Clinicopathological Characteristics of Pseudomyxoma Peritonei Originated from Ovaries
Fengcai Yan,1,2 Feng Shi,1,2 Xinbao Li,3 Chunkai Yu,1 Yulin Lin,3 Yan Li,1,3 Mulan Jin2 1Department of Pathology, Beijing Shijitan Hospital, Capital Medical University, Beijing, People’s Republic of China; 2Department of Pathology, Beijing Chaoyang Hospital, Capital Medical University, Bei...
Ausführliche Beschreibung
Gespeichert in:
| Autor*in: |
Yan F [verfasserIn] Shi F [verfasserIn] Li X [verfasserIn] Yu C [verfasserIn] Lin Y [verfasserIn] Li Y [verfasserIn] Jin M [verfasserIn] |
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E-Artikel |
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| Sprache: |
Englisch |
| Erschienen: |
2020 |
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| Übergeordnetes Werk: |
In: Cancer Management and Research - Dove Medical Press, 2009, (2020), Seite 7569-7578 |
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| Übergeordnetes Werk: |
year:2020 ; pages:7569-7578 |
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DOAJ045317402 |
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| 520 | |a Fengcai Yan,1,2 Feng Shi,1,2 Xinbao Li,3 Chunkai Yu,1 Yulin Lin,3 Yan Li,1,3 Mulan Jin2 1Department of Pathology, Beijing Shijitan Hospital, Capital Medical University, Beijing, People’s Republic of China; 2Department of Pathology, Beijing Chaoyang Hospital, Capital Medical University, Beijing, People’s Republic of China; 3Department of Peritoneal Cancer Surgery, Beijing Shijitan Hospital, Capital Medical University, Beijing, People’s Republic of ChinaCorrespondence: Mulan Jin Email kinmokuran163.comObjective: This study aims to demonstrate clinicopathological characteristics and immunohistopathological phenotypes of pseudomyxoma peritonei (PMP) originated from ovaries.Methods: The primary origin of PMP was explored by reviewing H&E sections retrospectively and performing a series of immunohistochemical staining on CK7, CK20, CDX2, CEA, Villin, SATB2, CA125, ER, PR, and MUC.Results: Among 310 PMP patients, a few originated from extra-appendix, whereas eight cases were of ovarian origin (2.6%), including three teratoma-associated ovarian mucinous tumors and five primary ovarian mucinous tumors with spontaneous or iatrogenic rupture, respectively. Most peritoneal metastases were acellular mucin or low-grade mucinous carcinoma peritonei (6/8, 75%), while the rest were high-grade mucinous carcinoma peritonei (2/8, 25%). Tumors were positive for CK20, CDX2, CEA, and Villin. SATB2 was specifically diffuse positive in teratoma-associated ovarian mucinous tumors, and negative in primary ovarian mucinous tumors. Differential expression of MUC was observed in these tumors.Conclusion: PMP of ovarian origin is extremely rare. The precise diagnosis requires serial sections of the appendix or suspicious tissue to exclude appendiceal mucinous neoplasms, as well as comprehensive analysis of clinical features, surgical findings, histopathological characteristics, and immunohistochemistry on specific biomarkers.Keywords: pseudomyxoma peritonei, PMP, ovary, mucinous tumor | ||
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(DE-627)DOAJ045317402 (DE-599)DOAJ2d4c2a1c1bbe44f88d29baeab956d497 DE-627 ger DE-627 rakwb eng RC254-282 Yan F verfasserin aut Clinicopathological Characteristics of Pseudomyxoma Peritonei Originated from Ovaries 2020 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Fengcai Yan,1,2 Feng Shi,1,2 Xinbao Li,3 Chunkai Yu,1 Yulin Lin,3 Yan Li,1,3 Mulan Jin2 1Department of Pathology, Beijing Shijitan Hospital, Capital Medical University, Beijing, People’s Republic of China; 2Department of Pathology, Beijing Chaoyang Hospital, Capital Medical University, Beijing, People’s Republic of China; 3Department of Peritoneal Cancer Surgery, Beijing Shijitan Hospital, Capital Medical University, Beijing, People’s Republic of ChinaCorrespondence: Mulan Jin Email kinmokuran163.comObjective: This study aims to demonstrate clinicopathological characteristics and immunohistopathological phenotypes of pseudomyxoma peritonei (PMP) originated from ovaries.Methods: The primary origin of PMP was