Nonsyndromic cleft lip with or without cleft palate and cancer: Evaluation of a possible common genetic background through the analysis of GWAS data
Previous research suggests a genetic overlap between nonsyndromic cleft lip with or without cleft palate (NSCL/P) and cancer. The aim of the present study was to identify common genetic risk loci for NSCL/P and cancer entities that have been reported to co-occur with orofacial clefting. This was ach...
Ausführliche Beschreibung
Autor*in: |
Eva Dunkhase [verfasserIn] Kerstin U. Ludwig [verfasserIn] Michael Knapp [verfasserIn] Christine F. Skibola [verfasserIn] Jane C. Figueiredo [verfasserIn] Fay Julie Hosking [verfasserIn] Eva Ellinghaus [verfasserIn] Maria Teresa Landi [verfasserIn] Hongxia Ma [verfasserIn] Hidewaki Nakagawa [verfasserIn] Jong-Won Kim [verfasserIn] Jiali Han [verfasserIn] Ping Yang [verfasserIn] Anne C. Böhmer [verfasserIn] Manuel Mattheisen [verfasserIn] Markus M. Nöthen [verfasserIn] Elisabeth Mangold [verfasserIn] |
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E-Artikel |
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Sprache: |
Englisch |
Erschienen: |
2016 |
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Übergeordnetes Werk: |
In: Genomics Data - Elsevier, 2015, 10(2016), C, Seite 22-29 |
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Übergeordnetes Werk: |
volume:10 ; year:2016 ; number:C ; pages:22-29 |
Links: |
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DOI / URN: |
10.1016/j.gdata.2016.08.017 |
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10.1016/j.gdata.2016.08.017 doi (DE-627)DOAJ045061432 (DE-599)DOAJ7a30538659e64ef8947be8094f05e507 DE-627 ger DE-627 rakwb eng QH426-470 Eva Dunkhase verfasserin aut Nonsyndromic cleft lip with or without cleft palate and cancer: Evaluation of a possible common genetic background through the analysis of GWAS data 2016 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Previous research suggests a genetic overlap between nonsyndromic cleft lip with or without cleft palate (NSCL/P) and cancer. The aim of the present study was to identify common genetic risk loci for NSCL/P and cancer entities that have been reported to co-occur with orofacial clefting. This was achieved through the investigation of large genome-wide association study datasets. Investigations of 12 NSCL/P single nucleotide polymorphisms (SNPs) in 32 cancer datasets, and 204 cancer SNPs in two NSCL/P datasets, were performed. The SNPs rs13041247 (20q12) and rs6457327 (6p21.33) showed suggestive evidence for an association with both NSCL/P and a specific cancer entity. These loci harbor genes of biological relevance to oncogenesis (MAFB and OCT4, respectively). This study is the first to characterize possible pleiotropic risk loci for NSCL/P and cancer in a systematic manner. The data represent a starting point for future research by identifying a genetic link between NSCL/P and cancer. Cleft lip Cleft palate Genome-wide association study Single nucleotide polymorphism Cancer Genetics Kerstin U. Ludwig verfasserin aut Michael Knapp verfasserin aut Christine F. Skibola verfasserin aut Jane C. Figueiredo verfasserin aut Fay Julie Hosking verfasserin aut Eva Ellinghaus verfasserin aut Maria Teresa Landi verfasserin aut Hongxia Ma verfasserin aut Hidewaki Nakagawa verfasserin aut Jong-Won Kim verfasserin aut Jiali Han verfasserin aut Ping Yang verfasserin aut Anne C. Böhmer verfasserin aut Manuel Mattheisen verfasserin aut Markus M. Nöthen verfasserin aut Elisabeth Mangold verfasserin aut In Genomics Data Elsevier, 2015 10(2016), C, Seite 22-29 (DE-627)77685531X (DE-600)2751131-5 22135960 nnns volume:10 year:2016 number:C pages:22-29 https://doi.org/10.1016/j.gdata.2016.08.017 kostenfrei https://doaj.org/article/7a30538659e64ef8947be8094f05e507 kostenfrei http://www.sciencedirect.com/science/article/pii/S2213596016301131 kostenfrei https://doaj.org/toc/2213-5960 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ SSG-OLC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 10 2016 C 22-29 |
