Current Insights Into the Pathology of Canine Intervertebral Disc Extrusion-Induced Spinal Cord Injury
Spinal cord injury (SCI) in dogs is commonly attributed to intervertebral disc extrusion (IVDE). Over the last years substantial progress was made in the elucidation of factors contributing to the pathogenesis of this common canine disease. A detailed understanding of the underlying histopathologica...
Ausführliche Beschreibung
Gespeichert in:
| Autor*in: |
Ingo Spitzbarth [verfasserIn] Sarah A. Moore [verfasserIn] Veronika M. Stein [verfasserIn] Jonathan M. Levine [verfasserIn] Bianca Kühl [verfasserIn] Ingo Gerhauser [verfasserIn] Wolfgang Baumgärtner [verfasserIn] The Canine Spinal Cord Injury Consortium (CANSORT-SCI) [verfasserIn] Natasha J. Olby [verfasserIn] Kady M. Gjessing [verfasserIn] Rhanna M. Davidson [verfasserIn] Helen McWhorter [verfasserIn] Melissa J. Lewis [verfasserIn] Nick D. Jeffery [verfasserIn] Maureen E Mullins [verfasserIn] Ronaldo C. da Costa [verfasserIn] Yvette S. Nout-Lomas [verfasserIn] Joe Fenn [verfasserIn] Nicolas Granger [verfasserIn] Andrea Tipold [verfasserIn] Ji-Hey Lim [verfasserIn] Holger Volk [verfasserIn] |
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| Format: |
E-Artikel |
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| Sprache: |
Englisch |
| Erschienen: |
2020 |
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| Schlagwörter: |
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| Übergeordnetes Werk: |
In: Frontiers in Veterinary Science - Frontiers Media S.A., 2015, 7(2020) |
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| Übergeordnetes Werk: |
volume:7 ; year:2020 |
| Links: |
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| DOI / URN: |
10.3389/fvets.2020.595796 |
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| Katalog-ID: |
DOAJ045708223 |
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| 520 | |a Spinal cord injury (SCI) in dogs is commonly attributed to intervertebral disc extrusion (IVDE). Over the last years substantial progress was made in the elucidation of factors contributing to the pathogenesis of this common canine disease. A detailed understanding of the underlying histopathological and molecular alterations in the lesioned spinal cord represents a prerequisite to translate knowledge on the time course of secondary injury processes into the clinical setting. This review summarizes the current state of knowledge of the underlying pathology of canine IVDE-related SCI. Pathological alterations in the spinal cord of dogs affected by IVDE-related SCI include early and persisting axonal damage and glial responses, dominated by phagocytic microglia/macrophages. These processes are paralleled by a pro-inflammatory microenvironment with dysregulation of cytokines and matrix metalloproteinases within the spinal cord. These data mirror findings from a clinical and therapeutic perspective and can be used to identify biomarkers that are able to more precisely predict the clinical outcome. The pathogenesis of progressive myelomalacia, a devastating complication of SCI in dogs, is not understood in detail so far; however, a fulminant and exaggerating secondary injury response with massive reactive oxygen species formation seems to be involved in this unique neuropathological entity. There are substantial gaps in the knowledge of pathological changes in IVDE with respect to more advanced and chronic lesions and the potential involvement of demyelination. Moreover, the role of microglia/macrophage polarization in IVDE-related SCI still remains to be investigated. A close collaboration of clinical neurologists and veterinary pathologists will help to facilitate an integrative approach to a more detailed understanding of the molecular pathogenesis of canine IVDE and thus to identify therapeutic targets. | ||
