Clinical characteristics of distal gastric cancer in young adults from Northeastern Brazil

Abstract Background It has been suggested that distal gastric carcinoma (GC) in younger patients has a more aggressive outcome than in older patients, however this is a controversial issue. The aim of this study was to compare clinicopathological features between younger and older patients with GC i...
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Autor*in:	Manuel B. Braga-Neto [verfasserIn] Jessica Gomes Carneiro [verfasserIn] Alzira M. de Castro Barbosa [verfasserIn] Igor S. Silva [verfasserIn] Danielle C. Maia [verfasserIn] Felipe S. Maciel [verfasserIn] Rafael Jorge Alves de Alcântara [verfasserIn] Paulo Roberto L. Vasconscelos [verfasserIn] Lucia L. B. C. Braga [verfasserIn]

Format:	E-Artikel
Sprache:	Englisch

Erschienen:	2018

Schlagwörter:	Distal gastric cancer Young adults Risk factors Brazil

Übergeordnetes Werk:	In: BMC Cancer - BMC, 2003, 18(2018), 1, Seite 7
Übergeordnetes Werk:	volume:18 ; year:2018 ; number:1 ; pages:7

Links:	Link aufrufen Link aufrufen Link aufrufen Journal toc

DOI / URN:	10.1186/s12885-018-3995-4

Katalog-ID:	DOAJ045526648

Internformat


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520			\|a Abstract Background It has been suggested that distal gastric carcinoma (GC) in younger patients has a more aggressive outcome than in older patients, however this is a controversial issue. The aim of this study was to compare clinicopathological features between younger and older patients with GC in Northeastern Brazil. Methods A total of 207 patients with distal GC (41 patients ≤45 years, considered younger group, and 166 < 45 years, considered older group) were evaluated prospectively during a 6 year period. Results The mean patient age in the young group was 37.41 years old and 64.43 years in the older group. No significant difference was found regarding gender, area of residence, history of alcohol consumption, chronic tobacco smoking. Prevalence of first-degree GC history was 12.5% (7.3% in younger group vs. 13.9% in older; p < 0.46). The most frequent symptom was gastric pain and weight loss. Diffuse infiltrative cancer was more frequently seen in younger patients (70.70% vs. 33.70%, respectively; p < 0.01), as was histologically less differentiated tumors (63.40% vs. 33.10%; p < 0.01) and stage IV of GC (48.80% vs. 30.70%; p < 0.015). Five-year survival, evaluated in 82 patients, was lower in younger patients (p = 0.045); however, after adjusting for stage of GC in the multivariate analysis, this association did not remain significant. Family history of GC and gender had no impact on survival. Conclusions Younger patients showed higher prevalence of diffuse type of Lauren and lower survival that was attributed to higher rate of advanced stage of GC. Gastric cancer screening strategies should also be considered in younger individuals, especially in areas of high prevalence. Further studies are warranted to determine risk factors associated with gastric cancer in young adults.
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650		4	\|a Young adults
650		4	\|a Risk factors
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653		0	\|a Neoplasms. Tumors. Oncology. Including cancer and carcinogens
700	0		\|a Jessica Gomes Carneiro \|e verfasserin \|4 aut
700	0		\|a Alzira M. de Castro Barbosa \|e verfasserin \|4 aut
700	0		\|a Igor S. Silva \|e verfasserin \|4 aut
700	0		\|a Danielle C. Maia \|e verfasserin \|4 aut
700	0		\|a Felipe S. Maciel \|e verfasserin \|4 aut
700	0		\|a Rafael Jorge Alves de Alcântara \|e verfasserin \|4 aut
700	0		\|a Paulo Roberto L. Vasconscelos \|e verfasserin \|4 aut
700	0		\|a Lucia L. B. C. Braga \|e verfasserin \|4 aut
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allfields	10.1186/s12885-018-3995-4 doi (DE-627)DOAJ045526648 (DE-599)DOAJ2d1e1cd502714d7bbc942b2528d3fb43 DE-627 ger DE-627 rakwb eng RC254-282 Manuel B. Braga-Neto verfasserin aut Clinical characteristics of distal gastric cancer in young adults from Northeastern Brazil 2018 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Abstract Background It has been suggested that distal gastric carcinoma (GC) in younger patients has a more aggressive outcome than in older patients, however this is a controversial issue. The aim of this study was to compare clinicopathological features between younger and older patients with GC in Northeastern Brazil. Methods A total of 207 patients with distal GC (41 patients ≤45 