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10.1016/j.gdata.2016.08.017 doi (DE-627)DOAJ045061432 (DE-599)DOAJ7a30538659e64ef8947be8094f05e507 DE-627 ger DE-627 rakwb eng QH426-470 Eva Dunkhase verfasserin aut Nonsyndromic cleft lip with or without cleft palate and cancer: Evaluation of a possible common genetic background through the analysis of GWAS data 2016 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Previous research suggests a genetic overlap between nonsyndromic cleft lip with or without cleft palate (NSCL/P) and cancer. The aim of the present study was to identify common genetic risk loci for NSCL/P and cancer entities that have been reported to co-occur with orofacial clefting. This was achieved through the investigation of large genome-wide association study datasets. Investigations of 12 NSCL/P single nucleotide polymorphisms (SNPs) in 32 cancer datasets, and 204 cancer SNPs in two NSCL/P datasets, were performed. The SNPs rs13041247 (20q12) and rs6457327 (6p21.33) showed suggestive evidence for an association with both NSCL/P and a specific cancer entity. These loci harbor genes of biological relevance to oncogenesis (MAFB and OCT4, respectively). This study is the first to characterize possible pleiotropic risk loci for NSCL/P and cancer in a systematic manner. The data represent a starting point for future research by identifying a genetic link between NSCL/P and cancer. Cleft lip Cleft palate Genome-wide association study Single nucleotide polymorphism Cancer Genetics Kerstin U. Ludwig verfasserin aut Michael Knapp verfasserin aut Christine F. Skibola verfasserin aut Jane C. Figueiredo verfasserin aut Fay Julie Hosking verfasserin aut Eva Ellinghaus verfasserin aut Maria Teresa Landi verfasserin aut Hongxia Ma verfasserin aut Hidewaki Nakagawa verfasserin aut Jong-Won Kim verfasserin aut Jiali Han verfasserin aut Ping Yang verfasserin aut Anne C. Böhmer verfasserin aut Manuel Mattheisen verfasserin aut Markus M. Nöthen verfasserin aut Elisabeth Mangold verfasserin aut In Genomics Data Elsevier, 2015 10(2016), C, Seite 22-29 (DE-627)77685531X (DE-600)2751131-5 22135960 nnns volume:10 year:2016 number:C pages:22-29 https://doi.org/10.1016/j.gdata.2016.08.017 kostenfrei https://doaj.org/article/7a30538659e64ef8947be8094f05e507 kostenfrei http://www.sciencedirect.com/science/article/pii/S2213596016301131 kostenfrei https://doaj.org/toc/2213-5960 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ SSG-OLC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 10 2016 C 22-29 |
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10.1016/j.gdata.2016.08.017 doi (DE-627)DOAJ045061432 (DE-599)DOAJ7a30538659e64ef8947be8094f05e507 DE-627 ger DE-627 rakwb eng QH426-470 Eva Dunkhase verfasserin aut Nonsyndromic cleft lip with or without cleft palate and cancer: Evaluation of a possible common genetic background through the analysis of GWAS data 2016 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Previous research suggests a genetic overlap between nonsyndromic cleft lip with or without cleft palate (NSCL/P) and cancer. The aim of the present study was to identify common genetic risk loci for NSCL/P and cancer entities that have been reported to co-occur with orofacial clefting. This was achieved through the investigation of large genome-wide association study datasets. Investigations of 12 NSCL/P single nucleotide polymorphisms (SNPs) in 32 cancer datasets, and 204 cancer SNPs in two NSCL/P datasets, were performed. The SNPs rs13041247 (20q12) and rs6457327 (6p21.33) showed suggestive evidence for an association with both NSCL/P and a specific cancer entity. These loci harbor genes of biological