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10.3389/fvets.2020.595796 doi (DE-627)DOAJ045708223 (DE-599)DOAJ17c96aee2add4cca919c57a0a3c08361 DE-627 ger DE-627 rakwb eng SF600-1100 Ingo Spitzbarth verfasserin aut Current Insights Into the Pathology of Canine Intervertebral Disc Extrusion-Induced Spinal Cord Injury 2020 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Spinal cord injury (SCI) in dogs is commonly attributed to intervertebral disc extrusion (IVDE). Over the last years substantial progress was made in the elucidation of factors contributing to the pathogenesis of this common canine disease. A detailed understanding of the underlying histopathological and molecular alterations in the lesioned spinal cord represents a prerequisite to translate knowledge on the time course of secondary injury processes into the clinical setting. This review summarizes the current state of knowledge of the underlying pathology of canine IVDE-related SCI. Pathological alterations in the spinal cord of dogs affected by IVDE-related SCI include early and persisting axonal damage and glial responses, dominated by phagocytic microglia/macrophages. These processes are paralleled by a pro-inflammatory microenvironment with dysregulation of cytokines and matrix metalloproteinases within the spinal cord. These data mirror findings from a clinical and therapeutic perspective and can be used to identify biomarkers that are able to more precisely predict the clinical outcome. The pathogenesis of progressive myelomalacia, a devastating complication of SCI in dogs, is not understood in detail so far; however, a fulminant and exaggerating secondary injury response with massive reactive oxygen species formation seems to be involved in this unique neuropathological entity. There are substantial gaps in the knowledge of pathological changes in IVDE with respect to more advanced and chronic lesions and the potential involvement of demyelination. Moreover, the role of microglia/macrophage polarization in IVDE-related SCI still remains to be investigated. A close collaboration of clinical neurologists and veterinary pathologists will help to facilitate an integrative approach to a more detailed understanding of the molecular pathogenesis of canine IVDE and thus to identify therapeutic targets. spinal cord injury IVDE extrusion macrophage immunohistochemistry axonal damage Veterinary medicine Sarah A. Moore verfasserin aut Veronika M. Stein verfasserin aut Jonathan M. Levine verfasserin aut Bianca Kühl verfasserin aut Ingo Gerhauser verfasserin aut Wolfgang Baumgärtner verfasserin aut The Canine Spinal Cord Injury Consortium (CANSORT-SCI) verfasserin aut Sarah A. Moore verfasserin aut Natasha J. Olby verfasserin aut Kady M. Gjessing verfasserin aut Rhanna M. Davidson verfasserin aut Jonathan M. Levine verfasserin aut Helen McWhorter verfasserin aut Melissa J. Lewis verfasserin aut Nick D. Jeffery verfasserin aut Maureen E Mullins verfasserin aut Ronaldo C. da Costa verfasserin aut Yvette S. Nout-Lomas verfasserin aut Joe Fenn verfasserin aut Nicolas Granger verfasserin aut Ingo Spitzbarth verfasserin aut Veronika M. Stein verfasserin aut Andrea Tipold verfasserin aut Ji-Hey Lim verfasserin aut Holger Volk verfasserin aut In Frontiers in Veterinary Science Frontiers Media S.A., 2015 7(2020) (DE-627)835029417 (DE-600)2834243-4 22971769 nnns volume:7 year:2020 https://doi.org/10.3389/fvets.2020.595796 kostenfrei https://doaj.org/article/17c96aee2add4cca919c57a0a3c08361 kostenfrei https://www.frontiersin.org/articles/10.3389/fvets.2020.595796/full kostenfrei https://doaj.org/toc/2297-1769 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2003 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 7 2020 |
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10.3389/fvets.2020.595796 doi (DE-627)DOAJ045708223 (DE-599)DOAJ17c96aee2add4cca919c57a0a3c08361 DE-627 ger DE-627 rakwb eng SF600-1100 Ingo Spitzbarth verfasserin aut Current Insights Into the Pathology of Canine Intervertebral Disc Extrusion-Induced Spinal Cord Injury 2020 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Spinal cord injury (SCI) in dogs is commonly attributed to intervertebral disc extrusion (IVDE). Over the last years substantial progress was made in the elucidation of factors contributing to the pathogenesis of this common canine disease. A detailed understanding of the underlying histopathological and molecular alterations in the lesioned spinal cord represents a prerequisite to translate knowledge on the