Interferon Regulatory Factors Functioned as Activators of the Interferon Pathway in the Scallop Chlamys farreri
Interferon regulatory factors (IRFs) are a family of transcription factors that control many facets during innate and adaptive immune responses. Vertebrate IRFs play important roles in regulating the expression of interferons (IFNs) and IFN-stimulated genes, while only limited studies were conducted...
Ausführliche Beschreibung
Autor*in: |
Naina Hu [verfasserIn] Shanshan Lian [verfasserIn] Xiaomei Zhu [verfasserIn] Xiaomei Chen [verfasserIn] Fengzhi Sun [verfasserIn] Lingling Zhang [verfasserIn] Shi Wang [verfasserIn] Zhenmin Bao [verfasserIn] Jingjie Hu [verfasserIn] |
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E-Artikel |
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Sprache: |
Englisch |
Erschienen: |
2022 |
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Übergeordnetes Werk: |
In: Frontiers in Marine Science - Frontiers Media S.A., 2015, 9(2022) |
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Übergeordnetes Werk: |
volume:9 ; year:2022 |
Links: |
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DOI / URN: |
10.3389/fmars.2022.865707 |
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Katalog-ID: |
DOAJ045059713 |
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520 | |a Interferon regulatory factors (IRFs) are a family of transcription factors that control many facets during innate and adaptive immune responses. Vertebrate IRFs play important roles in regulating the expression of interferons (IFNs) and IFN-stimulated genes, while only limited studies were conducted on invertebrate IRFs. In the present study, four IRF family genes (CfIRF1, CfIRF1-like, CfIRF2, and CfIRF8) were identified from Zhikong scallop (Chlamys farreri) through whole-genome scanning. CfIRFs contain a highly conserved N-terminal DNA-binding domain and a variable C-terminal regulatory domain. CfIRFs were constitutively expressed during development as well as in adult tissues, especially in hepatopancreas, hemolymph, gill, and mantle. In hemolymph, qRT-PCR analysis revealed that CfIRF1, CfIRF1-like, and CfIRF2 were significantly upregulated in response to Vibrio anguillarum infection, and their encoding proteins could translocate into nucleus. Dual-luciferase reporter assay on CfIRF1, CfIRF1-like, and CfIRF2 showed that these three proteins were capable to induce a strong activation of ISRE promoters. Notably, in comparison with CfIRF1 and CfIRF1-like, CfIRF2 showed the most sensitive responses in coping with V. anguillarum, and consistently, CfIRF2 exhibited the most significant activation on ISRE. This study would provide valuable information for the innate immune roles of the IRF gene family in bivalve molluscs. | ||
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10.3389/fmars.2022.865707 doi (DE-627)DOAJ045059713 (DE-599)DOAJ954d72cd9e2649638177aa3b90ef7f98 DE-627 ger DE-627 rakwb eng QH1-199.5 Naina Hu verfasserin aut Interferon Regulatory Factors Functioned as Activators of the Interferon Pathway in the Scallop Chlamys farreri 2022 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Interferon regulatory factors (IRFs) are a family of transcription factors that control many facets during innate and adaptive immune responses. Vertebrate IRFs play important roles in regulating the expression of interferons (IFNs) and IFN-stimulated genes, while only limited studies were conducted on invertebrate IRFs. In the present study, four IRF family genes (CfIRF1, CfIRF1-like, CfIRF2, and CfIRF8) were identified from Zhikong scallop (Chlamys farreri) through whole-genome scanning. CfIRFs contain a highly conserved N-terminal DNA-binding domain and a variable C-terminal regulatory domain. CfIRFs were constitutively expressed during development as well as in adult tissues, especially in hepatopancreas, hemolymph, gill, and mantle. In hemolymph, qRT-PCR analysis revealed that CfIRF1, CfIRF1-like, and CfIRF2 were significantly upregulated in response to Vibrio anguillarum infection, and their encoding proteins could translocate into nucleus. Dual-luciferase reporter assay on CfIRF1, CfIRF1-like, and CfIRF2 showed that these three proteins were capable to induce a strong activation of ISRE promoters. Notably, in comparison with CfIRF1 and CfIRF1-like, CfIRF2 showed the most sensitive responses in coping with V. anguillarum, and consistently, CfIRF2 exhibited the most significant activation on ISRE. This study would provide valuable information for the innate immune roles of the IRF gene family in bivalve molluscs. Chlamys