Prevalence, seroconversion and mother-to-child transmission of dual and triplex infections of HIV, hepatitis B and C viruses among pregnant women in Nigeria: study protocol
Abstract Background Nigeria contributes significantly to the global burden of HIV, Hepatitis B and C infections, either singly or in combinations, despite progress in HIV care regionally and globally. Although some limited data on mono infection of HIV, Hepatitis B and C virus infections do exists,...
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2020 |
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In: Reproductive Health - BMC, 2004, 17(2020), 1, Seite 9 |
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| Übergeordnetes Werk: |
volume:17 ; year:2020 ; number:1 ; pages:9 |
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| DOI / URN: |
10.1186/s12978-020-00995-8 |
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| Katalog-ID: |
DOAJ045717524 |
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| 520 | |a Abstract Background Nigeria contributes significantly to the global burden of HIV, Hepatitis B and C infections, either singly or in combinations, despite progress in HIV care regionally and globally. Although some limited data on mono infection of HIV, Hepatitis B and C virus infections do exists, that of dual and triplex infections, including seroconversion and mother-to-child transmission (MTCT) rates necessary for planning to address the scourge of infections in pregnancy are not available. Objectives To determine the seroprevalence, rate of new infections, MTCT of dual and triple infections of HIV, Hepatitis B and C viruses and associated factors, among pregnant women in Nigeria. Method A multicenter prospective cohort study will be conducted in six tertiary health facilities randomly selected from the six geopolitical zones of Nigeria. All eligible pregnant women are to be tested at enrollment after informed consent for HIV, Hepatitis B and C virus infections. While those positive for at least two of the infections in any combination will be enrolled into the study and followed up to 6 weeks post-delivery, those negative for the three infections or positive for only one of the infections at enrolment will be retested at delivery using a rapid diagnostic test. On enrolment into the study relevant information, will be obtained, and laboratory test of CD4 count, liver function test and full blood counts, and prenatal ultrasonography will also be obtained/performed. Management of mother-newborns pairs will be according to appropriate national guidelines. All exposed newborns will be tested for HIV, HBV or HCV infection at birth and 6 weeks using PCR technique. The study data will be documented on the study case record forms. Data will be managed with SPSS for windows version 23. Ethical approval was obtained from National Health Research Ethics Committee (NHREC) (NHREC/01/01/2007–23/01/2020). Conclusion Pregnant women with multiple of HIV, HBV and HCV infections are at increased risk of hepatotoxicity, maternal and perinatal morbidity and mortality. Additionally, infected pregnant women transmit the virus to their unborn baby even when asymptomatic. Children born with any of the infection have significantly poorer quality of life and lower five-year survival rate. Unfortunately, the seroconversion and MTCT rates of dual or triplex infections among pregnant women in Nigeria have not been studied making planning for prevention and subsequent elimination of the viruses difficult. The study is expected to fill this knowledge gaps. Nigeria joining the rest of the world to eliminate the triple infection among children rest on the availability of adequate and reliable data generated from appropriately designed, and powered study using representative population sample. The establishment of the three-in-one study of prevalence, rate of new infection, rate and risk factor for MTCT of dual and triple infection of HIV, Hepatitis B and C viruses among pregnant women in Nigeria is urgently needed for policy development and planning for the improvement of the quality of life of mothers and the elimination of childhood triplex infection. | ||
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| 650 | 4 | |a HIV | |
| 650 | 4 | |a Multiple infection | |
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| 700 | 0 | |a Uchenna Chukwunonso Ogwaluonye |e verfasserin |4 aut | |
| 700 | 0 | |a Stephen Okoroafor Kalu |e verfasserin |4 aut | |
| 700 | 0 | |a Chinyere Ukamaka Onubogu |e verfasserin |4 aut | |
| 700 | 0 | |a Sussan Ifeyinwa Nweje |e verfasserin |4 aut | |
| 700 | 0 | |a Chinwe Elizabeth Uzochukwu |e verfasserin |4 aut | |
| 700 | 0 | |a Chike Henry Nwankwo |e verfasserin |4 aut | |
| 700 | 0 | |a Preye Owen Fiebai |e verfasserin |4 aut | |
| 700 | 0 | |a Olabisi Morebise Loto |e verfasserin |4 aut | |
| 700 | 0 | |a Godwin Otuodichinma Akaba |e verfasserin |4 aut | |
| 700 | 0 | |a Hadiza Abdullahi Usman |e verfasserin |4 aut | |
| 700 | 0 | |a Ayyuba Rabiu |e verfasserin |4 aut | |
| 700 | 0 | |a Richard Obinwanne Egeonu |e verfasserin |4 aut | |
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| 700 | 0 | |a Fatima Ele Aliyu |e verfasserin |4 aut | |
| 700 | 0 | |a Aisha Ismaila Numan |e verfasserin |4 aut | |
| 700 | 0 | |a Ogbonna Dennis Okoro |e verfasserin |4 aut | |
| 700 | 0 | |a Solace Amechi Omoruyi |e verfasserin |4 aut | |
| 700 | 0 | |a Ijeoma Chioma Oppah |e verfasserin |4 aut | |
| 700 | 0 | |a Ubong Inyang Anyang |e verfasserin |4 aut | |
| 700 | 0 | |a Aishat Ahmed |e verfasserin |4 aut | |
| 700 | 0 | |a Shirley Nneka Chukwurah |e verfasserin |4 aut | |
| 700 | 0 | |a Osita Samuel Umeononihu |e verfasserin |4 aut | |
| 700 | 0 | |a Rebecca Chinyelu Chukwuanukwu |e verfasserin |4 aut | |
| 700 | 0 | |a Eric Okechukwu Umeh |e verfasserin |4 aut | |
| 700 | 0 | |a Ekene Agatha Emeka |e verfasserin |4 aut | |
| 700 | 0 | |a Chukwuanugo Nkemakonam Ogbuagu |e verfasserin |4 aut | |
| 700 | 0 | |a Ibrahim Adamu Yakasai |e verfasserin |4 aut | |
| 700 | 0 | |a Oliver Chukwujekwu Ezechi |e verfasserin |4 aut | |
| 700 | 0 | |a Joseph Ifeanyichukwu Ikechebelu |e verfasserin |4 aut | |
| 700 | 0 | |a Triplex infection in pregnancy collaboration group |e verfasserin |4 aut | |
