Insights on the Extraction Performance of Alkanediols and Glycerol: Using <i<Juglans regia</i< L. Leaves as a Source of Bioactive Compounds

Glycerol and alkanediols are being studied as alternative solvents to extract phytochemicals from plant material, often as hydrogen bond donors in deep eutectic solvents (DESs). Many of those alcohols are liquid at room temperature, yet studies of their use as extraction solvents are scarce. In this...
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Autor*in:	Vanessa Vieira [verfasserIn] Ricardo C. Calhelha [verfasserIn] Lillian Barros [verfasserIn] João A. P. Coutinho [verfasserIn] Isabel C. F. R. Ferreira [verfasserIn] Olga Ferreira [verfasserIn]

Format:	E-Artikel
Sprache:	Englisch

Erschienen:	2020

Schlagwörter:	alkanediols glycerol phenolic compounds cytotoxicity anti-inflammatory activity

Übergeordnetes Werk:	In: Molecules - MDPI AG, 2003, 25(2020), 11, p 2497
Übergeordnetes Werk:	volume:25 ; year:2020 ; number:11, p 2497

Links:	Link aufrufen Link aufrufen Link aufrufen Journal toc

DOI / URN:	10.3390/molecules25112497

Katalog-ID:	DOAJ045412952

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520			\|a Glycerol and alkanediols are being studied as alternative solvents to extract phytochemicals from plant material, often as hydrogen bond donors in deep eutectic solvents (DESs). Many of those alcohols are liquid at room temperature, yet studies of their use as extraction solvents are scarce. In this work, glycerol and a series of alkanediols (1,2-ethanediol, 1,2-propanediol, 1,3-propanediol, 1,3-butanediol, 1,2-pentanediol, 1,5-pentanediol, and 1,2-hexanediol) were studied for the extraction of phenolic compounds from <i<Juglans regia</i< L. leaves, a rich source of this class of bioactive compounds. The extraction yield was quantified, and the bioactivity of both extracts and pure solvents was evaluated by measuring the anti-inflammatory and cytotoxic activities. The solvents showing the best combined results were 1,2 and 1,3-propanediol, as their extracts presented a high amount of phenolic compounds, close to the results of ethanol, and similar cytotoxicity against cervical carcinoma cells, with no impact on non-tumor porcine liver cells in the studied concentration range. On the other hand, none of the extracts (and solvents) presented anti-inflammatory activity. Overall, the results obtained in this work contribute to the study of alternative solvents that could potentially be used also as formulation media, highlighting the importance of walnut leaves as a source of bioactive compounds.
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allfields	10.3390/molecules25112497 doi (DE-627)DOAJ045412952 (DE-599)DOAJ10081447a7984140aad6f3abffc99640 DE-627 ger DE-627 rakwb eng QD241-441 Vanessa Vieira verfasserin aut Insights on the Extraction Performance of Alkanediols and Glycerol: Using <i<Juglans regia</i< L. Leaves as a Source of Bioactive Compounds 2020 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Glycerol and alkanediols are being studied as alternative solvents to extract phytochemicals from plant material, often as hydrogen bond donors in deep eutectic solvents (DESs). Many of those alcohols are liquid at room temperature, yet studies of their use as extraction solvents are scarce. In this work, glycerol and a series of alkanediols (1,2-ethanediol, 1,2-propanediol, 1,3-propanediol, 1,3-butanediol, 1,2-pentanediol, 1,5-pentanediol, and 1,2-hexanediol) were studied for the extraction of phenolic compounds from <i<Juglans regia</i< L. leaves, a rich source of this class of bioactive compounds. The extraction yield was quantified, and the bioactivity of both extracts and pure solvents was evaluated by measuring the anti-inflammatory and cytotoxic activities. The solvents showing the best combined results were 1,2 and 1,3-propanediol, as their extracts presented a high amount of phenolic compounds, close to the results of ethanol, and similar cytotoxicity against cervical carcinoma cells, with no impact on non-tumor porcine liver cells in the studied concentration range. On the other hand, none of the extracts (and solvents) presented anti-inflammatory activity. Overall, the results obtained in this work contribute to the study of alternative solvents that could potentially be used also as formulation media, highlighting the importance of walnut leaves as a source of bioactive compounds. alkanediols glycerol phenolic compounds <i<Juglans regia</i< L. cytotoxicity anti-inflammatory activity Organic chemistry Ricardo C. Calhelha verfasserin aut Lillian Barros verfasserin aut João A. P. Coutinho verfasserin aut Isabel C. F. R. Ferreira verfasserin aut Olga Ferreira verfasserin aut In Molecules MDPI AG, 2003 25(2020), 11, p 2497 (DE-627)311313132 (DE-600)2008644-1 14203049 nnns volume:25 year:2020 number:11, p 2497 https://doi.org/10.3390/molecules25112497 kostenfrei https://doaj.org/article/10081447a7984140aad6f3abffc99640 kostenfrei https://www.mdpi.com/1420-3049/25/11/2497 kostenfrei https://doaj.org/toc/1420-3049 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2005 GBV_ILN_2009 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2055 GBV_ILN_2111 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 25 2020 11, p 2497
