Cholecystokinin-8 treatment reduces acinar necrosis and edema of pigs with induced pancreatitis
Summary: Background: Acute pancreatitis is an inflammatory process of the pancreas and a leading cause of hospitalization amongst gastrointestinal disorders. Previously, cholecystokinin (CCK) has been described to play a role in regeneration of pancreas. The aim of this study was to analyse the fun...
Ausführliche Beschreibung
Autor*in: |
Katharina Grupp [verfasserIn] Sarah Bonk [verfasserIn] Annika Poppe [verfasserIn] Karin Wodack [verfasserIn] Matthias Reeh [verfasserIn] Andreas Gocht [verfasserIn] Oliver Mann [verfasserIn] Jakob R. Izbicki [verfasserIn] Kai Bachmann [verfasserIn] |
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Format: |
E-Artikel |
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Sprache: |
Englisch |
Erschienen: |
2020 |
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Übergeordnetes Werk: |
In: Asian Journal of Surgery - Elsevier, 2017, 43(2020), 1, Seite 272-277 |
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Übergeordnetes Werk: |
volume:43 ; year:2020 ; number:1 ; pages:272-277 |
Links: |
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DOI / URN: |
10.1016/j.asjsur.2019.05.002 |
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Katalog-ID: |
DOAJ04514222X |
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10.1016/j.asjsur.2019.05.002 doi (DE-627)DOAJ04514222X (DE-599)DOAJd91bd5c39abb4e00b84aa46647016687 DE-627 ger DE-627 rakwb eng RD1-811 Katharina Grupp verfasserin aut Cholecystokinin-8 treatment reduces acinar necrosis and edema of pigs with induced pancreatitis 2020 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Summary: Background: Acute pancreatitis is an inflammatory process of the pancreas and a leading cause of hospitalization amongst gastrointestinal disorders. Previously, cholecystokinin (CCK) has been described to play a role in regeneration of pancreas. The aim of this study was to analyse the function of cholecystokinin octapeptide (CCK-8) during induced pancreatitis in an animal model. Methods: Overall acute pancreatitis was induced in 38 pigs. After the induction of acute pancreatitis, half of the animals were treated with CCK-8. Intraoperative clinical data, postoperative blood parameters, ‘Porcine Well-being’ (PWB) and fitness score and post-mortal histopathological data were analysed. Results: At baseline, physiologically parameters of the pigs of both groups were comparable. No differences were observed regarding the overall survival of animals (p = 0.97). Postoperative PWB score were significantly enhanced in animals treated with CCK-8 as compared to the control group (p = 0.029). Moreover, histopathological analysis of the pancreatic tissue revealed that acinar necrosis and edema were significant reduced in the CCK-8 group in comparison to the control group (p = 0.016 and p = 0.019). Conclusions: In conclusion, we found that CCK-8 treatment reduces acinar necrosis and edema of pancreatic tissue after induction of an acute pancreatitis in pigs. Keywords: Acute pancreatitis, Experimental model, Cholecystokinin-8, CCK-8 Surgery Sarah Bonk verfasserin aut Annika Poppe verfasserin aut Karin Wodack verfasserin aut Matthias Reeh verfasserin aut Andreas Gocht verfasserin aut Oliver Mann verfasserin aut Jakob R. Izbicki verfasserin aut Kai Bachmann verfasserin aut In Asian Journal of Surgery Elsevier, 2017 43(2020), 1, Seite 272-277 (DE-627)324827164 (DE-600)2031317-2 10159584 nnns volume:43 year:2020 number:1 pages:272-277 https://doi.org/10.1016/j.asjsur.2019.05.002 kostenfrei https://doaj.org/article/d91bd5c39abb4e00b84aa46647016687 kostenfrei http://www.sciencedirect.com/science/article/pii/S1015958419300132 kostenfrei https://doaj.org/toc/1015-9584 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ SSG-OLC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 43 2020 1 272-277 |
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10.1016/j.asjsur.2019.05.002 doi (DE-627)DOAJ04514222X (DE-599)DOAJd91bd5c39abb4e00b84aa46647016687 DE-627 ger DE-627 rakwb eng RD1-811 Katharina Grupp verfasserin aut Cholecystokinin-8 treatment reduces acinar necrosis and edema of pigs with induced pancreatitis 2020 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Summary: Background: Acute pancreatitis is an inflammatory process of the pancreas and a leading cause of hospitalization amongst gastrointestinal disorders. Previously, cholecystokinin (CCK) has been described to play a role in regeneration of pancreas. The aim of this study was to analyse the function of cholecystokinin octapeptide (CCK-8) during induced pancreatitis in an animal model. Methods: Overall acute pancreatitis was induced in 38 pigs. After the induction of acute pancreatitis, half of the animals were treated with CCK-8. Intraoperative