Molecular identification of severe fever with thrombocytopenia syndrome viruses from tick and bitten patient in Southeast China

Abstract Background Severe fever and thrombocytopenia bunyavirus (SFTSV) infection causes severe fever and thrombocytopenia syndrome with high mortality. It is extremely rare that a transmitting tick can be directly captured in bite wounds, and that SFTSV can be isolated from both the captured tick...
Ausführliche Beschreibung

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Autor*in:	Yongxi Tong [verfasserIn] Qiujing Wang [verfasserIn] Yongfeng Fu [verfasserIn] Shibo Li [verfasserIn] Zhao Zhang [verfasserIn] Zheen Zhang [verfasserIn] Xuewen Yu [verfasserIn]

Format:	E-Artikel
Sprache:	Englisch

Erschienen:	2020

Schlagwörter:	SFTS SFTSV Tick Transmission

Übergeordnetes Werk:	In: Virology Journal - BMC, 2004, 17(2020), 1, Seite 5
Übergeordnetes Werk:	volume:17 ; year:2020 ; number:1 ; pages:5

Links:	Link aufrufen Link aufrufen Link aufrufen Journal toc

DOI / URN:	10.1186/s12985-020-01391-1

Katalog-ID:	DOAJ045293538

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520			\|a Abstract Background Severe fever and thrombocytopenia bunyavirus (SFTSV) infection causes severe fever and thrombocytopenia syndrome with high mortality. It is extremely rare that a transmitting tick can be directly captured in bite wounds, and that SFTSV can be isolated from both the captured tick and patient’s serum to establish a solid pathogen diagnosis. Case presentation We report a case infected with severe fever and thrombocytopenia bunyavirus. The 69-year-old male patient presented with fever and tenderness on two lymph nodes in the right groin. A visible tick bite mark appeared on right upper quadrant of the patient’s abdomen, and a live tick was captured in the bite wound upon physical examination. The virus was detected in both the blood of the patient and in the tick that stayed in the bite wound for 7 days. The phylogenetic analysis indicated that the SFTSV isolated from the tick and the patient’s serum sample belonged to type B, in which the L/S segment of these two isolates shared 100% homology, while the M segment had 99.9% homology. The bitten patient was given various supportive care, but eventually died of multiple organ failure. Conclusion The present case provides strong evidence of SFTSV transmission from H. longicornis to humans, and suggests that direct cross-species transmission can occur without additional intermediate hosts.
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700	0		\|a Xuewen Yu \|e verfasserin \|4 aut
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author_variant	y t yt q w qw y f yf s l sl z z zz z z zz x y xy
matchkey_str	article:1743422X:2020----::oeuaietfctoosvrfvrihhobctpnaydoeiuefotca
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publishDate	2020
allfields	10.1186/s12985-020-01391-1 doi (DE-627)DOAJ045293538 (DE-599)DOAJ1313bbb1fde84644a9638b11c3f7ce43 DE-627 ger DE-627 rakwb eng RC109-216 Yongxi Tong verfasserin aut Molecular identification of severe fever with thrombocytopenia syndrome viruses from tick and bitten patient in Southeast China 2020 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Abstract Background Severe fever and thrombocytopenia bunyavirus (SFTSV) infection causes severe fever and thrombocytopenia syndrome with high mortality. It is extremely rare that a transmitting tick can be directly captured in bite wounds, and that SFTSV can be isolated from both the captured tick and patient’s serum to establish a solid pathogen diagnosis. Case presentation We report a case infected with severe fever and thrombocytopenia bunyavirus. The 69-year-old male patient presented with fever and tenderness on two lymph nodes in the right groin. A visible tick bite mark appeared on right upper quadrant of the patient’s abdomen, and a live tick was captured in the bite wound upon physical examination. The virus was detected in both the blood of the patient and in the tick that stayed in the bite wound for 7 days. The phylogenetic analysis indicated that the SFTSV isolated from the tick and the patient’s serum sample belonged to type B, in which the L/S segment of these two isolates shared 100% homology, while the M segment had 99.9% homology. The bitten patient was given various supportive care, but eventually died of multiple organ failure. Conclusion The present case provides strong evidence of SFTSV transmission from H. longicornis to humans, and suggests that direct cross-species transmission can occur without additional intermediate hosts. SFTS SFTSV Tick Transmission