Thalidomide for the Treatment of Thrombocytopenia and Hypersplenism in Patients With Cirrhosis or Thalassemia

Hypersplenism and thrombocytopenia are common complications of liver cirrhosis or thalassemia, but current treatment strategies are limited. This study aimed to evaluate the efficacy and safety of thalidomide in the treatment of hypersplenism and thrombocytopenia in patients with liver cirrhosis or...
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Gespeichert in:

Autor*in:	Yaocheng Chen [verfasserIn] Ning Cai [verfasserIn] Yongrong Lai [verfasserIn] Weiwei Xu [verfasserIn] Jinyan Li [verfasserIn] Lan Huang [verfasserIn] Ying Huang [verfasserIn] Meiling Hu [verfasserIn] Huangju Yang [verfasserIn] Jiangming Chen [verfasserIn]

Format:	E-Artikel
Sprache:	Englisch

Erschienen:	2020

Schlagwörter:	thalidomide thrombocytopenia hypersplenism thalassemia liver cirrhosis

Übergeordnetes Werk:	In: Frontiers in Pharmacology - Frontiers Media S.A., 2010, 11(2020)
Übergeordnetes Werk:	volume:11 ; year:2020

Links:	Link aufrufen Link aufrufen Link aufrufen Journal toc

DOI / URN:	10.3389/fphar.2020.01137

Katalog-ID:	DOAJ045082901

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allfieldsSound	10.3389/fphar.2020.01137 doi (DE-627)DOAJ045082901 (DE-599)DOAJ494262d15c8c4e4ab313d6cdf731f9a3 DE-627 ger DE-627 rakwb eng RM1-950 Yaocheng Chen verfasserin aut Thalidomide for the Treatment of Thrombocytopenia and Hypersplenism in Patients With Cirrhosis or Thalassemia 2020 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Hypersplenism and thrombocytopenia are common complications of liver cirrhosis or thalassemia, but current treatment strategies are limited. This study aimed to evaluate the efficacy and safety of thalidomide in the treatment of hypersplenism and thrombocytopenia in patients with liver cirrhosis or thalassemia. A total of 31 patients with hepatic cirrhosis (n=19) or thalassemia (n=12) diagnosed with hypersplenism and thrombocytopenia (platelet count [PLT] <100×109/L) were included in this prospective cohort study between January 2015 and May 2017. Patients were treated with thalidomide (150–200 mg/d) plus conventional therapy. Spleen length, PLT, leukocyte count (WBC), absolute neutrophil count (ANC), and hemoglobin level (Hb) were measured at baseline, 3, 6, and 12 months. Any adverse events were noted. All of the 31 patients were showed a progressive increase PLT during the 12-month follow-up, and similar results were obtained when subgroup analyses were performed based on the primary disease (cirrhosis or thalassemia). WBC, ANC, and Hb also increased progressively during the 12-month follow-up. Spleen length decreased progressively during the follow-up. No serious adverse events occurred. Thalidomide is a potential treatment for thrombocytopenia caused by hypersplenism in patients with cirrhosis or thalassemia. thalidomide thrombocytopenia hypersplenism thalassemia liver cirrhosis Therapeutics. Pharmacology Ning Cai verfasserin aut Yongrong Lai verfasserin aut Weiwei Xu verfasserin aut Jinyan Li verfasserin aut Lan Huang verfasserin aut Ying Huang verfasserin aut Meiling Hu verfasserin aut Huangju Yang verfasserin aut Jiangming Chen verfasserin aut In Frontiers in Pharmacology Frontiers Media S.A., 2010 11(2020) (DE-627)642889392 (DE-600)2587355-6 16639812 nnns volume:11 year:2020 https://doi.org/10.3389/fphar.2020.01137 kostenfrei https://doaj.org/article/494262d15c8c4e4ab313d6cdf731f9a3 kostenfrei https://www.frontiersin.org/article/10.3389/fphar.2020.01137/full kostenfrei https://doaj.org/toc/1663-9812 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2003 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 11 2020
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authorswithroles_txt_mv	Yaocheng Chen @@aut@@ Ning Cai @@aut@@ Yongrong Lai @@aut@@ Weiwei Xu @@aut@@ Jinyan Li @@aut@@ Lan Huang @@aut@@ Ying Huang @@aut@@ Meiling Hu @@aut@@ Huangju Yang @@aut@@ Jiangming Chen @@aut@@
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callnumber-first	R - Medicine