clinical data, postoperative blood parameters, ‘Porcine Well-being’ (PWB) and fitness score and post-mortal histopathological data were analysed. Results: At baseline, physiologically parameters of the pigs of both groups were comparable. No differences were observed regarding the overall survival of animals (p = 0.97). Postoperative PWB score were significantly enhanced in animals treated with CCK-8 as compared to the control group (p = 0.029). Moreover, histopathological analysis of the pancreatic tissue revealed that acinar necrosis and edema were significant reduced in the CCK-8 group in comparison to the control group (p = 0.016 and p = 0.019). Conclusions: In conclusion, we found that CCK-8 treatment reduces acinar necrosis and edema of pancreatic tissue after induction of an acute pancreatitis in pigs. Keywords: Acute pancreatitis, Experimental model, Cholecystokinin-8, CCK-8 Surgery Sarah Bonk verfasserin aut Annika Poppe verfasserin aut Karin Wodack verfasserin aut Matthias Reeh verfasserin aut Andreas Gocht verfasserin aut Oliver Mann verfasserin aut Jakob R. Izbicki verfasserin aut Kai Bachmann verfasserin aut In Asian Journal of Surgery Elsevier, 2017 43(2020), 1, Seite 272-277 (DE-627)324827164 (DE-600)2031317-2 10159584 nnns volume:43 year:2020 number:1 pages:272-277 https://doi.org/10.1016/j.asjsur.2019.05.002 kostenfrei https://doaj.org/article/d91bd5c39abb4e00b84aa46647016687 kostenfrei http://www.sciencedirect.com/science/article/pii/S1015958419300132 kostenfrei https://doaj.org/toc/1015-9584 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ SSG-OLC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 43 2020 1 272-277 |
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10.1016/j.asjsur.2019.05.002 doi (DE-627)DOAJ04514222X (DE-599)DOAJd91bd5c39abb4e00b84aa46647016687 DE-627 ger DE-627 rakwb eng RD1-811 Katharina Grupp verfasserin aut Cholecystokinin-8 treatment reduces acinar necrosis and edema of pigs with induced pancreatitis 2020 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Summary: Background: Acute pancreatitis is an inflammatory process of the pancreas and a leading cause of hospitalization amongst gastrointestinal disorders. Previously, cholecystokinin (CCK) has been described to play a role in regeneration of pancreas. The aim of this study was to analyse the function of cholecystokinin octapeptide (CCK-8) during induced pancreatitis in an animal model. Methods: Overall acute pancreatitis was induced in 38 pigs. After the induction of acute pancreatitis, half of the animals were treated with CCK-8. Intraoperative clinical data, postoperative blood parameters, ‘Porcine Well-being’ (PWB) and fitness score and post-mortal histopathological data were analysed. Results: At baseline, physiologically parameters of the pigs of both groups were comparable. No differences were observed regarding the overall survival of animals (p = 0.97). Postoperative PWB score were significantly enhanced in animals treated with CCK-8 as compared to the control group (p = 0.029). Moreover, histopathological analysis of the pancreatic tissue revealed that acinar necrosis and edema were significant reduced in the CCK-8 group in comparison to the control group (p = 0.016 and p = 0.019). Conclusions: In conclusion, we found that CCK-8 treatment reduces acinar necrosis and edema of pancreatic tissue after induction of an acute pancreatitis in pigs. Keywords: Acute pancreatitis, Experimental model, Cholecystokinin-8, CCK-8 Surgery Sarah Bonk verfasserin aut Annika Poppe verfasserin aut Karin Wodack verfasserin aut Matthias Reeh verfasserin aut Andreas Gocht verfasserin aut Oliver Mann verfasserin aut Jakob R. Izbicki verfasserin aut Kai Bachmann verfasserin aut In Asian Journal of Surgery Elsevier, 2017 43(2020), 1, Seite 272-277 (DE-627)324827164 (DE-600)2031317-2 10159584 nnns volume:43 year:2020 number:1 pages:272-277 https://doi.org/10.1016/j.asjsur.2019.05.002 kostenfrei https://doaj.org/article/d91bd5c39abb4e00b84aa46647016687 kostenfrei http://www.sciencedirect.com/science/article/pii/S1015958419300132 kostenfrei https://doaj.org/toc/1015-9584 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ SSG-OLC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 43 2020 1 272-277 |