Infectious and parasitic diseases Qiujing Wang verfasserin aut Yongfeng Fu verfasserin aut Shibo Li verfasserin aut Zhao Zhang verfasserin aut Zheen Zhang verfasserin aut Xuewen Yu verfasserin aut In Virology Journal BMC, 2004 17(2020), 1, Seite 5 (DE-627)394165004 (DE-600)2160640-7 1743422X nnns volume:17 year:2020 number:1 pages:5 https://doi.org/10.1186/s12985-020-01391-1 kostenfrei https://doaj.org/article/1313bbb1fde84644a9638b11c3f7ce43 kostenfrei http://link.springer.com/article/10.1186/s12985-020-01391-1 kostenfrei https://doaj.org/toc/1743-422X Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2031 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2057 GBV_ILN_2061 GBV_ILN_2111 GBV_ILN_2113 GBV_ILN_2190 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 17 2020 1 5
spelling	10.1186/s12985-020-01391-1 doi (DE-627)DOAJ045293538 (DE-599)DOAJ1313bbb1fde84644a9638b11c3f7ce43 DE-627 ger DE-627 rakwb eng RC109-216 Yongxi Tong verfasserin aut Molecular identification of severe fever with thrombocytopenia syndrome viruses from tick and bitten patient in Southeast China 2020 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Abstract Background Severe fever and thrombocytopenia bunyavirus (SFTSV) infection causes severe fever and thrombocytopenia syndrome with high mortality. It is extremely rare that a transmitting tick can be directly captured in bite wounds, and that SFTSV can be isolated from both the captured tick and patient’s serum to establish a solid pathogen diagnosis. Case presentation We report a case infected with severe fever and thrombocytopenia bunyavirus. The 69-year-old male patient presented with fever and tenderness on two lymph nodes in the right groin. A visible tick bite mark appeared on right upper quadrant of the patient’s abdomen, and a live tick was captured in the bite wound upon physical examination. The virus was detected in both the blood of the patient and in the tick that stayed in the bite wound for 7 days. The phylogenetic analysis indicated that the SFTSV isolated from the tick and the patient’s serum sample belonged to type B, in which the L/S segment of these two isolates shared 100% homology, while the M segment had 99.9% homology. The bitten patient was given various supportive care, but eventually died of multiple organ failure. Conclusion The present case provides strong evidence of SFTSV transmission from H. longicornis to humans, and suggests that direct cross-species transmission can occur without additional intermediate hosts. SFTS SFTSV Tick Transmission Infectious and parasitic diseases Qiujing Wang verfasserin aut Yongfeng Fu verfasserin aut Shibo Li verfasserin aut Zhao Zhang verfasserin aut Zheen Zhang verfasserin aut Xuewen Yu verfasserin aut In Virology Journal BMC, 2004 17(2020), 1, Seite 5 (DE-627)394165004 (DE-600)2160640-7 1743422X nnns volume:17 year:2020 number:1 pages:5 https://doi.org/10.1186/s12985-020-01391-1 kostenfrei https://doaj.org/article/1313bbb1fde84644a9638b11c3f7ce43 kostenfrei http://link.springer.com/article/10.1186/s12985-020-01391-1 kostenfrei https://doaj.org/toc/1743-422X Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2031 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2057 GBV_ILN_2061 GBV_ILN_2111 GBV_ILN_2113 GBV_ILN_2190 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 17 2020 1 5
allfields_unstemmed	10.1186/s12985-020-01391-1 doi (DE-627)DOAJ045293538 (DE-599)DOAJ1313bbb1fde84644a9638b11c3f7ce43 DE-627 ger DE-627 rakwb eng RC109-216 Yongxi Tong verfasserin aut Molecular identification of severe fever with thrombocytopenia syndrome viruses from tick and bitten patient in Southeast China 2020 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Abstract Background Severe fever and thrombocytopenia bunyavirus (SFTSV) infection causes severe fever and thrombocytopenia syndrome with high mortality. It is extremely rare that a transmitting tick can be directly captured in bite wounds, and that SFTSV can be isolated from both the captured tick and patient’s serum to establish a solid pathogen diagnosis. Case presentation We report a case infected with severe fever and thrombocytopenia bunyavirus. The 69-year-old male patient presented with fever and tenderness on two lymph nodes in the right groin. A visible tick bite mark appeared on right upper quadrant of the patient’s abdomen, and a live tick was captured in the bite wound upon physical examination. The virus was detected in both the blood of the patient and in the tick that stayed in the bite wound for 7 days. The phylogenetic analysis indicated that the SFTSV isolated from the tick and the patient’s