farreri IRF transcriptional activation interferon-stimulated response element immune response Science Q General. Including nature conservation, geographical distribution Shanshan Lian verfasserin aut Shanshan Lian verfasserin aut Xiaomei Zhu verfasserin aut Xiaomei Chen verfasserin aut Fengzhi Sun verfasserin aut Lingling Zhang verfasserin aut Lingling Zhang verfasserin aut Shi Wang verfasserin aut Shi Wang verfasserin aut Shi Wang verfasserin aut Zhenmin Bao verfasserin aut Zhenmin Bao verfasserin aut Zhenmin Bao verfasserin aut Jingjie Hu verfasserin aut Jingjie Hu verfasserin aut In Frontiers in Marine Science Frontiers Media S.A., 2015 9(2022) (DE-627)779393945 (DE-600)2757748-X 22967745 nnns volume:9 year:2022 https://doi.org/10.3389/fmars.2022.865707 kostenfrei https://doaj.org/article/954d72cd9e2649638177aa3b90ef7f98 kostenfrei https://www.frontiersin.org/articles/10.3389/fmars.2022.865707/full kostenfrei https://doaj.org/toc/2296-7745 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_2003 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 9 2022 |
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10.3389/fmars.2022.865707 doi (DE-627)DOAJ045059713 (DE-599)DOAJ954d72cd9e2649638177aa3b90ef7f98 DE-627 ger DE-627 rakwb eng QH1-199.5 Naina Hu verfasserin aut Interferon Regulatory Factors Functioned as Activators of the Interferon Pathway in the Scallop Chlamys farreri 2022 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Interferon regulatory factors (IRFs) are a family of transcription factors that control many facets during innate and adaptive immune responses. Vertebrate IRFs play important roles in regulating the expression of interferons (IFNs) and IFN-stimulated genes, while only limited studies were conducted on invertebrate IRFs. In the present study, four IRF family genes (CfIRF1, CfIRF1-like, CfIRF2, and CfIRF8) were identified from Zhikong scallop (Chlamys farreri) through whole-genome scanning. CfIRFs contain a highly conserved N-terminal DNA-binding domain and a variable C-terminal regulatory domain. CfIRFs were constitutively expressed during development as well as in adult tissues, especially in hepatopancreas, hemolymph, gill, and mantle. In hemolymph, qRT-PCR analysis revealed that CfIRF1, CfIRF1-like, and CfIRF2 were significantly upregulated in response to Vibrio anguillarum infection, and their encoding proteins could translocate into nucleus. Dual-luciferase reporter assay on CfIRF1, CfIRF1-like, and CfIRF2 showed that these three proteins were capable to induce a strong activation of ISRE promoters. Notably, in comparison with CfIRF1 and CfIRF1-like, CfIRF2 showed the most sensitive responses in coping with V. anguillarum, and consistently, CfIRF2 exhibited the most significant activation on ISRE. This study would provide valuable information for the innate immune roles of the IRF gene family in bivalve molluscs. Chlamys farreri IRF transcriptional activation interferon-stimulated response element immune response Science Q General. Including nature conservation, geographical distribution Shanshan Lian verfasserin aut Shanshan Lian verfasserin aut Xiaomei Zhu verfasserin aut Xiaomei Chen verfasserin aut Fengzhi Sun verfasserin aut Lingling Zhang verfasserin aut Lingling Zhang verfasserin aut Shi Wang verfasserin aut Shi Wang verfasserin aut Shi Wang verfasserin aut Zhenmin Bao verfasserin aut Zhenmin Bao verfasserin aut Zhenmin Bao verfasserin aut Jingjie Hu verfasserin aut Jingjie Hu verfasserin aut In Frontiers in Marine Science Frontiers Media S.A., 2015 9(2022) (DE-627)779393945 (DE-600)2757748-X 22967745 nnns volume:9 year:2022 https://doi.org/10.3389/fmars.2022.865707 kostenfrei https://doaj.org/article/954d72cd9e2649638177aa3b90ef7f98 kostenfrei https://www.frontiersin.org/articles/10.3389/fmars.2022.865707/full kostenfrei https://doaj.org/toc/2296-7745 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_2003 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 9 2022 |
