Molecular characterization and functional annotation of a hypothetical protein (SCO0618) of A3(2)
Streptomyces coelicolor is a gram-positive soil bacterium which is well known for the production of several antibiotics used in various biotechnological applications. But numerous proteins from its genome are considered hypothetical proteins. Therefore, the present study aimed to reveal the function...
Ausführliche Beschreibung
Autor*in: |
Nadim Ferdous [verfasserIn] Mahjerin Nasrin Reza [verfasserIn] Md. Tabassum Hossain Emon [verfasserIn] Md. Shariful Islam [verfasserIn] A. K. M. Mohiuddin [verfasserIn] Mohammad Uzzal Hossain [verfasserIn] |
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Format: |
E-Artikel |
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Sprache: |
Englisch |
Erschienen: |
2020 |
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Übergeordnetes Werk: |
In: Genomics & Informatics - Korea Genome Organization, 2017, 18(2020), 3, p e28 |
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Übergeordnetes Werk: |
volume:18 ; year:2020 ; number:3, p e28 |
Links: |
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DOI / URN: |
10.5808/GI.2020.18.3.e28 |
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Katalog-ID: |
DOAJ045262128 |
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520 | |a Streptomyces coelicolor is a gram-positive soil bacterium which is well known for the production of several antibiotics used in various biotechnological applications. But numerous proteins from its genome are considered hypothetical proteins. Therefore, the present study aimed to reveal the functions of a hypothetical protein from the genome of S. coelicolor. Several bioinformatics tools were employed to predict the structure and function of this protein. Sequence similarity was searched through the available bioinformatics databases to find out the homologous protein. The secondary and tertiary structure were predicted and further validated with quality assessment tools. Furthermore, the active site and the interacting proteins were also explored with the utilization of CASTp and STRING server. The hypothetical protein showed the important biological activity having with two functional domain including POD-like_MBL-fold and rhodanese homology domain. The functional annotation exposed that the selected hypothetical protein could show the hydrolase activity. Furthermore, protein-protein interactions of selected hypothetical protein revealed several functional partners those have the significant role for the bacterial survival. At last, the current study depicts that the annotated hypothetical protein is linked with hydrolase activity which might be of great interest to the further research in bacterial genetics. | ||
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10.5808/GI.2020.18.3.e28 doi (DE-627)DOAJ045262128 (DE-599)DOAJd2784abd36f1489e9054e0781a84a5bb DE-627 ger DE-627 rakwb eng QH426-470 Nadim Ferdous verfasserin aut Molecular characterization and functional annotation of a hypothetical protein (SCO0618) of A3(2) 2020 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Streptomyces coelicolor is a gram-positive soil bacterium which is well known for the production of several antibiotics used in various biotechnological applications. But numerous proteins from its genome are considered hypothetical proteins. Therefore, the present study aimed to reveal the functions of a hypothetical protein from the genome of S. coelicolor. Several bioinformatics tools were employed to predict the structure and function of this protein. Sequence similarity was searched through the available bioinformatics databases to find out the homologous protein. The secondary and tertiary structure were predicted and further validated with quality assessment tools. Furthermore, the active site and the interacting proteins were also explored with the utilization of CASTp and STRING server. The hypothetical protein showed the important biological activity having with two functional domain including POD-like_MBL-fold and rhodanese homology domain. The functional annotation exposed that the selected hypothetical protein could show the hydrolase activity. Furthermore, protein-protein interactions of selected hypothetical protein revealed several functional partners those have the significant role for the bacterial survival. At last, the current study depicts that the annotated hypothetical protein is linked with hydrolase activity which might be of great interest to the further research in bacterial genetics. genome hypothetical protein modeling hydrolases Genetics Mahjerin Nasrin Reza verfasserin aut Md. Tabassum Hossain Emon verfasserin aut Md. Shariful Islam verfasserin aut A. K. M. Mohiuddin verfasserin aut Mohammad Uzzal Hossain verfasserin aut In Genomics & Informatics Korea Genome Organization, 2017 18(2020), 3, p e28 (DE-627)812496515 (DE-600)2802682-2 22340742 nnns volume:18 year:2020 number:3, p e28 https://doi.org/10.5808/GI.2020.18.3.e28 kostenfrei https://doaj.org/article/d2784abd36f1489e9054e0781a84a5bb kostenfrei http://genominfo.org/upload/pdf/gi-2020-18-3-e28.pdf kostenfrei https://doaj.org/toc/2234-0742 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4335 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 18 2020 3, p e28 |
