controlfield tag="007">cr uuu---uuuuu</controlfield><controlfield tag="008">230227s2022 xx \|\|\|\|\|o 00\| \|\|eng c</controlfield><datafield tag="024" ind1="7" ind2=" "><subfield code="a">10.1016/j.ijcchd.2022.100331</subfield><subfield code="2">doi</subfield></datafield><datafield tag="035" ind1=" " ind2=" "><subfield code="a">(DE-627)DOAJ045049238</subfield></datafield><datafield tag="035" ind1=" " ind2=" "><subfield code="a">(DE-599)DOAJb1769b65a4984df2a8d685b8f79d9b49</subfield></datafield><datafield tag="040" ind1=" " ind2=" "><subfield code="a">DE-627</subfield><subfield code="b">ger</subfield><subfield code="c">DE-627</subfield><subfield code="e">rakwb</subfield></datafield><datafield tag="041" ind1=" " ind2=" "><subfield code="a">eng</subfield></datafield><datafield tag="050" ind1=" " ind2="0"><subfield code="a">RC666-701</subfield></datafield><datafield tag="100" ind1="0" ind2=" "><subfield code="a">Chinthaka B. Samaranayake</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="245" ind1="1" ind2="0"><subfield code="a">Exercise ventilatory reserve predicts survival in adult congenital heart disease associated pulmonary arterial hypertension with Eisenmenger physiology</subfield></datafield><datafield tag="264" ind1=" " ind2="1"><subfield code="c">2022</subfield></datafield><datafield tag="336" ind1=" " ind2=" "><subfield code="a">Text</subfield><subfield code="b">txt</subfield><subfield code="2">rdacontent</subfield></datafield><datafield tag="337" ind1=" " ind2=" "><subfield code="a">Computermedien</subfield><subfield code="b">c</subfield><subfield code="2">rdamedia</subfield></datafield><datafield tag="338" ind1=" " ind2=" "><subfield code="a">Online-Ressource</subfield><subfield code="b">cr</subfield><subfield code="2">rdacarrier</subfield></datafield><datafield tag="520" ind1=" " ind2=" "><subfield code="a">Impaired ventilatory responses during exercise significantly contribute to breathlessness in patients with pulmonary arterial hypertension (PAH). Breathing reserve (BR) at peak exercise during cardiopulmonary exercise testing (CPET), a measure of the reserve in the ventilatory capacity, and as a PAH prognostic marker has not received wide attention. We assessed the prognostic value of a reduced BR (≤30% predicted) on survival in patients with two forms of PAH: congenital heart disease-associated PAH and Eisenmenger physiology (EIS) and idiopathic PAH (IPAH). Propensity score matched cohorts of 50 EIS and 50 IPAH patients who underwent CPET in our institution were included. Overall transplant-free survival at 5 and 10 years was assessed. Twenty-five (50.0%) EIS and 15 (33.3%) IPAH patients had a BR ≤ 30% at peak exercise (p = 0.047). Independent predictors of a BR ≤ 30% across all patients included cardiothoracic ratio on chest radiograph (HR 2.2, 95% CI 1.6–3.0, p = 0.01) and moderate to severe restriction on resting spirometry (HR 1.9, 95% CI 1.1–2.8, p = 0.03). A BR ≤ 30% was associated with a significantly higher risk of mortality in the EIS group at 10 years follow-up (HR 3.4, 95% CI 1.1 to 11.4, p = 0.045). Neither a BR ≤ 30% or <30% offered prognostic discrimination in IPAH. In summary, a BR <30% at peak exercise is associated with better survival in patients with EIS. Lung parenchymal restriction inferred from larger cardiothoracic ratios may contribute to reduced BR along with increased ventilatory drive.</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a">Pulmonary arterial hypertension</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a">Eisenmenger syndrome</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a">Exercise</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a">Ventilatory responses breathing reserve</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a">Ventilation</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a">Prognosis</subfield></datafield><datafield tag="653" ind1=" " ind2="0"><subfield code="a">Diseases of the circulatory (Cardiovascular) system</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Ruth McNiven</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Aleksander Kempny</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Carl Harries</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Laura C. Price</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Michael Gatzoulis</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Konstantinos Dimopoulos</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Stephen J. Wort</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Colm McCabe</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="773" ind1="0" ind2="8"><subfield code="i">In</subfield><subfield code="t">International Journal of Cardiology Congenital Heart Disease</subfield><subfield code="d">Elsevier, 2021</subfield><subfield code="g">7(2022), Seite 100331-</subfield><subfield code="w">(DE-627)1759387916</subfield><subfield code="x">26666685</subfield><subfield code="7">nnns</subfield></datafield><datafield tag="773" ind1="1" ind2="8"><subfield code="g">volume:7</subfield><subfield code="g">year:2022</subfield><subfield code="g">pages:100331-</subfield></datafield><datafield tag="856" ind1="4" ind2="0"><subfield code="u">https://doi.org/10.1016/j.ijcchd.2022.100331</subfield><subfield code="z">kostenfrei</subfield></datafield><datafield tag="856" ind1="4" ind2="0"><subfield code="u">https://doaj.org/article/b1769b65a4984df2a8d685b8f79d9b49</subfield><subfield code="z">kostenfrei</subfield></datafield><datafield tag="856" ind1="4" ind2="0"><subfield code="u">http://www.sciencedirect.com/science/article/pii/S2666668522000143</subfield><subfield