serum sample belonged to type B, in which the L/S segment of these two isolates shared 100% homology, while the M segment had 99.9% homology. The bitten patient was given various supportive care, but eventually died of multiple organ failure. Conclusion The present case provides strong evidence of SFTSV transmission from H. longicornis to humans, and suggests that direct cross-species transmission can occur without additional intermediate hosts. SFTS SFTSV Tick Transmission Infectious and parasitic diseases Qiujing Wang verfasserin aut Yongfeng Fu verfasserin aut Shibo Li verfasserin aut Zhao Zhang verfasserin aut Zheen Zhang verfasserin aut Xuewen Yu verfasserin aut In Virology Journal BMC, 2004 17(2020), 1, Seite 5 (DE-627)394165004 (DE-600)2160640-7 1743422X nnns volume:17 year:2020 number:1 pages:5 https://doi.org/10.1186/s12985-020-01391-1 kostenfrei https://doaj.org/article/1313bbb1fde84644a9638b11c3f7ce43 kostenfrei http://link.springer.com/article/10.1186/s12985-020-01391-1 kostenfrei https://doaj.org/toc/1743-422X Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2031 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2057 GBV_ILN_2061 GBV_ILN_2111 GBV_ILN_2113 GBV_ILN_2190 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 17 2020 1 5
allfieldsGer	10.1186/s12985-020-01391-1 doi (DE-627)DOAJ045293538 (DE-599)DOAJ1313bbb1fde84644a9638b11c3f7ce43 DE-627 ger DE-627 rakwb eng RC109-216 Yongxi Tong verfasserin aut Molecular identification of severe fever with thrombocytopenia syndrome viruses from tick and bitten patient in Southeast China 2020 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Abstract Background Severe fever and thrombocytopenia bunyavirus (SFTSV) infection causes severe fever and thrombocytopenia syndrome with high mortality. It is extremely rare that a transmitting tick can be directly captured in bite wounds, and that SFTSV can be isolated from both the captured tick and patient’s serum to establish a solid pathogen diagnosis. Case presentation We report a case infected with severe fever and thrombocytopenia bunyavirus. The 69-year-old male patient presented with fever and tenderness on two lymph nodes in the right groin. A visible tick bite mark appeared on right upper quadrant of the patient’s abdomen, and a live tick was captured in the bite wound upon physical examination. The virus was detected in both the blood of the patient and in the tick that stayed in the bite wound for 7 days. The phylogenetic analysis indicated that the SFTSV isolated from the tick and the patient’s serum sample belonged to type B, in which the L/S segment of these two isolates shared 100% homology, while the M segment had 99.9% homology. The bitten patient was given various supportive care, but eventually died of multiple organ failure. Conclusion The present case provides strong evidence of SFTSV transmission from H. longicornis to humans, and suggests that direct cross-species transmission can occur without additional intermediate hosts. SFTS SFTSV Tick Transmission Infectious and parasitic diseases Qiujing Wang verfasserin aut Yongfeng Fu verfasserin aut Shibo Li verfasserin aut Zhao Zhang verfasserin aut Zheen Zhang verfasserin aut Xuewen Yu verfasserin aut In Virology Journal BMC, 2004 17(2020), 1, Seite 5 (DE-627)394165004 (DE-600)2160640-7 1743422X nnns volume:17 year:2020 number:1 pages:5 https://doi.org/10.1186/s12985-020-01391-1 kostenfrei https://doaj.org/article/1313bbb1fde84644a9638b11c3f7ce43 kostenfrei http://link.springer.com/article/10.1186/s12985-020-01391-1 kostenfrei https://doaj.org/toc/1743-422X Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2031 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2057 GBV_ILN_2061 GBV_ILN_2111 GBV_ILN_2113 GBV_ILN_2190 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 17 2020 1 5
allfieldsSound	10.1186/s12985-020-01391-1 doi (DE-627)DOAJ045293538 (DE-599)DOAJ1313bbb1fde84644a9638b11c3f7ce43 DE-627 ger DE-627 rakwb eng RC109-216 Yongxi Tong verfasserin aut Molecular identification of severe fever with thrombocytopenia syndrome viruses from tick and bitten patient in Southeast China 2020 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Abstract Background Severe fever and thrombocytopenia bunyavirus (SFTSV) infection causes severe fever and thrombocytopenia syndrome with high mortality. It is extremely rare that a transmitting tick can be directly captured in bite wounds, and that SFTSV can be isolated from both the captured tick and patient’s serum to establish a solid pathogen diagnosis. Case presentation We report a case infected with severe fever and thrombocytopenia