Cholecystokinin-8 treatment reduces acinar necrosis and edema of pigs with induced pancreatitis

Summary: Background: Acute pancreatitis is an inflammatory process of the pancreas and a leading cause of hospitalization amongst gastrointestinal disorders. Previously, cholecystokinin (CCK) has been described to play a role in regeneration of pancreas. The aim of this study was to analyse the fun...
Ausführliche Beschreibung

Gespeichert in:

Autor*in:	Katharina Grupp [verfasserIn] Sarah Bonk [verfasserIn] Annika Poppe [verfasserIn] Karin Wodack [verfasserIn] Matthias Reeh [verfasserIn] Andreas Gocht [verfasserIn] Oliver Mann [verfasserIn] Jakob R. Izbicki [verfasserIn] Kai Bachmann [verfasserIn]

Format:	E-Artikel
Sprache:	Englisch

Erschienen:	2020

Übergeordnetes Werk:	In: Asian Journal of Surgery - Elsevier, 2017, 43(2020), 1, Seite 272-277
Übergeordnetes Werk:	volume:43 ; year:2020 ; number:1 ; pages:272-277

Links:	Link aufrufen Link aufrufen Link aufrufen Journal toc

DOI / URN:	10.1016/j.asjsur.2019.05.002

Katalog-ID:	DOAJ04514222X

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allfields	10.1016/j.asjsur.2019.05.002 doi (DE-627)DOAJ04514222X (DE-599)DOAJd91bd5c39abb4e00b84aa46647016687 DE-627 ger DE-627 rakwb eng RD1-811 Katharina Grupp verfasserin aut Cholecystokinin-8 treatment reduces acinar necrosis and edema of pigs with induced pancreatitis 2020 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Summary: Background: Acute pancreatitis is an inflammatory process of the pancreas and a leading cause of hospitalization amongst gastrointestinal disorders. Previously, cholecystokinin (CCK) has been described to play a role in regeneration of pancreas. The aim of this study was to analyse the function of cholecystokinin octapeptide (CCK-8) during induced pancreatitis in an animal model. Methods: Overall acute pancreatitis was induced in 38 pigs. After the induction of acute pancreatitis, half of the animals were treated with CCK-8. Intraoperative clinical data, postoperative blood parameters, ‘Porcine Well-being’ (PWB) and fitness score and post-mortal histopathological data were analysed. Results: At baseline, physiologically parameters of the pigs of both groups were comparable. No differences were observed regarding the overall survival of animals (p = 0.97). Postoperative PWB score were significantly enhanced in animals treated with CCK-8 as compared to the control group (p = 0.029). Moreover, histopathological analysis of the pancreatic tissue revealed that acinar necrosis and edema were significant reduced in the CCK-8 group in comparison to the control group (p = 0.016 and p = 0.019). Conclusions: In conclusion, we found that CCK-8 treatment reduces acinar necrosis and edema of pancreatic tissue after induction of an acute pancreatitis in pigs. Keywords: Acute pancreatitis, Experimental model, Cholecystokinin-8, CCK-8 Surgery Sarah Bonk verfasserin aut Annika Poppe verfasserin aut Karin Wodack verfasserin aut Matthias Reeh verfasserin aut Andreas Gocht verfasserin aut Oliver Mann verfasserin aut Jakob R. Izbicki verfasserin aut Kai Bachmann verfasserin aut In Asian Journal of Surgery Elsevier, 2017 43(2020), 1, Seite 272-277 (DE-627)324827164 (DE-600)2031317-2 10159584 nnns volume:43 year:2020 number:1 pages:272-277 https://doi.org/10.1016/j.asjsur.2019.05.002 kostenfrei https://doaj.org/article/d91bd5c39abb4e00b84aa46647016687 kostenfrei http://www.sciencedirect.com/science/article/pii/S1015958419300132 kostenfrei https://doaj.org/toc/1015-9584 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ SSG-OLC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 43 2020 1 272-277
spelling	10.1016/j.asjsur.2019.05.002 doi (DE-627)DOAJ04514222X (DE-599)DOAJd91bd5c39abb4e00b84aa46647016687 DE-627 ger DE-627 rakwb eng RD1-811 Katharina Grupp verfasserin aut Cholecystokinin-8 treatment reduces acinar necrosis and edema of pigs with induced pancreatitis 2020 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Summary: Background: Acute pancreatitis is an inflammatory process of the pancreas and a leading cause of hospitalization amongst gastrointestinal disorders. Previously, cholecystokinin (CCK) has been described to play a role in regeneration of pancreas. The aim of this study was to analyse the function of cholecystokinin octapeptide (CCK-8) during induced pancreatitis in an animal model. Methods: Overall acute pancreatitis was induced in 38 pigs. After the induction of acute pancreatitis, half of the animals were treated with CCK-8. Intraoperative clinical data, postoperative