code="z">kostenfrei</subfield></datafield><datafield tag="856" ind1="4" ind2="2"><subfield code="u">https://doaj.org/toc/2666-6685</subfield><subfield code="y">Journal toc</subfield><subfield code="z">kostenfrei</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_USEFLAG_A</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">SYSFLAG_A</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_DOAJ</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_20</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_22</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_23</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_24</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_31</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_39</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_40</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_60</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_62</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_63</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_65</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_69</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_73</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_74</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_95</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_105</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_110</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_151</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_161</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_170</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_206</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_213</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_224</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_230</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_285</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_293</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_602</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_2001</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_2003</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_2005</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_2006</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_2007</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_2008</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_2009</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_2010</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_2011</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_2014</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_2015</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_2020</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_2021</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_2025</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_2026</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_2027</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_2034</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_2038</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_2044</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_2048</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_2049</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_2050</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_2055</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_2056</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_2059</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_2061</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_2064</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_2088</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_2106</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_2110</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_2112</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_2122</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_2129</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_2143</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_2152</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_2153</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_2190</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_2232</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_2336</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_2470</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_2507</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_4012</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_4035</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_4037</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_4112</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_4125</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_4126</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_4242</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_4249</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_4251</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_4305</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_4306</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_4307</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_4313</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_4322</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_4323</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_4324</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_4325</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_4326</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_4333</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_4334</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_4338</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_4367</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_4393</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_4700</subfield></datafield><datafield tag="951" ind1=" " ind2=" "><subfield code="a">AR</subfield></datafield><datafield tag="952" ind1=" " ind2=" "><subfield code="d">7</subfield><subfield code="j">2022</subfield><subfield code="h">100331-</subfield></datafield></record></collection>