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10.1186/s12978-020-00995-8 doi (DE-627)DOAJ045717524 (DE-599)DOAJ2064669db65845a2bcf4a4aa8a37bb00 DE-627 ger DE-627 rakwb eng RG1-991 George Uchenna Eleje verfasserin aut Prevalence, seroconversion and mother-to-child transmission of dual and triplex infections of HIV, hepatitis B and C viruses among pregnant women in Nigeria: study protocol 2020 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Abstract Background Nigeria contributes significantly to the global burden of HIV, Hepatitis B and C infections, either singly or in combinations, despite progress in HIV care regionally and globally. Although some limited data on mono infection of HIV, Hepatitis B and C virus infections do exists, that of dual and triplex infections, including seroconversion and mother-to-child transmission (MTCT) rates necessary for planning to address the scourge of infections in pregnancy are not available. Objectives To determine the seroprevalence, rate of new infections, MTCT of dual and triple infections of HIV, Hepatitis B and C viruses and associated factors, among pregnant women in Nigeria. Method A multicenter prospective cohort study will be conducted in six tertiary health facilities randomly selected from the six geopolitical zones of Nigeria. All eligible pregnant women are to be tested at enrollment after informed consent for HIV, Hepatitis B and C virus infections. While those positive for at least two of the infections in any combination will be enrolled into the study and followed up to 6 weeks post-delivery, those negative for the three infections or positive for only one of the infections at enrolment will be retested at delivery using a rapid diagnostic test. On enrolment into the study relevant information, will be obtained, and laboratory test of CD4 count, liver function test and full blood counts, and prenatal ultrasonography will also be obtained/performed. Management of mother-newborns pairs will be according to appropriate national guidelines. All exposed newborns will be tested for HIV, HBV or HCV infection at birth and 6 weeks using PCR technique. The study data will be documented on the study case record forms. Data will be managed with SPSS for windows version 23. Ethical approval was obtained from National Health Research Ethics Committee (NHREC) (NHREC/01/01/2007–23/01/2020). Conclusion Pregnant women with multiple of HIV, HBV and HCV infections are at increased risk of hepatotoxicity, maternal and perinatal morbidity and mortality. Additionally, infected pregnant women transmit the virus to their unborn baby even when asymptomatic. Children born with any of the infection have significantly poorer quality of life and lower five-year survival rate. Unfortunately, the seroconversion and MTCT rates of dual or triplex infections among pregnant women in Nigeria have not been studied making planning for prevention and subsequent elimination of the viruses difficult. The study is expected to fill this knowledge gaps. Nigeria joining the rest of the world to eliminate the triple infection among children rest on the availability of adequate and reliable data generated from appropriately designed, and powered study using representative population sample. The establishment of the three-in-one study of prevalence, rate of new infection, rate and risk factor for MTCT of dual and triple infection of HIV, Hepatitis B and C viruses among pregnant women in Nigeria is urgently needed for policy development and planning for the improvement of the quality of life of mothers and the elimination of childhood triplex infection. Dual infection HBV HCV HIV Multiple infection Nigeria Gynecology and obstetrics Ikechukwu Innocent Mbachu verfasserin aut Uchenna Chukwunonso Ogwaluonye verfasserin aut Stephen Okoroafor Kalu verfasserin aut Chinyere Ukamaka Onubogu verfasserin aut Sussan Ifeyinwa Nweje verfasserin aut Chinwe Elizabeth Uzochukwu verfasserin aut Chike Henry Nwankwo verfasserin aut Preye Owen Fiebai verfasserin aut Olabisi Morebise Loto verfasserin aut Godwin Otuodichinma Akaba verfasserin aut Hadiza Abdullahi Usman verfasserin aut Ayyuba Rabiu verfasserin aut Richard Obinwanne Egeonu verfasserin aut Odion Emmanuel Igue verfasserin aut Bukola Abimbola Adesoji verfasserin aut Chiamaka Henrietta Jibuaku verfasserin aut Prince Ogbonnia Aja verfasserin aut Chiamaka Perpetua Chidozie verfasserin aut Hadiza Sani Ibrahim verfasserin aut Fatima Ele Aliyu verfasserin aut Aisha Ismaila Numan verfasserin aut Ogbonna Dennis Okoro verfasserin aut Solace Amechi Omoruyi verfasserin aut Ijeoma Chioma Oppah verfasserin aut Ubong Inyang Anyang verfasserin aut Aishat Ahmed verfasserin aut Shirley Nneka Chukwurah verfasserin aut Osita Samuel Umeononihu verfasserin aut Rebecca Chinyelu Chukwuanukwu verfasserin aut Eric Okechukwu Umeh verfasserin aut Ekene Agatha Emeka verfasserin aut Chukwuanugo Nkemakonam Ogbuagu verfasserin aut Ibrahim Adamu Yakasai verfasserin aut Oliver Chukwujekwu Ezechi verfasserin aut Joseph Ifeanyichukwu Ikechebelu verfasserin aut Triplex infection in pregnancy collaboration group verfasserin aut In Reproductive Health BMC, 2004 17(2020), 1, Seite 9 (DE-627)389462543 (DE-600)2149029-6 17424755 nnns volume:17 year:2020 number:1 pages:9 https://doi.org/10.1186/s12978-020-00995-8 kostenfrei https://doaj.org/article/2064669db65845a2bcf4a4aa8a37bb00 kostenfrei http://link.springer.com/article/10.1186/s12978-020-00995-8 kostenfrei https://doaj.org/toc/1742-4755 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2009 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2055 GBV_ILN_2111 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 17 2020 1 9 |
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10.1186/s12978-020-00995-8 doi (DE-627)DOAJ045717524 (DE-599)DOAJ2064669db65845a2bcf4a4aa8a37bb00 DE-627 ger DE-627 rakwb eng RG1-991 George Uchenna Eleje verfasserin aut Prevalence, seroconversion and mother-to-child transmission of dual and triplex infections of HIV, hepatitis B and C viruses among pregnant women in Nigeria: study protocol 2020 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Abstract Background Nigeria contributes significantly to the global burden of HIV, Hepatitis B and C infections, either singly or in combinations, despite progress in HIV care regionally and globally. Although some limited data on mono infection of HIV, Hepatitis B and C virus infections do exists, that of dual and triplex infections, including seroconversion and mother-to-child transmission (MTCT) rates necessary for planning to address the scourge of infections in pregnancy are not available. Objectives To determine the seroprevalence, rate of new infections, MTCT of dual and triple infections of HIV, Hepatitis B and C viruses and associated