time course of secondary injury processes into the clinical setting. This review summarizes the current state of knowledge of the underlying pathology of canine IVDE-related SCI. Pathological alterations in the spinal cord of dogs affected by IVDE-related SCI include early and persisting axonal damage and glial responses, dominated by phagocytic microglia/macrophages. These processes are paralleled by a pro-inflammatory microenvironment with dysregulation of cytokines and matrix metalloproteinases within the spinal cord. These data mirror findings from a clinical and therapeutic perspective and can be used to identify biomarkers that are able to more precisely predict the clinical outcome. The pathogenesis of progressive myelomalacia, a devastating complication of SCI in dogs, is not understood in detail so far; however, a fulminant and exaggerating secondary injury response with massive reactive oxygen species formation seems to be involved in this unique neuropathological entity. There are substantial gaps in the knowledge of pathological changes in IVDE with respect to more advanced and chronic lesions and the potential involvement of demyelination. Moreover, the role of microglia/macrophage polarization in IVDE-related SCI still remains to be investigated. A close collaboration of clinical neurologists and veterinary pathologists will help to facilitate an integrative approach to a more detailed understanding of the molecular pathogenesis of canine IVDE and thus to identify therapeutic targets. spinal cord injury IVDE extrusion macrophage immunohistochemistry axonal damage Veterinary medicine Sarah A. Moore verfasserin aut Veronika M. Stein verfasserin aut Jonathan M. Levine verfasserin aut Bianca Kühl verfasserin aut Ingo Gerhauser verfasserin aut Wolfgang Baumgärtner verfasserin aut The Canine Spinal Cord Injury Consortium (CANSORT-SCI) verfasserin aut Sarah A. Moore verfasserin aut Natasha J. Olby verfasserin aut Kady M. Gjessing verfasserin aut Rhanna M. Davidson verfasserin aut Jonathan M. Levine verfasserin aut Helen McWhorter verfasserin aut Melissa J. Lewis verfasserin aut Nick D. Jeffery verfasserin aut Maureen E Mullins verfasserin aut Ronaldo C. da Costa verfasserin aut Yvette S. Nout-Lomas verfasserin aut Joe Fenn verfasserin aut Nicolas Granger verfasserin aut Ingo Spitzbarth verfasserin aut Veronika M. Stein verfasserin aut Andrea Tipold verfasserin aut Ji-Hey Lim verfasserin aut Holger Volk verfasserin aut In Frontiers in Veterinary Science Frontiers Media S.A., 2015 7(2020) (DE-627)835029417 (DE-600)2834243-4 22971769 nnns volume:7 year:2020 https://doi.org/10.3389/fvets.2020.595796 kostenfrei https://doaj.org/article/17c96aee2add4cca919c57a0a3c08361 kostenfrei https://www.frontiersin.org/articles/10.3389/fvets.2020.595796/full kostenfrei https://doaj.org/toc/2297-1769 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2003 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 7 2020 |
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10.3389/fvets.2020.595796 doi (DE-627)DOAJ045708223 (DE-599)DOAJ17c96aee2add4cca919c57a0a3c08361 DE-627 ger DE-627 rakwb eng SF600-1100 Ingo Spitzbarth verfasserin aut Current Insights Into the Pathology of Canine Intervertebral Disc Extrusion-Induced Spinal Cord Injury 2020 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Spinal cord injury (SCI) in dogs is commonly attributed to intervertebral disc extrusion (IVDE). Over the last years substantial progress was made in the elucidation of factors contributing to the pathogenesis of this common canine disease. A detailed understanding of the underlying histopathological and molecular alterations in the lesioned spinal cord represents a prerequisite to translate knowledge on the time course of secondary injury processes into the clinical setting. This review summarizes the current state of knowledge of the underlying pathology of canine IVDE-related SCI. Pathological alterations in the spinal cord of dogs affected by IVDE-related SCI include early and persisting axonal damage and glial responses, dominated by phagocytic microglia/macrophages. These processes are paralleled by a pro-inflammatory microenvironment with