blood parameters, ‘Porcine Well-being’ (PWB) and fitness score and post-mortal histopathological data were analysed. Results: At baseline, physiologically parameters of the pigs of both groups were comparable. No differences were observed regarding the overall survival of animals (p = 0.97). Postoperative PWB score were significantly enhanced in animals treated with CCK-8 as compared to the control group (p = 0.029). Moreover, histopathological analysis of the pancreatic tissue revealed that acinar necrosis and edema were significant reduced in the CCK-8 group in comparison to the control group (p = 0.016 and p = 0.019). Conclusions: In conclusion, we found that CCK-8 treatment reduces acinar necrosis and edema of pancreatic tissue after induction of an acute pancreatitis in pigs. Keywords: Acute pancreatitis, Experimental model, Cholecystokinin-8, CCK-8 Surgery Sarah Bonk verfasserin aut Annika Poppe verfasserin aut Karin Wodack verfasserin aut Matthias Reeh verfasserin aut Andreas Gocht verfasserin aut Oliver Mann verfasserin aut Jakob R. Izbicki verfasserin aut Kai Bachmann verfasserin aut In Asian Journal of Surgery Elsevier, 2017 43(2020), 1, Seite 272-277 (DE-627)324827164 (DE-600)2031317-2 10159584 nnns volume:43 year:2020 number:1 pages:272-277 https://doi.org/10.1016/j.asjsur.2019.05.002 kostenfrei https://doaj.org/article/d91bd5c39abb4e00b84aa46647016687 kostenfrei http://www.sciencedirect.com/science/article/pii/S1015958419300132 kostenfrei https://doaj.org/toc/1015-9584 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ SSG-OLC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 43 2020 1 272-277
allfields_unstemmed	10.1016/j.asjsur.2019.05.002 doi (DE-627)DOAJ04514222X (DE-599)DOAJd91bd5c39abb4e00b84aa46647016687 DE-627 ger DE-627 rakwb eng RD1-811 Katharina Grupp verfasserin aut Cholecystokinin-8 treatment reduces acinar necrosis and edema of pigs with induced pancreatitis 2020 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Summary: Background: Acute pancreatitis is an inflammatory process of the pancreas and a leading cause of hospitalization amongst gastrointestinal disorders. Previously, cholecystokinin (CCK) has been described to play a role in regeneration of pancreas. The aim of this study was to analyse the function of cholecystokinin octapeptide (CCK-8) during induced pancreatitis in an animal model. Methods: Overall acute pancreatitis was induced in 38 pigs. After the induction of acute pancreatitis, half of the animals were treated with CCK-8. Intraoperative clinical data, postoperative blood parameters, ‘Porcine Well-being’ (PWB) and fitness score and post-mortal histopathological data were analysed. Results: At baseline, physiologically parameters of the pigs of both groups were comparable. No differences were observed regarding the overall survival of animals (p = 0.97). Postoperative PWB score were significantly enhanced in animals treated with CCK-8 as compared to the control group (p = 0.029). Moreover, histopathological analysis of the pancreatic tissue revealed that acinar necrosis and edema were significant reduced in the CCK-8 group in comparison to the control group (p = 0.016 and p = 0.019). Conclusions: In conclusion, we found that CCK-8 treatment reduces acinar necrosis and edema of pancreatic tissue after induction of an acute pancreatitis in pigs. Keywords: Acute pancreatitis, Experimental model, Cholecystokinin-8, CCK-8 Surgery Sarah Bonk verfasserin aut Annika Poppe verfasserin aut Karin Wodack verfasserin aut Matthias Reeh verfasserin aut Andreas Gocht verfasserin aut Oliver Mann verfasserin aut Jakob R. Izbicki verfasserin aut Kai Bachmann verfasserin aut In Asian Journal of Surgery Elsevier, 2017 43(2020), 1, Seite 272-277 (DE-627)324827164 (DE-600)2031317-2 10159584 nnns volume:43 year:2020 number:1 pages:272-277 https://doi.org/10.1016/j.asjsur.2019.05.002 kostenfrei https://doaj.org/article/d91bd5c39abb4e00b84aa46647016687 kostenfrei http://www.sciencedirect.com/science/article/pii/S1015958419300132 kostenfrei https://doaj.org/toc/1015-9584 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ SSG-OLC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 43 2020 1 272-277