bunyavirus. The 69-year-old male patient presented with fever and tenderness on two lymph nodes in the right groin. A visible tick bite mark appeared on right upper quadrant of the patient’s abdomen, and a live tick was captured in the bite wound upon physical examination. The virus was detected in both the blood of the patient and in the tick that stayed in the bite wound for 7 days. The phylogenetic analysis indicated that the SFTSV isolated from the tick and the patient’s serum sample belonged to type B, in which the L/S segment of these two isolates shared 100% homology, while the M segment had 99.9% homology. The bitten patient was given various supportive care, but eventually died of multiple organ failure. Conclusion The present case provides strong evidence of SFTSV transmission from H. longicornis to humans, and suggests that direct cross-species transmission can occur without additional intermediate hosts. SFTS SFTSV Tick Transmission Infectious and parasitic diseases Qiujing Wang verfasserin aut Yongfeng Fu verfasserin aut Shibo Li verfasserin aut Zhao Zhang verfasserin aut Zheen Zhang verfasserin aut Xuewen Yu verfasserin aut In Virology Journal BMC, 2004 17(2020), 1, Seite 5 (DE-627)394165004 (DE-600)2160640-7 1743422X nnns volume:17 year:2020 number:1 pages:5 https://doi.org/10.1186/s12985-020-01391-1 kostenfrei https://doaj.org/article/1313bbb1fde84644a9638b11c3f7ce43 kostenfrei http://link.springer.com/article/10.1186/s12985-020-01391-1 kostenfrei https://doaj.org/toc/1743-422X Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2031 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2057 GBV_ILN_2061 GBV_ILN_2111 GBV_ILN_2113 GBV_ILN_2190 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 17 2020 1 5
language	English
source	In Virology Journal 17(2020), 1, Seite 5 volume:17 year:2020 number:1 pages:5
sourceStr	In Virology Journal 17(2020), 1, Seite 5 volume:17 year:2020 number:1 pages:5
format_phy_str_mv	Article
institution	findex.gbv.de
topic_facet	SFTS SFTSV Tick Transmission Infectious and parasitic diseases
isfreeaccess_bool	true
container_title	Virology Journal
authorswithroles_txt_mv	Yongxi Tong @@aut@@ Qiujing Wang @@aut@@ Yongfeng Fu @@aut@@ Shibo Li @@aut@@ Zhao Zhang @@aut@@ Zheen Zhang @@aut@@ Xuewen Yu @@aut@@
publishDateDaySort_date	2020-01-01T00:00:00Z
hierarchy_top_id	394165004
id	DOAJ045293538
language_de	englisch
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callnumber-first	R - Medicine
author	Yongxi Tong
spellingShingle	Yongxi Tong misc RC109-216 misc SFTS misc SFTSV misc Tick misc Transmission misc Infectious and parasitic diseases Molecular identification of severe fever with thrombocytopenia syndrome viruses from tick and bitten patient in Southeast China
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topic_title	RC109-216 Molecular identification of severe fever with thrombocytopenia syndrome viruses from tick and bitten patient in Southeast China SFTS SFTSV Tick Transmission
topic	misc RC109-216 misc SFTS misc SFTSV misc Tick misc Transmission misc Infectious and parasitic diseases
topic_unstemmed	misc RC109-216 misc SFTS misc SFTSV misc Tick misc Transmission misc Infectious and parasitic diseases
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title	Molecular identification of severe fever with thrombocytopenia syndrome viruses from tick and bitten patient in Southeast China
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title_full	Molecular identification of severe fever with thrombocytopenia syndrome viruses from tick and bitten patient in Southeast China
author_sort	Yongxi Tong
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author_browse	Yongxi Tong Qiujing Wang Yongfeng Fu Shibo Li Zhao Zhang Zheen Zhang Xuewen Yu
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class	RC109-216
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doi_str_mv	10.1186/s12985-020-01391-1
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title_sort	molecular identification of severe fever with thrombocytopenia syndrome viruses from tick and bitten patient in southeast china
callnumber	RC109-216
title_auth	Molecular identification of severe fever with thrombocytopenia syndrome viruses from tick and bitten patient in Southeast China