dysregulation of cytokines and matrix metalloproteinases within the spinal cord. These data mirror findings from a clinical and therapeutic perspective and can be used to identify biomarkers that are able to more precisely predict the clinical outcome. The pathogenesis of progressive myelomalacia, a devastating complication of SCI in dogs, is not understood in detail so far; however, a fulminant and exaggerating secondary injury response with massive reactive oxygen species formation seems to be involved in this unique neuropathological entity. There are substantial gaps in the knowledge of pathological changes in IVDE with respect to more advanced and chronic lesions and the potential involvement of demyelination. Moreover, the role of microglia/macrophage polarization in IVDE-related SCI still remains to be investigated. A close collaboration of clinical neurologists and veterinary pathologists will help to facilitate an integrative approach to a more detailed understanding of the molecular pathogenesis of canine IVDE and thus to identify therapeutic targets. spinal cord injury IVDE extrusion macrophage immunohistochemistry axonal damage Veterinary medicine Sarah A. Moore verfasserin aut Veronika M. Stein verfasserin aut Jonathan M. Levine verfasserin aut Bianca Kühl verfasserin aut Ingo Gerhauser verfasserin aut Wolfgang Baumgärtner verfasserin aut The Canine Spinal Cord Injury Consortium (CANSORT-SCI) verfasserin aut Sarah A. Moore verfasserin aut Natasha J. Olby verfasserin aut Kady M. Gjessing verfasserin aut Rhanna M. Davidson verfasserin aut Jonathan M. Levine verfasserin aut Helen McWhorter verfasserin aut Melissa J. Lewis verfasserin aut Nick D. Jeffery verfasserin aut Maureen E Mullins verfasserin aut Ronaldo C. da Costa verfasserin aut Yvette S. Nout-Lomas verfasserin aut Joe Fenn verfasserin aut Nicolas Granger verfasserin aut Ingo Spitzbarth verfasserin aut Veronika M. Stein verfasserin aut Andrea Tipold verfasserin aut Ji-Hey Lim verfasserin aut Holger Volk verfasserin aut In Frontiers in Veterinary Science Frontiers Media S.A., 2015 7(2020) (DE-627)835029417 (DE-600)2834243-4 22971769 nnns volume:7 year:2020 https://doi.org/10.3389/fvets.2020.595796 kostenfrei https://doaj.org/article/17c96aee2add4cca919c57a0a3c08361 kostenfrei https://www.frontiersin.org/articles/10.3389/fvets.2020.595796/full kostenfrei https://doaj.org/toc/2297-1769 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2003 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 7 2020 |
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10.3389/fvets.2020.595796 doi (DE-627)DOAJ045708223 (DE-599)DOAJ17c96aee2add4cca919c57a0a3c08361 DE-627 ger DE-627 rakwb eng SF600-1100 Ingo Spitzbarth verfasserin aut Current Insights Into the Pathology of Canine Intervertebral Disc Extrusion-Induced Spinal Cord Injury 2020 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Spinal cord injury (SCI) in dogs is commonly attributed to intervertebral disc extrusion (IVDE). Over the last years substantial progress was made in the elucidation of factors contributing to the pathogenesis of this common canine disease. A detailed understanding of the underlying histopathological and molecular alterations in the lesioned spinal cord represents a prerequisite to translate knowledge on the time course of secondary injury processes into the clinical setting. This review summarizes the current state of knowledge of the underlying pathology of canine IVDE-related SCI. Pathological alterations in the spinal cord of dogs affected by IVDE-related SCI include early and persisting axonal damage and glial responses, dominated by phagocytic microglia/macrophages. These processes are paralleled by a pro-inflammatory microenvironment with dysregulation of cytokines and matrix metalloproteinases within the spinal cord. These data mirror findings from a clinical and therapeutic perspective and can be used to identify biomarkers that are able to more precisely predict the clinical outcome. The pathogenesis of progressive myelomalacia, a devastating complication of SCI in dogs, is not understood in detail so far; however, a fulminant and exaggerating secondary injury response with massive