factors, among pregnant women in Nigeria. Method A multicenter prospective cohort study will be conducted in six tertiary health facilities randomly selected from the six geopolitical zones of Nigeria. All eligible pregnant women are to be tested at enrollment after informed consent for HIV, Hepatitis B and C virus infections. While those positive for at least two of the infections in any combination will be enrolled into the study and followed up to 6 weeks post-delivery, those negative for the three infections or positive for only one of the infections at enrolment will be retested at delivery using a rapid diagnostic test. On enrolment into the study relevant information, will be obtained, and laboratory test of CD4 count, liver function test and full blood counts, and prenatal ultrasonography will also be obtained/performed. Management of mother-newborns pairs will be according to appropriate national guidelines. All exposed newborns will be tested for HIV, HBV or HCV infection at birth and 6 weeks using PCR technique. The study data will be documented on the study case record forms. Data will be managed with SPSS for windows version 23. Ethical approval was obtained from National Health Research Ethics Committee (NHREC) (NHREC/01/01/2007–23/01/2020). Conclusion Pregnant women with multiple of HIV, HBV and HCV infections are at increased risk of hepatotoxicity, maternal and perinatal morbidity and mortality. Additionally, infected pregnant women transmit the virus to their unborn baby even when asymptomatic. Children born with any of the infection have significantly poorer quality of life and lower five-year survival rate. Unfortunately, the seroconversion and MTCT rates of dual or triplex infections among pregnant women in Nigeria have not been studied making planning for prevention and subsequent elimination of the viruses difficult. The study is expected to fill this knowledge gaps. Nigeria joining the rest of the world to eliminate the triple infection among children rest on the availability of adequate and reliable data generated from appropriately designed, and powered study using representative population sample. The establishment of the three-in-one study of prevalence, rate of new infection, rate and risk factor for MTCT of dual and triple infection of HIV, Hepatitis B and C viruses among pregnant women in Nigeria is urgently needed for policy development and planning for the improvement of the quality of life of mothers and the elimination of childhood triplex infection. Dual infection HBV HCV HIV Multiple infection Nigeria Gynecology and obstetrics Ikechukwu Innocent Mbachu verfasserin aut Uchenna Chukwunonso Ogwaluonye verfasserin aut Stephen Okoroafor Kalu verfasserin aut Chinyere Ukamaka Onubogu verfasserin aut Sussan Ifeyinwa Nweje verfasserin aut Chinwe Elizabeth Uzochukwu verfasserin aut Chike Henry Nwankwo verfasserin aut Preye Owen Fiebai verfasserin aut Olabisi Morebise Loto verfasserin aut Godwin Otuodichinma Akaba verfasserin aut Hadiza Abdullahi Usman verfasserin aut Ayyuba Rabiu verfasserin aut Richard Obinwanne Egeonu verfasserin aut Odion Emmanuel Igue verfasserin aut Bukola Abimbola Adesoji verfasserin aut Chiamaka Henrietta Jibuaku verfasserin aut Prince Ogbonnia Aja verfasserin aut Chiamaka Perpetua Chidozie verfasserin aut Hadiza Sani Ibrahim verfasserin aut Fatima Ele Aliyu verfasserin aut Aisha Ismaila Numan verfasserin aut Ogbonna Dennis Okoro verfasserin aut Solace Amechi Omoruyi verfasserin aut Ijeoma Chioma Oppah verfasserin aut Ubong Inyang Anyang verfasserin aut Aishat Ahmed verfasserin aut Shirley Nneka Chukwurah verfasserin aut Osita Samuel Umeononihu verfasserin aut Rebecca Chinyelu Chukwuanukwu verfasserin aut Eric Okechukwu Umeh verfasserin aut Ekene Agatha Emeka verfasserin aut Chukwuanugo Nkemakonam Ogbuagu verfasserin aut Ibrahim Adamu Yakasai verfasserin aut Oliver Chukwujekwu Ezechi verfasserin aut Joseph Ifeanyichukwu Ikechebelu verfasserin aut Triplex infection in pregnancy collaboration group verfasserin aut In Reproductive Health BMC, 2004 17(2020), 1, Seite 9 (DE-627)389462543 (DE-600)2149029-6 17424755 nnns volume:17 year:2020 number:1 pages:9 https://doi.org/10.1186/s12978-020-00995-8 kostenfrei https://doaj.org/article/2064669db65845a2bcf4a4aa8a37bb00 kostenfrei http://link.springer.com/article/10.1186/s12978-020-00995-8 kostenfrei https://doaj.org/toc/1742-4755 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2009 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2055 GBV_ILN_2111 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 17 2020 1 9 |
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10.1186/s12978-020-00995-8 doi (DE-627)DOAJ045717524 (DE-599)DOAJ2064669db65845a2bcf4a4aa8a37bb00 DE-627 ger DE-627 rakwb eng RG1-991 George Uchenna Eleje verfasserin aut Prevalence, seroconversion and mother-to-child transmission of dual and triplex infections of HIV, hepatitis B and C viruses among pregnant women in Nigeria: study protocol 2020 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Abstract Background Nigeria contributes significantly to the global burden of HIV, Hepatitis B and C infections, either singly or in combinations, despite progress in HIV care regionally and globally. Although some limited data on mono infection of HIV, Hepatitis B and C virus infections do exists, that of dual and triplex infections, including seroconversion and mother-to-child transmission (MTCT) rates necessary for planning to address the scourge of infections in pregnancy are not available. Objectives To determine the seroprevalence, rate of new infections, MTCT of dual and triple infections of HIV, Hepatitis B and C viruses and associated factors, among pregnant women in Nigeria. Method A multicenter prospective cohort study will be conducted in six tertiary health facilities randomly selected from the six geopolitical zones of Nigeria. All eligible pregnant women are to be tested at enrollment after informed consent for HIV, Hepatitis B and C virus infections. While those positive for at least two of the infections in any combination will be enrolled into the study and followed up to 6 weeks post-delivery, those negative for the three infections or positive for only one of the infections at enrolment will be retested at delivery using a rapid diagnostic test. On enrolment into the study relevant information, will be obtained, and laboratory test of CD4 count, liver function test and full blood counts, and prenatal ultrasonography will also be obtained/performed. Management of