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10.5808/GI.2020.18.3.e28 doi (DE-627)DOAJ045262128 (DE-599)DOAJd2784abd36f1489e9054e0781a84a5bb DE-627 ger DE-627 rakwb eng QH426-470 Nadim Ferdous verfasserin aut Molecular characterization and functional annotation of a hypothetical protein (SCO0618) of A3(2) 2020 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Streptomyces coelicolor is a gram-positive soil bacterium which is well known for the production of several antibiotics used in various biotechnological applications. But numerous proteins from its genome are considered hypothetical proteins. Therefore, the present study aimed to reveal the functions of a hypothetical protein from the genome of S. coelicolor. Several bioinformatics tools were employed to predict the structure and function of this protein. Sequence similarity was searched through the available bioinformatics databases to find out the homologous protein. The secondary and tertiary structure were predicted and further validated with quality assessment tools. Furthermore, the active site and the interacting proteins were also explored with the utilization of CASTp and STRING server. The hypothetical protein showed the important biological activity having with two functional domain including POD-like_MBL-fold and rhodanese homology domain. The functional annotation exposed that the selected hypothetical protein could show the hydrolase activity. Furthermore, protein-protein interactions of selected hypothetical protein revealed several functional partners those have the significant role for the bacterial survival. At last, the current study depicts that the annotated hypothetical protein is linked with hydrolase activity which might be of great interest to the further research in bacterial genetics. genome hypothetical protein modeling hydrolases Genetics Mahjerin Nasrin Reza verfasserin aut Md. Tabassum Hossain Emon verfasserin aut Md. Shariful Islam verfasserin aut A. K. M. Mohiuddin verfasserin aut Mohammad Uzzal Hossain verfasserin aut In Genomics & Informatics Korea Genome Organization, 2017 18(2020), 3, p e28 (DE-627)812496515 (DE-600)2802682-2 22340742 nnns volume:18 year:2020 number:3, p e28 https://doi.org/10.5808/GI.2020.18.3.e28 kostenfrei https://doaj.org/article/d2784abd36f1489e9054e0781a84a5bb kostenfrei http://genominfo.org/upload/pdf/gi-2020-18-3-e28.pdf kostenfrei https://doaj.org/toc/2234-0742 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4335 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 18 2020 3, p e28 |
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10.5808/GI.2020.18.3.e28 doi (DE-627)DOAJ045262128 (DE-599)DOAJd2784abd36f1489e9054e0781a84a5bb DE-627 ger DE-627 rakwb eng QH426-470 Nadim Ferdous verfasserin aut Molecular characterization and functional annotation of a hypothetical protein (SCO0618) of A3(2) 2020 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Streptomyces coelicolor is a gram-positive soil bacterium which is well known for the production of several antibiotics used in various biotechnological applications. But numerous proteins from its genome are considered hypothetical proteins. Therefore, the present study aimed to reveal the functions of a hypothetical protein from the genome of S. coelicolor. Several bioinformatics tools were employed to predict the structure and function of this protein. Sequence similarity was searched through the available bioinformatics databases to find out the homologous protein. The secondary and tertiary structure were predicted and further validated with quality assessment tools. Furthermore, the active site and the interacting proteins were also explored with the utilization of CASTp and STRING server. The hypothetical protein showed the important biological activity having with two functional domain including POD-like_MBL-fold and rhodanese homology domain. The functional annotation exposed that the selected hypothetical protein could show the hydrolase activity. Furthermore, protein-protein interactions of selected hypothetical protein revealed several functional partners those have the significant role for the bacterial survival. At last, the current study depicts that the annotated hypothetical protein is linked with hydrolase activity which might be of great interest to the further research in bacterial genetics. genome hypothetical protein modeling hydrolases Genetics Mahjerin Nasrin Reza verfasserin aut Md. Tabassum Hossain Emon verfasserin aut Md. Shariful Islam verfasserin aut A. K. M. Mohiuddin verfasserin aut Mohammad Uzzal Hossain verfasserin aut In Genomics & Informatics Korea Genome Organization, 2017 18(2020), 3, p e28 (DE-627)812496515 (DE-600)2802682-2 22340742 nnns volume:18 year:2020 number:3, p e28 https://doi.org/10.5808/GI.2020.18.3.e28 kostenfrei https://doaj.org/article/d2784abd36f1489e9054e0781a84a5bb kostenfrei http://genominfo.org/upload/pdf/gi-2020-18-3-e28.pdf kostenfrei https://doaj.org/toc/2234-0742 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4335 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 18 2020 3, p e28 |