years, considered younger group, and 166 < 45 years, considered older group) were evaluated prospectively during a 6 year period. Results The mean patient age in the young group was 37.41 years old and 64.43 years in the older group. No significant difference was found regarding gender, area of residence, history of alcohol consumption, chronic tobacco smoking. Prevalence of first-degree GC history was 12.5% (7.3% in younger group vs. 13.9% in older; p < 0.46). The most frequent symptom was gastric pain and weight loss. Diffuse infiltrative cancer was more frequently seen in younger patients (70.70% vs. 33.70%, respectively; p < 0.01), as was histologically less differentiated tumors (63.40% vs. 33.10%; p < 0.01) and stage IV of GC (48.80% vs. 30.70%; p < 0.015). Five-year survival, evaluated in 82 patients, was lower in younger patients (p = 0.045); however, after adjusting for stage of GC in the multivariate analysis, this association did not remain significant. Family history of GC and gender had no impact on survival. Conclusions Younger patients showed higher prevalence of diffuse type of Lauren and lower survival that was attributed to higher rate of advanced stage of GC. Gastric cancer screening strategies should also be considered in younger individuals, especially in areas of high prevalence. Further studies are warranted to determine risk factors associated with gastric cancer in young adults. Distal gastric cancer Young adults Risk factors Brazil Neoplasms. Tumors. Oncology. Including cancer and carcinogens Jessica Gomes Carneiro verfasserin aut Alzira M. de Castro Barbosa verfasserin aut Igor S. Silva verfasserin aut Danielle C. Maia verfasserin aut Felipe S. Maciel verfasserin aut Rafael Jorge Alves de Alcântara verfasserin aut Paulo Roberto L. Vasconscelos verfasserin aut Lucia L. B. C. Braga verfasserin aut In BMC Cancer BMC, 2003 18(2018), 1, Seite 7 (DE-627)326643710 (DE-600)2041352-X 14712407 nnns volume:18 year:2018 number:1 pages:7 https://doi.org/10.1186/s12885-018-3995-4 kostenfrei https://doaj.org/article/2d1e1cd502714d7bbc942b2528d3fb43 kostenfrei http://link.springer.com/article/10.1186/s12885-018-3995-4 kostenfrei https://doaj.org/toc/1471-2407 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ SSG-OLC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2031 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2057 GBV_ILN_2061 GBV_ILN_2111 GBV_ILN_2113 GBV_ILN_2190 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 18 2018 1 7
spelling	10.1186/s12885-018-3995-4 doi (DE-627)DOAJ045526648 (DE-599)DOAJ2d1e1cd502714d7bbc942b2528d3fb43 DE-627 ger DE-627 rakwb eng RC254-282 Manuel B. Braga-Neto verfasserin aut Clinical characteristics of distal gastric cancer in young adults from Northeastern Brazil 2018 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Abstract Background It has been suggested that distal gastric carcinoma (GC) in younger patients has a more aggressive outcome than in older patients, however this is a controversial issue. The aim of this study was to compare clinicopathological features between younger and older patients with GC in Northeastern Brazil. Methods A total of 207 patients with distal GC (41 patients ≤45 years, considered younger group, and 166 < 45 years, considered older group) were evaluated prospectively during a 6 year period. Results The mean patient age in the young group was 37.41 years old and 64.43 years in the older group. No significant difference was found regarding gender, area of residence, history of alcohol consumption, chronic tobacco smoking. Prevalence of first-degree GC history was 12.5% (7.3% in younger group vs. 13.9% in older; p < 0.46). The most frequent symptom was gastric pain and weight loss. Diffuse infiltrative cancer was more frequently seen in younger patients (70.70% vs. 33.70%, respectively; p < 0.01), as was histologically less differentiated tumors (63.40% vs. 33.10%; p < 0.01) and stage IV of GC (48.80% vs. 30.70%; p < 0.015). Five-year survival, evaluated in 82 patients, was lower in younger patients (p = 0.045); however, after adjusting for stage of GC in the multivariate analysis, this association did not remain significant. Family history of GC and gender had no impact on survival. Conclusions Younger patients showed higher prevalence of diffuse type of Lauren and lower survival that was attributed to higher rate of advanced stage of GC. Gastric cancer screening strategies should also be considered in younger individuals, especially in areas of high