explored by reviewing H&E sections retrospectively and performing a series of immunohistochemical staining on CK7, CK20, CDX2, CEA, Villin, SATB2, CA125, ER, PR, and MUC.Results: Among 310 PMP patients, a few originated from extra-appendix, whereas eight cases were of ovarian origin (2.6%), including three teratoma-associated ovarian mucinous tumors and five primary ovarian mucinous tumors with spontaneous or iatrogenic rupture, respectively. Most peritoneal metastases were acellular mucin or low-grade mucinous carcinoma peritonei (6/8, 75%), while the rest were high-grade mucinous carcinoma peritonei (2/8, 25%). Tumors were positive for CK20, CDX2, CEA, and Villin. SATB2 was specifically diffuse positive in teratoma-associated ovarian mucinous tumors, and negative in primary ovarian mucinous tumors. Differential expression of MUC was observed in these tumors.Conclusion: PMP of ovarian origin is extremely rare. The precise diagnosis requires serial sections of the appendix or suspicious tissue to exclude appendiceal mucinous neoplasms, as well as comprehensive analysis of clinical features, surgical findings, histopathological characteristics, and immunohistochemistry on specific biomarkers.Keywords: pseudomyxoma peritonei, PMP, ovary, mucinous tumor pseudomyxoma peritonei (pmp) ovary mucinous tumor Neoplasms. Tumors. Oncology. Including cancer and carcinogens Shi F verfasserin aut Li X verfasserin aut Yu C verfasserin aut Lin Y verfasserin aut Li Y verfasserin aut Jin M verfasserin aut In Cancer Management and Research Dove Medical Press, 2009 (2020), Seite 7569-7578 (DE-627)606030840 (DE-600)2508013-1 11791322 nnns year:2020 pages:7569-7578 https://doaj.org/article/2d4c2a1c1bbe44f88d29baeab956d497 kostenfrei https://www.dovepress.com/clinicopathological-characteristics-of-pseudomyxoma-peritonei-originat-peer-reviewed-article-CMAR kostenfrei https://doaj.org/toc/1179-1322 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2003 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 2020 7569-7578 |
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(DE-627)DOAJ045317402 (DE-599)DOAJ2d4c2a1c1bbe44f88d29baeab956d497 DE-627 ger DE-627 rakwb eng RC254-282 Yan F verfasserin aut Clinicopathological Characteristics of Pseudomyxoma Peritonei Originated from Ovaries 2020 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Fengcai Yan,1,2 Feng Shi,1,2 Xinbao Li,3 Chunkai Yu,1 Yulin Lin,3 Yan Li,1,3 Mulan Jin2 1Department of Pathology, Beijing Shijitan Hospital, Capital Medical University, Beijing, People’s Republic of China; 2Department of Pathology, Beijing Chaoyang Hospital, Capital Medical University, Beijing, People’s Republic of China; 3Department of Peritoneal Cancer Surgery, Beijing Shijitan Hospital, Capital Medical University, Beijing, People’s Republic of ChinaCorrespondence: Mulan Jin Email kinmokuran163.comObjective: This study aims to demonstrate clinicopathological characteristics and immunohistopathological phenotypes of pseudomyxoma peritonei (PMP) originated from ovaries.Methods: The primary origin of PMP was explored by reviewing H&E sections retrospectively and performing a series of immunohistochemical staining on CK7, CK20, CDX2, CEA, Villin, SATB2, CA125, ER, PR, and MUC.Results: Among 310 PMP patients, a few originated from extra-appendix, whereas eight cases were of ovarian origin (2.6%), including three teratoma-associated ovarian mucinous tumors and five primary ovarian mucinous tumors with spontaneous or iatrogenic rupture, respectively. Most peritoneal metastases were acellular mucin or low-grade mucinous carcinoma peritonei (6/8, 75%), while the rest were high-grade mucinous carcinoma peritonei (2/8, 25%). Tumors were positive for CK20, CDX2, CEA, and Villin. SATB2 was specifically diffuse positive in teratoma-associated ovarian mucinous tumors, and negative in primary ovarian mucinous tumors. Differential expression of MUC was observed in these tumors.Conclusion: PMP of ovarian origin is extremely rare. The precise diagnosis requires serial sections of the appendix or suspicious tissue to exclude appendiceal mucinous neoplasms, as well as comprehensive analysis of clinical