callnumber-first	R - Medicine
author	Chinthaka B. Samaranayake
spellingShingle	Chinthaka B. Samaranayake misc RC666-701 misc Pulmonary arterial hypertension misc Eisenmenger syndrome misc Exercise misc Ventilatory responses breathing reserve misc Ventilation misc Prognosis misc Diseases of the circulatory (Cardiovascular) system Exercise ventilatory reserve predicts survival in adult congenital heart disease associated pulmonary arterial hypertension with Eisenmenger physiology
authorStr	Chinthaka B. Samaranayake
ppnlink_with_tag_str_mv	@@773@@(DE-627)1759387916
format	electronic Article
delete_txt_mv	keep
author_role	aut aut aut aut aut aut aut aut aut
collection	DOAJ
remote_str	true
callnumber-label	RC666-701
illustrated	Not Illustrated
issn	26666685
topic_title	RC666-701 Exercise ventilatory reserve predicts survival in adult congenital heart disease associated pulmonary arterial hypertension with Eisenmenger physiology Pulmonary arterial hypertension Eisenmenger syndrome Exercise Ventilatory responses breathing reserve Ventilation Prognosis
topic	misc RC666-701 misc Pulmonary arterial hypertension misc Eisenmenger syndrome misc Exercise misc Ventilatory responses breathing reserve misc Ventilation misc Prognosis misc Diseases of the circulatory (Cardiovascular) system
topic_unstemmed	misc RC666-701 misc Pulmonary arterial hypertension misc Eisenmenger syndrome misc Exercise misc Ventilatory responses breathing reserve misc Ventilation misc Prognosis misc Diseases of the circulatory (Cardiovascular) system
topic_browse	misc RC666-701 misc Pulmonary arterial hypertension misc Eisenmenger syndrome misc Exercise misc Ventilatory responses breathing reserve misc Ventilation misc Prognosis misc Diseases of the circulatory (Cardiovascular) system
format_facet	Elektronische Aufsätze Aufsätze Elektronische Ressource
format_main_str_mv	Text Zeitschrift/Artikel
carriertype_str_mv	cr
hierarchy_parent_title	International Journal of Cardiology Congenital Heart Disease
hierarchy_parent_id	1759387916
hierarchy_top_title	International Journal of Cardiology Congenital Heart Disease
isfreeaccess_txt	true
familylinks_str_mv	(DE-627)1759387916
title	Exercise ventilatory reserve predicts survival in adult congenital heart disease associated pulmonary arterial hypertension with Eisenmenger physiology
ctrlnum	(DE-627)DOAJ045049238 (DE-599)DOAJb1769b65a4984df2a8d685b8f79d9b49
title_full	Exercise ventilatory reserve predicts survival in adult congenital heart disease associated pulmonary arterial hypertension with Eisenmenger physiology
author_sort	Chinthaka B. Samaranayake
journal	International Journal of Cardiology Congenital Heart Disease
journalStr	International Journal of Cardiology Congenital Heart Disease
callnumber-first-code	R
lang_code	eng
isOA_bool	true
recordtype	marc
publishDateSort	2022
contenttype_str_mv	txt
container_start_page	100331
author_browse	Chinthaka B. Samaranayake Ruth McNiven Aleksander Kempny Carl Harries Laura C. Price Michael Gatzoulis Konstantinos Dimopoulos Stephen J. Wort Colm McCabe
container_volume	7
class	RC666-701
format_se	Elektronische Aufsätze
author-letter	Chinthaka B. Samaranayake
doi_str_mv	10.1016/j.ijcchd.2022.100331
author2-role	verfasserin
title_sort	exercise ventilatory reserve predicts survival in adult congenital heart disease associated pulmonary arterial hypertension with eisenmenger physiology
callnumber	RC666-701
title_auth	Exercise ventilatory reserve predicts survival in adult congenital heart disease associated pulmonary arterial hypertension with Eisenmenger physiology
abstract	Impaired ventilatory responses during exercise significantly contribute to breathlessness in patients with pulmonary arterial hypertension (PAH). Breathing reserve (BR) at peak exercise during cardiopulmonary exercise testing (CPET), a measure of the reserve in the ventilatory capacity, and as a PAH prognostic marker has not received wide attention. We assessed the prognostic value of a reduced BR (≤30% predicted) on survival in patients with two forms of PAH: congenital heart disease-associated PAH and Eisenmenger physiology (EIS) and idiopathic PAH (IPAH). Propensity score matched cohorts of 50 EIS and 50 IPAH patients who underwent CPET in our institution were included. Overall transplant-free survival at 5 and 10 years was assessed. Twenty-five (50.0%) EIS and 15 (33.3%) IPAH patients had a BR ≤ 30% at peak exercise (p = 0.047). Independent predictors of a BR ≤ 30% across all patients included cardiothoracic ratio on chest radiograph (HR 2.2, 95% CI 1.6–3.0, p = 0.01) and moderate to severe restriction on resting spirometry (HR 1.9, 95% CI 1.1–2.8, p = 0.03). A BR ≤ 30% was associated with a significantly higher risk of mortality in the EIS group at 10 years follow-up (HR 3.4, 95% CI 1.1 to 11.4, p = 0.045). Neither a BR ≤ 30% or <30% offered prognostic discrimination in IPAH. In summary, a BR <30% at peak exercise is associated with better survival in patients with EIS. Lung parenchymal restriction inferred from larger cardiothoracic ratios may contribute to reduced BR along with increased ventilatory drive.
