Reductions in Postprandial Plasma Allantoin Concentrations With Increasing Doses of Polyphenol Rich Curry Intake – A Randomized Crossover Trial

While dietary or supplementary antioxidants are thought to inhibit or delay oxidation of biological molecules, their utility in vivo has been marred by equivocal evidence. Consumption of polyphenol rich foods has been thought to alleviate postprandial oxidative stress and/or improve endothelial func...
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Autor*in:	Sumanto Haldar [verfasserIn] Leroy Sivappiragasam Pakkiri [verfasserIn] Joseph Lim [verfasserIn] Siok Ching Chia [verfasserIn] Shalini Ponnalagu [verfasserIn] Chester Lee Drum [verfasserIn] Christiani Jeyakumar Henry [verfasserIn]

Format:	E-Artikel
Sprache:	Englisch

Erschienen:	2019

Schlagwörter:	allantoin F2-isoprostanes peripheral arterial tonometry spices polyphenols

Übergeordnetes Werk:	In: Frontiers in Physiology - Frontiers Media S.A., 2011, 9(2019)
Übergeordnetes Werk:	volume:9 ; year:2019

Links:	Link aufrufen Link aufrufen Link aufrufen Journal toc

DOI / URN:	10.3389/fphys.2018.01899

Katalog-ID:	DOAJ045059292

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allfields	10.3389/fphys.2018.01899 doi (DE-627)DOAJ045059292 (DE-599)DOAJe35ad4edd4dc46c0ac4d8fb4bbbd3b60 DE-627 ger DE-627 rakwb eng QP1-981 Sumanto Haldar verfasserin aut Reductions in Postprandial Plasma Allantoin Concentrations With Increasing Doses of Polyphenol Rich Curry Intake – A Randomized Crossover Trial 2019 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier While dietary or supplementary antioxidants are thought to inhibit or delay oxidation of biological molecules, their utility in vivo has been marred by equivocal evidence. Consumption of polyphenol rich foods has been thought to alleviate postprandial oxidative stress and/or improve endothelial function. Although, previous studies suggested the utility of allantoin as a biomarker of oxidative stress, controlled dose response studies with dietary antioxidants to test this in humans have been limited. We therefore investigated the effects of 2 doses of polyphenol rich curry consumption on postprandial plasma concentrations of allantoin, allantoin to uric acid ratio, F2-isoprostanes using liquid chromatography-tandem mass spectrometry (LCMS-MS) and measured endothelial function using peripheral arterial tonometry (endoPAT). In a randomized controlled crossover trial in 17 non-smoking, healthy, Chinese men, aged 23.7 ± 2.4 years and BMI 23.1 ± 2.3 kg/m2, the volunteers consumed 3 test meals in a random order, consisting of either non-curry Dose 0 Control (D0C, 0 g spices), or Dose 1 Curry (D1C, 6 g spices) or Dose 2 Curry (D2C, 12 g spices), after overnight fast. There were significant reductions in postprandial allantoin concentrations (p < 0.001) and allantoin to uric acid ratio (p < 0.001) at 2 h and 3 h following test meal consumption, indicating improvements in postprandial redox balance with increasing curry doses, although there were no differences between treatments on F2-isoprostane concentrations or on RHI (measured at 2 h only). Allantoin may have a utility as a biomarker of redox balance, in an acute setting. The study was registered at www.clinicaltrials.gov (Identifier No. NCT02599272). allantoin F2-isoprostanes peripheral arterial tonometry spices polyphenols Physiology Leroy Sivappiragasam Pakkiri verfasserin aut Leroy Sivappiragasam Pakkiri verfasserin aut Joseph Lim verfasserin aut Siok Ching Chia verfasserin aut Shalini Ponnalagu verfasserin aut Chester Lee Drum verfasserin aut Chester Lee Drum verfasserin aut Christiani Jeyakumar Henry verfasserin aut Christiani Jeyakumar Henry verfasserin aut In Frontiers in Physiology Frontiers Media S.A., 2011 9(2019) (DE-627)631498788 (DE-600)2564217-0 1664042X nnns volume:9 year:2019 https://doi.org/10.3389/fphys.2018.01899 kostenfrei https://doaj.org/article/e35ad4edd4dc46c0ac4d8fb4bbbd3b60 kostenfrei https://www.frontiersin.org/article/10.3389/fphys.2018.01899/full kostenfrei https://doaj.org/toc/1664-042X Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2003 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 9 2019