prevalence. Further studies are warranted to determine risk factors associated with gastric cancer in young adults. Distal gastric cancer Young adults Risk factors Brazil Neoplasms. Tumors. Oncology. Including cancer and carcinogens Jessica Gomes Carneiro verfasserin aut Alzira M. de Castro Barbosa verfasserin aut Igor S. Silva verfasserin aut Danielle C. Maia verfasserin aut Felipe S. Maciel verfasserin aut Rafael Jorge Alves de Alcântara verfasserin aut Paulo Roberto L. Vasconscelos verfasserin aut Lucia L. B. C. Braga verfasserin aut In BMC Cancer BMC, 2003 18(2018), 1, Seite 7 (DE-627)326643710 (DE-600)2041352-X 14712407 nnns volume:18 year:2018 number:1 pages:7 https://doi.org/10.1186/s12885-018-3995-4 kostenfrei https://doaj.org/article/2d1e1cd502714d7bbc942b2528d3fb43 kostenfrei http://link.springer.com/article/10.1186/s12885-018-3995-4 kostenfrei https://doaj.org/toc/1471-2407 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ SSG-OLC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2031 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2057 GBV_ILN_2061 GBV_ILN_2111 GBV_ILN_2113 GBV_ILN_2190 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 18 2018 1 7
allfields_unstemmed	10.1186/s12885-018-3995-4 doi (DE-627)DOAJ045526648 (DE-599)DOAJ2d1e1cd502714d7bbc942b2528d3fb43 DE-627 ger DE-627 rakwb eng RC254-282 Manuel B. Braga-Neto verfasserin aut Clinical characteristics of distal gastric cancer in young adults from Northeastern Brazil 2018 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Abstract Background It has been suggested that distal gastric carcinoma (GC) in younger patients has a more aggressive outcome than in older patients, however this is a controversial issue. The aim of this study was to compare clinicopathological features between younger and older patients with GC in Northeastern Brazil. Methods A total of 207 patients with distal GC (41 patients ≤45 years, considered younger group, and 166 < 45 years, considered older group) were evaluated prospectively during a 6 year period. Results The mean patient age in the young group was 37.41 years old and 64.43 years in the older group. No significant difference was found regarding gender, area of residence, history of alcohol consumption, chronic tobacco smoking. Prevalence of first-degree GC history was 12.5% (7.3% in younger group vs. 13.9% in older; p < 0.46). The most frequent symptom was gastric pain and weight loss. Diffuse infiltrative cancer was more frequently seen in younger patients (70.70% vs. 33.70%, respectively; p < 0.01), as was histologically less differentiated tumors (63.40% vs. 33.10%; p < 0.01) and stage IV of GC (48.80% vs. 30.70%; p < 0.015). Five-year survival, evaluated in 82 patients, was lower in younger patients (p = 0.045); however, after adjusting for stage of GC in the multivariate analysis, this association did not remain significant. Family history of GC and gender had no impact on survival. Conclusions Younger patients showed higher prevalence of diffuse type of Lauren and lower survival that was attributed to higher rate of advanced stage of GC. Gastric cancer screening strategies should also be considered in younger individuals, especially in areas of high prevalence. Further studies are warranted to determine risk factors associated with gastric cancer in young adults. Distal gastric cancer Young adults Risk factors Brazil Neoplasms. Tumors. Oncology. Including cancer and carcinogens Jessica Gomes Carneiro verfasserin aut Alzira M. de Castro Barbosa verfasserin aut Igor S. Silva verfasserin aut Danielle C. Maia verfasserin aut Felipe S. Maciel verfasserin aut Rafael Jorge Alves de Alcântara verfasserin aut Paulo Roberto L. Vasconscelos verfasserin aut Lucia L. B. C. Braga verfasserin aut In BMC Cancer BMC, 2003 18(2018), 1, Seite 7 (DE-627)326643710 (DE-600)2041352-X 14712407 nnns volume:18 year:2018 number:1 pages:7 https://doi.org/10.1186/s12885-018-3995-4 kostenfrei https://doaj.org/article/2d1e1cd502714d7bbc942b2528d3fb43 kostenfrei http://link.springer.com/article/10.1186/s12885-018-3995-4 kostenfrei https://doaj.org/toc/1471-2407 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ SSG-OLC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2031 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2057 GBV_ILN_2061 GBV_ILN_2111 GBV_ILN_2113 GBV_ILN_2190 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 18 2018 1 7