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10.3389/fmars.2022.865707 doi (DE-627)DOAJ045059713 (DE-599)DOAJ954d72cd9e2649638177aa3b90ef7f98 DE-627 ger DE-627 rakwb eng QH1-199.5 Naina Hu verfasserin aut Interferon Regulatory Factors Functioned as Activators of the Interferon Pathway in the Scallop Chlamys farreri 2022 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Interferon regulatory factors (IRFs) are a family of transcription factors that control many facets during innate and adaptive immune responses. Vertebrate IRFs play important roles in regulating the expression of interferons (IFNs) and IFN-stimulated genes, while only limited studies were conducted on invertebrate IRFs. In the present study, four IRF family genes (CfIRF1, CfIRF1-like, CfIRF2, and CfIRF8) were identified from Zhikong scallop (Chlamys farreri) through whole-genome scanning. CfIRFs contain a highly conserved N-terminal DNA-binding domain and a variable C-terminal regulatory domain. CfIRFs were constitutively expressed during development as well as in adult tissues, especially in hepatopancreas, hemolymph, gill, and mantle. In hemolymph, qRT-PCR analysis revealed that CfIRF1, CfIRF1-like, and CfIRF2 were significantly upregulated in response to Vibrio anguillarum infection, and their encoding proteins could translocate into nucleus. Dual-luciferase reporter assay on CfIRF1, CfIRF1-like, and CfIRF2 showed that these three proteins were capable to induce a strong activation of ISRE promoters. Notably, in comparison with CfIRF1 and CfIRF1-like, CfIRF2 showed the most sensitive responses in coping with V. anguillarum, and consistently, CfIRF2 exhibited the most significant activation on ISRE. This study would provide valuable information for the innate immune roles of the IRF gene family in bivalve molluscs. Chlamys farreri IRF transcriptional activation interferon-stimulated response element immune response Science Q General. Including nature conservation, geographical distribution Shanshan Lian verfasserin aut Shanshan Lian verfasserin aut Xiaomei Zhu verfasserin aut Xiaomei Chen verfasserin aut Fengzhi Sun verfasserin aut Lingling Zhang verfasserin aut Lingling Zhang verfasserin aut Shi Wang verfasserin aut Shi Wang verfasserin aut Shi Wang verfasserin aut Zhenmin Bao verfasserin aut Zhenmin Bao verfasserin aut Zhenmin Bao verfasserin aut Jingjie Hu verfasserin aut Jingjie Hu verfasserin aut In Frontiers in Marine Science Frontiers Media S.A., 2015 9(2022) (DE-627)779393945 (DE-600)2757748-X 22967745 nnns volume:9 year:2022 https://doi.org/10.3389/fmars.2022.865707 kostenfrei https://doaj.org/article/954d72cd9e2649638177aa3b90ef7f98 kostenfrei https://www.frontiersin.org/articles/10.3389/fmars.2022.865707/full kostenfrei https://doaj.org/toc/2296-7745 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_2003 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 9 2022 |
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10.3389/fmars.2022.865707 doi (DE-627)DOAJ045059713 (DE-599)DOAJ954d72cd9e2649638177aa3b90ef7f98 DE-627 ger DE-627 rakwb eng QH1-199.5 Naina Hu verfasserin aut Interferon Regulatory Factors Functioned as Activators of the Interferon Pathway in the Scallop Chlamys farreri 2022 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Interferon regulatory factors (IRFs) are a family of transcription factors that control many facets during innate and adaptive immune responses. Vertebrate IRFs play important roles in regulating the expression of interferons (IFNs) and IFN-stimulated genes, while only limited studies were conducted on invertebrate IRFs. In the present study, four IRF family genes (CfIRF1, CfIRF1-like, CfIRF2, and CfIRF8) were identified from Zhikong scallop (Chlamys farreri) through whole-genome scanning. CfIRFs contain a highly conserved N-terminal DNA-binding domain and a variable C-terminal regulatory domain. CfIRFs were constitutively expressed during development as well as in adult tissues, especially in hepatopancreas, hemolymph, gill, and mantle. In hemolymph, qRT-PCR analysis revealed that CfIRF1, CfIRF1-like, and CfIRF2 were significantly upregulated in response to Vibrio anguillarum infection, and their encoding proteins could translocate into nucleus. Dual-luciferase reporter assay on CfIRF1, CfIRF1-like, and CfIRF2 showed that these three proteins were capable to induce a strong activation of ISRE promoters. Notably, in comparison with CfIRF1 and CfIRF1-like, CfIRF2 showed the most sensitive responses in coping with V. anguillarum, and consistently, CfIRF2 exhibited the most significant activation on ISRE. This study would provide valuable information for the innate immune roles of the IRF gene family in bivalve molluscs. Chlamys farreri IRF transcriptional activation interferon-stimulated response element immune response Science Q General. Including nature conservation, geographical distribution Shanshan Lian verfasserin aut Shanshan Lian verfasserin aut Xiaomei Zhu verfasserin aut Xiaomei Chen verfasserin aut Fengzhi Sun verfasserin aut Lingling Zhang verfasserin aut Lingling Zhang verfasserin aut Shi Wang verfasserin aut Shi Wang verfasserin aut Shi Wang verfasserin aut Zhenmin Bao verfasserin aut Zhenmin Bao verfasserin aut Zhenmin Bao verfasserin aut Jingjie Hu verfasserin aut Jingjie Hu verfasserin aut In Frontiers in Marine Science Frontiers Media S.A., 2015 9(2022) (DE-627)779393945 (DE-600)2757748-X 22967745 nnns volume:9 year:2022 https://doi.org/10.3389/fmars.2022.865707 kostenfrei https://doaj.org/article/954d72cd9e2649638177aa3b90ef7f98 kostenfrei https://www.frontiersin.org/articles/10.3389/fmars.2022.865707/full kostenfrei https://doaj.org/toc/2296-7745 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_2003 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 9 2022 |