spelling	10.3389/fphys.2018.01899 doi (DE-627)DOAJ045059292 (DE-599)DOAJe35ad4edd4dc46c0ac4d8fb4bbbd3b60 DE-627 ger DE-627 rakwb eng QP1-981 Sumanto Haldar verfasserin aut Reductions in Postprandial Plasma Allantoin Concentrations With Increasing Doses of Polyphenol Rich Curry Intake – A Randomized Crossover Trial 2019 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier While dietary or supplementary antioxidants are thought to inhibit or delay oxidation of biological molecules, their utility in vivo has been marred by equivocal evidence. Consumption of polyphenol rich foods has been thought to alleviate postprandial oxidative stress and/or improve endothelial function. Although, previous studies suggested the utility of allantoin as a biomarker of oxidative stress, controlled dose response studies with dietary antioxidants to test this in humans have been limited. We therefore investigated the effects of 2 doses of polyphenol rich curry consumption on postprandial plasma concentrations of allantoin, allantoin to uric acid ratio, F2-isoprostanes using liquid chromatography-tandem mass spectrometry (LCMS-MS) and measured endothelial function using peripheral arterial tonometry (endoPAT). In a randomized controlled crossover trial in 17 non-smoking, healthy, Chinese men, aged 23.7 ± 2.4 years and BMI 23.1 ± 2.3 kg/m2, the volunteers consumed 3 test meals in a random order, consisting of either non-curry Dose 0 Control (D0C, 0 g spices), or Dose 1 Curry (D1C, 6 g spices) or Dose 2 Curry (D2C, 12 g spices), after overnight fast. There were significant reductions in postprandial allantoin concentrations (p < 0.001) and allantoin to uric acid ratio (p < 0.001) at 2 h and 3 h following test meal consumption, indicating improvements in postprandial redox balance with increasing curry doses, although there were no differences between treatments on F2-isoprostane concentrations or on RHI (measured at 2 h only). Allantoin may have a utility as a biomarker of redox balance, in an acute setting. The study was registered at www.clinicaltrials.gov (Identifier No. NCT02599272). allantoin F2-isoprostanes peripheral arterial tonometry spices polyphenols Physiology Leroy Sivappiragasam Pakkiri verfasserin aut Leroy Sivappiragasam Pakkiri verfasserin aut Joseph Lim verfasserin aut Siok Ching Chia verfasserin aut Shalini Ponnalagu verfasserin aut Chester Lee Drum verfasserin aut Chester Lee Drum verfasserin aut Christiani Jeyakumar Henry verfasserin aut Christiani Jeyakumar Henry verfasserin aut In Frontiers in Physiology Frontiers Media S.A., 2011 9(2019) (DE-627)631498788 (DE-600)2564217-0 1664042X nnns volume:9 year:2019 https://doi.org/10.3389/fphys.2018.01899 kostenfrei https://doaj.org/article/e35ad4edd4dc46c0ac4d8fb4bbbd3b60 kostenfrei https://www.frontiersin.org/article/10.3389/fphys.2018.01899/full kostenfrei https://doaj.org/toc/1664-042X Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2003 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 9 2019
allfields_unstemmed	10.3389/fphys.2018.01899 doi (DE-627)DOAJ045059292 (DE-599)DOAJe35ad4edd4dc46c0ac4d8fb4bbbd3b60 DE-627 ger DE-627 rakwb eng QP1-981 Sumanto Haldar verfasserin aut Reductions in Postprandial Plasma Allantoin Concentrations With Increasing Doses of Polyphenol Rich Curry Intake – A Randomized Crossover Trial 2019 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier While dietary or supplementary antioxidants are thought to inhibit or delay oxidation of biological molecules, their utility in vivo has been marred by equivocal evidence. Consumption of polyphenol rich foods has been thought to alleviate postprandial oxidative stress and/or improve endothelial function. Although, previous studies suggested the utility of allantoin as a biomarker of oxidative stress, controlled dose response studies with dietary antioxidants to test this in humans have been limited. We therefore investigated the effects of 