mother-newborns pairs will be according to appropriate national guidelines. All exposed newborns will be tested for HIV, HBV or HCV infection at birth and 6 weeks using PCR technique. The study data will be documented on the study case record forms. Data will be managed with SPSS for windows version 23. Ethical approval was obtained from National Health Research Ethics Committee (NHREC) (NHREC/01/01/2007–23/01/2020). Conclusion Pregnant women with multiple of HIV, HBV and HCV infections are at increased risk of hepatotoxicity, maternal and perinatal morbidity and mortality. Additionally, infected pregnant women transmit the virus to their unborn baby even when asymptomatic. Children born with any of the infection have significantly poorer quality of life and lower five-year survival rate. Unfortunately, the seroconversion and MTCT rates of dual or triplex infections among pregnant women in Nigeria have not been studied making planning for prevention and subsequent elimination of the viruses difficult. The study is expected to fill this knowledge gaps. Nigeria joining the rest of the world to eliminate the triple infection among children rest on the availability of adequate and reliable data generated from appropriately designed, and powered study using representative population sample. The establishment of the three-in-one study of prevalence, rate of new infection, rate and risk factor for MTCT of dual and triple infection of HIV, Hepatitis B and C viruses among pregnant women in Nigeria is urgently needed for policy development and planning for the improvement of the quality of life of mothers and the elimination of childhood triplex infection. Dual infection HBV HCV HIV Multiple infection Nigeria Gynecology and obstetrics Ikechukwu Innocent Mbachu verfasserin aut Uchenna Chukwunonso Ogwaluonye verfasserin aut Stephen Okoroafor Kalu verfasserin aut Chinyere Ukamaka Onubogu verfasserin aut Sussan Ifeyinwa Nweje verfasserin aut Chinwe Elizabeth Uzochukwu verfasserin aut Chike Henry Nwankwo verfasserin aut Preye Owen Fiebai verfasserin aut Olabisi Morebise Loto verfasserin aut Godwin Otuodichinma Akaba verfasserin aut Hadiza Abdullahi Usman verfasserin aut Ayyuba Rabiu verfasserin aut Richard Obinwanne Egeonu verfasserin aut Odion Emmanuel Igue verfasserin aut Bukola Abimbola Adesoji verfasserin aut Chiamaka Henrietta Jibuaku verfasserin aut Prince Ogbonnia Aja verfasserin aut Chiamaka Perpetua Chidozie verfasserin aut Hadiza Sani Ibrahim verfasserin aut Fatima Ele Aliyu verfasserin aut Aisha Ismaila Numan verfasserin aut Ogbonna Dennis Okoro verfasserin aut Solace Amechi Omoruyi verfasserin aut Ijeoma Chioma Oppah verfasserin aut Ubong Inyang Anyang verfasserin aut Aishat Ahmed verfasserin aut Shirley Nneka Chukwurah verfasserin aut Osita Samuel Umeononihu verfasserin aut Rebecca Chinyelu Chukwuanukwu verfasserin aut Eric Okechukwu Umeh verfasserin aut Ekene Agatha Emeka verfasserin aut Chukwuanugo Nkemakonam Ogbuagu verfasserin aut Ibrahim Adamu Yakasai verfasserin aut Oliver Chukwujekwu Ezechi verfasserin aut Joseph Ifeanyichukwu Ikechebelu verfasserin aut Triplex infection in pregnancy collaboration group verfasserin aut In Reproductive Health BMC, 2004 17(2020), 1, Seite 9 (DE-627)389462543 (DE-600)2149029-6 17424755 nnns volume:17 year:2020 number:1 pages:9 https://doi.org/10.1186/s12978-020-00995-8 kostenfrei https://doaj.org/article/2064669db65845a2bcf4a4aa8a37bb00 kostenfrei http://link.springer.com/article/10.1186/s12978-020-00995-8 kostenfrei https://doaj.org/toc/1742-4755 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2009 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2055 GBV_ILN_2111 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 17 2020 1 9 |
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10.1186/s12978-020-00995-8 doi (DE-627)DOAJ045717524 (DE-599)DOAJ2064669db65845a2bcf4a4aa8a37bb00 DE-627 ger DE-627 rakwb eng RG1-991 George Uchenna Eleje verfasserin aut Prevalence, seroconversion and mother-to-child transmission of dual and triplex infections of HIV, hepatitis B and C viruses among pregnant women in Nigeria: study protocol 2020 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Abstract Background Nigeria contributes significantly to the global burden of HIV, Hepatitis B and C infections, either singly or in combinations, despite progress in HIV care regionally and globally. Although some limited data on mono infection of HIV, Hepatitis B and C virus infections do exists, that of dual and triplex infections, including seroconversion and mother-to-child transmission (MTCT) rates necessary for planning to address the scourge of infections in pregnancy are not available. Objectives To determine the seroprevalence, rate of new infections, MTCT of dual and triple infections of HIV, Hepatitis B and C viruses and associated factors, among pregnant women in Nigeria. Method A multicenter prospective cohort study will be conducted in six tertiary health facilities randomly selected from the six geopolitical zones of Nigeria. All eligible pregnant women are to be tested at enrollment after informed consent for HIV, Hepatitis B and C virus infections. While those positive for at least two of the infections in any combination will be enrolled into the study and followed up to 6 weeks post-delivery, those negative for the three infections or positive for only one of the infections at enrolment will be retested at delivery using a rapid diagnostic test. On enrolment into the study relevant information, will be obtained, and laboratory test of CD4 count, liver function test and full blood counts, and prenatal ultrasonography will also be obtained/performed. Management of mother-newborns pairs will be according to appropriate national guidelines. All exposed newborns will be tested for HIV, HBV or HCV infection at birth and 6 weeks using PCR technique. The study data will be documented on the study case record forms. Data will be managed with SPSS for windows version 23. Ethical approval was obtained from National Health Research Ethics Committee (NHREC) (NHREC/01/01/2007–23/01/2020). Conclusion Pregnant women with multiple of HIV, HBV and HCV infections are at increased risk of hepatotoxicity, maternal and perinatal morbidity and mortality. Additionally, infected pregnant women transmit the virus to their unborn baby even when asymptomatic. Children born with any of the infection have significantly poorer quality of life and lower five-year survival rate. Unfortunately, the seroconversion and MTCT rates of dual or