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10.3389/fmars.2022.865707 doi (DE-627)DOAJ045059713 (DE-599)DOAJ954d72cd9e2649638177aa3b90ef7f98 DE-627 ger DE-627 rakwb eng QH1-199.5 Naina Hu verfasserin aut Interferon Regulatory Factors Functioned as Activators of the Interferon Pathway in the Scallop Chlamys farreri 2022 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Interferon regulatory factors (IRFs) are a family of transcription factors that control many facets during innate and adaptive immune responses. Vertebrate IRFs play important roles in regulating the expression of interferons (IFNs) and IFN-stimulated genes, while only limited studies were conducted on invertebrate IRFs. In the present study, four IRF family genes (CfIRF1, CfIRF1-like, CfIRF2, and CfIRF8) were identified from Zhikong scallop (Chlamys farreri) through whole-genome scanning. CfIRFs contain a highly conserved N-terminal DNA-binding domain and a variable C-terminal regulatory domain. CfIRFs were constitutively expressed during development as well as in adult tissues, especially in hepatopancreas, hemolymph, gill, and mantle. In hemolymph, qRT-PCR analysis revealed that CfIRF1, CfIRF1-like, and CfIRF2 were significantly upregulated in response to Vibrio anguillarum infection, and their encoding proteins could translocate into nucleus. Dual-luciferase reporter assay on CfIRF1, CfIRF1-like, and CfIRF2 showed that these three proteins were capable to induce a strong activation of ISRE promoters. Notably, in comparison with CfIRF1 and CfIRF1-like, CfIRF2 showed the most sensitive responses in coping with V. anguillarum, and consistently, CfIRF2 exhibited the most significant activation on ISRE. This study would provide valuable information for the innate immune roles of the IRF gene family in bivalve molluscs. Chlamys farreri IRF transcriptional activation interferon-stimulated response element immune response Science Q General. Including nature conservation, geographical distribution Shanshan Lian verfasserin aut Shanshan Lian verfasserin aut Xiaomei Zhu verfasserin aut Xiaomei Chen verfasserin aut Fengzhi Sun verfasserin aut Lingling Zhang verfasserin aut Lingling Zhang verfasserin aut Shi Wang verfasserin aut Shi Wang verfasserin aut Shi Wang verfasserin aut Zhenmin Bao verfasserin aut Zhenmin Bao verfasserin aut Zhenmin Bao verfasserin aut Jingjie Hu verfasserin aut Jingjie Hu verfasserin aut In Frontiers in Marine Science Frontiers Media S.A., 2015 9(2022) (DE-627)779393945 (DE-600)2757748-X 22967745 nnns volume:9 year:2022 https://doi.org/10.3389/fmars.2022.865707 kostenfrei https://doaj.org/article/954d72cd9e2649638177aa3b90ef7f98 kostenfrei https://www.frontiersin.org/articles/10.3389/fmars.2022.865707/full kostenfrei https://doaj.org/toc/2296-7745 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_2003 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 9 2022 |
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interferon regulatory factors functioned as activators of the interferon pathway in the scallop chlamys farreri |
callnumber |
QH1-199.5 |
title_auth |
Interferon Regulatory Factors Functioned as Activators of the Interferon Pathway in the Scallop Chlamys farreri |
abstract |
Interferon regulatory factors (IRFs) are a family of transcription factors that control many facets during innate and adaptive immune responses. Vertebrate IRFs play important roles in regulating the expression of interferons (IFNs) and IFN-stimulated genes, while only limited studies were conducted on invertebrate IRFs. In the present study, four IRF family genes (CfIRF1, CfIRF1-like, CfIRF2, and CfIRF8) were identified from Zhikong scallop (Chlamys farreri) through whole-genome scanning. CfIRFs contain a highly conserved N-terminal DNA-binding domain and a variable C-terminal regulatory domain. CfIRFs were constitutively expressed during development as well as in adult tissues, especially in hepatopancreas, hemolymph, gill, and mantle. In hemolymph, qRT-PCR analysis revealed that CfIRF1, CfIRF1-like, and CfIRF2 were significantly upregulated in response to Vibrio anguillarum infection, and their encoding proteins could translocate into nucleus. Dual-luciferase reporter assay on CfIRF1, CfIRF1-like, and CfIRF2 showed that these three proteins were capable to induce a strong activation of ISRE promoters. Notably, in comparison with CfIRF1 and CfIRF1-like, CfIRF2 showed the most sensitive responses in coping with V. anguillarum, and consistently, CfIRF2 exhibited the most significant activation on ISRE. This study would provide valuable information for the innate immune roles of the IRF gene family in bivalve molluscs. |