reactive oxygen species formation seems to be involved in this unique neuropathological entity. There are substantial gaps in the knowledge of pathological changes in IVDE with respect to more advanced and chronic lesions and the potential involvement of demyelination. Moreover, the role of microglia/macrophage polarization in IVDE-related SCI still remains to be investigated. A close collaboration of clinical neurologists and veterinary pathologists will help to facilitate an integrative approach to a more detailed understanding of the molecular pathogenesis of canine IVDE and thus to identify therapeutic targets. spinal cord injury IVDE extrusion macrophage immunohistochemistry axonal damage Veterinary medicine Sarah A. Moore verfasserin aut Veronika M. Stein verfasserin aut Jonathan M. Levine verfasserin aut Bianca Kühl verfasserin aut Ingo Gerhauser verfasserin aut Wolfgang Baumgärtner verfasserin aut The Canine Spinal Cord Injury Consortium (CANSORT-SCI) verfasserin aut Sarah A. Moore verfasserin aut Natasha J. Olby verfasserin aut Kady M. Gjessing verfasserin aut Rhanna M. Davidson verfasserin aut Jonathan M. Levine verfasserin aut Helen McWhorter verfasserin aut Melissa J. Lewis verfasserin aut Nick D. Jeffery verfasserin aut Maureen E Mullins verfasserin aut Ronaldo C. da Costa verfasserin aut Yvette S. Nout-Lomas verfasserin aut Joe Fenn verfasserin aut Nicolas Granger verfasserin aut Ingo Spitzbarth verfasserin aut Veronika M. Stein verfasserin aut Andrea Tipold verfasserin aut Ji-Hey Lim verfasserin aut Holger Volk verfasserin aut In Frontiers in Veterinary Science Frontiers Media S.A., 2015 7(2020) (DE-627)835029417 (DE-600)2834243-4 22971769 nnns volume:7 year:2020 https://doi.org/10.3389/fvets.2020.595796 kostenfrei https://doaj.org/article/17c96aee2add4cca919c57a0a3c08361 kostenfrei https://www.frontiersin.org/articles/10.3389/fvets.2020.595796/full kostenfrei https://doaj.org/toc/2297-1769 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2003 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 7 2020 |
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10.3389/fvets.2020.595796 doi (DE-627)DOAJ045708223 (DE-599)DOAJ17c96aee2add4cca919c57a0a3c08361 DE-627 ger DE-627 rakwb eng SF600-1100 Ingo Spitzbarth verfasserin aut Current Insights Into the Pathology of Canine Intervertebral Disc Extrusion-Induced Spinal Cord Injury 2020 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Spinal cord injury (SCI) in dogs is commonly attributed to intervertebral disc extrusion (IVDE). Over the last years substantial progress was made in the elucidation of factors contributing to the pathogenesis of this common canine disease. A detailed understanding of the underlying histopathological and molecular alterations in the lesioned spinal cord represents a prerequisite to translate knowledge on the time course of secondary injury processes into the clinical setting. This review summarizes the current state of knowledge of the underlying pathology of canine IVDE-related SCI. Pathological alterations in the spinal cord of dogs affected by IVDE-related SCI include early and persisting axonal damage and glial responses, dominated by phagocytic microglia/macrophages. These processes are paralleled by a pro-inflammatory microenvironment with dysregulation of cytokines and matrix metalloproteinases within the spinal cord. These data mirror findings from a clinical and therapeutic perspective and can be used to identify biomarkers that are able to more precisely predict the clinical outcome. The pathogenesis of progressive myelomalacia, a devastating complication of SCI in dogs, is not understood in detail so far; however, a fulminant and exaggerating secondary injury response with massive reactive oxygen species formation seems to be involved in this unique neuropathological entity. There are substantial gaps in the knowledge of pathological changes in IVDE with respect to more advanced and chronic lesions and the potential involvement of demyelination. Moreover, the role of microglia/macrophage polarization in IVDE-related SCI still remains to be investigated. A close collaboration of clinical neurologists and veterinary pathologists