spelling	10.3390/molecules25112497 doi (DE-627)DOAJ045412952 (DE-599)DOAJ10081447a7984140aad6f3abffc99640 DE-627 ger DE-627 rakwb eng QD241-441 Vanessa Vieira verfasserin aut Insights on the Extraction Performance of Alkanediols and Glycerol: Using <i<Juglans regia</i< L. Leaves as a Source of Bioactive Compounds 2020 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Glycerol and alkanediols are being studied as alternative solvents to extract phytochemicals from plant material, often as hydrogen bond donors in deep eutectic solvents (DESs). Many of those alcohols are liquid at room temperature, yet studies of their use as extraction solvents are scarce. In this work, glycerol and a series of alkanediols (1,2-ethanediol, 1,2-propanediol, 1,3-propanediol, 1,3-butanediol, 1,2-pentanediol, 1,5-pentanediol, and 1,2-hexanediol) were studied for the extraction of phenolic compounds from <i<Juglans regia</i< L. leaves, a rich source of this class of bioactive compounds. The extraction yield was quantified, and the bioactivity of both extracts and pure solvents was evaluated by measuring the anti-inflammatory and cytotoxic activities. The solvents showing the best combined results were 1,2 and 1,3-propanediol, as their extracts presented a high amount of phenolic compounds, close to the results of ethanol, and similar cytotoxicity against cervical carcinoma cells, with no impact on non-tumor porcine liver cells in the studied concentration range. On the other hand, none of the extracts (and solvents) presented anti-inflammatory activity. Overall, the results obtained in this work contribute to the study of alternative solvents that could potentially be used also as formulation media, highlighting the importance of walnut leaves as a source of bioactive compounds. alkanediols glycerol phenolic compounds <i<Juglans regia</i< L. cytotoxicity anti-inflammatory activity Organic chemistry Ricardo C. Calhelha verfasserin aut Lillian Barros verfasserin aut João A. P. Coutinho verfasserin aut Isabel C. F. R. Ferreira verfasserin aut Olga Ferreira verfasserin aut In Molecules MDPI AG, 2003 25(2020), 11, p 2497 (DE-627)311313132 (DE-600)2008644-1 14203049 nnns volume:25 year:2020 number:11, p 2497 https://doi.org/10.3390/molecules25112497 kostenfrei https://doaj.org/article/10081447a7984140aad6f3abffc99640 kostenfrei https://www.mdpi.com/1420-3049/25/11/2497 kostenfrei https://doaj.org/toc/1420-3049 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2005 GBV_ILN_2009 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2055 GBV_ILN_2111 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 25 2020 11, p 2497
allfields_unstemmed	10.3390/molecules25112497 doi (DE-627)DOAJ045412952 (DE-599)DOAJ10081447a7984140aad6f3abffc99640 DE-627 ger DE-627 rakwb eng QD241-441 Vanessa Vieira verfasserin aut Insights on the Extraction Performance of Alkanediols and Glycerol: Using <i<Juglans regia</i< L. Leaves as a Source of Bioactive Compounds 2020 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Glycerol and alkanediols are being studied as alternative solvents to extract phytochemicals from plant material, often as hydrogen bond donors in deep eutectic solvents (DESs). Many of those alcohols are liquid at room temperature, yet studies of their use as extraction solvents are scarce. In this work, glycerol and a series of alkanediols (1,2-ethanediol, 1,2-propanediol, 1,3-propanediol, 1,3-butanediol, 1,2-pentanediol, 1,5-pentanediol, and 1,2-hexanediol) were studied for the extraction of phenolic compounds from <i<Juglans regia</i< L. leaves, a rich source of this class of bioactive compounds. The extraction yield was quantified, and the bioactivity of both extracts and pure solvents was evaluated by measuring the anti-inflammatory and cytotoxic activities. The solvents showing the best combined results were 1,2 and 1,3-propanediol, as their extracts presented a high amount of phenolic compounds, close