2 doses of polyphenol rich curry consumption on postprandial plasma concentrations of allantoin, allantoin to uric acid ratio, F2-isoprostanes using liquid chromatography-tandem mass spectrometry (LCMS-MS) and measured endothelial function using peripheral arterial tonometry (endoPAT). In a randomized controlled crossover trial in 17 non-smoking, healthy, Chinese men, aged 23.7 ± 2.4 years and BMI 23.1 ± 2.3 kg/m2, the volunteers consumed 3 test meals in a random order, consisting of either non-curry Dose 0 Control (D0C, 0 g spices), or Dose 1 Curry (D1C, 6 g spices) or Dose 2 Curry (D2C, 12 g spices), after overnight fast. There were significant reductions in postprandial allantoin concentrations (p < 0.001) and allantoin to uric acid ratio (p < 0.001) at 2 h and 3 h following test meal consumption, indicating improvements in postprandial redox balance with increasing curry doses, although there were no differences between treatments on F2-isoprostane concentrations or on RHI (measured at 2 h only). Allantoin may have a utility as a biomarker of redox balance, in an acute setting. The study was registered at www.clinicaltrials.gov (Identifier No. NCT02599272). allantoin F2-isoprostanes peripheral arterial tonometry spices polyphenols Physiology Leroy Sivappiragasam Pakkiri verfasserin aut Leroy Sivappiragasam Pakkiri verfasserin aut Joseph Lim verfasserin aut Siok Ching Chia verfasserin aut Shalini Ponnalagu verfasserin aut Chester Lee Drum verfasserin aut Chester Lee Drum verfasserin aut Christiani Jeyakumar Henry verfasserin aut Christiani Jeyakumar Henry verfasserin aut In Frontiers in Physiology Frontiers Media S.A., 2011 9(2019) (DE-627)631498788 (DE-600)2564217-0 1664042X nnns volume:9 year:2019 https://doi.org/10.3389/fphys.2018.01899 kostenfrei https://doaj.org/article/e35ad4edd4dc46c0ac4d8fb4bbbd3b60 kostenfrei https://www.frontiersin.org/article/10.3389/fphys.2018.01899/full kostenfrei https://doaj.org/toc/1664-042X Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2003 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 9 2019
allfieldsGer	10.3389/fphys.2018.01899 doi (DE-627)DOAJ045059292 (DE-599)DOAJe35ad4edd4dc46c0ac4d8fb4bbbd3b60 DE-627 ger DE-627 rakwb eng QP1-981 Sumanto Haldar verfasserin aut Reductions in Postprandial Plasma Allantoin Concentrations With Increasing Doses of Polyphenol Rich Curry Intake – A Randomized Crossover Trial 2019 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier While dietary or supplementary antioxidants are thought to inhibit or delay oxidation of biological molecules, their utility in vivo has been marred by equivocal evidence. Consumption of polyphenol rich foods has been thought to alleviate postprandial oxidative stress and/or improve endothelial function. Although, previous studies suggested the utility of allantoin as a biomarker of oxidative stress, controlled dose response studies with dietary antioxidants to test this in humans have been limited. We therefore investigated the effects of 2 doses of polyphenol rich curry consumption on postprandial plasma concentrations of allantoin, allantoin to uric acid ratio, F2-isoprostanes using liquid chromatography-tandem mass spectrometry (LCMS-MS) and measured endothelial function using peripheral arterial tonometry (endoPAT). In a randomized controlled crossover trial in 17 non-smoking, healthy, Chinese men, aged 23.7 ± 2.4 years and BMI 23.1 ± 2.3 kg/m2, the volunteers consumed 3 test meals in a random order, consisting of either non-curry Dose 0 Control (D0C, 0 g spices), or Dose 1 Curry (D1C, 6 g spices) or Dose 2 Curry (D2C, 12 g spices), after overnight fast. There were significant reductions in postprandial allantoin concentrations (p < 0.001) and allantoin to uric acid ratio (p < 0.001) at 2 h and 3 h following test meal consumption, indicating improvements in postprandial redox balance with increasing curry doses, although there were no differences between treatments on F2-isoprostane concentrations or on RHI (measured at 2 h only). Allantoin may have a utility as a biomarker of