Application and design of esterase-responsive nanoparticles for cancer therapy

Nanoparticles have been developed for tumor treatment due to the enhanced permeability and retention effects. However, lack of specific cancer cells selectivity results in low delivery efficiency and undesired side effects. In that case, the stimuli-responsive nanoparticles system designed for the s...
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Autor*in:	Haonan Dong [verfasserIn] Long Pang [verfasserIn] Hailin Cong [verfasserIn] Youqing Shen [verfasserIn] Bing Yu [verfasserIn]

Format:	E-Artikel
Sprache:	Englisch

Erschienen:	2019

Schlagwörter:	esterase-responsive nanoparticles drug carriers gene therapy photosensitizers fluorescent imaging

Übergeordnetes Werk:	In: Drug Delivery - Taylor & Francis Group, 2017, 26(2019), 1, Seite 416-432
Übergeordnetes Werk:	volume:26 ; year:2019 ; number:1 ; pages:416-432

Links:	Link aufrufen Link aufrufen Link aufrufen Journal toc Journal toc

DOI / URN:	10.1080/10717544.2019.1588424

Katalog-ID:	DOAJ045421757

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source	In Drug Delivery 26(2019), 1, Seite 416-432 volume:26 year:2019 number:1 pages:416-432
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authorswithroles_txt_mv	Haonan Dong @@aut@@ Long Pang @@aut@@ Hailin Cong @@aut@@ Youqing Shen @@aut@@ Bing Yu @@aut@@
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author	Haonan Dong
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topic	misc RM1-950 misc esterase-responsive nanoparticles misc drug carriers misc gene therapy misc photosensitizers misc fluorescent imaging misc Therapeutics. Pharmacology
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title	Application and design of esterase-responsive nanoparticles for cancer therapy
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title_sort	application and design of esterase-responsive nanoparticles for cancer therapy
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title_auth	Application and design of esterase-responsive nanoparticles for cancer therapy
abstract	Nanoparticles have been developed for tumor treatment due to the enhanced permeability and retention effects. However, lack of specific cancer cells selectivity results in low delivery efficiency and undesired side effects. In that case, the stimuli-responsive nanoparticles system designed for the specific structure and physicochemical properties of tumors have attracted more and more attention of researchers. Esterase-responsive nanoparticle system is widely used due to the overexpressed esterase in tumor cells. For a rational designed esterase-responsive nanoparticle, ester bonds and nanoparticle structures are the key characters. In this review, we overviewed the design of esterase-responsive nanoparticles, including ester bonds design and nano-structure design, and analyzed the fitness of each design for different application. In the end, the outlook of esterase-responsive nanoparticle is looking forward.
abstractGer	Nanoparticles have been developed for tumor treatment due to the enhanced permeability and retention effects. However, lack of specific cancer cells selectivity results in low delivery efficiency and undesired side effects. In that case, the stimuli-responsive nanoparticles system designed for the specific structure and physicochemical properties of tumors have attracted more and more attention of researchers. Esterase-responsive nanoparticle system is widely used due to the overexpressed esterase in tumor cells. For a rational designed esterase-responsive nanoparticle, ester bonds and nanoparticle structures are the key characters. In this review, we overviewed the design of esterase-responsive nanoparticles, including ester bonds design and nano-structure design, and analyzed the fitness of each design for different application. In the end, the outlook of esterase-responsive nanoparticle is looking forward.
abstract_unstemmed	Nanoparticles have been developed for tumor treatment due to the enhanced permeability and retention effects. However, lack of specific cancer cells selectivity results in low delivery efficiency and undesired side effects. In that case, the stimuli-responsive nanoparticles system designed for the specific structure and physicochemical properties of tumors have attracted more and more attention of researchers. Esterase-responsive nanoparticle system is widely used due to the overexpressed esterase in tumor cells. For a rational designed esterase-responsive nanoparticle, ester bonds and nanoparticle structures are the key characters. In this review, we overviewed the design of esterase-responsive nanoparticles, including ester bonds design and nano-structure design, and analyzed the fitness of each design for different application. In the end, the outlook of esterase-responsive nanoparticle is looking forward.
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title_short	Application and design of esterase-responsive nanoparticles for cancer therapy
url	https://doi.org/10.1080/10717544.2019.1588424 https://doaj.org/article/f9684ff5cb014d1d943575c139894d3a http://dx.doi.org/10.1080/10717544.2019.1588424 https://doaj.org/toc/1071-7544 https://doaj.org/toc/1521-0464
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Application and design of esterase-responsive nanoparticles for cancer therapy

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