to the results of ethanol, and similar cytotoxicity against cervical carcinoma cells, with no impact on non-tumor porcine liver cells in the studied concentration range. On the other hand, none of the extracts (and solvents) presented anti-inflammatory activity. Overall, the results obtained in this work contribute to the study of alternative solvents that could potentially be used also as formulation media, highlighting the importance of walnut leaves as a source of bioactive compounds. alkanediols glycerol phenolic compounds <i<Juglans regia</i< L. cytotoxicity anti-inflammatory activity Organic chemistry Ricardo C. Calhelha verfasserin aut Lillian Barros verfasserin aut João A. P. Coutinho verfasserin aut Isabel C. F. R. Ferreira verfasserin aut Olga Ferreira verfasserin aut In Molecules MDPI AG, 2003 25(2020), 11, p 2497 (DE-627)311313132 (DE-600)2008644-1 14203049 nnns volume:25 year:2020 number:11, p 2497 https://doi.org/10.3390/molecules25112497 kostenfrei https://doaj.org/article/10081447a7984140aad6f3abffc99640 kostenfrei https://www.mdpi.com/1420-3049/25/11/2497 kostenfrei https://doaj.org/toc/1420-3049 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2005 GBV_ILN_2009 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2055 GBV_ILN_2111 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 25 2020 11, p 2497
allfieldsGer	10.3390/molecules25112497 doi (DE-627)DOAJ045412952 (DE-599)DOAJ10081447a7984140aad6f3abffc99640 DE-627 ger DE-627 rakwb eng QD241-441 Vanessa Vieira verfasserin aut Insights on the Extraction Performance of Alkanediols and Glycerol: Using <i<Juglans regia</i< L. Leaves as a Source of Bioactive Compounds 2020 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Glycerol and alkanediols are being studied as alternative solvents to extract phytochemicals from plant material, often as hydrogen bond donors in deep eutectic solvents (DESs). Many of those alcohols are liquid at room temperature, yet studies of their use as extraction solvents are scarce. In this work, glycerol and a series of alkanediols (1,2-ethanediol, 1,2-propanediol, 1,3-propanediol, 1,3-butanediol, 1,2-pentanediol, 1,5-pentanediol, and 1,2-hexanediol) were studied for the extraction of phenolic compounds from <i<Juglans regia</i< L. leaves, a rich source of this class of bioactive compounds. The extraction yield was quantified, and the bioactivity of both extracts and pure solvents was evaluated by measuring the anti-inflammatory and cytotoxic activities. The solvents showing the best combined results were 1,2 and 1,3-propanediol, as their extracts presented a high amount of phenolic compounds, close to the results of ethanol, and similar cytotoxicity against cervical carcinoma cells, with no impact on non-tumor porcine liver cells in the studied concentration range. On the other hand, none of the extracts (and solvents) presented anti-inflammatory activity. Overall, the results obtained in this work contribute to the study of alternative solvents that could potentially be used also as formulation media, highlighting the importance of walnut leaves as a source of bioactive compounds. alkanediols glycerol phenolic compounds <i<Juglans regia</i< L. cytotoxicity anti-inflammatory activity Organic chemistry Ricardo C. Calhelha verfasserin aut Lillian Barros verfasserin aut João A. P. Coutinho verfasserin aut Isabel C. F. R. Ferreira verfasserin aut Olga Ferreira verfasserin aut In Molecules MDPI AG, 2003 25(2020), 11, p 2497 (DE-627)311313132 (DE-600)2008644-1 14203049 nnns volume:25 year:2020 number:11, p 2497 https://doi.org/10.3390/molecules25112497 kostenfrei https://doaj.org/article/10081447a7984140aad6f3abffc99640 kostenfrei https://www.mdpi.com/1420-3049/25/11/2497 kostenfrei https://doaj.org/toc/1420-3049 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2005 GBV_ILN_2009 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2055 GBV_ILN_2111 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 25 2020 11, p 2497