allfieldsGer	10.1186/s12885-018-3995-4 doi (DE-627)DOAJ045526648 (DE-599)DOAJ2d1e1cd502714d7bbc942b2528d3fb43 DE-627 ger DE-627 rakwb eng RC254-282 Manuel B. Braga-Neto verfasserin aut Clinical characteristics of distal gastric cancer in young adults from Northeastern Brazil 2018 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Abstract Background It has been suggested that distal gastric carcinoma (GC) in younger patients has a more aggressive outcome than in older patients, however this is a controversial issue. The aim of this study was to compare clinicopathological features between younger and older patients with GC in Northeastern Brazil. Methods A total of 207 patients with distal GC (41 patients ≤45 years, considered younger group, and 166 < 45 years, considered older group) were evaluated prospectively during a 6 year period. Results The mean patient age in the young group was 37.41 years old and 64.43 years in the older group. No significant difference was found regarding gender, area of residence, history of alcohol consumption, chronic tobacco smoking. Prevalence of first-degree GC history was 12.5% (7.3% in younger group vs. 13.9% in older; p < 0.46). The most frequent symptom was gastric pain and weight loss. Diffuse infiltrative cancer was more frequently seen in younger patients (70.70% vs. 33.70%, respectively; p < 0.01), as was histologically less differentiated tumors (63.40% vs. 33.10%; p < 0.01) and stage IV of GC (48.80% vs. 30.70%; p < 0.015). Five-year survival, evaluated in 82 patients, was lower in younger patients (p = 0.045); however, after adjusting for stage of GC in the multivariate analysis, this association did not remain significant. Family history of GC and gender had no impact on survival. Conclusions Younger patients showed higher prevalence of diffuse type of Lauren and lower survival that was attributed to higher rate of advanced stage of GC. Gastric cancer screening strategies should also be considered in younger individuals, especially in areas of high prevalence. Further studies are warranted to determine risk factors associated with gastric cancer in young adults. Distal gastric cancer Young adults Risk factors Brazil Neoplasms. Tumors. Oncology. Including cancer and carcinogens Jessica Gomes Carneiro verfasserin aut Alzira M. de Castro Barbosa verfasserin aut Igor S. Silva verfasserin aut Danielle C. Maia verfasserin aut Felipe S. Maciel verfasserin aut Rafael Jorge Alves de Alcântara verfasserin aut Paulo Roberto L. Vasconscelos verfasserin aut Lucia L. B. C. Braga verfasserin aut In BMC Cancer BMC, 2003 18(2018), 1, Seite 7 (DE-627)326643710 (DE-600)2041352-X 14712407 nnns volume:18 year:2018 number:1 pages:7 https://doi.org/10.1186/s12885-018-3995-4 kostenfrei https://doaj.org/article/2d1e1cd502714d7bbc942b2528d3fb43 kostenfrei http://link.springer.com/article/10.1186/s12885-018-3995-4 kostenfrei https://doaj.org/toc/1471-2407 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ SSG-OLC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2031 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2057 GBV_ILN_2061 GBV_ILN_2111 GBV_ILN_2113 GBV_ILN_2190 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 18 2018 1 7
allfieldsSound	10.1186/s12885-018-3995-4 doi (DE-627)DOAJ045526648 (DE-599)DOAJ2d1e1cd502714d7bbc942b2528d3fb43 DE-627 ger DE-627 rakwb eng RC254-282 Manuel B. Braga-Neto verfasserin aut Clinical characteristics of distal gastric cancer in young adults from Northeastern Brazil 2018 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Abstract Background It has been suggested that distal gastric carcinoma (GC) in younger patients has a more aggressive outcome than in older patients, however this is a controversial issue. The aim of this study was to compare clinicopathological features between younger and older patients with GC in Northeastern Brazil. Methods A total of 207 patients with distal GC (41 patients ≤45 years, considered younger group, and 166 < 45 years, considered older group) were evaluated prospectively during a 6 year period. Results The mean patient age in the young group was 37.41 years old and 64.43 years in the older group. No significant difference was found regarding gender, area of residence, history of alcohol consumption, chronic tobacco smoking. Prevalence of first-degree GC history was 12.5% (7.3% in younger group vs. 13.9% in older; p < 0.46). The most frequent symptom was gastric pain and weight loss. Diffuse infiltrative cancer was more frequently seen in younger patients (70.70% vs. 33.70%, respectively; p < 0.01), as was histologically less differentiated tumors (63.40% vs. 