A few-layer graphene/chlorin e6 hybrid nanomaterial and its application in photodynamic therapy against Candida albicans

The global emergence of multidrug resistance of fungal infections and the decline in the discovery of new antibiotics are increasingly prevalent causes of hospital-acquired infections, among other major challenges in the global health care sector. There is an urgent need to develop noninvasive, nont...
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Autor*in:	Selene Acosta [verfasserIn] Carlos Moreno-Aguilar [verfasserIn] Dania Hernández-Sánchez [verfasserIn] Beatriz Morales-Cruzado [verfasserIn] Erick Sarmiento-Gomez [verfasserIn] Carla Bittencourt [verfasserIn] Luis Octavio Sánchez-Vargas [verfasserIn] Mildred Quintana [verfasserIn]

Format:	E-Artikel
Sprache:	Englisch

Erschienen:	2020

Schlagwörter:	chlorin e6 few-layer graphene (flg) hybrid nanomaterial photodynamic therapy (pdt) photosensitizer

Übergeordnetes Werk:	In: Beilstein Journal of Nanotechnology - Beilstein-Institut, 2012, 11(2020), 1, Seite 1054-1061
Übergeordnetes Werk:	volume:11 ; year:2020 ; number:1 ; pages:1054-1061

Links:	Link aufrufen Link aufrufen Link aufrufen Journal toc

DOI / URN:	10.3762/bjnano.11.90

Katalog-ID:	DOAJ045427836

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allfields	10.3762/bjnano.11.90 doi (DE-627)DOAJ045427836 (DE-599)DOAJa7d67c01d11b46eba89b5b7854c92477 DE-627 ger DE-627 rakwb eng TP1-1185 QC1-999 Selene Acosta verfasserin aut A few-layer graphene/chlorin e6 hybrid nanomaterial and its application in photodynamic therapy against Candida albicans 2020 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier The global emergence of multidrug resistance of fungal infections and the decline in the discovery of new antibiotics are increasingly prevalent causes of hospital-acquired infections, among other major challenges in the global health care sector. There is an urgent need to develop noninvasive, nontoxic, and new antinosocomial approaches that work more effectively and faster than current antibiotics. In this work, we report on a biocompatible hybrid nanomaterial composed of few-layer graphene and chlorin e6 (FLG-Ce6) for the photodynamic treatment (PDT) of Candida albicans. We show that the FLG-Ce6 hybrid nanomaterial displays enhanced reactive oxygen species (ROS) generation compared with Ce6. The enhancement is up to 5-fold when irradiated for 15 min at 632 nm with a red light-emitting diode (LED). The viability of C. albicans in the presence of FLG-Ce6 was measured 48 h after photoactivation. An antifungal effect was observed only when the culture/FLG-Ce6 hybrid was exposed to the light source. C. albicans is rendered completely unviable after exposure to ROS generated by the excited FLG-Ce6 hybrid nanomaterial. An increased PDT effect was observed with the FLG-Ce6 hybrid nanomaterial by a significant reduction in the viability of C. albicans, by up to 95%. This is a marked improvement compared to Ce6 without FLG, which reduces the viability of C. albicans to only 10%. The antifungal action of the hybrid nanomaterial can be activated by a synergistic mechanism of energy transfer of the absorbed light from Ce6 to FLG. The novel FLG-Ce6 hybrid nanomaterial in combination with the red LED light irradiation can be used in the development of a wide range of antinosocomial devices and coatings. chlorin e6 few-layer graphene (flg) hybrid nanomaterial photodynamic therapy (pdt) photosensitizer Technology T Chemical technology Science Q Physics Carlos Moreno-Aguilar verfasserin aut Dania Hernández-Sánchez verfasserin aut Beatriz Morales-Cruzado verfasserin aut Erick Sarmiento-Gomez verfasserin aut Carla Bittencourt verfasserin aut Luis Octavio Sánchez-Vargas verfasserin aut Mildred Quintana verfasserin aut In Beilstein Journal of Nanotechnology Beilstein-Institut, 2012 11(2020), 1, Seite 1054-1061 (DE-627)640860400 (DE-600)2583584-1 21904286 nnns volume:11 year:2020 number:1 pages:1054-1061 https://doi.org/10.3762/bjnano.11.90 kostenfrei https://doaj.org/article/a7d67c01d11b46eba89b5b7854c92477 kostenfrei https://doi.org/10.3762/bjnano.11.90 kostenfrei https://doaj.org/toc/2190-4286 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ SSG-OLC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_213 GBV_ILN_230 GBV_ILN_267 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4335 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 11 2020 1 1054-1061