allfieldsSound	10.3390/molecules25112497 doi (DE-627)DOAJ045412952 (DE-599)DOAJ10081447a7984140aad6f3abffc99640 DE-627 ger DE-627 rakwb eng QD241-441 Vanessa Vieira verfasserin aut Insights on the Extraction Performance of Alkanediols and Glycerol: Using <i<Juglans regia</i< L. Leaves as a Source of Bioactive Compounds 2020 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Glycerol and alkanediols are being studied as alternative solvents to extract phytochemicals from plant material, often as hydrogen bond donors in deep eutectic solvents (DESs). Many of those alcohols are liquid at room temperature, yet studies of their use as extraction solvents are scarce. In this work, glycerol and a series of alkanediols (1,2-ethanediol, 1,2-propanediol, 1,3-propanediol, 1,3-butanediol, 1,2-pentanediol, 1,5-pentanediol, and 1,2-hexanediol) were studied for the extraction of phenolic compounds from <i<Juglans regia</i< L. leaves, a rich source of this class of bioactive compounds. The extraction yield was quantified, and the bioactivity of both extracts and pure solvents was evaluated by measuring the anti-inflammatory and cytotoxic activities. The solvents showing the best combined results were 1,2 and 1,3-propanediol, as their extracts presented a high amount of phenolic compounds, close to the results of ethanol, and similar cytotoxicity against cervical carcinoma cells, with no impact on non-tumor porcine liver cells in the studied concentration range. On the other hand, none of the extracts (and solvents) presented anti-inflammatory activity. Overall, the results obtained in this work contribute to the study of alternative solvents that could potentially be used also as formulation media, highlighting the importance of walnut leaves as a source of bioactive compounds. alkanediols glycerol phenolic compounds <i<Juglans regia</i< L. cytotoxicity anti-inflammatory activity Organic chemistry Ricardo C. Calhelha verfasserin aut Lillian Barros verfasserin aut João A. P. Coutinho verfasserin aut Isabel C. F. R. Ferreira verfasserin aut Olga Ferreira verfasserin aut In Molecules MDPI AG, 2003 25(2020), 11, p 2497 (DE-627)311313132 (DE-600)2008644-1 14203049 nnns volume:25 year:2020 number:11, p 2497 https://doi.org/10.3390/molecules25112497 kostenfrei https://doaj.org/article/10081447a7984140aad6f3abffc99640 kostenfrei https://www.mdpi.com/1420-3049/25/11/2497 kostenfrei https://doaj.org/toc/1420-3049 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2005 GBV_ILN_2009 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2055 GBV_ILN_2111 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 25 2020 11, p 2497
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callnumber-first	Q - Science
author	Vanessa Vieira
spellingShingle	Vanessa Vieira misc QD241-441 misc alkanediols misc glycerol misc phenolic compounds misc <i<Juglans regia</i< L. misc cytotoxicity misc anti-inflammatory activity misc Organic chemistry Insights on the Extraction Performance of Alkanediols and Glycerol: Using <i<Juglans regia</i< L. Leaves as a Source of Bioactive Compounds
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topic_title	QD241-441 Insights on the Extraction Performance of Alkanediols and Glycerol: Using <i<Juglans regia</i< L. Leaves as a Source of Bioactive Compounds alkanediols glycerol phenolic compounds <i<Juglans regia</i< L. cytotoxicity anti-inflammatory activity
topic	misc QD241-441 misc alkanediols misc glycerol misc phenolic compounds misc <i<Juglans regia</i< L. misc cytotoxicity misc anti-inflammatory activity misc Organic chemistry
topic_unstemmed	misc QD241-441 misc alkanediols misc glycerol misc phenolic compounds misc <i<Juglans regia</i< L. misc cytotoxicity misc anti-inflammatory activity misc Organic chemistry
topic_browse	misc QD241-441 misc alkanediols misc glycerol misc phenolic compounds misc <i<Juglans regia</i< L. misc cytotoxicity misc anti-inflammatory activity misc Organic chemistry
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title	Insights on the Extraction Performance of Alkanediols and Glycerol: Using <i<Juglans regia</i< L. Leaves as a Source of Bioactive Compounds
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title_full	Insights on the Extraction Performance of Alkanediols and Glycerol: Using <i<Juglans regia</i< L. Leaves as a Source of Bioactive Compounds
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author_browse	Vanessa Vieira Ricardo C. Calhelha Lillian Barros João A. P. Coutinho Isabel C. F. R. Ferreira Olga Ferreira
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title_sort	insights on the extraction performance of alkanediols and glycerol: using <i<juglans regia</i< l. leaves as a source of bioactive compounds
callnumber	QD241-441
title_auth	Insights on the Extraction Performance of Alkanediols and Glycerol: Using <i<Juglans regia</i< L. Leaves as a Source of Bioactive Compounds