triplex infections among pregnant women in Nigeria have not been studied making planning for prevention and subsequent elimination of the viruses difficult. The study is expected to fill this knowledge gaps. Nigeria joining the rest of the world to eliminate the triple infection among children rest on the availability of adequate and reliable data generated from appropriately designed, and powered study using representative population sample. The establishment of the three-in-one study of prevalence, rate of new infection, rate and risk factor for MTCT of dual and triple infection of HIV, Hepatitis B and C viruses among pregnant women in Nigeria is urgently needed for policy development and planning for the improvement of the quality of life of mothers and the elimination of childhood triplex infection. Dual infection HBV HCV HIV Multiple infection Nigeria Gynecology and obstetrics Ikechukwu Innocent Mbachu verfasserin aut Uchenna Chukwunonso Ogwaluonye verfasserin aut Stephen Okoroafor Kalu verfasserin aut Chinyere Ukamaka Onubogu verfasserin aut Sussan Ifeyinwa Nweje verfasserin aut Chinwe Elizabeth Uzochukwu verfasserin aut Chike Henry Nwankwo verfasserin aut Preye Owen Fiebai verfasserin aut Olabisi Morebise Loto verfasserin aut Godwin Otuodichinma Akaba verfasserin aut Hadiza Abdullahi Usman verfasserin aut Ayyuba Rabiu verfasserin aut Richard Obinwanne Egeonu verfasserin aut Odion Emmanuel Igue verfasserin aut Bukola Abimbola Adesoji verfasserin aut Chiamaka Henrietta Jibuaku verfasserin aut Prince Ogbonnia Aja verfasserin aut Chiamaka Perpetua Chidozie verfasserin aut Hadiza Sani Ibrahim verfasserin aut Fatima Ele Aliyu verfasserin aut Aisha Ismaila Numan verfasserin aut Ogbonna Dennis Okoro verfasserin aut Solace Amechi Omoruyi verfasserin aut Ijeoma Chioma Oppah verfasserin aut Ubong Inyang Anyang verfasserin aut Aishat Ahmed verfasserin aut Shirley Nneka Chukwurah verfasserin aut Osita Samuel Umeononihu verfasserin aut Rebecca Chinyelu Chukwuanukwu verfasserin aut Eric Okechukwu Umeh verfasserin aut Ekene Agatha Emeka verfasserin aut Chukwuanugo Nkemakonam Ogbuagu verfasserin aut Ibrahim Adamu Yakasai verfasserin aut Oliver Chukwujekwu Ezechi verfasserin aut Joseph Ifeanyichukwu Ikechebelu verfasserin aut Triplex infection in pregnancy collaboration group verfasserin aut In Reproductive Health BMC, 2004 17(2020), 1, Seite 9 (DE-627)389462543 (DE-600)2149029-6 17424755 nnns volume:17 year:2020 number:1 pages:9 https://doi.org/10.1186/s12978-020-00995-8 kostenfrei https://doaj.org/article/2064669db65845a2bcf4a4aa8a37bb00 kostenfrei http://link.springer.com/article/10.1186/s12978-020-00995-8 kostenfrei https://doaj.org/toc/1742-4755 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2009 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2055 GBV_ILN_2111 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 17 2020 1 9 |
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10.1186/s12978-020-00995-8 doi (DE-627)DOAJ045717524 (DE-599)DOAJ2064669db65845a2bcf4a4aa8a37bb00 DE-627 ger DE-627 rakwb eng RG1-991 George Uchenna Eleje verfasserin aut Prevalence, seroconversion and mother-to-child transmission of dual and triplex infections of HIV, hepatitis B and C viruses among pregnant women in Nigeria: study protocol 2020 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Abstract Background Nigeria contributes significantly to the global burden of HIV, Hepatitis B and C infections, either singly or in combinations, despite progress in HIV care regionally and globally. Although some limited data on mono infection of HIV, Hepatitis B and C virus infections do exists, that of dual and triplex infections, including seroconversion and mother-to-child transmission (MTCT) rates necessary for planning to address the scourge of infections in pregnancy are not available. Objectives To determine the seroprevalence, rate of new infections, MTCT of dual and triple infections of HIV, Hepatitis B and C viruses and associated factors, among pregnant women in Nigeria. Method A multicenter prospective cohort study will be conducted in six tertiary health facilities randomly selected from the six geopolitical zones of Nigeria. All eligible pregnant women are to be tested at enrollment after informed consent for HIV, Hepatitis B and C virus infections. While those positive for at least two of the infections in any combination will be enrolled into the study and followed up to 6 weeks post-delivery, those negative for the three infections or positive for only one of the infections at enrolment will be retested at delivery using a rapid diagnostic test. On enrolment into the study relevant information, will be obtained, and laboratory test of CD4 count, liver function test and full blood counts, and prenatal ultrasonography will also be obtained/performed. Management of mother-newborns pairs will be according to appropriate national guidelines. All exposed newborns will be tested for HIV, HBV or HCV infection at birth and 6 weeks using PCR technique. The study data will be documented on the study case record forms. Data will be managed with SPSS for windows version 23. Ethical approval was obtained from National Health Research Ethics Committee (NHREC) (NHREC/01/01/2007–23/01/2020). Conclusion Pregnant women with multiple of HIV, HBV and HCV infections are at increased risk of hepatotoxicity, maternal and perinatal morbidity and mortality. Additionally, infected pregnant women transmit the virus to their unborn baby even when asymptomatic. Children born with any of the infection have significantly poorer quality of life and lower five-year survival rate. Unfortunately, the seroconversion and MTCT rates of dual or triplex infections among pregnant women in Nigeria have not been studied making planning for prevention and subsequent elimination of the viruses difficult. The study is expected to fill this knowledge gaps. Nigeria joining the rest of the world to eliminate the triple infection among children rest on the availability of adequate and reliable data generated from appropriately designed, and powered study using representative population sample. The establishment of the three-in-one study of prevalence, rate of new infection, rate and risk factor for MTCT of dual and triple infection of HIV, Hepatitis B and C viruses among pregnant women in Nigeria is urgently needed for policy development and planning for the improvement of the quality of life of mothers and the elimination of childhood triplex infection. Dual infection HBV HCV HIV Multiple