redox balance, in an acute setting. The study was registered at www.clinicaltrials.gov (Identifier No. NCT02599272). allantoin F2-isoprostanes peripheral arterial tonometry spices polyphenols Physiology Leroy Sivappiragasam Pakkiri verfasserin aut Leroy Sivappiragasam Pakkiri verfasserin aut Joseph Lim verfasserin aut Siok Ching Chia verfasserin aut Shalini Ponnalagu verfasserin aut Chester Lee Drum verfasserin aut Chester Lee Drum verfasserin aut Christiani Jeyakumar Henry verfasserin aut Christiani Jeyakumar Henry verfasserin aut In Frontiers in Physiology Frontiers Media S.A., 2011 9(2019) (DE-627)631498788 (DE-600)2564217-0 1664042X nnns volume:9 year:2019 https://doi.org/10.3389/fphys.2018.01899 kostenfrei https://doaj.org/article/e35ad4edd4dc46c0ac4d8fb4bbbd3b60 kostenfrei https://www.frontiersin.org/article/10.3389/fphys.2018.01899/full kostenfrei https://doaj.org/toc/1664-042X Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2003 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 9 2019
allfieldsSound	10.3389/fphys.2018.01899 doi (DE-627)DOAJ045059292 (DE-599)DOAJe35ad4edd4dc46c0ac4d8fb4bbbd3b60 DE-627 ger DE-627 rakwb eng QP1-981 Sumanto Haldar verfasserin aut Reductions in Postprandial Plasma Allantoin Concentrations With Increasing Doses of Polyphenol Rich Curry Intake – A Randomized Crossover Trial 2019 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier While dietary or supplementary antioxidants are thought to inhibit or delay oxidation of biological molecules, their utility in vivo has been marred by equivocal evidence. Consumption of polyphenol rich foods has been thought to alleviate postprandial oxidative stress and/or improve endothelial function. Although, previous studies suggested the utility of allantoin as a biomarker of oxidative stress, controlled dose response studies with dietary antioxidants to test this in humans have been limited. We therefore investigated the effects of 2 doses of polyphenol rich curry consumption on postprandial plasma concentrations of allantoin, allantoin to uric acid ratio, F2-isoprostanes using liquid chromatography-tandem mass spectrometry (LCMS-MS) and measured endothelial function using peripheral arterial tonometry (endoPAT). In a randomized controlled crossover trial in 17 non-smoking, healthy, Chinese men, aged 23.7 ± 2.4 years and BMI 23.1 ± 2.3 kg/m2, the volunteers consumed 3 test meals in a random order, consisting of either non-curry Dose 0 Control (D0C, 0 g spices), or Dose 1 Curry (D1C, 6 g spices) or Dose 2 Curry (D2C, 12 g spices), after overnight fast. There were significant reductions in postprandial allantoin concentrations (p < 0.001) and allantoin to uric acid ratio (p < 0.001) at 2 h and 3 h following test meal consumption, indicating improvements in postprandial redox balance with increasing curry doses, although there were no differences between treatments on F2-isoprostane concentrations or on RHI (measured at 2 h only). Allantoin may have a utility as a biomarker of redox balance, in an acute setting. The study was registered at www.clinicaltrials.gov (Identifier No. NCT02599272). allantoin F2-isoprostanes peripheral arterial tonometry spices polyphenols Physiology Leroy Sivappiragasam Pakkiri verfasserin aut Leroy Sivappiragasam Pakkiri verfasserin aut Joseph Lim verfasserin aut Siok Ching Chia verfasserin aut Shalini Ponnalagu verfasserin aut Chester Lee Drum verfasserin aut Chester Lee Drum verfasserin aut Christiani Jeyakumar Henry verfasserin aut Christiani Jeyakumar Henry verfasserin aut In Frontiers in Physiology Frontiers Media S.A., 2011 9(2019) (DE-627)631498788 (DE-600)2564217-0 1664042X nnns volume:9 year:2019 https://doi.org/10.3389/fphys.2018.01899 kostenfrei https://doaj.org/article/e35ad4edd4dc46c0ac4d8fb4bbbd3b60 kostenfrei https://www.frontiersin.org/article/10.3389/fphys.2018.01899/full kostenfrei https://doaj.org/toc/1664-042X Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2003 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 9 2019
language	English