relevance to oncogenesis (MAFB and OCT4, respectively). This study is the first to characterize possible pleiotropic risk loci for NSCL/P and cancer in a systematic manner. The data represent a starting point for future research by identifying a genetic link between NSCL/P and cancer. Cleft lip Cleft palate Genome-wide association study Single nucleotide polymorphism Cancer Genetics Kerstin U. Ludwig verfasserin aut Michael Knapp verfasserin aut Christine F. Skibola verfasserin aut Jane C. Figueiredo verfasserin aut Fay Julie Hosking verfasserin aut Eva Ellinghaus verfasserin aut Maria Teresa Landi verfasserin aut Hongxia Ma verfasserin aut Hidewaki Nakagawa verfasserin aut Jong-Won Kim verfasserin aut Jiali Han verfasserin aut Ping Yang verfasserin aut Anne C. Böhmer verfasserin aut Manuel Mattheisen verfasserin aut Markus M. Nöthen verfasserin aut Elisabeth Mangold verfasserin aut In Genomics Data Elsevier, 2015 10(2016), C, Seite 22-29 (DE-627)77685531X (DE-600)2751131-5 22135960 nnns volume:10 year:2016 number:C pages:22-29 https://doi.org/10.1016/j.gdata.2016.08.017 kostenfrei https://doaj.org/article/7a30538659e64ef8947be8094f05e507 kostenfrei http://www.sciencedirect.com/science/article/pii/S2213596016301131 kostenfrei https://doaj.org/toc/2213-5960 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ SSG-OLC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 10 2016 C 22-29 |
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10.1016/j.gdata.2016.08.017 doi (DE-627)DOAJ045061432 (DE-599)DOAJ7a30538659e64ef8947be8094f05e507 DE-627 ger DE-627 rakwb eng QH426-470 Eva Dunkhase verfasserin aut Nonsyndromic cleft lip with or without cleft palate and cancer: Evaluation of a possible common genetic background through the analysis of GWAS data 2016 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Previous research suggests a genetic overlap between nonsyndromic cleft lip with or without cleft palate (NSCL/P) and cancer. The aim of the present study was to identify common genetic risk loci for NSCL/P and cancer entities that have been reported to co-occur with orofacial clefting. This was achieved through the investigation of large genome-wide association study datasets. Investigations of 12 NSCL/P single nucleotide polymorphisms (SNPs) in 32 cancer datasets, and 204 cancer SNPs in two NSCL/P datasets, were performed. The SNPs rs13041247 (20q12) and rs6457327 (6p21.33) showed suggestive evidence for an association with both NSCL/P and a specific cancer entity. These loci harbor genes of biological relevance to oncogenesis (MAFB and OCT4, respectively). This study is the first to characterize possible pleiotropic risk loci for NSCL/P and cancer in a systematic manner. The data represent a starting point for future research by identifying a genetic link between NSCL/P and cancer. Cleft lip Cleft palate Genome-wide association study Single nucleotide polymorphism Cancer Genetics Kerstin U. Ludwig verfasserin aut Michael Knapp verfasserin aut Christine F. Skibola verfasserin aut Jane C. Figueiredo verfasserin aut Fay Julie Hosking verfasserin aut Eva Ellinghaus verfasserin aut Maria Teresa Landi verfasserin aut Hongxia Ma verfasserin aut Hidewaki Nakagawa verfasserin aut Jong-Won Kim verfasserin aut Jiali Han verfasserin aut Ping Yang verfasserin aut Anne C. Böhmer verfasserin aut Manuel Mattheisen verfasserin aut Markus M. Nöthen verfasserin aut Elisabeth Mangold verfasserin aut In Genomics Data Elsevier, 2015 10(2016), C, Seite 22-29 (DE-627)77685531X (DE-600)2751131-5 22135960 nnns volume:10 year:2016 number:C pages:22-29 https://doi.org/10.1016/j.gdata.2016.08.017 kostenfrei https://doaj.org/article/7a30538659e64ef8947be8094f05e507 kostenfrei http://www.sciencedirect.com/science/article/pii/S2213596016301131 kostenfrei https://doaj.org/toc/2213-5960 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ SSG-OLC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 10 2016 C 22-29 |