infection Nigeria Gynecology and obstetrics Ikechukwu Innocent Mbachu verfasserin aut Uchenna Chukwunonso Ogwaluonye verfasserin aut Stephen Okoroafor Kalu verfasserin aut Chinyere Ukamaka Onubogu verfasserin aut Sussan Ifeyinwa Nweje verfasserin aut Chinwe Elizabeth Uzochukwu verfasserin aut Chike Henry Nwankwo verfasserin aut Preye Owen Fiebai verfasserin aut Olabisi Morebise Loto verfasserin aut Godwin Otuodichinma Akaba verfasserin aut Hadiza Abdullahi Usman verfasserin aut Ayyuba Rabiu verfasserin aut Richard Obinwanne Egeonu verfasserin aut Odion Emmanuel Igue verfasserin aut Bukola Abimbola Adesoji verfasserin aut Chiamaka Henrietta Jibuaku verfasserin aut Prince Ogbonnia Aja verfasserin aut Chiamaka Perpetua Chidozie verfasserin aut Hadiza Sani Ibrahim verfasserin aut Fatima Ele Aliyu verfasserin aut Aisha Ismaila Numan verfasserin aut Ogbonna Dennis Okoro verfasserin aut Solace Amechi Omoruyi verfasserin aut Ijeoma Chioma Oppah verfasserin aut Ubong Inyang Anyang verfasserin aut Aishat Ahmed verfasserin aut Shirley Nneka Chukwurah verfasserin aut Osita Samuel Umeononihu verfasserin aut Rebecca Chinyelu Chukwuanukwu verfasserin aut Eric Okechukwu Umeh verfasserin aut Ekene Agatha Emeka verfasserin aut Chukwuanugo Nkemakonam Ogbuagu verfasserin aut Ibrahim Adamu Yakasai verfasserin aut Oliver Chukwujekwu Ezechi verfasserin aut Joseph Ifeanyichukwu Ikechebelu verfasserin aut Triplex infection in pregnancy collaboration group verfasserin aut In Reproductive Health BMC, 2004 17(2020), 1, Seite 9 (DE-627)389462543 (DE-600)2149029-6 17424755 nnns volume:17 year:2020 number:1 pages:9 https://doi.org/10.1186/s12978-020-00995-8 kostenfrei https://doaj.org/article/2064669db65845a2bcf4a4aa8a37bb00 kostenfrei http://link.springer.com/article/10.1186/s12978-020-00995-8 kostenfrei https://doaj.org/toc/1742-4755 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2009 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2055 GBV_ILN_2111 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 17 2020 1 9 |
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George Uchenna Eleje @@aut@@ Ikechukwu Innocent Mbachu @@aut@@ Uchenna Chukwunonso Ogwaluonye @@aut@@ Stephen Okoroafor Kalu @@aut@@ Chinyere Ukamaka Onubogu @@aut@@ Sussan Ifeyinwa Nweje @@aut@@ Chinwe Elizabeth Uzochukwu @@aut@@ Chike Henry Nwankwo @@aut@@ Preye Owen Fiebai @@aut@@ Olabisi Morebise Loto @@aut@@ Godwin Otuodichinma Akaba @@aut@@ Hadiza Abdullahi Usman @@aut@@ Ayyuba Rabiu @@aut@@ Richard Obinwanne Egeonu @@aut@@ Odion Emmanuel Igue @@aut@@ Bukola Abimbola Adesoji @@aut@@ Chiamaka Henrietta Jibuaku @@aut@@ Prince Ogbonnia Aja @@aut@@ Chiamaka Perpetua Chidozie @@aut@@ Hadiza Sani Ibrahim @@aut@@ Fatima Ele Aliyu @@aut@@ Aisha Ismaila Numan @@aut@@ Ogbonna Dennis Okoro @@aut@@ Solace Amechi Omoruyi @@aut@@ Ijeoma Chioma Oppah @@aut@@ Ubong Inyang Anyang @@aut@@ Aishat Ahmed @@aut@@ Shirley Nneka Chukwurah @@aut@@ Osita Samuel Umeononihu @@aut@@ Rebecca Chinyelu Chukwuanukwu @@aut@@ Eric Okechukwu Umeh @@aut@@ Ekene Agatha Emeka @@aut@@ Chukwuanugo Nkemakonam Ogbuagu @@aut@@ Ibrahim Adamu Yakasai @@aut@@ Oliver Chukwujekwu Ezechi @@aut@@ Joseph Ifeanyichukwu Ikechebelu @@aut@@ Triplex infection in pregnancy collaboration group @@aut@@ |
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Although some limited data on mono infection of HIV, Hepatitis B and C virus infections do exists, that of dual and triplex infections, including seroconversion and mother-to-child transmission (MTCT) rates necessary for planning to address the scourge of infections in pregnancy are not available. Objectives To determine the seroprevalence, rate of new infections, MTCT of dual and triple infections of HIV, Hepatitis B and C viruses and associated factors, among pregnant women in Nigeria. Method A multicenter prospective cohort study will be conducted in six tertiary health facilities randomly selected from the six geopolitical zones of Nigeria. All eligible pregnant women are to be tested at enrollment after informed consent for HIV, Hepatitis B and C virus infections. While those positive for at least two of the infections in any combination will be enrolled into the study and followed up to 6 weeks post-delivery, those negative for the three infections or positive for only one of the infections at enrolment will be retested at delivery using a rapid diagnostic test. On enrolment into the study relevant information, will be obtained, and laboratory test of CD4 count, liver function test and full blood counts, and prenatal ultrasonography will also be obtained/performed. Management of mother-newborns pairs will be according to appropriate national guidelines. All exposed newborns will be tested for HIV, HBV or HCV infection at birth and 6 weeks using PCR technique. The study data will be documented on the study case record forms. Data will be managed with SPSS for windows version 23. Ethical approval was obtained from National Health Research Ethics Committee (NHREC) (NHREC/01/01/2007–23/01/2020). 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George Uchenna Eleje |
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George Uchenna Eleje misc RG1-991 misc Dual infection misc HBV misc HCV misc HIV misc Multiple infection misc Nigeria misc Gynecology and obstetrics Prevalence, seroconversion and mother-to-child transmission of dual and triplex infections of HIV, hepatitis B and C viruses among pregnant women in Nigeria: study protocol |
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RG1-991 Prevalence, seroconversion and mother-to-child transmission of dual and triplex infections of HIV, hepatitis B and C viruses among pregnant women in Nigeria: study protocol Dual infection HBV HCV HIV Multiple infection Nigeria |
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misc RG1-991 misc Dual infection misc HBV misc HCV misc HIV misc Multiple infection misc Nigeria misc Gynecology and obstetrics |
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Prevalence, seroconversion and mother-to-child transmission of dual and triplex infections of HIV, hepatitis B and C viruses among pregnant women in Nigeria: study protocol |