features, surgical findings, histopathological characteristics, and immunohistochemistry on specific biomarkers.Keywords: pseudomyxoma peritonei, PMP, ovary, mucinous tumor pseudomyxoma peritonei (pmp) ovary mucinous tumor Neoplasms. Tumors. Oncology. Including cancer and carcinogens Shi F verfasserin aut Li X verfasserin aut Yu C verfasserin aut Lin Y verfasserin aut Li Y verfasserin aut Jin M verfasserin aut In Cancer Management and Research Dove Medical Press, 2009 (2020), Seite 7569-7578 (DE-627)606030840 (DE-600)2508013-1 11791322 nnns year:2020 pages:7569-7578 https://doaj.org/article/2d4c2a1c1bbe44f88d29baeab956d497 kostenfrei https://www.dovepress.com/clinicopathological-characteristics-of-pseudomyxoma-peritonei-originat-peer-reviewed-article-CMAR kostenfrei https://doaj.org/toc/1179-1322 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2003 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 2020 7569-7578 |
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(DE-627)DOAJ045317402 (DE-599)DOAJ2d4c2a1c1bbe44f88d29baeab956d497 DE-627 ger DE-627 rakwb eng RC254-282 Yan F verfasserin aut Clinicopathological Characteristics of Pseudomyxoma Peritonei Originated from Ovaries 2020 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Fengcai Yan,1,2 Feng Shi,1,2 Xinbao Li,3 Chunkai Yu,1 Yulin Lin,3 Yan Li,1,3 Mulan Jin2 1Department of Pathology, Beijing Shijitan Hospital, Capital Medical University, Beijing, People’s Republic of China; 2Department of Pathology, Beijing Chaoyang Hospital, Capital Medical University, Beijing, People’s Republic of China; 3Department of Peritoneal Cancer Surgery, Beijing Shijitan Hospital, Capital Medical University, Beijing, People’s Republic of ChinaCorrespondence: Mulan Jin Email kinmokuran163.comObjective: This study aims to demonstrate clinicopathological characteristics and immunohistopathological phenotypes of pseudomyxoma peritonei (PMP) originated from ovaries.Methods: The primary origin of PMP was explored by reviewing H&E sections retrospectively and performing a series of immunohistochemical staining on CK7, CK20, CDX2, CEA, Villin, SATB2, CA125, ER, PR, and MUC.Results: Among 310 PMP patients, a few originated from extra-appendix, whereas eight cases were of ovarian origin (2.6%), including three teratoma-associated ovarian mucinous tumors and five primary ovarian mucinous tumors with spontaneous or iatrogenic rupture, respectively. Most peritoneal metastases were acellular mucin or low-grade mucinous carcinoma peritonei (6/8, 75%), while the rest were high-grade mucinous carcinoma peritonei (2/8, 25%). Tumors were positive for CK20, CDX2, CEA, and Villin. SATB2 was specifically diffuse positive in teratoma-associated ovarian mucinous tumors, and negative in primary ovarian mucinous tumors. Differential expression of MUC was observed in these tumors.Conclusion: PMP of ovarian origin is extremely rare. The precise diagnosis requires serial sections of the appendix or suspicious tissue to exclude appendiceal mucinous neoplasms, as well as comprehensive analysis of clinical features, surgical findings, histopathological characteristics, and immunohistochemistry on specific biomarkers.Keywords: pseudomyxoma peritonei, PMP, ovary, mucinous tumor pseudomyxoma peritonei (pmp) ovary mucinous tumor Neoplasms. Tumors. Oncology. Including cancer and carcinogens Shi F verfasserin aut Li X verfasserin aut Yu C verfasserin aut Lin Y verfasserin aut Li Y verfasserin aut Jin M verfasserin aut In Cancer Management and Research Dove Medical Press, 2009 (2020), Seite 7569-7578 (DE-627)606030840 (DE-600)2508013-1 11791322 nnns year:2020 pages:7569-7578 https://doaj.org/article/2d4c2a1c1bbe44f88d29baeab956d497 kostenfrei https://www.dovepress.com/clinicopathological-characteristics-of-pseudomyxoma-peritonei-originat-peer-reviewed-article-CMAR kostenfrei https://doaj.org/toc/1179-1322 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2003 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 2020 7569-7578 |