33.10%; p < 0.01) and stage IV of GC (48.80% vs. 30.70%; p < 0.015). Five-year survival, evaluated in 82 patients, was lower in younger patients (p = 0.045); however, after adjusting for stage of GC in the multivariate analysis, this association did not remain significant. Family history of GC and gender had no impact on survival. Conclusions Younger patients showed higher prevalence of diffuse type of Lauren and lower survival that was attributed to higher rate of advanced stage of GC. Gastric cancer screening strategies should also be considered in younger individuals, especially in areas of high prevalence. Further studies are warranted to determine risk factors associated with gastric cancer in young adults. Distal gastric cancer Young adults Risk factors Brazil Neoplasms. Tumors. Oncology. Including cancer and carcinogens Jessica Gomes Carneiro verfasserin aut Alzira M. de Castro Barbosa verfasserin aut Igor S. Silva verfasserin aut Danielle C. Maia verfasserin aut Felipe S. Maciel verfasserin aut Rafael Jorge Alves de Alcântara verfasserin aut Paulo Roberto L. Vasconscelos verfasserin aut Lucia L. B. C. Braga verfasserin aut In BMC Cancer BMC, 2003 18(2018), 1, Seite 7 (DE-627)326643710 (DE-600)2041352-X 14712407 nnns volume:18 year:2018 number:1 pages:7 https://doi.org/10.1186/s12885-018-3995-4 kostenfrei https://doaj.org/article/2d1e1cd502714d7bbc942b2528d3fb43 kostenfrei http://link.springer.com/article/10.1186/s12885-018-3995-4 kostenfrei https://doaj.org/toc/1471-2407 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ SSG-OLC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2031 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2057 GBV_ILN_2061 GBV_ILN_2111 GBV_ILN_2113 GBV_ILN_2190 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 18 2018 1 7
language	English
source	In BMC Cancer 18(2018), 1, Seite 7 volume:18 year:2018 number:1 pages:7
sourceStr	In BMC Cancer 18(2018), 1, Seite 7 volume:18 year:2018 number:1 pages:7
format_phy_str_mv	Article
institution	findex.gbv.de
topic_facet	Distal gastric cancer Young adults Risk factors Brazil Neoplasms. Tumors. Oncology. Including cancer and carcinogens
isfreeaccess_bool	true
container_title	BMC Cancer
authorswithroles_txt_mv	Manuel B. Braga-Neto @@aut@@ Jessica Gomes Carneiro @@aut@@ Alzira M. de Castro Barbosa @@aut@@ Igor S. Silva @@aut@@ Danielle C. Maia @@aut@@ Felipe S. Maciel @@aut@@ Rafael Jorge Alves de Alcântara @@aut@@ Paulo Roberto L. Vasconscelos @@aut@@ Lucia L. B. C. Braga @@aut@@
publishDateDaySort_date	2018-01-01T00:00:00Z
hierarchy_top_id	326643710
id	DOAJ045526648
language_de	englisch
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Braga-Neto</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="245" ind1="1" ind2="0"><subfield code="a">Clinical characteristics of distal gastric cancer in young adults from Northeastern Brazil</subfield></datafield><datafield tag="264" ind1=" " ind2="1"><subfield code="c">2018</subfield></datafield><datafield tag="336" ind1=" " ind2=" "><subfield code="a">Text</subfield><subfield code="b">txt</subfield><subfield code="2">rdacontent</subfield></datafield><datafield tag="337" ind1=" " ind2=" "><subfield code="a">Computermedien</subfield><subfield code="b">c</subfield><subfield code="2">rdamedia</subfield></datafield><datafield tag="338" ind1=" " ind2=" "><subfield code="a">Online-Ressource</subfield><subfield code="b">cr</subfield><subfield code="2">rdacarrier</subfield></datafield><datafield tag="520" ind1=" " ind2=" "><subfield code="a">Abstract Background It has been suggested that distal gastric carcinoma (GC) in younger patients has a more aggressive outcome than in older patients, however this is a controversial issue. The aim of this study was to compare clinicopathological features between younger and older patients with GC in Northeastern Brazil. Methods A total of 207 patients with distal GC (41 patients ≤45 years, considered younger group, and 166 < 45 years, considered older group) were evaluated prospectively during a 6 year period. Results The mean patient age in the young group was 37.41 years old and 64.43 years in the older group. No significant difference was found regarding gender, area of residence, history of alcohol consumption, chronic tobacco smoking. Prevalence of first-degree GC history was 12.5% (7.3% in younger group vs. 13.9% in older; p < 0.46). The most frequent symptom was gastric pain and weight loss. Diffuse infiltrative cancer was more frequently seen in younger patients (70.70% vs. 