allfieldsGer	10.1016/j.asjsur.2019.05.002 doi (DE-627)DOAJ04514222X (DE-599)DOAJd91bd5c39abb4e00b84aa46647016687 DE-627 ger DE-627 rakwb eng RD1-811 Katharina Grupp verfasserin aut Cholecystokinin-8 treatment reduces acinar necrosis and edema of pigs with induced pancreatitis 2020 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Summary: Background: Acute pancreatitis is an inflammatory process of the pancreas and a leading cause of hospitalization amongst gastrointestinal disorders. Previously, cholecystokinin (CCK) has been described to play a role in regeneration of pancreas. The aim of this study was to analyse the function of cholecystokinin octapeptide (CCK-8) during induced pancreatitis in an animal model. Methods: Overall acute pancreatitis was induced in 38 pigs. After the induction of acute pancreatitis, half of the animals were treated with CCK-8. Intraoperative clinical data, postoperative blood parameters, ‘Porcine Well-being’ (PWB) and fitness score and post-mortal histopathological data were analysed. Results: At baseline, physiologically parameters of the pigs of both groups were comparable. No differences were observed regarding the overall survival of animals (p = 0.97). Postoperative PWB score were significantly enhanced in animals treated with CCK-8 as compared to the control group (p = 0.029). Moreover, histopathological analysis of the pancreatic tissue revealed that acinar necrosis and edema were significant reduced in the CCK-8 group in comparison to the control group (p = 0.016 and p = 0.019). Conclusions: In conclusion, we found that CCK-8 treatment reduces acinar necrosis and edema of pancreatic tissue after induction of an acute pancreatitis in pigs. Keywords: Acute pancreatitis, Experimental model, Cholecystokinin-8, CCK-8 Surgery Sarah Bonk verfasserin aut Annika Poppe verfasserin aut Karin Wodack verfasserin aut Matthias Reeh verfasserin aut Andreas Gocht verfasserin aut Oliver Mann verfasserin aut Jakob R. Izbicki verfasserin aut Kai Bachmann verfasserin aut In Asian Journal of Surgery Elsevier, 2017 43(2020), 1, Seite 272-277 (DE-627)324827164 (DE-600)2031317-2 10159584 nnns volume:43 year:2020 number:1 pages:272-277 https://doi.org/10.1016/j.asjsur.2019.05.002 kostenfrei https://doaj.org/article/d91bd5c39abb4e00b84aa46647016687 kostenfrei http://www.sciencedirect.com/science/article/pii/S1015958419300132 kostenfrei https://doaj.org/toc/1015-9584 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ SSG-OLC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 43 2020 1 272-277
allfieldsSound	10.1016/j.asjsur.2019.05.002 doi (DE-627)DOAJ04514222X (DE-599)DOAJd91bd5c39abb4e00b84aa46647016687 DE-627 ger DE-627 rakwb eng RD1-811 Katharina Grupp verfasserin aut Cholecystokinin-8 treatment reduces acinar necrosis and edema of pigs with induced pancreatitis 2020 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Summary: Background: Acute pancreatitis is an inflammatory process of the pancreas and a leading cause of hospitalization amongst gastrointestinal disorders. Previously, cholecystokinin (CCK) has been described to play a role in regeneration of pancreas. The aim of this study was to analyse the function of cholecystokinin octapeptide (CCK-8) during induced pancreatitis in an animal model. Methods: Overall acute pancreatitis was induced in 38 pigs. After the induction of acute pancreatitis, half of the animals were treated with CCK-8. Intraoperative clinical data, postoperative blood parameters, ‘Porcine Well-being’ (PWB) and fitness score and post-mortal histopathological data were analysed. Results: At baseline, physiologically parameters of the pigs of both groups were comparable. No differences were observed regarding the overall survival of animals (p = 0.97). Postoperative PWB score were significantly enhanced in animals treated with CCK-8 as compared to the control group (p = 0.029). Moreover, histopathological analysis of the pancreatic tissue revealed that acinar necrosis and edema were significant reduced in the CCK-8 group in comparison to the control group (p = 0.016 and p = 0.019). Conclusions: In conclusion, we found that CCK-8 treatment reduces acinar necrosis and edema of pancreatic tissue after induction of an acute pancreatitis in pigs. Keywords: Acute pancreatitis, Experimental model, Cholecystokinin-8, CCK-8 Surgery Sarah Bonk verfasserin aut Annika Poppe verfasserin aut Karin Wodack verfasserin aut Matthias Reeh verfasserin aut Andreas Gocht verfasserin aut Oliver Mann verfasserin aut Jakob R. Izbicki verfasserin aut Kai Bachmann verfasserin aut In Asian Journal of Surgery Elsevier, 2017 43(2020), 1, Seite 272-277 (DE-627)324827164 (DE-600)2031317-2 10159584 nnns volume:43 year:2020 number:1 pages:272-277 https://doi.org/10.1016/j.asjsur.2019.05.002 kostenfrei https://doaj.org/article/d91bd5c39abb4e00b84aa46647016687 kostenfrei http://www.sciencedirect.com/science/article/pii/S1015958419300132 kostenfrei https://doaj.org/toc/1015-9584 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ SSG-OLC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 43 2020 1 272-277