abstract	Glycerol and alkanediols are being studied as alternative solvents to extract phytochemicals from plant material, often as hydrogen bond donors in deep eutectic solvents (DESs). Many of those alcohols are liquid at room temperature, yet studies of their use as extraction solvents are scarce. In this work, glycerol and a series of alkanediols (1,2-ethanediol, 1,2-propanediol, 1,3-propanediol, 1,3-butanediol, 1,2-pentanediol, 1,5-pentanediol, and 1,2-hexanediol) were studied for the extraction of phenolic compounds from <i<Juglans regia</i< L. leaves, a rich source of this class of bioactive compounds. The extraction yield was quantified, and the bioactivity of both extracts and pure solvents was evaluated by measuring the anti-inflammatory and cytotoxic activities. The solvents showing the best combined results were 1,2 and 1,3-propanediol, as their extracts presented a high amount of phenolic compounds, close to the results of ethanol, and similar cytotoxicity against cervical carcinoma cells, with no impact on non-tumor porcine liver cells in the studied concentration range. On the other hand, none of the extracts (and solvents) presented anti-inflammatory activity. Overall, the results obtained in this work contribute to the study of alternative solvents that could potentially be used also as formulation media, highlighting the importance of walnut leaves as a source of bioactive compounds.
abstractGer	Glycerol and alkanediols are being studied as alternative solvents to extract phytochemicals from plant material, often as hydrogen bond donors in deep eutectic solvents (DESs). Many of those alcohols are liquid at room temperature, yet studies of their use as extraction solvents are scarce. In this work, glycerol and a series of alkanediols (1,2-ethanediol, 1,2-propanediol, 1,3-propanediol, 1,3-butanediol, 1,2-pentanediol, 1,5-pentanediol, and 1,2-hexanediol) were studied for the extraction of phenolic compounds from <i<Juglans regia</i< L. leaves, a rich source of this class of bioactive compounds. The extraction yield was quantified, and the bioactivity of both extracts and pure solvents was evaluated by measuring the anti-inflammatory and cytotoxic activities. The solvents showing the best combined results were 1,2 and 1,3-propanediol, as their extracts presented a high amount of phenolic compounds, close to the results of ethanol, and similar cytotoxicity against cervical carcinoma cells, with no impact on non-tumor porcine liver cells in the studied concentration range. On the other hand, none of the extracts (and solvents) presented anti-inflammatory activity. Overall, the results obtained in this work contribute to the study of alternative solvents that could potentially be used also as formulation media, highlighting the importance of walnut leaves as a source of bioactive compounds.
abstract_unstemmed	Glycerol and alkanediols are being studied as alternative solvents to extract phytochemicals from plant material, often as hydrogen bond donors in deep eutectic solvents (DESs). Many of those alcohols are liquid at room temperature, yet studies of their use as extraction solvents are scarce. In this work, glycerol and a series of alkanediols (1,2-ethanediol, 1,2-propanediol, 1,3-propanediol, 1,3-butanediol, 1,2-pentanediol, 1,5-pentanediol, and 1,2-hexanediol) were studied for the extraction of phenolic compounds from <i<Juglans regia</i< L. leaves, a rich source of this class of bioactive compounds. The extraction yield was quantified, and the bioactivity of both extracts and pure solvents was evaluated by measuring the anti-inflammatory and cytotoxic activities. The solvents showing the best combined results were 1,2 and 1,3-propanediol, as their extracts presented a high amount of phenolic compounds, close to the results of ethanol, and similar cytotoxicity against cervical carcinoma cells, with no impact on non-tumor porcine liver cells in the studied concentration range. On the other hand, none of the extracts (and solvents) presented anti-inflammatory activity. Overall, the results obtained in this work contribute to the study of alternative solvents that could potentially be used also as formulation media, highlighting the importance of walnut leaves as a source of bioactive compounds.
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container_issue	11, p 2497
title_short	Insights on the Extraction Performance of Alkanediols and Glycerol: Using <i<Juglans regia</i< L. Leaves as a Source of Bioactive Compounds
url	https://doi.org/10.3390/molecules25112497 https://doaj.org/article/10081447a7984140aad6f3abffc99640 https://www.mdpi.com/1420-3049/25/11/2497 https://doaj.org/toc/1420-3049
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Insights on the Extraction Performance of Alkanediols and Glycerol: Using <i<Juglans regia</i< L. Leaves as a Source of Bioactive Compounds

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