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(DE-627)DOAJ045317402 (DE-599)DOAJ2d4c2a1c1bbe44f88d29baeab956d497 DE-627 ger DE-627 rakwb eng RC254-282 Yan F verfasserin aut Clinicopathological Characteristics of Pseudomyxoma Peritonei Originated from Ovaries 2020 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Fengcai Yan,1,2 Feng Shi,1,2 Xinbao Li,3 Chunkai Yu,1 Yulin Lin,3 Yan Li,1,3 Mulan Jin2 1Department of Pathology, Beijing Shijitan Hospital, Capital Medical University, Beijing, People’s Republic of China; 2Department of Pathology, Beijing Chaoyang Hospital, Capital Medical University, Beijing, People’s Republic of China; 3Department of Peritoneal Cancer Surgery, Beijing Shijitan Hospital, Capital Medical University, Beijing, People’s Republic of ChinaCorrespondence: Mulan Jin Email kinmokuran163.comObjective: This study aims to demonstrate clinicopathological characteristics and immunohistopathological phenotypes of pseudomyxoma peritonei (PMP) originated from ovaries.Methods: The primary origin of PMP was explored by reviewing H&E sections retrospectively and performing a series of immunohistochemical staining on CK7, CK20, CDX2, CEA, Villin, SATB2, CA125, ER, PR, and MUC.Results: Among 310 PMP patients, a few originated from extra-appendix, whereas eight cases were of ovarian origin (2.6%), including three teratoma-associated ovarian mucinous tumors and five primary ovarian mucinous tumors with spontaneous or iatrogenic rupture, respectively. Most peritoneal metastases were acellular mucin or low-grade mucinous carcinoma peritonei (6/8, 75%), while the rest were high-grade mucinous carcinoma peritonei (2/8, 25%). Tumors were positive for CK20, CDX2, CEA, and Villin. SATB2 was specifically diffuse positive in teratoma-associated ovarian mucinous tumors, and negative in primary ovarian mucinous tumors. Differential expression of MUC was observed in these tumors.Conclusion: PMP of ovarian origin is extremely rare. The precise diagnosis requires serial sections of the appendix or suspicious tissue to exclude appendiceal mucinous neoplasms, as well as comprehensive analysis of clinical features, surgical findings, histopathological characteristics, and immunohistochemistry on specific biomarkers.Keywords: pseudomyxoma peritonei, PMP, ovary, mucinous tumor pseudomyxoma peritonei (pmp) ovary mucinous tumor Neoplasms. Tumors. Oncology. Including cancer and carcinogens Shi F verfasserin aut Li X verfasserin aut Yu C verfasserin aut Lin Y verfasserin aut Li Y verfasserin aut Jin M verfasserin aut In Cancer Management and Research Dove Medical Press, 2009 (2020), Seite 7569-7578 (DE-627)606030840 (DE-600)2508013-1 11791322 nnns year:2020 pages:7569-7578 https://doaj.org/article/2d4c2a1c1bbe44f88d29baeab956d497 kostenfrei https://www.dovepress.com/clinicopathological-characteristics-of-pseudomyxoma-peritonei-originat-peer-reviewed-article-CMAR kostenfrei https://doaj.org/toc/1179-1322 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2003 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 2020 7569-7578 |
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(DE-627)DOAJ045317402 (DE-599)DOAJ2d4c2a1c1bbe44f88d29baeab956d497 DE-627 ger DE-627 rakwb eng RC254-282 Yan F verfasserin aut Clinicopathological Characteristics of Pseudomyxoma Peritonei Originated from Ovaries 2020 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Fengcai Yan,1,2 Feng Shi,1,2 Xinbao Li,3 Chunkai Yu,1 Yulin Lin,3 Yan Li,1,3 Mulan Jin2 1Department of Pathology, Beijing Shijitan Hospital, Capital Medical University, Beijing, People’s Republic of China; 2Department of Pathology, Beijing Chaoyang Hospital, Capital Medical University, Beijing, People’s Republic of China; 3Department of Peritoneal Cancer Surgery, Beijing Shijitan Hospital, Capital Medical University, Beijing, People’s Republic of ChinaCorrespondence: Mulan Jin Email kinmokuran163.comObjective: This study aims to demonstrate clinicopathological characteristics and immunohistopathological phenotypes of pseudomyxoma peritonei (PMP) originated from ovaries.Methods: The primary origin of PMP was explored by reviewing H&E sections retrospectively and performing a series of immunohistochemical staining on CK7, CK20, CDX2, CEA, Villin, SATB2, CA125, ER, PR, and MUC.Results: Among 310 PMP patients, a few originated from