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10.1016/j.asjsur.2019.05.002 doi (DE-627)DOAJ04514222X (DE-599)DOAJd91bd5c39abb4e00b84aa46647016687 DE-627 ger DE-627 rakwb eng RD1-811 Katharina Grupp verfasserin aut Cholecystokinin-8 treatment reduces acinar necrosis and edema of pigs with induced pancreatitis 2020 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Summary: Background: Acute pancreatitis is an inflammatory process of the pancreas and a leading cause of hospitalization amongst gastrointestinal disorders. Previously, cholecystokinin (CCK) has been described to play a role in regeneration of pancreas. The aim of this study was to analyse the function of cholecystokinin octapeptide (CCK-8) during induced pancreatitis in an animal model. Methods: Overall acute pancreatitis was induced in 38 pigs. After the induction of acute pancreatitis, half of the animals were treated with CCK-8. Intraoperative clinical data, postoperative blood parameters, ‘Porcine Well-being’ (PWB) and fitness score and post-mortal histopathological data were analysed. Results: At baseline, physiologically parameters of the pigs of both groups were comparable. No differences were observed regarding the overall survival of animals (p = 0.97). Postoperative PWB score were significantly enhanced in animals treated with CCK-8 as compared to the control group (p = 0.029). Moreover, histopathological analysis of the pancreatic tissue revealed that acinar necrosis and edema were significant reduced in the CCK-8 group in comparison to the control group (p = 0.016 and p = 0.019). Conclusions: In conclusion, we found that CCK-8 treatment reduces acinar necrosis and edema of pancreatic tissue after induction of an acute pancreatitis in pigs. Keywords: Acute pancreatitis, Experimental model, Cholecystokinin-8, CCK-8 Surgery Sarah Bonk verfasserin aut Annika Poppe verfasserin aut Karin Wodack verfasserin aut Matthias Reeh verfasserin aut Andreas Gocht verfasserin aut Oliver Mann verfasserin aut Jakob R. Izbicki verfasserin aut Kai Bachmann verfasserin aut In Asian Journal of Surgery Elsevier, 2017 43(2020), 1, Seite 272-277 (DE-627)324827164 (DE-600)2031317-2 10159584 nnns volume:43 year:2020 number:1 pages:272-277 https://doi.org/10.1016/j.asjsur.2019.05.002 kostenfrei https://doaj.org/article/d91bd5c39abb4e00b84aa46647016687 kostenfrei http://www.sciencedirect.com/science/article/pii/S1015958419300132 kostenfrei https://doaj.org/toc/1015-9584 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ SSG-OLC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 43 2020 1 272-277 |
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10.1016/j.asjsur.2019.05.002 doi (DE-627)DOAJ04514222X (DE-599)DOAJd91bd5c39abb4e00b84aa46647016687 DE-627 ger DE-627 rakwb eng RD1-811 Katharina Grupp verfasserin aut Cholecystokinin-8 treatment reduces acinar necrosis and edema of pigs with induced pancreatitis 2020 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Summary: Background: Acute pancreatitis is an inflammatory process of the pancreas and a leading cause of hospitalization amongst gastrointestinal disorders. Previously, cholecystokinin (CCK) has been described to play a role in regeneration of pancreas. The aim of this study was to analyse the function of cholecystokinin octapeptide (CCK-8) during induced pancreatitis in an animal model. Methods: Overall acute pancreatitis was induced in 38 pigs. After the induction of acute pancreatitis, half of the animals were treated with CCK-8. Intraoperative clinical data, postoperative blood parameters, ‘Porcine Well-being’ (PWB) and fitness score and post-mortal histopathological data were analysed. Results: At baseline, physiologically parameters of the pigs of both groups were comparable. No differences were observed regarding the overall survival of animals (p = 0.97). Postoperative PWB score were significantly enhanced in animals treated with CCK-8 as compared to the control group (p = 0.029). Moreover, histopathological analysis of the pancreatic tissue revealed that acinar necrosis and edema were significant reduced in the CCK-8 group in comparison to the control group (p = 0.016 and p = 0.019). Conclusions: In conclusion, we found that CCK-8 treatment reduces acinar necrosis and edema of pancreatic tissue after induction of an acute pancreatitis in pigs. Keywords: Acute pancreatitis, Experimental model, Cholecystokinin-8, CCK-8 Surgery Sarah Bonk verfasserin aut Annika Poppe verfasserin aut Karin Wodack verfasserin aut Matthias Reeh verfasserin aut Andreas Gocht verfasserin aut Oliver Mann verfasserin aut Jakob R. Izbicki verfasserin aut Kai Bachmann verfasserin aut In Asian Journal of Surgery Elsevier, 2017 43(2020), 1, Seite 272-277 (DE-627)324827164 (DE-600)2031317-2 10159584 nnns volume:43 year:2020 number:1 pages:272-277 https://doi.org/10.1016/j.asjsur.2019.05.002 kostenfrei https://doaj.org/article/d91bd5c39abb4e00b84aa46647016687 kostenfrei http://www.sciencedirect.com/science/article/pii/S1015958419300132 kostenfrei https://doaj.org/toc/1015-9584 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ SSG-OLC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 43 2020 1 272-277 |
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Cholecystokinin-8 treatment reduces acinar necrosis and edema of pigs with induced pancreatitis |