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George Uchenna Eleje Ikechukwu Innocent Mbachu Uchenna Chukwunonso Ogwaluonye Stephen Okoroafor Kalu Chinyere Ukamaka Onubogu Sussan Ifeyinwa Nweje Chinwe Elizabeth Uzochukwu Chike Henry Nwankwo Preye Owen Fiebai Olabisi Morebise Loto Godwin Otuodichinma Akaba Hadiza Abdullahi Usman Ayyuba Rabiu Richard Obinwanne Egeonu Odion Emmanuel Igue Bukola Abimbola Adesoji Chiamaka Henrietta Jibuaku Prince Ogbonnia Aja Chiamaka Perpetua Chidozie Hadiza Sani Ibrahim Fatima Ele Aliyu Aisha Ismaila Numan Ogbonna Dennis Okoro Solace Amechi Omoruyi Ijeoma Chioma Oppah Ubong Inyang Anyang Aishat Ahmed Shirley Nneka Chukwurah Osita Samuel Umeononihu Rebecca Chinyelu Chukwuanukwu Eric Okechukwu Umeh Ekene Agatha Emeka Chukwuanugo Nkemakonam Ogbuagu Ibrahim Adamu Yakasai Oliver Chukwujekwu Ezechi Joseph Ifeanyichukwu Ikechebelu Triplex infection in pregnancy collaboration group |
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prevalence, seroconversion and mother-to-child transmission of dual and triplex infections of hiv, hepatitis b and c viruses among pregnant women in nigeria: study protocol |
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RG1-991 |
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Prevalence, seroconversion and mother-to-child transmission of dual and triplex infections of HIV, hepatitis B and C viruses among pregnant women in Nigeria: study protocol |
| abstract |
Abstract Background Nigeria contributes significantly to the global burden of HIV, Hepatitis B and C infections, either singly or in combinations, despite progress in HIV care regionally and globally. Although some limited data on mono infection of HIV, Hepatitis B and C virus infections do exists, that of dual and triplex infections, including seroconversion and mother-to-child transmission (MTCT) rates necessary for planning to address the scourge of infections in pregnancy are not available. Objectives To determine the seroprevalence, rate of new infections, MTCT of dual and triple infections of HIV, Hepatitis B and C viruses and associated factors, among pregnant women in Nigeria. Method A multicenter prospective cohort study will be conducted in six tertiary health facilities randomly selected from the six geopolitical zones of Nigeria. All eligible pregnant women are to be tested at enrollment after informed consent for HIV, Hepatitis B and C virus infections. While those positive for at least two of the infections in any combination will be enrolled into the study and followed up to 6 weeks post-delivery, those negative for the three infections or positive for only one of the infections at enrolment will be retested at delivery using a rapid diagnostic test. On enrolment into the study relevant information, will be obtained, and laboratory test of CD4 count, liver function test and full blood counts, and prenatal ultrasonography will also be obtained/performed. Management of mother-newborns pairs will be according to appropriate national guidelines. All exposed newborns will be tested for HIV, HBV or HCV infection at birth and 6 weeks using PCR technique. The study data will be documented on the study case record forms. Data will be managed with SPSS for windows version 23. Ethical approval was obtained from National Health Research Ethics Committee (NHREC) (NHREC/01/01/2007–23/01/2020). Conclusion Pregnant women with multiple of HIV, HBV and HCV infections are at increased risk of hepatotoxicity, maternal and perinatal morbidity and mortality. Additionally, infected pregnant women transmit the virus to their unborn baby even when asymptomatic. Children born with any of the infection have significantly poorer quality of life and lower five-year survival rate. Unfortunately, the seroconversion and MTCT rates of dual or triplex infections among pregnant women in Nigeria have not been studied making planning for prevention and subsequent elimination of the viruses difficult. The study is expected to fill this knowledge gaps. Nigeria joining the rest of the world to eliminate the triple infection among children rest on the availability of adequate and reliable data generated from appropriately designed, and powered study using representative population sample. The establishment of the three-in-one study of prevalence, rate of new infection, rate and risk factor for MTCT of dual and triple infection of HIV, Hepatitis B and C viruses among pregnant women in Nigeria is urgently needed for policy development and planning for the improvement of the quality of life of mothers and the elimination of childhood triplex infection. |
| abstractGer |
Abstract Background Nigeria contributes significantly to the global burden of HIV, Hepatitis B and C infections, either singly or in combinations, despite progress in HIV care regionally and globally. Although some limited data on mono infection of HIV, Hepatitis B and C virus infections do exists, that of dual and triplex infections, including seroconversion and mother-to-child transmission (MTCT) rates necessary for planning to address the scourge of infections in pregnancy are not available. Objectives To determine the seroprevalence, rate of new infections, MTCT of dual and triple infections of HIV, Hepatitis B and C viruses and associated factors, among pregnant women in Nigeria. Method A multicenter prospective cohort study will be conducted in six tertiary health facilities randomly selected from the six geopolitical zones of Nigeria. All eligible pregnant women are to be tested at enrollment after informed consent for HIV, Hepatitis B and C virus infections. While those positive for at least two of the infections in any combination will be enrolled into the study and followed up to 6 weeks post-delivery, those negative for the three infections or positive for only one of the infections at enrolment will be retested at delivery using a rapid diagnostic test. On enrolment into the study relevant information, will be obtained, and laboratory test of CD4 count, liver function test and full blood counts, and prenatal ultrasonography will also be obtained/performed. Management of mother-newborns pairs will be according to appropriate national guidelines. All exposed newborns will be tested for HIV, HBV or HCV infection at birth and 6 weeks using PCR technique. The study data will be documented on the study case record forms. Data will be managed with SPSS for windows version 23. Ethical approval was obtained from National Health Research Ethics Committee (NHREC) (NHREC/01/01/2007–23/01/2020). Conclusion Pregnant women with multiple of HIV, HBV and HCV infections are at increased risk of hepatotoxicity, maternal and perinatal morbidity and mortality. Additionally, infected pregnant women transmit the virus to their unborn baby even when asymptomatic. Children born with any of the infection have significantly poorer quality of life and lower five-year survival rate. Unfortunately, the seroconversion and MTCT rates of dual or triplex infections among pregnant women in Nigeria have not been studied making planning for prevention and subsequent elimination of the viruses difficult. The study is expected to fill this knowledge gaps. Nigeria joining the rest of the world to eliminate the triple infection among children rest on the availability of adequate and reliable data generated from appropriately designed, and powered study using representative population sample. The establishment of the three-in-one study of prevalence, rate of new infection, rate and risk factor for MTCT of dual and triple infection of HIV, Hepatitis B and C viruses among pregnant women in Nigeria is urgently needed for policy development and planning for the improvement of the quality of life of mothers and the elimination of childhood triplex infection. |