source	In Frontiers in Physiology 9(2019) volume:9 year:2019
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topic_facet	allantoin F2-isoprostanes peripheral arterial tonometry spices polyphenols Physiology
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container_title	Frontiers in Physiology
authorswithroles_txt_mv	Sumanto Haldar @@aut@@ Leroy Sivappiragasam Pakkiri @@aut@@ Joseph Lim @@aut@@ Siok Ching Chia @@aut@@ Shalini Ponnalagu @@aut@@ Chester Lee Drum @@aut@@ Christiani Jeyakumar Henry @@aut@@
publishDateDaySort_date	2019-01-01T00:00:00Z
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topic_title	QP1-981 Reductions in Postprandial Plasma Allantoin Concentrations With Increasing Doses of Polyphenol Rich Curry Intake – A Randomized Crossover Trial allantoin F2-isoprostanes peripheral arterial tonometry spices polyphenols
topic	misc QP1-981 misc allantoin misc F2-isoprostanes misc peripheral arterial tonometry misc spices misc polyphenols misc Physiology
topic_unstemmed	misc QP1-981 misc allantoin misc F2-isoprostanes misc peripheral arterial tonometry misc spices misc polyphenols misc Physiology
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title	Reductions in Postprandial Plasma Allantoin Concentrations With Increasing Doses of Polyphenol Rich Curry Intake – A Randomized Crossover Trial
ctrlnum	(DE-627)DOAJ045059292 (DE-599)DOAJe35ad4edd4dc46c0ac4d8fb4bbbd3b60
title_full	Reductions in Postprandial Plasma Allantoin Concentrations With Increasing Doses of Polyphenol Rich Curry Intake – A Randomized Crossover Trial
author_sort	Sumanto Haldar
journal	Frontiers in Physiology
journalStr	Frontiers in Physiology
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author_browse	Sumanto Haldar Leroy Sivappiragasam Pakkiri Joseph Lim Siok Ching Chia Shalini Ponnalagu Chester Lee Drum Christiani Jeyakumar Henry
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author-letter	Sumanto Haldar
doi_str_mv	10.3389/fphys.2018.01899
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title_sort	reductions in postprandial plasma allantoin concentrations with increasing doses of polyphenol rich curry intake – a randomized crossover trial
callnumber	QP1-981
title_auth	Reductions in Postprandial Plasma Allantoin Concentrations With Increasing Doses of Polyphenol Rich Curry Intake – A Randomized Crossover Trial
abstract	While dietary or supplementary antioxidants are thought to inhibit or delay oxidation of biological molecules, their utility in vivo has been marred by equivocal evidence. Consumption of polyphenol rich foods has been thought to alleviate postprandial oxidative stress and/or improve endothelial function. Although, previous studies suggested the utility of allantoin as a biomarker of oxidative stress, controlled dose response studies with dietary antioxidants to test this in humans have been limited. We therefore investigated the effects of 2 doses of polyphenol rich curry consumption on postprandial plasma concentrations of allantoin, allantoin to uric acid ratio, F2-isoprostanes using liquid chromatography-tandem mass spectrometry (LCMS-MS) and measured endothelial function using peripheral arterial tonometry (endoPAT). In a randomized controlled crossover trial in 17 non-smoking, healthy, Chinese men, aged 23.7 ± 2.4 years and BMI 23.1 ± 2.3 kg/m2, the volunteers consumed 3 test meals in a random order, consisting of either non-curry Dose 0 Control (D0C, 0 g spices), or Dose 1 Curry (D1C, 6 g spices) or Dose 2 Curry (D2C, 12 g spices), after overnight fast. There were significant reductions in postprandial allantoin concentrations (p < 0.001) and allantoin to uric acid ratio (p < 0.001) at 2 h and 3 h following test meal consumption, indicating improvements in postprandial redox balance with increasing curry doses, although there were no differences between treatments on F2-isoprostane concentrations or on RHI (measured at 2 h only). Allantoin may have a utility as a biomarker of redox balance, in an acute setting. The study was registered at www.clinicaltrials.gov (Identifier No. NCT02599272).