will help to facilitate an integrative approach to a more detailed understanding of the molecular pathogenesis of canine IVDE and thus to identify therapeutic targets. spinal cord injury IVDE extrusion macrophage immunohistochemistry axonal damage Veterinary medicine Sarah A. Moore verfasserin aut Veronika M. Stein verfasserin aut Jonathan M. Levine verfasserin aut Bianca Kühl verfasserin aut Ingo Gerhauser verfasserin aut Wolfgang Baumgärtner verfasserin aut The Canine Spinal Cord Injury Consortium (CANSORT-SCI) verfasserin aut Sarah A. Moore verfasserin aut Natasha J. Olby verfasserin aut Kady M. Gjessing verfasserin aut Rhanna M. Davidson verfasserin aut Jonathan M. Levine verfasserin aut Helen McWhorter verfasserin aut Melissa J. Lewis verfasserin aut Nick D. Jeffery verfasserin aut Maureen E Mullins verfasserin aut Ronaldo C. da Costa verfasserin aut Yvette S. Nout-Lomas verfasserin aut Joe Fenn verfasserin aut Nicolas Granger verfasserin aut Ingo Spitzbarth verfasserin aut Veronika M. Stein verfasserin aut Andrea Tipold verfasserin aut Ji-Hey Lim verfasserin aut Holger Volk verfasserin aut In Frontiers in Veterinary Science Frontiers Media S.A., 2015 7(2020) (DE-627)835029417 (DE-600)2834243-4 22971769 nnns volume:7 year:2020 https://doi.org/10.3389/fvets.2020.595796 kostenfrei https://doaj.org/article/17c96aee2add4cca919c57a0a3c08361 kostenfrei https://www.frontiersin.org/articles/10.3389/fvets.2020.595796/full kostenfrei https://doaj.org/toc/2297-1769 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2003 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 7 2020 |
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Ingo Spitzbarth @@aut@@ Sarah A. Moore @@aut@@ Veronika M. Stein @@aut@@ Jonathan M. Levine @@aut@@ Bianca Kühl @@aut@@ Ingo Gerhauser @@aut@@ Wolfgang Baumgärtner @@aut@@ The Canine Spinal Cord Injury Consortium (CANSORT-SCI) @@aut@@ Natasha J. Olby @@aut@@ Kady M. Gjessing @@aut@@ Rhanna M. Davidson @@aut@@ Helen McWhorter @@aut@@ Melissa J. Lewis @@aut@@ Nick D. Jeffery @@aut@@ Maureen E Mullins @@aut@@ Ronaldo C. da Costa @@aut@@ Yvette S. Nout-Lomas @@aut@@ Joe Fenn @@aut@@ Nicolas Granger @@aut@@ Andrea Tipold @@aut@@ Ji-Hey Lim @@aut@@ Holger Volk @@aut@@ |
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Current Insights Into the Pathology of Canine Intervertebral Disc Extrusion-Induced Spinal Cord Injury |
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Spinal cord injury (SCI) in dogs is commonly attributed to intervertebral disc extrusion (IVDE). Over the last years substantial progress was made in the elucidation of factors contributing to the pathogenesis of this common canine disease. A detailed understanding of the underlying histopathological and molecular alterations in the lesioned spinal cord represents a prerequisite to translate knowledge on the time course of secondary injury processes into the clinical setting. This review summarizes the current state of knowledge of the underlying pathology of canine IVDE-related SCI. Pathological alterations in the spinal cord of dogs affected by IVDE-related SCI include early and persisting axonal damage and glial responses, dominated by phagocytic microglia/macrophages. These processes are paralleled by a pro-inflammatory microenvironment with dysregulation of cytokines and matrix metalloproteinases within the spinal cord. These data mirror findings from a clinical and therapeutic perspective and can be used to identify biomarkers that are able to more precisely predict the clinical outcome. The pathogenesis of progressive myelomalacia, a devastating complication of SCI in dogs, is not understood in detail so far; however, a fulminant and exaggerating secondary injury response with massive reactive oxygen species formation seems to be involved in this unique neuropathological entity. There are substantial gaps in the knowledge of pathological changes in IVDE with respect to more advanced and chronic lesions and the potential involvement of demyelination. Moreover, the role of microglia/macrophage polarization in IVDE-related SCI still remains to be investigated. A close collaboration of clinical neurologists and veterinary pathologists will help to facilitate an integrative approach to a more detailed understanding of the molecular pathogenesis of canine IVDE and thus to identify therapeutic targets. |