spelling	10.3762/bjnano.11.90 doi (DE-627)DOAJ045427836 (DE-599)DOAJa7d67c01d11b46eba89b5b7854c92477 DE-627 ger DE-627 rakwb eng TP1-1185 QC1-999 Selene Acosta verfasserin aut A few-layer graphene/chlorin e6 hybrid nanomaterial and its application in photodynamic therapy against Candida albicans 2020 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier The global emergence of multidrug resistance of fungal infections and the decline in the discovery of new antibiotics are increasingly prevalent causes of hospital-acquired infections, among other major challenges in the global health care sector. There is an urgent need to develop noninvasive, nontoxic, and new antinosocomial approaches that work more effectively and faster than current antibiotics. In this work, we report on a biocompatible hybrid nanomaterial composed of few-layer graphene and chlorin e6 (FLG-Ce6) for the photodynamic treatment (PDT) of Candida albicans. We show that the FLG-Ce6 hybrid nanomaterial displays enhanced reactive oxygen species (ROS) generation compared with Ce6. The enhancement is up to 5-fold when irradiated for 15 min at 632 nm with a red light-emitting diode (LED). The viability of C. albicans in the presence of FLG-Ce6 was measured 48 h after photoactivation. An antifungal effect was observed only when the culture/FLG-Ce6 hybrid was exposed to the light source. C. albicans is rendered completely unviable after exposure to ROS generated by the excited FLG-Ce6 hybrid nanomaterial. An increased PDT effect was observed with the FLG-Ce6 hybrid nanomaterial by a significant reduction in the viability of C. albicans, by up to 95%. This is a marked improvement compared to Ce6 without FLG, which reduces the viability of C. albicans to only 10%. The antifungal action of the hybrid nanomaterial can be activated by a synergistic mechanism of energy transfer of the absorbed light from Ce6 to FLG. The novel FLG-Ce6 hybrid nanomaterial in combination with the red LED light irradiation can be used in the development of a wide range of antinosocomial devices and coatings. chlorin e6 few-layer graphene (flg) hybrid nanomaterial photodynamic therapy (pdt) photosensitizer Technology T Chemical technology Science Q Physics Carlos Moreno-Aguilar verfasserin aut Dania Hernández-Sánchez verfasserin aut Beatriz Morales-Cruzado verfasserin aut Erick Sarmiento-Gomez verfasserin aut Carla Bittencourt verfasserin aut Luis Octavio Sánchez-Vargas verfasserin aut Mildred Quintana verfasserin aut In Beilstein Journal of Nanotechnology Beilstein-Institut, 2012 11(2020), 1, Seite 1054-1061 (DE-627)640860400 (DE-600)2583584-1 21904286 nnns volume:11 year:2020 number:1 pages:1054-1061 https://doi.org/10.3762/bjnano.11.90 kostenfrei https://doaj.org/article/a7d67c01d11b46eba89b5b7854c92477 kostenfrei https://doi.org/10.3762/bjnano.11.90 kostenfrei https://doaj.org/toc/2190-4286 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ SSG-OLC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_213 GBV_ILN_230 GBV_ILN_267 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4335 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 11 2020 1 1054-1061
allfields_unstemmed	10.3762/bjnano.11.90 doi (DE-627)DOAJ045427836 (DE-599)DOAJa7d67c01d11b46eba89b5b7854c92477 DE-627 ger DE-627 rakwb eng TP1-1185 QC1-999 Selene Acosta verfasserin aut A few-layer graphene/chlorin e6 hybrid nanomaterial and its application in photodynamic therapy against Candida albicans 2020 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier The global emergence of multidrug resistance of fungal infections and the decline in the discovery of new antibiotics are increasingly prevalent causes of hospital-acquired infections, among other major challenges in the global health care sector. There is an urgent need to develop noninvasive, nontoxic, and new antinosocomial approaches that work more effectively and faster than current antibiotics. In this work, we report on a biocompatible hybrid nanomaterial composed of few-layer graphene and chlorin e6 (FLG-Ce6) for the photodynamic treatment (PDT) of Candida albicans. We show that the FLG-Ce6 hybrid nanomaterial displays enhanced reactive oxygen species (ROS) generation compared with Ce6. The enhancement is up to 5-fold when irradiated for 15 min at 632 nm with a red light-emitting