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10.1016/j.gdata.2016.08.017 doi (DE-627)DOAJ045061432 (DE-599)DOAJ7a30538659e64ef8947be8094f05e507 DE-627 ger DE-627 rakwb eng QH426-470 Eva Dunkhase verfasserin aut Nonsyndromic cleft lip with or without cleft palate and cancer: Evaluation of a possible common genetic background through the analysis of GWAS data 2016 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Previous research suggests a genetic overlap between nonsyndromic cleft lip with or without cleft palate (NSCL/P) and cancer. The aim of the present study was to identify common genetic risk loci for NSCL/P and cancer entities that have been reported to co-occur with orofacial clefting. This was achieved through the investigation of large genome-wide association study datasets. Investigations of 12 NSCL/P single nucleotide polymorphisms (SNPs) in 32 cancer datasets, and 204 cancer SNPs in two NSCL/P datasets, were performed. The SNPs rs13041247 (20q12) and rs6457327 (6p21.33) showed suggestive evidence for an association with both NSCL/P and a specific cancer entity. These loci harbor genes of biological relevance to oncogenesis (MAFB and OCT4, respectively). This study is the first to characterize possible pleiotropic risk loci for NSCL/P and cancer in a systematic manner. The data represent a starting point for future research by identifying a genetic link between NSCL/P and cancer. Cleft lip Cleft palate Genome-wide association study Single nucleotide polymorphism Cancer Genetics Kerstin U. Ludwig verfasserin aut Michael Knapp verfasserin aut Christine F. Skibola verfasserin aut Jane C. Figueiredo verfasserin aut Fay Julie Hosking verfasserin aut Eva Ellinghaus verfasserin aut Maria Teresa Landi verfasserin aut Hongxia Ma verfasserin aut Hidewaki Nakagawa verfasserin aut Jong-Won Kim verfasserin aut Jiali Han verfasserin aut Ping Yang verfasserin aut Anne C. Böhmer verfasserin aut Manuel Mattheisen verfasserin aut Markus M. Nöthen verfasserin aut Elisabeth Mangold verfasserin aut In Genomics Data Elsevier, 2015 10(2016), C, Seite 22-29 (DE-627)77685531X (DE-600)2751131-5 22135960 nnns volume:10 year:2016 number:C pages:22-29 https://doi.org/10.1016/j.gdata.2016.08.017 kostenfrei https://doaj.org/article/7a30538659e64ef8947be8094f05e507 kostenfrei http://www.sciencedirect.com/science/article/pii/S2213596016301131 kostenfrei https://doaj.org/toc/2213-5960 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ SSG-OLC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 10 2016 C 22-29 |
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Eva Dunkhase @@aut@@ Kerstin U. Ludwig @@aut@@ Michael Knapp @@aut@@ Christine F. Skibola @@aut@@ Jane C. Figueiredo @@aut@@ Fay Julie Hosking @@aut@@ Eva Ellinghaus @@aut@@ Maria Teresa Landi @@aut@@ Hongxia Ma @@aut@@ Hidewaki Nakagawa @@aut@@ Jong-Won Kim @@aut@@ Jiali Han @@aut@@ Ping Yang @@aut@@ Anne C. Böhmer @@aut@@ Manuel Mattheisen @@aut@@ Markus M. Nöthen @@aut@@ Elisabeth Mangold @@aut@@ |
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2016-01-01T00:00:00Z |
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nonsyndromic cleft lip with or without cleft palate and cancer: evaluation of a possible common genetic background through the analysis of gwas data |
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Nonsyndromic cleft lip with or without cleft palate and cancer: Evaluation of a possible common genetic background through the analysis of GWAS data |