33.70%, respectively; p < 0.01), as was histologically less differentiated tumors (63.40% vs. 33.10%; p < 0.01) and stage IV of GC (48.80% vs. 30.70%; p < 0.015). Five-year survival, evaluated in 82 patients, was lower in younger patients (p = 0.045); however, after adjusting for stage of GC in the multivariate analysis, this association did not remain significant. Family history of GC and gender had no impact on survival. Conclusions Younger patients showed higher prevalence of diffuse type of Lauren and lower survival that was attributed to higher rate of advanced stage of GC. Gastric cancer screening strategies should also be considered in younger individuals, especially in areas of high prevalence. 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callnumber-first	R - Medicine
author	Manuel B. Braga-Neto
spellingShingle	Manuel B. Braga-Neto misc RC254-282 misc Distal gastric cancer misc Young adults misc Risk factors misc Brazil misc Neoplasms. Tumors. Oncology. Including cancer and carcinogens Clinical characteristics of distal gastric cancer in young adults from Northeastern Brazil
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topic_title	RC254-282 Clinical characteristics of distal gastric cancer in young adults from Northeastern Brazil Distal gastric cancer Young adults Risk factors Brazil
topic	misc RC254-282 misc Distal gastric cancer misc Young adults misc Risk factors misc Brazil misc Neoplasms. Tumors. Oncology. Including cancer and carcinogens
topic_unstemmed	misc RC254-282 misc Distal gastric cancer misc Young adults misc Risk factors misc Brazil misc Neoplasms. Tumors. Oncology. Including cancer and carcinogens
topic_browse	misc RC254-282 misc Distal gastric cancer misc Young adults misc Risk factors misc Brazil misc Neoplasms. Tumors. Oncology. Including cancer and carcinogens
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title	Clinical characteristics of distal gastric cancer in young adults from Northeastern Brazil
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title_full	Clinical characteristics of distal gastric cancer in young adults from Northeastern Brazil
author_sort	Manuel B. Braga-Neto
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author_browse	Manuel B. Braga-Neto Jessica Gomes Carneiro Alzira M. de Castro Barbosa Igor S. Silva Danielle C. Maia Felipe S. Maciel Rafael Jorge Alves de Alcântara Paulo Roberto L. Vasconscelos Lucia L. B. C. Braga
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title_sort	clinical characteristics of distal gastric cancer in young adults from northeastern brazil
callnumber	RC254-282
title_auth	Clinical characteristics of distal gastric cancer in young adults from Northeastern Brazil
abstract	Abstract Background It has been suggested that distal gastric carcinoma (GC) in younger patients has a more aggressive outcome than in older patients, however this is a controversial issue. The aim of this study was to compare clinicopathological features between younger and older patients with GC in Northeastern Brazil. Methods A total of 207 patients with distal GC (41 patients ≤45 years, considered younger group, and 166 < 45 years, considered older group) were evaluated prospectively during a 6 year period. Results The mean patient age in the young group was 37.41 years old and 64.43 years in the older group. No significant difference was found regarding gender, area of residence, history of alcohol consumption, chronic tobacco smoking. Prevalence of first-degree GC history was 12.5% (7.3% in younger group vs. 13.9% in older; p < 0.46). The most frequent symptom was gastric pain and weight loss. Diffuse infiltrative cancer was more frequently seen in younger patients (70.70% vs. 33.70%, respectively; p < 0.01), as was histologically less differentiated tumors (63.40% vs. 33.10%; p < 0.01) and stage IV of GC (48.80% vs. 30.70%; p < 0.015). Five-year survival, evaluated in 82 patients, was lower in younger patients (p = 0.045); however, after adjusting for stage of GC in the multivariate analysis, this association did not remain significant. Family history of GC and gender had no impact on survival. Conclusions Younger patients showed higher prevalence of diffuse type of Lauren and lower survival that was attributed to higher rate of advanced stage of GC. Gastric cancer screening strategies should also be considered in younger individuals, especially in areas of high prevalence. Further studies are warranted to determine risk factors associated with gastric cancer in young adults.