abstractGer |
Interferon regulatory factors (IRFs) are a family of transcription factors that control many facets during innate and adaptive immune responses. Vertebrate IRFs play important roles in regulating the expression of interferons (IFNs) and IFN-stimulated genes, while only limited studies were conducted on invertebrate IRFs. In the present study, four IRF family genes (CfIRF1, CfIRF1-like, CfIRF2, and CfIRF8) were identified from Zhikong scallop (Chlamys farreri) through whole-genome scanning. CfIRFs contain a highly conserved N-terminal DNA-binding domain and a variable C-terminal regulatory domain. CfIRFs were constitutively expressed during development as well as in adult tissues, especially in hepatopancreas, hemolymph, gill, and mantle. In hemolymph, qRT-PCR analysis revealed that CfIRF1, CfIRF1-like, and CfIRF2 were significantly upregulated in response to Vibrio anguillarum infection, and their encoding proteins could translocate into nucleus. Dual-luciferase reporter assay on CfIRF1, CfIRF1-like, and CfIRF2 showed that these three proteins were capable to induce a strong activation of ISRE promoters. Notably, in comparison with CfIRF1 and CfIRF1-like, CfIRF2 showed the most sensitive responses in coping with V. anguillarum, and consistently, CfIRF2 exhibited the most significant activation on ISRE. This study would provide valuable information for the innate immune roles of the IRF gene family in bivalve molluscs. |
abstract_unstemmed |
Interferon regulatory factors (IRFs) are a family of transcription factors that control many facets during innate and adaptive immune responses. Vertebrate IRFs play important roles in regulating the expression of interferons (IFNs) and IFN-stimulated genes, while only limited studies were conducted on invertebrate IRFs. In the present study, four IRF family genes (CfIRF1, CfIRF1-like, CfIRF2, and CfIRF8) were identified from Zhikong scallop (Chlamys farreri) through whole-genome scanning. CfIRFs contain a highly conserved N-terminal DNA-binding domain and a variable C-terminal regulatory domain. CfIRFs were constitutively expressed during development as well as in adult tissues, especially in hepatopancreas, hemolymph, gill, and mantle. In hemolymph, qRT-PCR analysis revealed that CfIRF1, CfIRF1-like, and CfIRF2 were significantly upregulated in response to Vibrio anguillarum infection, and their encoding proteins could translocate into nucleus. Dual-luciferase reporter assay on CfIRF1, CfIRF1-like, and CfIRF2 showed that these three proteins were capable to induce a strong activation of ISRE promoters. Notably, in comparison with CfIRF1 and CfIRF1-like, CfIRF2 showed the most sensitive responses in coping with V. anguillarum, and consistently, CfIRF2 exhibited the most significant activation on ISRE. This study would provide valuable information for the innate immune roles of the IRF gene family in bivalve molluscs. |
collection_details |
GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_2003 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 |
title_short |
Interferon Regulatory Factors Functioned as Activators of the Interferon Pathway in the Scallop Chlamys farreri |
url |
https://doi.org/10.3389/fmars.2022.865707 https://doaj.org/article/954d72cd9e2649638177aa3b90ef7f98 https://www.frontiersin.org/articles/10.3389/fmars.2022.865707/full https://doaj.org/toc/2296-7745 |
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author2 |
Shanshan Lian Xiaomei Zhu Xiaomei Chen Fengzhi Sun Lingling Zhang Shi Wang Zhenmin Bao Jingjie Hu |
author2Str |
Shanshan Lian Xiaomei Zhu Xiaomei Chen Fengzhi Sun Lingling Zhang Shi Wang Zhenmin Bao Jingjie Hu |
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callnumber-subject |
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doi_str |
10.3389/fmars.2022.865707 |
callnumber-a |
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up_date |
2024-07-04T01:30:29.085Z |
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