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Previous research suggests a genetic overlap between nonsyndromic cleft lip with or without cleft palate (NSCL/P) and cancer. The aim of the present study was to identify common genetic risk loci for NSCL/P and cancer entities that have been reported to co-occur with orofacial clefting. This was achieved through the investigation of large genome-wide association study datasets. Investigations of 12 NSCL/P single nucleotide polymorphisms (SNPs) in 32 cancer datasets, and 204 cancer SNPs in two NSCL/P datasets, were performed. The SNPs rs13041247 (20q12) and rs6457327 (6p21.33) showed suggestive evidence for an association with both NSCL/P and a specific cancer entity. These loci harbor genes of biological relevance to oncogenesis (MAFB and OCT4, respectively). This study is the first to characterize possible pleiotropic risk loci for NSCL/P and cancer in a systematic manner. The data represent a starting point for future research by identifying a genetic link between NSCL/P and cancer. |
abstractGer |
Previous research suggests a genetic overlap between nonsyndromic cleft lip with or without cleft palate (NSCL/P) and cancer. The aim of the present study was to identify common genetic risk loci for NSCL/P and cancer entities that have been reported to co-occur with orofacial clefting. This was achieved through the investigation of large genome-wide association study datasets. Investigations of 12 NSCL/P single nucleotide polymorphisms (SNPs) in 32 cancer datasets, and 204 cancer SNPs in two NSCL/P datasets, were performed. The SNPs rs13041247 (20q12) and rs6457327 (6p21.33) showed suggestive evidence for an association with both NSCL/P and a specific cancer entity. These loci harbor genes of biological relevance to oncogenesis (MAFB and OCT4, respectively). This study is the first to characterize possible pleiotropic risk loci for NSCL/P and cancer in a systematic manner. The data represent a starting point for future research by identifying a genetic link between NSCL/P and cancer. |
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Previous research suggests a genetic overlap between nonsyndromic cleft lip with or without cleft palate (NSCL/P) and cancer. The aim of the present study was to identify common genetic risk loci for NSCL/P and cancer entities that have been reported to co-occur with orofacial clefting. This was achieved through the investigation of large genome-wide association study datasets. Investigations of 12 NSCL/P single nucleotide polymorphisms (SNPs) in 32 cancer datasets, and 204 cancer SNPs in two NSCL/P datasets, were performed. The SNPs rs13041247 (20q12) and rs6457327 (6p21.33) showed suggestive evidence for an association with both NSCL/P and a specific cancer entity. These loci harbor genes of biological relevance to oncogenesis (MAFB and OCT4, respectively). This study is the first to characterize possible pleiotropic risk loci for NSCL/P and cancer in a systematic manner. The data represent a starting point for future research by identifying a genetic link between NSCL/P and cancer. |
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Nonsyndromic cleft lip with or without cleft palate and cancer: Evaluation of a possible common genetic background through the analysis of GWAS data |
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The aim of the present study was to identify common genetic risk loci for NSCL/P and cancer entities that have been reported to co-occur with orofacial clefting. This was achieved through the investigation of large genome-wide association study datasets. Investigations of 12 NSCL/P single nucleotide polymorphisms (SNPs) in 32 cancer datasets, and 204 cancer SNPs in two NSCL/P datasets, were performed. The SNPs rs13041247 (20q12) and rs6457327 (6p21.33) showed suggestive evidence for an association with both NSCL/P and a specific cancer entity. These loci harbor genes of biological relevance to oncogenesis (MAFB and OCT4, respectively). This study is the first to characterize possible pleiotropic risk loci for NSCL/P and cancer in a systematic manner. 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