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10.5808/GI.2020.18.3.e28 doi (DE-627)DOAJ045262128 (DE-599)DOAJd2784abd36f1489e9054e0781a84a5bb DE-627 ger DE-627 rakwb eng QH426-470 Nadim Ferdous verfasserin aut Molecular characterization and functional annotation of a hypothetical protein (SCO0618) of A3(2) 2020 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Streptomyces coelicolor is a gram-positive soil bacterium which is well known for the production of several antibiotics used in various biotechnological applications. But numerous proteins from its genome are considered hypothetical proteins. Therefore, the present study aimed to reveal the functions of a hypothetical protein from the genome of S. coelicolor. Several bioinformatics tools were employed to predict the structure and function of this protein. Sequence similarity was searched through the available bioinformatics databases to find out the homologous protein. The secondary and tertiary structure were predicted and further validated with quality assessment tools. Furthermore, the active site and the interacting proteins were also explored with the utilization of CASTp and STRING server. The hypothetical protein showed the important biological activity having with two functional domain including POD-like_MBL-fold and rhodanese homology domain. The functional annotation exposed that the selected hypothetical protein could show the hydrolase activity. Furthermore, protein-protein interactions of selected hypothetical protein revealed several functional partners those have the significant role for the bacterial survival. At last, the current study depicts that the annotated hypothetical protein is linked with hydrolase activity which might be of great interest to the further research in bacterial genetics. genome hypothetical protein modeling hydrolases Genetics Mahjerin Nasrin Reza verfasserin aut Md. Tabassum Hossain Emon verfasserin aut Md. Shariful Islam verfasserin aut A. K. M. Mohiuddin verfasserin aut Mohammad Uzzal Hossain verfasserin aut In Genomics & Informatics Korea Genome Organization, 2017 18(2020), 3, p e28 (DE-627)812496515 (DE-600)2802682-2 22340742 nnns volume:18 year:2020 number:3, p e28 https://doi.org/10.5808/GI.2020.18.3.e28 kostenfrei https://doaj.org/article/d2784abd36f1489e9054e0781a84a5bb kostenfrei http://genominfo.org/upload/pdf/gi-2020-18-3-e28.pdf kostenfrei https://doaj.org/toc/2234-0742 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4335 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 18 2020 3, p e28 |
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10.5808/GI.2020.18.3.e28 doi (DE-627)DOAJ045262128 (DE-599)DOAJd2784abd36f1489e9054e0781a84a5bb DE-627 ger DE-627 rakwb eng QH426-470 Nadim Ferdous verfasserin aut Molecular characterization and functional annotation of a hypothetical protein (SCO0618) of A3(2) 2020 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Streptomyces coelicolor is a gram-positive soil bacterium which is well known for the production of several antibiotics used in various biotechnological applications. But numerous proteins from its genome are considered hypothetical proteins. Therefore, the present study aimed to reveal the functions of a hypothetical protein from the genome of S. coelicolor. Several bioinformatics tools were employed to predict the structure and function of this protein. Sequence similarity was searched through the available bioinformatics databases to find out the homologous protein. The secondary and tertiary structure were predicted and further validated with quality assessment tools. Furthermore, the active site and the interacting proteins were also explored with the utilization of CASTp and STRING server. The hypothetical protein showed the important biological activity having with two functional domain including POD-like_MBL-fold and rhodanese homology domain. The functional annotation exposed that the selected hypothetical protein could show the hydrolase activity. Furthermore, protein-protein interactions of selected hypothetical protein revealed several functional partners those have the significant role for the bacterial survival. At last, the current study depicts that the annotated hypothetical protein is linked with hydrolase activity which might be of great interest to the further research in bacterial genetics. genome hypothetical protein modeling hydrolases Genetics Mahjerin Nasrin Reza verfasserin aut Md. Tabassum Hossain Emon verfasserin aut Md. Shariful Islam verfasserin aut A. K. M. Mohiuddin verfasserin aut Mohammad Uzzal Hossain verfasserin aut In Genomics & Informatics Korea Genome Organization, 2017 18(2020), 3, p e28 (DE-627)812496515 (DE-600)2802682-2 22340742 nnns volume:18 year:2020 number:3, p e28 https://doi.org/10.5808/GI.2020.18.3.e28 kostenfrei https://doaj.org/article/d2784abd36f1489e9054e0781a84a5bb kostenfrei http://genominfo.org/upload/pdf/gi-2020-18-3-e28.pdf kostenfrei https://doaj.org/toc/2234-0742 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4335 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 18 2020 3, p e28 |