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authorswithroles_txt_mv	Katharina Grupp @@aut@@ Sarah Bonk @@aut@@ Annika Poppe @@aut@@ Karin Wodack @@aut@@ Matthias Reeh @@aut@@ Andreas Gocht @@aut@@ Oliver Mann @@aut@@ Jakob R. Izbicki @@aut@@ Kai Bachmann @@aut@@
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Previously, cholecystokinin (CCK) has been described to play a role in regeneration of pancreas. The aim of this study was to analyse the function of cholecystokinin octapeptide (CCK-8) during induced pancreatitis in an animal model. Methods: Overall acute pancreatitis was induced in 38 pigs. After the induction of acute pancreatitis, half of the animals were treated with CCK-8. Intraoperative clinical data, postoperative blood parameters, ‘Porcine Well-being’ (PWB) and fitness score and post-mortal histopathological data were analysed. Results: At baseline, physiologically parameters of the pigs of both groups were comparable. No differences were observed regarding the overall survival of animals (p = 0.97). Postoperative PWB score were significantly enhanced in animals treated with CCK-8 as compared to the control group (p = 0.029). Moreover, histopathological analysis of the pancreatic tissue revealed that acinar necrosis and edema were significant reduced in the CCK-8 group in comparison to the control group (p = 0.016 and p = 0.019). Conclusions: In conclusion, we found that CCK-8 treatment reduces acinar necrosis and edema of pancreatic tissue after induction of an acute pancreatitis in pigs. 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callnumber-first	R - Medicine
author	Katharina Grupp
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topic_title	RD1-811 Cholecystokinin-8 treatment reduces acinar necrosis and edema of pigs with induced pancreatitis
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title	Cholecystokinin-8 treatment reduces acinar necrosis and edema of pigs with induced pancreatitis
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title_full	Cholecystokinin-8 treatment reduces acinar necrosis and edema of pigs with induced pancreatitis
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author_browse	Katharina Grupp Sarah Bonk Annika Poppe Karin Wodack Matthias Reeh Andreas Gocht Oliver Mann Jakob R. Izbicki Kai Bachmann
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author-letter	Katharina Grupp
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title_sort	cholecystokinin-8 treatment reduces acinar necrosis and edema of pigs with induced pancreatitis
callnumber	RD1-811
title_auth	Cholecystokinin-8 treatment reduces acinar necrosis and edema of pigs with induced pancreatitis
abstract	Summary: Background: Acute pancreatitis is an inflammatory process of the pancreas and a leading cause of hospitalization amongst gastrointestinal disorders. Previously, cholecystokinin (CCK) has been described to play a role in regeneration of pancreas. The aim of this study was to analyse the function of cholecystokinin octapeptide (CCK-8) during induced pancreatitis in an animal model. Methods: Overall acute pancreatitis was induced in 38 pigs. After the induction of acute pancreatitis, half of the animals were treated with CCK-8. Intraoperative clinical data, postoperative blood parameters, ‘Porcine Well-being’ (PWB) and fitness score and post-mortal histopathological data were analysed. Results: At baseline, physiologically parameters of the pigs of both groups were comparable. No differences were observed regarding the overall survival of animals (p = 0.97). Postoperative PWB score were significantly enhanced in animals treated with CCK-8 as compared to the control group (p = 0.029). Moreover, histopathological analysis of the pancreatic tissue revealed that acinar necrosis and edema were significant reduced in the CCK-8 group in comparison to the control group (p = 0.016 and p = 0.019). Conclusions: In conclusion, we found that CCK-8 treatment reduces acinar necrosis and edema of pancreatic tissue after induction of an acute pancreatitis in pigs. Keywords: Acute pancreatitis, Experimental model, Cholecystokinin-8, CCK-8