abstractGer	While dietary or supplementary antioxidants are thought to inhibit or delay oxidation of biological molecules, their utility in vivo has been marred by equivocal evidence. Consumption of polyphenol rich foods has been thought to alleviate postprandial oxidative stress and/or improve endothelial function. Although, previous studies suggested the utility of allantoin as a biomarker of oxidative stress, controlled dose response studies with dietary antioxidants to test this in humans have been limited. We therefore investigated the effects of 2 doses of polyphenol rich curry consumption on postprandial plasma concentrations of allantoin, allantoin to uric acid ratio, F2-isoprostanes using liquid chromatography-tandem mass spectrometry (LCMS-MS) and measured endothelial function using peripheral arterial tonometry (endoPAT). In a randomized controlled crossover trial in 17 non-smoking, healthy, Chinese men, aged 23.7 ± 2.4 years and BMI 23.1 ± 2.3 kg/m2, the volunteers consumed 3 test meals in a random order, consisting of either non-curry Dose 0 Control (D0C, 0 g spices), or Dose 1 Curry (D1C, 6 g spices) or Dose 2 Curry (D2C, 12 g spices), after overnight fast. There were significant reductions in postprandial allantoin concentrations (p < 0.001) and allantoin to uric acid ratio (p < 0.001) at 2 h and 3 h following test meal consumption, indicating improvements in postprandial redox balance with increasing curry doses, although there were no differences between treatments on F2-isoprostane concentrations or on RHI (measured at 2 h only). Allantoin may have a utility as a biomarker of redox balance, in an acute setting. The study was registered at www.clinicaltrials.gov (Identifier No. NCT02599272).
abstract_unstemmed	While dietary or supplementary antioxidants are thought to inhibit or delay oxidation of biological molecules, their utility in vivo has been marred by equivocal evidence. Consumption of polyphenol rich foods has been thought to alleviate postprandial oxidative stress and/or improve endothelial function. Although, previous studies suggested the utility of allantoin as a biomarker of oxidative stress, controlled dose response studies with dietary antioxidants to test this in humans have been limited. We therefore investigated the effects of 2 doses of polyphenol rich curry consumption on postprandial plasma concentrations of allantoin, allantoin to uric acid ratio, F2-isoprostanes using liquid chromatography-tandem mass spectrometry (LCMS-MS) and measured endothelial function using peripheral arterial tonometry (endoPAT). In a randomized controlled crossover trial in 17 non-smoking, healthy, Chinese men, aged 23.7 ± 2.4 years and BMI 23.1 ± 2.3 kg/m2, the volunteers consumed 3 test meals in a random order, consisting of either non-curry Dose 0 Control (D0C, 0 g spices), or Dose 1 Curry (D1C, 6 g spices) or Dose 2 Curry (D2C, 12 g spices), after overnight fast. There were significant reductions in postprandial allantoin concentrations (p < 0.001) and allantoin to uric acid ratio (p < 0.001) at 2 h and 3 h following test meal consumption, indicating improvements in postprandial redox balance with increasing curry doses, although there were no differences between treatments on F2-isoprostane concentrations or on RHI (measured at 2 h only). Allantoin may have a utility as a biomarker of redox balance, in an acute setting. The study was registered at www.clinicaltrials.gov (Identifier No. NCT02599272).
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title_short	Reductions in Postprandial Plasma Allantoin Concentrations With Increasing Doses of Polyphenol Rich Curry Intake – A Randomized Crossover Trial
url	https://doi.org/10.3389/fphys.2018.01899 https://doaj.org/article/e35ad4edd4dc46c0ac4d8fb4bbbd3b60 https://www.frontiersin.org/article/10.3389/fphys.2018.01899/full https://doaj.org/toc/1664-042X
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author2	Leroy Sivappiragasam Pakkiri Joseph Lim Siok Ching Chia Shalini Ponnalagu Chester Lee Drum Christiani Jeyakumar Henry
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