abstractGer	Impaired ventilatory responses during exercise significantly contribute to breathlessness in patients with pulmonary arterial hypertension (PAH). Breathing reserve (BR) at peak exercise during cardiopulmonary exercise testing (CPET), a measure of the reserve in the ventilatory capacity, and as a PAH prognostic marker has not received wide attention. We assessed the prognostic value of a reduced BR (≤30% predicted) on survival in patients with two forms of PAH: congenital heart disease-associated PAH and Eisenmenger physiology (EIS) and idiopathic PAH (IPAH). Propensity score matched cohorts of 50 EIS and 50 IPAH patients who underwent CPET in our institution were included. Overall transplant-free survival at 5 and 10 years was assessed. Twenty-five (50.0%) EIS and 15 (33.3%) IPAH patients had a BR ≤ 30% at peak exercise (p = 0.047). Independent predictors of a BR ≤ 30% across all patients included cardiothoracic ratio on chest radiograph (HR 2.2, 95% CI 1.6–3.0, p = 0.01) and moderate to severe restriction on resting spirometry (HR 1.9, 95% CI 1.1–2.8, p = 0.03). A BR ≤ 30% was associated with a significantly higher risk of mortality in the EIS group at 10 years follow-up (HR 3.4, 95% CI 1.1 to 11.4, p = 0.045). Neither a BR ≤ 30% or <30% offered prognostic discrimination in IPAH. In summary, a BR <30% at peak exercise is associated with better survival in patients with EIS. Lung parenchymal restriction inferred from larger cardiothoracic ratios may contribute to reduced BR along with increased ventilatory drive.
abstract_unstemmed	Impaired ventilatory responses during exercise significantly contribute to breathlessness in patients with pulmonary arterial hypertension (PAH). Breathing reserve (BR) at peak exercise during cardiopulmonary exercise testing (CPET), a measure of the reserve in the ventilatory capacity, and as a PAH prognostic marker has not received wide attention. We assessed the prognostic value of a reduced BR (≤30% predicted) on survival in patients with two forms of PAH: congenital heart disease-associated PAH and Eisenmenger physiology (EIS) and idiopathic PAH (IPAH). Propensity score matched cohorts of 50 EIS and 50 IPAH patients who underwent CPET in our institution were included. Overall transplant-free survival at 5 and 10 years was assessed. Twenty-five (50.0%) EIS and 15 (33.3%) IPAH patients had a BR ≤ 30% at peak exercise (p = 0.047). Independent predictors of a BR ≤ 30% across all patients included cardiothoracic ratio on chest radiograph (HR 2.2, 95% CI 1.6–3.0, p = 0.01) and moderate to severe restriction on resting spirometry (HR 1.9, 95% CI 1.1–2.8, p = 0.03). A BR ≤ 30% was associated with a significantly higher risk of mortality in the EIS group at 10 years follow-up (HR 3.4, 95% CI 1.1 to 11.4, p = 0.045). Neither a BR ≤ 30% or <30% offered prognostic discrimination in IPAH. In summary, a BR <30% at peak exercise is associated with better survival in patients with EIS. Lung parenchymal restriction inferred from larger cardiothoracic ratios may contribute to reduced BR along with increased ventilatory drive.