author	Yaocheng Chen
spellingShingle	Yaocheng Chen misc RM1-950 misc thalidomide misc thrombocytopenia misc hypersplenism misc thalassemia misc liver cirrhosis misc Therapeutics. Pharmacology Thalidomide for the Treatment of Thrombocytopenia and Hypersplenism in Patients With Cirrhosis or Thalassemia
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topic_title	RM1-950 Thalidomide for the Treatment of Thrombocytopenia and Hypersplenism in Patients With Cirrhosis or Thalassemia thalidomide thrombocytopenia hypersplenism thalassemia liver cirrhosis
topic	misc RM1-950 misc thalidomide misc thrombocytopenia misc hypersplenism misc thalassemia misc liver cirrhosis misc Therapeutics. Pharmacology
topic_unstemmed	misc RM1-950 misc thalidomide misc thrombocytopenia misc hypersplenism misc thalassemia misc liver cirrhosis misc Therapeutics. Pharmacology
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title	Thalidomide for the Treatment of Thrombocytopenia and Hypersplenism in Patients With Cirrhosis or Thalassemia
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title_full	Thalidomide for the Treatment of Thrombocytopenia and Hypersplenism in Patients With Cirrhosis or Thalassemia
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title_sort	thalidomide for the treatment of thrombocytopenia and hypersplenism in patients with cirrhosis or thalassemia
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title_auth	Thalidomide for the Treatment of Thrombocytopenia and Hypersplenism in Patients With Cirrhosis or Thalassemia
abstract	Hypersplenism and thrombocytopenia are common complications of liver cirrhosis or thalassemia, but current treatment strategies are limited. This study aimed to evaluate the efficacy and safety of thalidomide in the treatment of hypersplenism and thrombocytopenia in patients with liver cirrhosis or thalassemia. A total of 31 patients with hepatic cirrhosis (n=19) or thalassemia (n=12) diagnosed with hypersplenism and thrombocytopenia (platelet count [PLT] <100×109/L) were included in this prospective cohort study between January 2015 and May 2017. Patients were treated with thalidomide (150–200 mg/d) plus conventional therapy. Spleen length, PLT, leukocyte count (WBC), absolute neutrophil count (ANC), and hemoglobin level (Hb) were measured at baseline, 3, 6, and 12 months. Any adverse events were noted. All of the 31 patients were showed a progressive increase PLT during the 12-month follow-up, and similar results were obtained when subgroup analyses were performed based on the primary disease (cirrhosis or thalassemia). WBC, ANC, and Hb also increased progressively during the 12-month follow-up. Spleen length decreased progressively during the follow-up. No serious adverse events occurred. Thalidomide is a potential treatment for thrombocytopenia caused by hypersplenism in patients with cirrhosis or thalassemia.
abstractGer	Hypersplenism and thrombocytopenia are common complications of liver cirrhosis or thalassemia, but current treatment strategies are limited. This study aimed to evaluate the efficacy and safety of thalidomide in the treatment of hypersplenism and thrombocytopenia in patients with liver cirrhosis or thalassemia. A total of 31 patients with hepatic cirrhosis (n=19) or thalassemia (n=12) diagnosed with hypersplenism and thrombocytopenia (platelet count [PLT] <100×109/L) were included in this prospective cohort study between January 2015 and May 2017. Patients were treated with thalidomide (150–200 mg/d) plus conventional therapy. Spleen length, PLT, leukocyte count (WBC), absolute neutrophil count (ANC), and hemoglobin level (Hb) were measured at baseline, 3, 6, and 12 months. Any adverse events were noted. All of the 31 patients were showed a progressive increase PLT during the 12-month follow-up, and similar results were obtained when subgroup analyses were performed based on the primary disease (cirrhosis or thalassemia). WBC, ANC, and Hb also increased progressively during the 12-month follow-up. Spleen length decreased progressively during the follow-up. No serious adverse events occurred. Thalidomide is a potential treatment for thrombocytopenia caused by hypersplenism in patients with cirrhosis or thalassemia.