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Summary: Background: Acute pancreatitis is an inflammatory process of the pancreas and a leading cause of hospitalization amongst gastrointestinal disorders. Previously, cholecystokinin (CCK) has been described to play a role in regeneration of pancreas. The aim of this study was to analyse the function of cholecystokinin octapeptide (CCK-8) during induced pancreatitis in an animal model. Methods: Overall acute pancreatitis was induced in 38 pigs. After the induction of acute pancreatitis, half of the animals were treated with CCK-8. Intraoperative clinical data, postoperative blood parameters, ‘Porcine Well-being’ (PWB) and fitness score and post-mortal histopathological data were analysed. Results: At baseline, physiologically parameters of the pigs of both groups were comparable. No differences were observed regarding the overall survival of animals (p = 0.97). Postoperative PWB score were significantly enhanced in animals treated with CCK-8 as compared to the control group (p = 0.029). Moreover, histopathological analysis of the pancreatic tissue revealed that acinar necrosis and edema were significant reduced in the CCK-8 group in comparison to the control group (p = 0.016 and p = 0.019). Conclusions: In conclusion, we found that CCK-8 treatment reduces acinar necrosis and edema of pancreatic tissue after induction of an acute pancreatitis in pigs. Keywords: Acute pancreatitis, Experimental model, Cholecystokinin-8, CCK-8 |
abstractGer |
Summary: Background: Acute pancreatitis is an inflammatory process of the pancreas and a leading cause of hospitalization amongst gastrointestinal disorders. Previously, cholecystokinin (CCK) has been described to play a role in regeneration of pancreas. The aim of this study was to analyse the function of cholecystokinin octapeptide (CCK-8) during induced pancreatitis in an animal model. Methods: Overall acute pancreatitis was induced in 38 pigs. After the induction of acute pancreatitis, half of the animals were treated with CCK-8. Intraoperative clinical data, postoperative blood parameters, ‘Porcine Well-being’ (PWB) and fitness score and post-mortal histopathological data were analysed. Results: At baseline, physiologically parameters of the pigs of both groups were comparable. No differences were observed regarding the overall survival of animals (p = 0.97). Postoperative PWB score were significantly enhanced in animals treated with CCK-8 as compared to the control group (p = 0.029). Moreover, histopathological analysis of the pancreatic tissue revealed that acinar necrosis and edema were significant reduced in the CCK-8 group in comparison to the control group (p = 0.016 and p = 0.019). Conclusions: In conclusion, we found that CCK-8 treatment reduces acinar necrosis and edema of pancreatic tissue after induction of an acute pancreatitis in pigs. Keywords: Acute pancreatitis, Experimental model, Cholecystokinin-8, CCK-8 |
abstract_unstemmed |
Summary: Background: Acute pancreatitis is an inflammatory process of the pancreas and a leading cause of hospitalization amongst gastrointestinal disorders. Previously, cholecystokinin (CCK) has been described to play a role in regeneration of pancreas. The aim of this study was to analyse the function of cholecystokinin octapeptide (CCK-8) during induced pancreatitis in an animal model. Methods: Overall acute pancreatitis was induced in 38 pigs. After the induction of acute pancreatitis, half of the animals were treated with CCK-8. Intraoperative clinical data, postoperative blood parameters, ‘Porcine Well-being’ (PWB) and fitness score and post-mortal histopathological data were analysed. Results: At baseline, physiologically parameters of the pigs of both groups were comparable. No differences were observed regarding the overall survival of animals (p = 0.97). Postoperative PWB score were significantly enhanced in animals treated with CCK-8 as compared to the control group (p = 0.029). Moreover, histopathological analysis of the pancreatic tissue revealed that acinar necrosis and edema were significant reduced in the CCK-8 group in comparison to the control group (p = 0.016 and p = 0.019). Conclusions: In conclusion, we found that CCK-8 treatment reduces acinar necrosis and edema of pancreatic tissue after induction of an acute pancreatitis in pigs. Keywords: Acute pancreatitis, Experimental model, Cholecystokinin-8, CCK-8 |
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Moreover, histopathological analysis of the pancreatic tissue revealed that acinar necrosis and edema were significant reduced in the CCK-8 group in comparison to the control group (p = 0.016 and p = 0.019). Conclusions: In conclusion, we found that CCK-8 treatment reduces acinar necrosis and edema of pancreatic tissue after induction of an acute pancreatitis in pigs. 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