diode (LED). The viability of C. albicans in the presence of FLG-Ce6 was measured 48 h after photoactivation. An antifungal effect was observed only when the culture/FLG-Ce6 hybrid was exposed to the light source. C. albicans is rendered completely unviable after exposure to ROS generated by the excited FLG-Ce6 hybrid nanomaterial. An increased PDT effect was observed with the FLG-Ce6 hybrid nanomaterial by a significant reduction in the viability of C. albicans, by up to 95%. This is a marked improvement compared to Ce6 without FLG, which reduces the viability of C. albicans to only 10%. The antifungal action of the hybrid nanomaterial can be activated by a synergistic mechanism of energy transfer of the absorbed light from Ce6 to FLG. The novel FLG-Ce6 hybrid nanomaterial in combination with the red LED light irradiation can be used in the development of a wide range of antinosocomial devices and coatings. chlorin e6 few-layer graphene (flg) hybrid nanomaterial photodynamic therapy (pdt) photosensitizer Technology T Chemical technology Science Q Physics Carlos Moreno-Aguilar verfasserin aut Dania Hernández-Sánchez verfasserin aut Beatriz Morales-Cruzado verfasserin aut Erick Sarmiento-Gomez verfasserin aut Carla Bittencourt verfasserin aut Luis Octavio Sánchez-Vargas verfasserin aut Mildred Quintana verfasserin aut In Beilstein Journal of Nanotechnology Beilstein-Institut, 2012 11(2020), 1, Seite 1054-1061 (DE-627)640860400 (DE-600)2583584-1 21904286 nnns volume:11 year:2020 number:1 pages:1054-1061 https://doi.org/10.3762/bjnano.11.90 kostenfrei https://doaj.org/article/a7d67c01d11b46eba89b5b7854c92477 kostenfrei https://doi.org/10.3762/bjnano.11.90 kostenfrei https://doaj.org/toc/2190-4286 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ SSG-OLC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_213 GBV_ILN_230 GBV_ILN_267 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4335 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 11 2020 1 1054-1061
allfieldsGer	10.3762/bjnano.11.90 doi (DE-627)DOAJ045427836 (DE-599)DOAJa7d67c01d11b46eba89b5b7854c92477 DE-627 ger DE-627 rakwb eng TP1-1185 QC1-999 Selene Acosta verfasserin aut A few-layer graphene/chlorin e6 hybrid nanomaterial and its application in photodynamic therapy against Candida albicans 2020 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier The global emergence of multidrug resistance of fungal infections and the decline in the discovery of new antibiotics are increasingly prevalent causes of hospital-acquired infections, among other major challenges in the global health care sector. There is an urgent need to develop noninvasive, nontoxic, and new antinosocomial approaches that work more effectively and faster than current antibiotics. In this work, we report on a biocompatible hybrid nanomaterial composed of few-layer graphene and chlorin e6 (FLG-Ce6) for the photodynamic treatment (PDT) of Candida albicans. We show that the FLG-Ce6 hybrid nanomaterial displays enhanced reactive oxygen species (ROS) generation compared with Ce6. The enhancement is up to 5-fold when irradiated for 15 min at 632 nm with a red light-emitting diode (LED). The viability of C. albicans in the presence of FLG-Ce6 was measured 48 h after photoactivation. An antifungal effect was observed only when the culture/FLG-Ce6 hybrid was exposed to the light source. C. albicans is rendered completely unviable after exposure to ROS generated by the excited FLG-Ce6 hybrid nanomaterial. An increased PDT effect was observed with the FLG-Ce6 hybrid nanomaterial by a significant reduction in the viability of C. albicans, by up to 95%. This is a marked improvement compared to Ce6 without FLG, which reduces the viability of C. albicans to only 10%. The antifungal action of the hybrid nanomaterial can be activated by a synergistic mechanism of energy transfer of the absorbed light from Ce6 to FLG. The novel FLG-Ce6 hybrid nanomaterial in combination with the red LED light irradiation can be used in the development of a wide range of antinosocomial devices and coatings. chlorin e6 few-layer graphene (flg) hybrid nanomaterial photodynamic therapy (pdt) photosensitizer Technology T Chemical technology Science Q Physics Carlos Moreno-Aguilar verfasserin aut Dania Hernández-Sánchez verfasserin aut Beatriz Morales-Cruzado verfasserin aut Erick Sarmiento-Gomez verfasserin aut Carla