abstractGer	Summary: Background: Acute pancreatitis is an inflammatory process of the pancreas and a leading cause of hospitalization amongst gastrointestinal disorders. Previously, cholecystokinin (CCK) has been described to play a role in regeneration of pancreas. The aim of this study was to analyse the function of cholecystokinin octapeptide (CCK-8) during induced pancreatitis in an animal model. Methods: Overall acute pancreatitis was induced in 38 pigs. After the induction of acute pancreatitis, half of the animals were treated with CCK-8. Intraoperative clinical data, postoperative blood parameters, ‘Porcine Well-being’ (PWB) and fitness score and post-mortal histopathological data were analysed. Results: At baseline, physiologically parameters of the pigs of both groups were comparable. No differences were observed regarding the overall survival of animals (p = 0.97). Postoperative PWB score were significantly enhanced in animals treated with CCK-8 as compared to the control group (p = 0.029). Moreover, histopathological analysis of the pancreatic tissue revealed that acinar necrosis and edema were significant reduced in the CCK-8 group in comparison to the control group (p = 0.016 and p = 0.019). Conclusions: In conclusion, we found that CCK-8 treatment reduces acinar necrosis and edema of pancreatic tissue after induction of an acute pancreatitis in pigs. Keywords: Acute pancreatitis, Experimental model, Cholecystokinin-8, CCK-8
abstract_unstemmed	Summary: Background: Acute pancreatitis is an inflammatory process of the pancreas and a leading cause of hospitalization amongst gastrointestinal disorders. Previously, cholecystokinin (CCK) has been described to play a role in regeneration of pancreas. The aim of this study was to analyse the function of cholecystokinin octapeptide (CCK-8) during induced pancreatitis in an animal model. Methods: Overall acute pancreatitis was induced in 38 pigs. After the induction of acute pancreatitis, half of the animals were treated with CCK-8. Intraoperative clinical data, postoperative blood parameters, ‘Porcine Well-being’ (PWB) and fitness score and post-mortal histopathological data were analysed. Results: At baseline, physiologically parameters of the pigs of both groups were comparable. No differences were observed regarding the overall survival of animals (p = 0.97). Postoperative PWB score were significantly enhanced in animals treated with CCK-8 as compared to the control group (p = 0.029). Moreover, histopathological analysis of the pancreatic tissue revealed that acinar necrosis and edema were significant reduced in the CCK-8 group in comparison to the control group (p = 0.016 and p = 0.019). Conclusions: In conclusion, we found that CCK-8 treatment reduces acinar necrosis and edema of pancreatic tissue after induction of an acute pancreatitis in pigs. Keywords: Acute pancreatitis, Experimental model, Cholecystokinin-8, CCK-8
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title_short	Cholecystokinin-8 treatment reduces acinar necrosis and edema of pigs with induced pancreatitis
url	https://doi.org/10.1016/j.asjsur.2019.05.002 https://doaj.org/article/d91bd5c39abb4e00b84aa46647016687 http://www.sciencedirect.com/science/article/pii/S1015958419300132 https://doaj.org/toc/1015-9584
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author2	Sarah Bonk Annika Poppe Karin Wodack Matthias Reeh Andreas Gocht Oliver Mann Jakob R. Izbicki Kai Bachmann
author2Str	Sarah Bonk Annika Poppe Karin Wodack Matthias Reeh Andreas Gocht Oliver Mann Jakob R. Izbicki Kai Bachmann
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doi_str	10.1016/j.asjsur.2019.05.002
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up_date	2024-07-04T01:49:17.670Z
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Izbicki</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Kai Bachmann</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="773" ind1="0" ind2="8"><subfield code="i">In</subfield><subfield code="t">Asian Journal of Surgery</subfield><subfield code="d">Elsevier, 2017</subfield><subfield code="g">43(2020), 1, Seite 272-277</subfield><subfield code="w">(DE-627)324827164</subfield><subfield code="w">(DE-600)2031317-2</subfield><subfield code="x">10159584</subfield><subfield code="7">nnns</subfield></datafield><datafield tag="773" ind1="1" ind2="8"><subfield code="g">volume:43</subfield><subfield code="g">year:2020</subfield><subfield code="g">number:1</subfield><subfield code="g">pages:272-277</subfield></datafield><datafield tag="856" ind1="4" ind2="0"><subfield 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Cholecystokinin-8 treatment reduces acinar necrosis and edema of pigs with induced pancreatitis

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