| abstract_unstemmed |
Abstract Background Nigeria contributes significantly to the global burden of HIV, Hepatitis B and C infections, either singly or in combinations, despite progress in HIV care regionally and globally. Although some limited data on mono infection of HIV, Hepatitis B and C virus infections do exists, that of dual and triplex infections, including seroconversion and mother-to-child transmission (MTCT) rates necessary for planning to address the scourge of infections in pregnancy are not available. Objectives To determine the seroprevalence, rate of new infections, MTCT of dual and triple infections of HIV, Hepatitis B and C viruses and associated factors, among pregnant women in Nigeria. Method A multicenter prospective cohort study will be conducted in six tertiary health facilities randomly selected from the six geopolitical zones of Nigeria. All eligible pregnant women are to be tested at enrollment after informed consent for HIV, Hepatitis B and C virus infections. While those positive for at least two of the infections in any combination will be enrolled into the study and followed up to 6 weeks post-delivery, those negative for the three infections or positive for only one of the infections at enrolment will be retested at delivery using a rapid diagnostic test. On enrolment into the study relevant information, will be obtained, and laboratory test of CD4 count, liver function test and full blood counts, and prenatal ultrasonography will also be obtained/performed. Management of mother-newborns pairs will be according to appropriate national guidelines. All exposed newborns will be tested for HIV, HBV or HCV infection at birth and 6 weeks using PCR technique. The study data will be documented on the study case record forms. Data will be managed with SPSS for windows version 23. Ethical approval was obtained from National Health Research Ethics Committee (NHREC) (NHREC/01/01/2007–23/01/2020). Conclusion Pregnant women with multiple of HIV, HBV and HCV infections are at increased risk of hepatotoxicity, maternal and perinatal morbidity and mortality. Additionally, infected pregnant women transmit the virus to their unborn baby even when asymptomatic. Children born with any of the infection have significantly poorer quality of life and lower five-year survival rate. Unfortunately, the seroconversion and MTCT rates of dual or triplex infections among pregnant women in Nigeria have not been studied making planning for prevention and subsequent elimination of the viruses difficult. The study is expected to fill this knowledge gaps. Nigeria joining the rest of the world to eliminate the triple infection among children rest on the availability of adequate and reliable data generated from appropriately designed, and powered study using representative population sample. The establishment of the three-in-one study of prevalence, rate of new infection, rate and risk factor for MTCT of dual and triple infection of HIV, Hepatitis B and C viruses among pregnant women in Nigeria is urgently needed for policy development and planning for the improvement of the quality of life of mothers and the elimination of childhood triplex infection. |
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Prevalence, seroconversion and mother-to-child transmission of dual and triplex infections of HIV, hepatitis B and C viruses among pregnant women in Nigeria: study protocol |
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https://doi.org/10.1186/s12978-020-00995-8 https://doaj.org/article/2064669db65845a2bcf4a4aa8a37bb00 http://link.springer.com/article/10.1186/s12978-020-00995-8 https://doaj.org/toc/1742-4755 |
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Ikechukwu Innocent Mbachu Uchenna Chukwunonso Ogwaluonye Stephen Okoroafor Kalu Chinyere Ukamaka Onubogu Sussan Ifeyinwa Nweje Chinwe Elizabeth Uzochukwu Chike Henry Nwankwo Preye Owen Fiebai Olabisi Morebise Loto Godwin Otuodichinma Akaba Hadiza Abdullahi Usman Ayyuba Rabiu Richard Obinwanne Egeonu Odion Emmanuel Igue Bukola Abimbola Adesoji Chiamaka Henrietta Jibuaku Prince Ogbonnia Aja Chiamaka Perpetua Chidozie Hadiza Sani Ibrahim Fatima Ele Aliyu Aisha Ismaila Numan Ogbonna Dennis Okoro Solace Amechi Omoruyi Ijeoma Chioma Oppah Ubong Inyang Anyang Aishat Ahmed Shirley Nneka Chukwurah Osita Samuel Umeononihu Rebecca Chinyelu Chukwuanukwu Eric Okechukwu Umeh Ekene Agatha Emeka Chukwuanugo Nkemakonam Ogbuagu Ibrahim Adamu Yakasai Oliver Chukwujekwu Ezechi Joseph Ifeanyichukwu Ikechebelu Triplex infection in pregnancy collaboration group |
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Ikechukwu Innocent Mbachu Uchenna Chukwunonso Ogwaluonye Stephen Okoroafor Kalu Chinyere Ukamaka Onubogu Sussan Ifeyinwa Nweje Chinwe Elizabeth Uzochukwu Chike Henry Nwankwo Preye Owen Fiebai Olabisi Morebise Loto Godwin Otuodichinma Akaba Hadiza Abdullahi Usman Ayyuba Rabiu Richard Obinwanne Egeonu Odion Emmanuel Igue Bukola Abimbola Adesoji Chiamaka Henrietta Jibuaku Prince Ogbonnia Aja Chiamaka Perpetua Chidozie Hadiza Sani Ibrahim Fatima Ele Aliyu Aisha Ismaila Numan Ogbonna Dennis Okoro Solace Amechi Omoruyi Ijeoma Chioma Oppah Ubong Inyang Anyang Aishat Ahmed Shirley Nneka Chukwurah Osita Samuel Umeononihu Rebecca Chinyelu Chukwuanukwu Eric Okechukwu Umeh Ekene Agatha Emeka Chukwuanugo Nkemakonam Ogbuagu Ibrahim Adamu Yakasai Oliver Chukwujekwu Ezechi Joseph Ifeanyichukwu Ikechebelu Triplex infection in pregnancy collaboration group |
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10.1186/s12978-020-00995-8 |
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| score |
7.4024124 |