collection_details	GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2034 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2088 GBV_ILN_2106 GBV_ILN_2110 GBV_ILN_2112 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2470 GBV_ILN_2507 GBV_ILN_4012 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4393 GBV_ILN_4700
title_short	Exercise ventilatory reserve predicts survival in adult congenital heart disease associated pulmonary arterial hypertension with Eisenmenger physiology
url	https://doi.org/10.1016/j.ijcchd.2022.100331 https://doaj.org/article/b1769b65a4984df2a8d685b8f79d9b49 http://www.sciencedirect.com/science/article/pii/S2666668522000143 https://doaj.org/toc/2666-6685
remote_bool	true
author2	Ruth McNiven Aleksander Kempny Carl Harries Laura C. Price Michael Gatzoulis Konstantinos Dimopoulos Stephen J. Wort Colm McCabe
author2Str	Ruth McNiven Aleksander Kempny Carl Harries Laura C. Price Michael Gatzoulis Konstantinos Dimopoulos Stephen J. Wort Colm McCabe
ppnlink	1759387916
callnumber-subject	RC - Internal Medicine
mediatype_str_mv	c
isOA_txt	true
hochschulschrift_bool	false
doi_str	10.1016/j.ijcchd.2022.100331
callnumber-a	RC666-701
up_date	2024-07-04T01:28:06.298Z
_version_	1803609950179557376
fullrecord_marcxml	<?xml version="1.0" encoding="UTF-8"?><collection xmlns="http://www.loc.gov/MARC21/slim"><record><leader>01000caa a22002652 4500</leader><controlfield tag="001">DOAJ045049238</controlfield><controlfield tag="003">DE-627</controlfield><controlfield tag="005">20230308090110.0</controlfield><controlfield tag="007">cr uuu---uuuuu</controlfield><controlfield tag="008">230227s2022 xx \|\|\|\|\|o 00\| \|\|eng c</controlfield><datafield tag="024" ind1="7" ind2=" "><subfield code="a">10.1016/j.ijcchd.2022.100331</subfield><subfield code="2">doi</subfield></datafield><datafield tag="035" ind1=" " ind2=" "><subfield code="a">(DE-627)DOAJ045049238</subfield></datafield><datafield tag="035" ind1=" " ind2=" "><subfield code="a">(DE-599)DOAJb1769b65a4984df2a8d685b8f79d9b49</subfield></datafield><datafield tag="040" ind1=" " ind2=" "><subfield code="a">DE-627</subfield><subfield code="b">ger</subfield><subfield code="c">DE-627</subfield><subfield code="e">rakwb</subfield></datafield><datafield tag="041" ind1=" " ind2=" "><subfield code="a">eng</subfield></datafield><datafield tag="050" ind1=" " ind2="0"><subfield code="a">RC666-701</subfield></datafield><datafield tag="100" ind1="0" ind2=" "><subfield code="a">Chinthaka B. Samaranayake</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="245" ind1="1" ind2="0"><subfield code="a">Exercise ventilatory reserve predicts survival in adult congenital heart disease associated pulmonary arterial hypertension with Eisenmenger physiology</subfield></datafield><datafield tag="264" ind1=" " ind2="1"><subfield code="c">2022</subfield></datafield><datafield tag="336" ind1=" " ind2=" "><subfield code="a">Text</subfield><subfield code="b">txt</subfield><subfield code="2">rdacontent</subfield></datafield><datafield tag="337" ind1=" " ind2=" "><subfield code="a">Computermedien</subfield><subfield code="b">c</subfield><subfield code="2">rdamedia</subfield></datafield><datafield tag="338" ind1=" " ind2=" "><subfield code="a">Online-Ressource</subfield><subfield code="b">cr</subfield><subfield code="2">rdacarrier</subfield></datafield><datafield tag="520" ind1=" " ind2=" "><subfield code="a">Impaired ventilatory responses during exercise significantly contribute to breathlessness in patients with pulmonary arterial hypertension (PAH). Breathing reserve (BR) at peak exercise during cardiopulmonary exercise testing (CPET), a measure of the reserve in the ventilatory capacity, and as a PAH prognostic marker has not received wide attention. We assessed the prognostic value of a reduced BR (≤30% predicted) on survival in patients with two forms of PAH: congenital heart disease-associated PAH and Eisenmenger physiology (EIS) and idiopathic PAH (IPAH). Propensity score matched cohorts of 50 EIS and 50 IPAH patients who underwent CPET in our institution were included. Overall transplant-free survival at 5 and 10 years was assessed. Twenty-five (50.0%) EIS and 15 (33.3%) IPAH patients had a BR ≤ 30% at peak exercise (p = 0.047). Independent predictors of a BR ≤ 30% across all patients included cardiothoracic ratio on chest radiograph (HR 2.2, 95% CI 1.6–3.0, p = 0.01) and moderate to severe restriction on resting spirometry (HR 1.9, 95% CI 1.1–2.8, p = 0.03). A BR ≤ 30% was associated with a significantly higher risk of mortality in the EIS group at 10 years follow-up (HR 3.4, 95% CI 1.1 to 11.4, p = 0.045). Neither a BR ≤ 30% or <30% offered prognostic discrimination in IPAH. In summary, a BR <30% at peak exercise is associated with better survival in patients with EIS. Lung parenchymal restriction inferred from larger cardiothoracic ratios may contribute to reduced BR along with increased ventilatory drive.</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a">Pulmonary arterial hypertension</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a">Eisenmenger syndrome</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a">Exercise</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a">Ventilatory responses breathing reserve</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a">Ventilation</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a">Prognosis</subfield></datafield><datafield tag="653" ind1=" " ind2="0"><subfield code="a">Diseases of the circulatory (Cardiovascular) system</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Ruth McNiven</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Aleksander Kempny</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Carl Harries</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Laura C. Price</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Michael Gatzoulis</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Konstantinos Dimopoulos</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Stephen J. Wort</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Colm McCabe</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="773" ind1="0" ind2="8"><subfield code="i">In</subfield><subfield code="t">International Journal of Cardiology Congenital Heart Disease</subfield><subfield code="d">Elsevier, 2021</subfield><subfield code="g">7(2022), Seite 100331-</subfield><subfield code="w">(DE-627)1759387916</subfield><subfield code="x">26666685</subfield><subfield code="7">nnns</subfield></datafield><datafield tag="773" ind1="1" ind2="8"><subfield code="g">volume:7</subfield><subfield code="g">year:2022</subfield><subfield code="g">pages:100331-</subfield></datafield><datafield tag="856" ind1="4" ind2="0"><subfield code="u">https://doi.org/10.1016/j.ijcchd.2022.100331</subfield><subfield