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Spinal cord injury (SCI) in dogs is commonly attributed to intervertebral disc extrusion (IVDE). Over the last years substantial progress was made in the elucidation of factors contributing to the pathogenesis of this common canine disease. A detailed understanding of the underlying histopathological and molecular alterations in the lesioned spinal cord represents a prerequisite to translate knowledge on the time course of secondary injury processes into the clinical setting. This review summarizes the current state of knowledge of the underlying pathology of canine IVDE-related SCI. Pathological alterations in the spinal cord of dogs affected by IVDE-related SCI include early and persisting axonal damage and glial responses, dominated by phagocytic microglia/macrophages. These processes are paralleled by a pro-inflammatory microenvironment with dysregulation of cytokines and matrix metalloproteinases within the spinal cord. These data mirror findings from a clinical and therapeutic perspective and can be used to identify biomarkers that are able to more precisely predict the clinical outcome. The pathogenesis of progressive myelomalacia, a devastating complication of SCI in dogs, is not understood in detail so far; however, a fulminant and exaggerating secondary injury response with massive reactive oxygen species formation seems to be involved in this unique neuropathological entity. There are substantial gaps in the knowledge of pathological changes in IVDE with respect to more advanced and chronic lesions and the potential involvement of demyelination. Moreover, the role of microglia/macrophage polarization in IVDE-related SCI still remains to be investigated. A close collaboration of clinical neurologists and veterinary pathologists will help to facilitate an integrative approach to a more detailed understanding of the molecular pathogenesis of canine IVDE and thus to identify therapeutic targets. |
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Spinal cord injury (SCI) in dogs is commonly attributed to intervertebral disc extrusion (IVDE). Over the last years substantial progress was made in the elucidation of factors contributing to the pathogenesis of this common canine disease. A detailed understanding of the underlying histopathological and molecular alterations in the lesioned spinal cord represents a prerequisite to translate knowledge on the time course of secondary injury processes into the clinical setting. This review summarizes the current state of knowledge of the underlying pathology of canine IVDE-related SCI. Pathological alterations in the spinal cord of dogs affected by IVDE-related SCI include early and persisting axonal damage and glial responses, dominated by phagocytic microglia/macrophages. These processes are paralleled by a pro-inflammatory microenvironment with dysregulation of cytokines and matrix metalloproteinases within the spinal cord. These data mirror findings from a clinical and therapeutic perspective and can be used to identify biomarkers that are able to more precisely predict the clinical outcome. The pathogenesis of progressive myelomalacia, a devastating complication of SCI in dogs, is not understood in detail so far; however, a fulminant and exaggerating secondary injury response with massive reactive oxygen species formation seems to be involved in this unique neuropathological entity. There are substantial gaps in the knowledge of pathological changes in IVDE with respect to more advanced and chronic lesions and the potential involvement of demyelination. Moreover, the role of microglia/macrophage polarization in IVDE-related SCI still remains to be investigated. A close collaboration of clinical neurologists and veterinary pathologists will help to facilitate an integrative approach to a more detailed understanding of the molecular pathogenesis of canine IVDE and thus to identify therapeutic targets. |
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