abstract_unstemmed	Hypersplenism and thrombocytopenia are common complications of liver cirrhosis or thalassemia, but current treatment strategies are limited. This study aimed to evaluate the efficacy and safety of thalidomide in the treatment of hypersplenism and thrombocytopenia in patients with liver cirrhosis or thalassemia. A total of 31 patients with hepatic cirrhosis (n=19) or thalassemia (n=12) diagnosed with hypersplenism and thrombocytopenia (platelet count [PLT] <100×109/L) were included in this prospective cohort study between January 2015 and May 2017. Patients were treated with thalidomide (150–200 mg/d) plus conventional therapy. Spleen length, PLT, leukocyte count (WBC), absolute neutrophil count (ANC), and hemoglobin level (Hb) were measured at baseline, 3, 6, and 12 months. Any adverse events were noted. All of the 31 patients were showed a progressive increase PLT during the 12-month follow-up, and similar results were obtained when subgroup analyses were performed based on the primary disease (cirrhosis or thalassemia). WBC, ANC, and Hb also increased progressively during the 12-month follow-up. Spleen length decreased progressively during the follow-up. No serious adverse events occurred. Thalidomide is a potential treatment for thrombocytopenia caused by hypersplenism in patients with cirrhosis or thalassemia.
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title_short	Thalidomide for the Treatment of Thrombocytopenia and Hypersplenism in Patients With Cirrhosis or Thalassemia
url	https://doi.org/10.3389/fphar.2020.01137 https://doaj.org/article/494262d15c8c4e4ab313d6cdf731f9a3 https://www.frontiersin.org/article/10.3389/fphar.2020.01137/full https://doaj.org/toc/1663-9812
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author2	Ning Cai Yongrong Lai Weiwei Xu Jinyan Li Lan Huang Ying Huang Meiling Hu Huangju Yang Jiangming Chen
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up_date	2024-07-04T01:36:06.975Z
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This study aimed to evaluate the efficacy and safety of thalidomide in the treatment of hypersplenism and thrombocytopenia in patients with liver cirrhosis or thalassemia. A total of 31 patients with hepatic cirrhosis (n=19) or thalassemia (n=12) diagnosed with hypersplenism and thrombocytopenia (platelet count [PLT] &lt;100×109/L) were included in this prospective cohort study between January 2015 and May 2017. Patients were treated with thalidomide (150–200 mg/d) plus conventional therapy. Spleen length, PLT, leukocyte count (WBC), absolute neutrophil count (ANC), and hemoglobin level (Hb) were measured at baseline, 3, 6, and 12 months. Any adverse events were noted. All of the 31 patients were showed a progressive increase PLT during the 12-month follow-up, and similar results were obtained when subgroup analyses were performed based on the primary disease (cirrhosis or thalassemia). WBC, ANC, and Hb also increased progressively during the 12-month follow-up. Spleen length decreased progressively during the follow-up. No serious adverse events occurred. Thalidomide is a potential treatment for thrombocytopenia caused by hypersplenism in patients with cirrhosis or thalassemia.</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a">thalidomide</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a">thrombocytopenia</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a">hypersplenism</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a">thalassemia</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a">liver cirrhosis</subfield></datafield><datafield tag="653" ind1=" " ind2="0"><subfield code="a">Therapeutics. 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Thalidomide for the Treatment of Thrombocytopenia and Hypersplenism in Patients With Cirrhosis or Thalassemia

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