abstract	Abstract Background Severe fever and thrombocytopenia bunyavirus (SFTSV) infection causes severe fever and thrombocytopenia syndrome with high mortality. It is extremely rare that a transmitting tick can be directly captured in bite wounds, and that SFTSV can be isolated from both the captured tick and patient’s serum to establish a solid pathogen diagnosis. Case presentation We report a case infected with severe fever and thrombocytopenia bunyavirus. The 69-year-old male patient presented with fever and tenderness on two lymph nodes in the right groin. A visible tick bite mark appeared on right upper quadrant of the patient’s abdomen, and a live tick was captured in the bite wound upon physical examination. The virus was detected in both the blood of the patient and in the tick that stayed in the bite wound for 7 days. The phylogenetic analysis indicated that the SFTSV isolated from the tick and the patient’s serum sample belonged to type B, in which the L/S segment of these two isolates shared 100% homology, while the M segment had 99.9% homology. The bitten patient was given various supportive care, but eventually died of multiple organ failure. Conclusion The present case provides strong evidence of SFTSV transmission from H. longicornis to humans, and suggests that direct cross-species transmission can occur without additional intermediate hosts.
abstractGer	Abstract Background Severe fever and thrombocytopenia bunyavirus (SFTSV) infection causes severe fever and thrombocytopenia syndrome with high mortality. It is extremely rare that a transmitting tick can be directly captured in bite wounds, and that SFTSV can be isolated from both the captured tick and patient’s serum to establish a solid pathogen diagnosis. Case presentation We report a case infected with severe fever and thrombocytopenia bunyavirus. The 69-year-old male patient presented with fever and tenderness on two lymph nodes in the right groin. A visible tick bite mark appeared on right upper quadrant of the patient’s abdomen, and a live tick was captured in the bite wound upon physical examination. The virus was detected in both the blood of the patient and in the tick that stayed in the bite wound for 7 days. The phylogenetic analysis indicated that the SFTSV isolated from the tick and the patient’s serum sample belonged to type B, in which the L/S segment of these two isolates shared 100% homology, while the M segment had 99.9% homology. The bitten patient was given various supportive care, but eventually died of multiple organ failure. Conclusion The present case provides strong evidence of SFTSV transmission from H. longicornis to humans, and suggests that direct cross-species transmission can occur without additional intermediate hosts.
abstract_unstemmed	Abstract Background Severe fever and thrombocytopenia bunyavirus (SFTSV) infection causes severe fever and thrombocytopenia syndrome with high mortality. It is extremely rare that a transmitting tick can be directly captured in bite wounds, and that SFTSV can be isolated from both the captured tick and patient’s serum to establish a solid pathogen diagnosis. Case presentation We report a case infected with severe fever and thrombocytopenia bunyavirus. The 69-year-old male patient presented with fever and tenderness on two lymph nodes in the right groin. A visible tick bite mark appeared on right upper quadrant of the patient’s abdomen, and a live tick was captured in the bite wound upon physical examination. The virus was detected in both the blood of the patient and in the tick that stayed in the bite wound for 7 days. The phylogenetic analysis indicated that the SFTSV isolated from the tick and the patient’s serum sample belonged to type B, in which the L/S segment of these two isolates shared 100% homology, while the M segment had 99.9% homology. The bitten patient was given various supportive care, but eventually died of multiple organ failure. Conclusion The present case provides strong evidence of SFTSV transmission from H. longicornis to humans, and suggests that direct cross-species transmission can occur without additional intermediate hosts.
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title_short	Molecular identification of severe fever with thrombocytopenia syndrome viruses from tick and bitten patient in Southeast China
url	https://doi.org/10.1186/s12985-020-01391-1 https://doaj.org/article/1313bbb1fde84644a9638b11c3f7ce43 http://link.springer.com/article/10.1186/s12985-020-01391-1 https://doaj.org/toc/1743-422X
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author2	Qiujing Wang Yongfeng Fu Shibo Li Zhao Zhang Zheen Zhang Xuewen Yu
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up_date	2024-07-03T14:08:26.727Z
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Molecular identification of severe fever with thrombocytopenia syndrome viruses from tick and bitten patient in Southeast China

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