extra-appendix, whereas eight cases were of ovarian origin (2.6%), including three teratoma-associated ovarian mucinous tumors and five primary ovarian mucinous tumors with spontaneous or iatrogenic rupture, respectively. Most peritoneal metastases were acellular mucin or low-grade mucinous carcinoma peritonei (6/8, 75%), while the rest were high-grade mucinous carcinoma peritonei (2/8, 25%). Tumors were positive for CK20, CDX2, CEA, and Villin. SATB2 was specifically diffuse positive in teratoma-associated ovarian mucinous tumors, and negative in primary ovarian mucinous tumors. Differential expression of MUC was observed in these tumors.Conclusion: PMP of ovarian origin is extremely rare. The precise diagnosis requires serial sections of the appendix or suspicious tissue to exclude appendiceal mucinous neoplasms, as well as comprehensive analysis of clinical features, surgical findings, histopathological characteristics, and immunohistochemistry on specific biomarkers.Keywords: pseudomyxoma peritonei, PMP, ovary, mucinous tumor pseudomyxoma peritonei (pmp) ovary mucinous tumor Neoplasms. Tumors. Oncology. Including cancer and carcinogens Shi F verfasserin aut Li X verfasserin aut Yu C verfasserin aut Lin Y verfasserin aut Li Y verfasserin aut Jin M verfasserin aut In Cancer Management and Research Dove Medical Press, 2009 (2020), Seite 7569-7578 (DE-627)606030840 (DE-600)2508013-1 11791322 nnns year:2020 pages:7569-7578 https://doaj.org/article/2d4c2a1c1bbe44f88d29baeab956d497 kostenfrei https://www.dovepress.com/clinicopathological-characteristics-of-pseudomyxoma-peritonei-originat-peer-reviewed-article-CMAR kostenfrei https://doaj.org/toc/1179-1322 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2003 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 2020 7569-7578 |
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Fengcai Yan,1,2 Feng Shi,1,2 Xinbao Li,3 Chunkai Yu,1 Yulin Lin,3 Yan Li,1,3 Mulan Jin2 1Department of Pathology, Beijing Shijitan Hospital, Capital Medical University, Beijing, People’s Republic of China; 2Department of Pathology, Beijing Chaoyang Hospital, Capital Medical University, Beijing, People’s Republic of China; 3Department of Peritoneal Cancer Surgery, Beijing Shijitan Hospital, Capital Medical University, Beijing, People’s Republic of ChinaCorrespondence: Mulan Jin Email kinmokuran163.comObjective: This study aims to demonstrate clinicopathological characteristics and immunohistopathological phenotypes of pseudomyxoma peritonei (PMP) originated from ovaries.Methods: The primary origin of PMP was explored by reviewing H&E sections retrospectively and performing a series of immunohistochemical staining on CK7, CK20, CDX2, CEA, Villin, SATB2, CA125, ER, PR, and MUC.Results: Among 310 PMP patients, a few originated from extra-appendix, whereas eight cases were of ovarian origin (2.6%), including three teratoma-associated ovarian mucinous tumors and five primary ovarian mucinous tumors with spontaneous or iatrogenic rupture, respectively. Most peritoneal metastases were acellular mucin or low-grade mucinous carcinoma peritonei (6/8, 75%), while the rest were high-grade mucinous carcinoma peritonei (2/8, 25%). Tumors were positive for CK20, CDX2, CEA, and Villin. SATB2 was specifically diffuse positive in teratoma-associated ovarian mucinous tumors, and negative in primary ovarian mucinous tumors. Differential expression of MUC was observed in these tumors.Conclusion: PMP of ovarian origin is extremely rare. The precise diagnosis requires serial sections of the appendix or suspicious tissue to exclude appendiceal mucinous neoplasms, as well as comprehensive analysis of clinical features, surgical findings, histopathological characteristics, and immunohistochemistry on specific biomarkers.Keywords: pseudomyxoma peritonei, PMP, ovary, mucinous tumor |