code="z">kostenfrei</subfield></datafield><datafield tag="856" ind1="4" ind2="0"><subfield code="u">https://doaj.org/article/b1769b65a4984df2a8d685b8f79d9b49</subfield><subfield code="z">kostenfrei</subfield></datafield><datafield tag="856" ind1="4" ind2="0"><subfield code="u">http://www.sciencedirect.com/science/article/pii/S2666668522000143</subfield><subfield code="z">kostenfrei</subfield></datafield><datafield tag="856" ind1="4" ind2="2"><subfield code="u">https://doaj.org/toc/2666-6685</subfield><subfield code="y">Journal toc</subfield><subfield code="z">kostenfrei</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_USEFLAG_A</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">SYSFLAG_A</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_DOAJ</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_20</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_22</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_23</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_24</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_31</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_39</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_40</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_60</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_62</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_63</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_65</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_69</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_73</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_74</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_95</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_105</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_110</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_151</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_161</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_170</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_206</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_213</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_224</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_230</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_285</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_293</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_602</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_2001</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_2003</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_2005</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_2006</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_2007</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_2008</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_2009</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_2010</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_2011</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_2014</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_2015</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_2020</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_2021</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_2025</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_2026</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_2027</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_2034</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_2038</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_2044</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_2048</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_2049</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_2050</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_2055</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_2056</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_2059</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_2061</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_2064</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_2088</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_2106</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_2110</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_2112</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_2122</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_2129</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_2143</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_2152</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_2153</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_2190</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_2232</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_2336</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_2470</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_2507</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_4012</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_4035</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_4037</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_4112</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_4125</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_4126</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_4242</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_4249</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_4251</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_4305</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_4306</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_4307</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_4313</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_4322</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_4323</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_4324</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_4325</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_4326</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_4333</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_4334</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_4338</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_4367</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_4393</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_4700</subfield></datafield><datafield tag="951" ind1=" " ind2=" "><subfield code="a">AR</subfield></datafield><datafield tag="952" ind1=" " ind2=" "><subfield code="d">7</subfield><subfield code="j">2022</subfield><subfield code="h">100331-</subfield></datafield></record></collection>
score	7.4009085

Nicht das Richtige dabei?

Schreiben Sie uns!

Exercise ventilatory reserve predicts survival in adult congenital heart disease associated pulmonary arterial hypertension with Eisenmenger physiology

Nicht das Richtige dabei?

Zugang & Verfügbarkeit

Vorhandene Bände

Nicht das Richtige dabei?