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Molecular characterization and functional annotation of a hypothetical protein (SCO0618) of A3(2) |
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Streptomyces coelicolor is a gram-positive soil bacterium which is well known for the production of several antibiotics used in various biotechnological applications. But numerous proteins from its genome are considered hypothetical proteins. Therefore, the present study aimed to reveal the functions of a hypothetical protein from the genome of S. coelicolor. Several bioinformatics tools were employed to predict the structure and function of this protein. Sequence similarity was searched through the available bioinformatics databases to find out the homologous protein. The secondary and tertiary structure were predicted and further validated with quality assessment tools. Furthermore, the active site and the interacting proteins were also explored with the utilization of CASTp and STRING server. The hypothetical protein showed the important biological activity having with two functional domain including POD-like_MBL-fold and rhodanese homology domain. The functional annotation exposed that the selected hypothetical protein could show the hydrolase activity. Furthermore, protein-protein interactions of selected hypothetical protein revealed several functional partners those have the significant role for the bacterial survival. At last, the current study depicts that the annotated hypothetical protein is linked with hydrolase activity which might be of great interest to the further research in bacterial genetics. |
abstractGer |
Streptomyces coelicolor is a gram-positive soil bacterium which is well known for the production of several antibiotics used in various biotechnological applications. But numerous proteins from its genome are considered hypothetical proteins. Therefore, the present study aimed to reveal the functions of a hypothetical protein from the genome of S. coelicolor. Several bioinformatics tools were employed to predict the structure and function of this protein. Sequence similarity was searched through the available bioinformatics databases to find out the homologous protein. The secondary and tertiary structure were predicted and further validated with quality assessment tools. Furthermore, the active site and the interacting proteins were also explored with the utilization of CASTp and STRING server. The hypothetical protein showed the important biological activity having with two functional domain including POD-like_MBL-fold and rhodanese homology domain. The functional annotation exposed that the selected hypothetical protein could show the hydrolase activity. Furthermore, protein-protein interactions of selected hypothetical protein revealed several functional partners those have the significant role for the bacterial survival. At last, the current study depicts that the annotated hypothetical protein is linked with hydrolase activity which might be of great interest to the further research in bacterial genetics. |
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Streptomyces coelicolor is a gram-positive soil bacterium which is well known for the production of several antibiotics used in various biotechnological applications. But numerous proteins from its genome are considered hypothetical proteins. Therefore, the present study aimed to reveal the functions of a hypothetical protein from the genome of S. coelicolor. Several bioinformatics tools were employed to predict the structure and function of this protein. Sequence similarity was searched through the available bioinformatics databases to find out the homologous protein. The secondary and tertiary structure were predicted and further validated with quality assessment tools. Furthermore, the active site and the interacting proteins were also explored with the utilization of CASTp and STRING server. The hypothetical protein showed the important biological activity having with two functional domain including POD-like_MBL-fold and rhodanese homology domain. The functional annotation exposed that the selected hypothetical protein could show the hydrolase activity. Furthermore, protein-protein interactions of selected hypothetical protein revealed several functional partners those have the significant role for the bacterial survival. At last, the current study depicts that the annotated hypothetical protein is linked with hydrolase activity which might be of great interest to the further research in bacterial genetics. |
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