abstractGer	Abstract Background It has been suggested that distal gastric carcinoma (GC) in younger patients has a more aggressive outcome than in older patients, however this is a controversial issue. The aim of this study was to compare clinicopathological features between younger and older patients with GC in Northeastern Brazil. Methods A total of 207 patients with distal GC (41 patients ≤45 years, considered younger group, and 166 < 45 years, considered older group) were evaluated prospectively during a 6 year period. Results The mean patient age in the young group was 37.41 years old and 64.43 years in the older group. No significant difference was found regarding gender, area of residence, history of alcohol consumption, chronic tobacco smoking. Prevalence of first-degree GC history was 12.5% (7.3% in younger group vs. 13.9% in older; p < 0.46). The most frequent symptom was gastric pain and weight loss. Diffuse infiltrative cancer was more frequently seen in younger patients (70.70% vs. 33.70%, respectively; p < 0.01), as was histologically less differentiated tumors (63.40% vs. 33.10%; p < 0.01) and stage IV of GC (48.80% vs. 30.70%; p < 0.015). Five-year survival, evaluated in 82 patients, was lower in younger patients (p = 0.045); however, after adjusting for stage of GC in the multivariate analysis, this association did not remain significant. Family history of GC and gender had no impact on survival. Conclusions Younger patients showed higher prevalence of diffuse type of Lauren and lower survival that was attributed to higher rate of advanced stage of GC. Gastric cancer screening strategies should also be considered in younger individuals, especially in areas of high prevalence. Further studies are warranted to determine risk factors associated with gastric cancer in young adults.
abstract_unstemmed	Abstract Background It has been suggested that distal gastric carcinoma (GC) in younger patients has a more aggressive outcome than in older patients, however this is a controversial issue. The aim of this study was to compare clinicopathological features between younger and older patients with GC in Northeastern Brazil. Methods A total of 207 patients with distal GC (41 patients ≤45 years, considered younger group, and 166 < 45 years, considered older group) were evaluated prospectively during a 6 year period. Results The mean patient age in the young group was 37.41 years old and 64.43 years in the older group. No significant difference was found regarding gender, area of residence, history of alcohol consumption, chronic tobacco smoking. Prevalence of first-degree GC history was 12.5% (7.3% in younger group vs. 13.9% in older; p < 0.46). The most frequent symptom was gastric pain and weight loss. Diffuse infiltrative cancer was more frequently seen in younger patients (70.70% vs. 33.70%, respectively; p < 0.01), as was histologically less differentiated tumors (63.40% vs. 33.10%; p < 0.01) and stage IV of GC (48.80% vs. 30.70%; p < 0.015). Five-year survival, evaluated in 82 patients, was lower in younger patients (p = 0.045); however, after adjusting for stage of GC in the multivariate analysis, this association did not remain significant. Family history of GC and gender had no impact on survival. Conclusions Younger patients showed higher prevalence of diffuse type of Lauren and lower survival that was attributed to higher rate of advanced stage of GC. Gastric cancer screening strategies should also be considered in younger individuals, especially in areas of high prevalence. Further studies are warranted to determine risk factors associated with gastric cancer in young adults.
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title_short	Clinical characteristics of distal gastric cancer in young adults from Northeastern Brazil
url	https://doi.org/10.1186/s12885-018-3995-4 https://doaj.org/article/2d1e1cd502714d7bbc942b2528d3fb43 http://link.springer.com/article/10.1186/s12885-018-3995-4 https://doaj.org/toc/1471-2407
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Clinical characteristics of distal gastric cancer in young adults from Northeastern Brazil

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