Bittencourt verfasserin aut Luis Octavio Sánchez-Vargas verfasserin aut Mildred Quintana verfasserin aut In Beilstein Journal of Nanotechnology Beilstein-Institut, 2012 11(2020), 1, Seite 1054-1061 (DE-627)640860400 (DE-600)2583584-1 21904286 nnns volume:11 year:2020 number:1 pages:1054-1061 https://doi.org/10.3762/bjnano.11.90 kostenfrei https://doaj.org/article/a7d67c01d11b46eba89b5b7854c92477 kostenfrei https://doi.org/10.3762/bjnano.11.90 kostenfrei https://doaj.org/toc/2190-4286 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ SSG-OLC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_213 GBV_ILN_230 GBV_ILN_267 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4335 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 11 2020 1 1054-1061
allfieldsSound	10.3762/bjnano.11.90 doi (DE-627)DOAJ045427836 (DE-599)DOAJa7d67c01d11b46eba89b5b7854c92477 DE-627 ger DE-627 rakwb eng TP1-1185 QC1-999 Selene Acosta verfasserin aut A few-layer graphene/chlorin e6 hybrid nanomaterial and its application in photodynamic therapy against Candida albicans 2020 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier The global emergence of multidrug resistance of fungal infections and the decline in the discovery of new antibiotics are increasingly prevalent causes of hospital-acquired infections, among other major challenges in the global health care sector. There is an urgent need to develop noninvasive, nontoxic, and new antinosocomial approaches that work more effectively and faster than current antibiotics. In this work, we report on a biocompatible hybrid nanomaterial composed of few-layer graphene and chlorin e6 (FLG-Ce6) for the photodynamic treatment (PDT) of Candida albicans. We show that the FLG-Ce6 hybrid nanomaterial displays enhanced reactive oxygen species (ROS) generation compared with Ce6. The enhancement is up to 5-fold when irradiated for 15 min at 632 nm with a red light-emitting diode (LED). The viability of C. albicans in the presence of FLG-Ce6 was measured 48 h after photoactivation. An antifungal effect was observed only when the culture/FLG-Ce6 hybrid was exposed to the light source. C. albicans is rendered completely unviable after exposure to ROS generated by the excited FLG-Ce6 hybrid nanomaterial. An increased PDT effect was observed with the FLG-Ce6 hybrid nanomaterial by a significant reduction in the viability of C. albicans, by up to 95%. This is a marked improvement compared to Ce6 without FLG, which reduces the viability of C. albicans to only 10%. The antifungal action of the hybrid nanomaterial can be activated by a synergistic mechanism of energy transfer of the absorbed light from Ce6 to FLG. The novel FLG-Ce6 hybrid nanomaterial in combination with the red LED light irradiation can be used in the development of a wide range of antinosocomial devices and coatings. chlorin e6 few-layer graphene (flg) hybrid nanomaterial photodynamic therapy (pdt) photosensitizer Technology T Chemical technology Science Q Physics Carlos Moreno-Aguilar verfasserin aut Dania Hernández-Sánchez verfasserin aut Beatriz Morales-Cruzado verfasserin aut Erick Sarmiento-Gomez verfasserin aut Carla Bittencourt verfasserin aut Luis Octavio Sánchez-Vargas verfasserin aut Mildred Quintana verfasserin aut In Beilstein Journal of Nanotechnology Beilstein-Institut, 2012 11(2020), 1, Seite 1054-1061 (DE-627)640860400 (DE-600)2583584-1 21904286 nnns volume:11 year:2020 number:1 pages:1054-1061 https://doi.org/10.3762/bjnano.11.90 kostenfrei https://doaj.org/article/a7d67c01d11b46eba89b5b7854c92477 kostenfrei https://doi.org/10.3762/bjnano.11.90 kostenfrei https://doaj.org/toc/2190-4286 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ SSG-OLC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_213 GBV_ILN_230 GBV_ILN_267 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4335 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 11 2020 1 1054-1061
language	English
source	In Beilstein Journal of Nanotechnology 11(2020), 1, Seite 1054-1061 volume:11 year:2020 number:1 pages:1054-1061
sourceStr	In Beilstein Journal of Nanotechnology 11(2020), 1, Seite 1054-1061 volume:11 year:2020 number:1 pages:1054-1061
format_phy_str_mv	Article
institution	findex.gbv.de
topic_facet	chlorin e6 few-layer graphene (flg) hybrid nanomaterial photodynamic therapy (pdt) photosensitizer Technology T Chemical technology Science Q Physics