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Fengcai Yan,1,2 Feng Shi,1,2 Xinbao Li,3 Chunkai Yu,1 Yulin Lin,3 Yan Li,1,3 Mulan Jin2 1Department of Pathology, Beijing Shijitan Hospital, Capital Medical University, Beijing, People’s Republic of China; 2Department of Pathology, Beijing Chaoyang Hospital, Capital Medical University, Beijing, People’s Republic of China; 3Department of Peritoneal Cancer Surgery, Beijing Shijitan Hospital, Capital Medical University, Beijing, People’s Republic of ChinaCorrespondence: Mulan Jin Email kinmokuran163.comObjective: This study aims to demonstrate clinicopathological characteristics and immunohistopathological phenotypes of pseudomyxoma peritonei (PMP) originated from ovaries.Methods: The primary origin of PMP was explored by reviewing H&E sections retrospectively and performing a series of immunohistochemical staining on CK7, CK20, CDX2, CEA, Villin, SATB2, CA125, ER, PR, and MUC.Results: Among 310 PMP patients, a few originated from extra-appendix, whereas eight cases were of ovarian origin (2.6%), including three teratoma-associated ovarian mucinous tumors and five primary ovarian mucinous tumors with spontaneous or iatrogenic rupture, respectively. Most peritoneal metastases were acellular mucin or low-grade mucinous carcinoma peritonei (6/8, 75%), while the rest were high-grade mucinous carcinoma peritonei (2/8, 25%). Tumors were positive for CK20, CDX2, CEA, and Villin. SATB2 was specifically diffuse positive in teratoma-associated ovarian mucinous tumors, and negative in primary ovarian mucinous tumors. Differential expression of MUC was observed in these tumors.Conclusion: PMP of ovarian origin is extremely rare. The precise diagnosis requires serial sections of the appendix or suspicious tissue to exclude appendiceal mucinous neoplasms, as well as comprehensive analysis of clinical features, surgical findings, histopathological characteristics, and immunohistochemistry on specific biomarkers.Keywords: pseudomyxoma peritonei, PMP, ovary, mucinous tumor |
| abstract_unstemmed |
Fengcai Yan,1,2 Feng Shi,1,2 Xinbao Li,3 Chunkai Yu,1 Yulin Lin,3 Yan Li,1,3 Mulan Jin2 1Department of Pathology, Beijing Shijitan Hospital, Capital Medical University, Beijing, People’s Republic of China; 2Department of Pathology, Beijing Chaoyang Hospital, Capital Medical University, Beijing, People’s Republic of China; 3Department of Peritoneal Cancer Surgery, Beijing Shijitan Hospital, Capital Medical University, Beijing, People’s Republic of ChinaCorrespondence: Mulan Jin Email kinmokuran163.comObjective: This study aims to demonstrate clinicopathological characteristics and immunohistopathological phenotypes of pseudomyxoma peritonei (PMP) originated from ovaries.Methods: The primary origin of PMP was explored by reviewing H&E sections retrospectively and performing a series of immunohistochemical staining on CK7, CK20, CDX2, CEA, Villin, SATB2, CA125, ER, PR, and MUC.Results: Among 310 PMP patients, a few originated from extra-appendix, whereas eight cases were of ovarian origin (2.6%), including three teratoma-associated ovarian mucinous tumors and five primary ovarian mucinous tumors with spontaneous or iatrogenic rupture, respectively. Most peritoneal metastases were acellular mucin or low-grade mucinous carcinoma peritonei (6/8, 75%), while the rest were high-grade mucinous carcinoma peritonei (2/8, 25%). Tumors were positive for CK20, CDX2, CEA, and Villin. SATB2 was specifically diffuse positive in teratoma-associated ovarian mucinous tumors, and negative in primary ovarian mucinous tumors. Differential expression of MUC was observed in these tumors.Conclusion: PMP of ovarian origin is extremely rare. The precise diagnosis requires serial sections of the appendix or suspicious tissue to exclude appendiceal mucinous neoplasms, as well as comprehensive analysis of clinical features, surgical findings, histopathological characteristics, and immunohistochemistry on specific biomarkers.Keywords: pseudomyxoma peritonei, PMP, ovary, mucinous tumor |
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Clinicopathological Characteristics of Pseudomyxoma Peritonei Originated from Ovaries |
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https://doaj.org/article/2d4c2a1c1bbe44f88d29baeab956d497 https://www.dovepress.com/clinicopathological-characteristics-of-pseudomyxoma-peritonei-originat-peer-reviewed-article-CMAR https://doaj.org/toc/1179-1322 |
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