isfreeaccess_bool	true
container_title	Beilstein Journal of Nanotechnology
authorswithroles_txt_mv	Selene Acosta @@aut@@ Carlos Moreno-Aguilar @@aut@@ Dania Hernández-Sánchez @@aut@@ Beatriz Morales-Cruzado @@aut@@ Erick Sarmiento-Gomez @@aut@@ Carla Bittencourt @@aut@@ Luis Octavio Sánchez-Vargas @@aut@@ Mildred Quintana @@aut@@
publishDateDaySort_date	2020-01-01T00:00:00Z
hierarchy_top_id	640860400
id	DOAJ045427836
language_de	englisch
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callnumber-first	T - Technology
author	Selene Acosta
spellingShingle	Selene Acosta misc TP1-1185 misc QC1-999 misc chlorin e6 misc few-layer graphene (flg) misc hybrid nanomaterial misc photodynamic therapy (pdt) misc photosensitizer misc Technology misc T misc Chemical technology misc Science misc Q misc Physics A few-layer graphene/chlorin e6 hybrid nanomaterial and its application in photodynamic therapy against Candida albicans
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topic_title	TP1-1185 QC1-999 A few-layer graphene/chlorin e6 hybrid nanomaterial and its application in photodynamic therapy against Candida albicans chlorin e6 few-layer graphene (flg) hybrid nanomaterial photodynamic therapy (pdt) photosensitizer
topic	misc TP1-1185 misc QC1-999 misc chlorin e6 misc few-layer graphene (flg) misc hybrid nanomaterial misc photodynamic therapy (pdt) misc photosensitizer misc Technology misc T misc Chemical technology misc Science misc Q misc Physics
topic_unstemmed	misc TP1-1185 misc QC1-999 misc chlorin e6 misc few-layer graphene (flg) misc hybrid nanomaterial misc photodynamic therapy (pdt) misc photosensitizer misc Technology misc T misc Chemical technology misc Science misc Q misc Physics
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title	A few-layer graphene/chlorin e6 hybrid nanomaterial and its application in photodynamic therapy against Candida albicans
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title_full	A few-layer graphene/chlorin e6 hybrid nanomaterial and its application in photodynamic therapy against Candida albicans
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author_browse	Selene Acosta Carlos Moreno-Aguilar Dania Hernández-Sánchez Beatriz Morales-Cruzado Erick Sarmiento-Gomez Carla Bittencourt Luis Octavio Sánchez-Vargas Mildred Quintana
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title_sort	few-layer graphene/chlorin e6 hybrid nanomaterial and its application in photodynamic therapy against candida albicans
callnumber	TP1-1185
title_auth	A few-layer graphene/chlorin e6 hybrid nanomaterial and its application in photodynamic therapy against Candida albicans
abstract	The global emergence of multidrug resistance of fungal infections and the decline in the discovery of new antibiotics are increasingly prevalent causes of hospital-acquired infections, among other major challenges in the global health care sector. There is an urgent need to develop noninvasive, nontoxic, and new antinosocomial approaches that work more effectively and faster than current antibiotics. In this work, we report on a biocompatible hybrid nanomaterial composed of few-layer graphene and chlorin e6 (FLG-Ce6) for the photodynamic treatment (PDT) of Candida albicans. We show that the FLG-Ce6 hybrid nanomaterial displays enhanced reactive oxygen species (ROS) generation compared with Ce6. The enhancement is up to 5-fold when irradiated for 15 min at 632 nm with a red light-emitting diode (LED). The viability of C. albicans in the presence of FLG-Ce6 was measured 48 h after photoactivation. An antifungal effect was observed only when the culture/FLG-Ce6 hybrid was exposed to the light source. C. albicans is rendered completely unviable after exposure to ROS generated by the excited FLG-Ce6 hybrid nanomaterial. An increased PDT effect was observed with the FLG-Ce6 hybrid nanomaterial by a significant reduction in the viability of C. albicans, by up to 95%. This is a marked improvement compared to Ce6 without FLG, which reduces the viability of C. albicans to only 10%. The antifungal action of the hybrid nanomaterial can be activated by a synergistic mechanism of energy transfer of the absorbed light from Ce6 to FLG. The novel FLG-Ce6 hybrid nanomaterial in combination with the red LED light irradiation can be used in the development of a wide range of antinosocomial devices and coatings.
abstractGer	The global emergence of multidrug resistance of fungal infections and the decline in the discovery of new antibiotics are increasingly prevalent causes of hospital-acquired infections, among other major challenges in the global health care sector. There is an urgent need to develop noninvasive, nontoxic, and new antinosocomial approaches that work more effectively and faster than current antibiotics. In this work, we report on a biocompatible hybrid nanomaterial composed of few-layer graphene and chlorin e6 (FLG-Ce6) for the photodynamic treatment (PDT) of Candida albicans. We show that the FLG-Ce6 hybrid nanomaterial displays enhanced reactive oxygen species (ROS) generation compared with Ce6. The enhancement is up to 5-fold when irradiated for 15 min at 632 nm with a red light-emitting diode (LED). The viability of C. albicans in the presence of FLG-Ce6 was measured 48 h after photoactivation. An antifungal effect was observed only when the culture/FLG-Ce6 hybrid was exposed to the light source. C. albicans is rendered completely unviable after exposure to ROS generated by the excited FLG-Ce6 hybrid nanomaterial. An increased PDT effect was observed with the FLG-Ce6 hybrid nanomaterial by a significant reduction in the viability of C. albicans, by up to 95%. This is a marked improvement compared to Ce6 without FLG, which reduces the viability of C. albicans to only 10%. The antifungal action of the hybrid nanomaterial can be activated by a synergistic mechanism of energy transfer of the absorbed light from Ce6 to FLG. The novel FLG-Ce6 hybrid nanomaterial in combination with the red LED light irradiation can be used in the development of a wide range of antinosocomial devices and coatings.
abstract_unstemmed	The global emergence of multidrug resistance of fungal infections and the decline in the discovery of new antibiotics are increasingly prevalent causes of hospital-acquired infections, among other major challenges in the global health care sector. There is an urgent need to develop noninvasive, nontoxic, and new antinosocomial approaches that work more effectively and faster than current antibiotics. In this work, we report on a biocompatible hybrid nanomaterial composed of few-layer graphene and chlorin e6 (FLG-Ce6) for the photodynamic treatment (PDT) of Candida albicans. We show that the FLG-Ce6 hybrid nanomaterial displays enhanced reactive oxygen species (ROS) generation compared with Ce6. The enhancement is up to 5-fold when irradiated for 15 min at 632 nm with a red light-emitting diode (LED). The viability of C. albicans in the presence of FLG-Ce6 was measured 48 h after photoactivation. An antifungal effect was observed only when the culture/FLG-Ce6 hybrid was exposed to the light source. C. albicans is rendered completely unviable after exposure to ROS generated by the excited FLG-Ce6 hybrid nanomaterial. An increased PDT effect was observed with the FLG-Ce6 hybrid nanomaterial by a significant reduction in the viability of C. albicans, by up to 95%. This is a marked improvement compared to Ce6 without FLG, which reduces the viability of C. albicans to only 10%. The antifungal action of the hybrid nanomaterial can be activated by a synergistic mechanism of energy transfer of the absorbed light from Ce6 to FLG. The novel FLG-Ce6 hybrid nanomaterial in combination with the red LED light irradiation can be used in the development of a wide range of antinosocomial devices and coatings.
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title_short	A few-layer graphene/chlorin e6 hybrid nanomaterial and its application in photodynamic therapy against Candida albicans
url	https://doi.org/10.3762/bjnano.11.90 https://doaj.org/article/a7d67c01d11b46eba89b5b7854c92477 https://doaj.org/toc/2190-4286
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author2	Carlos Moreno-Aguilar Dania Hernández-Sánchez Beatriz Morales-Cruzado Erick Sarmiento-Gomez Carla Bittencourt Luis Octavio Sánchez-Vargas Mildred Quintana
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