Influence of seasonal changes on disease activity and distribution of affected joints in rheumatoid arthritis

Abstract Background Previous studies suggest that RA activity is sensitive to seasonal changes. This study explored the influence of season on RA activity, particularly the distribution of affected joints, using a nationwide database in Japan. Methods We investigated 12,839 patients whose RA activit...
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Autor*in:	Hiroaki Mori [verfasserIn] Tetsuji Sawada [verfasserIn] Susumu Nishiyama [verfasserIn] Kota Shimada [verfasserIn] Koichiro Tahara [verfasserIn] Haeru Hayashi [verfasserIn] Eri Kato [verfasserIn] Mayu Tago [verfasserIn] Toshihiro Matsui [verfasserIn] Shigeto Tohma [verfasserIn]

Format:	E-Artikel
Sprache:	Englisch

Erschienen:	2019

Schlagwörter:	Rheumatoid arthritis Epidemiology Seasonality Disease activity

Übergeordnetes Werk:	In: BMC Musculoskeletal Disorders - BMC, 2003, 20(2019), 1, Seite 8
Übergeordnetes Werk:	volume:20 ; year:2019 ; number:1 ; pages:8

Links:	Link aufrufen Link aufrufen Link aufrufen Journal toc

DOI / URN:	10.1186/s12891-019-2418-2

Katalog-ID:	DOAJ045723443

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520			\|a Abstract Background Previous studies suggest that RA activity is sensitive to seasonal changes. This study explored the influence of season on RA activity, particularly the distribution of affected joints, using a nationwide database in Japan. Methods We investigated 12,839 patients whose RA activity was recorded in spring (n = 3250), summer (n = 916), fall (n = 1021), and winter (n = 7652). Disease activity score (DAS) 28-CRP, simplified disease activity index (SDAI), and clinical disease activity index (CDAI) were used as indices of disease activity. Disease activity was also assessed according to DAS28-CRP scores (remission, low, moderate, or high). The affected joint distribution was investigated using novel joint indices (x, y, z), where x and y are indices for the upper and lower joints, respectively, and z is the index for large joint predominance. Results Mean DAS28-CRP and median SDAI and CDAI scores were highest in spring and lowest in fall. There was a significant difference in the DAS28-CRP for fall versus spring and winter. Fall was associated with a higher remission rate, and spring and winter with high and moderate RA activity, respectively. Significant differences in x, y, SDAI, and CDAI scores were found for spring versus summer, fall, and winter, in addition to fall versus winter (except in y). There was no seasonal difference in the z index. Conclusions RA activity in the upper and lower extremities may be highest in spring, followed by winter. Seasonal changes should be considered in patients with RA to better understand their symptoms.
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allfields	10.1186/s12891-019-2418-2 doi (DE-627)DOAJ045723443 (DE-599)DOAJb62fa40f738c4d6c86b69a4d8f1408e9 DE-627 ger DE-627 rakwb eng RC925-935 Hiroaki Mori verfasserin aut Influence of seasonal changes on disease activity and distribution of affected joints in rheumatoid arthritis 2019 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Abstract Background Previous studies suggest that RA activity is sensitive to seasonal changes. This study explored the influence of season on RA activity, particularly the distribution of affected joints, using a nationwide database in Japan. Methods We investigated 12,839 patients whose RA activity was recorded in spring (n = 3250), summer (n = 916), fall (n = 1021), and winter (n = 7652). Disease activity score (DAS) 28-CRP, simplified disease activity index (SDAI), and clinical disease activity index (CDAI) were used as indices of disease activity. Disease activity was also assessed according to DAS28-CRP scores (remission, low, moderate, or high). The affected joint distribution was investigated using novel joint indices (x, y, z), where x and y are indices for the upper and lower joints, respectively, and z is the index for large joint predominance. Results Mean DAS28-CRP and median SDAI and CDAI scores were highest in spring and lowest in fall. There was a significant difference in the DAS28-CRP for fall versus spring and winter. Fall was associated with a higher remission rate, and spring and winter with high and moderate RA activity, respectively. Significant differences in x, y, SDAI, and CDAI scores were found for spring versus summer, fall, and winter, in addition to fall versus winter (except in y). There was no seasonal difference in the z index. Conclusions RA activity in the upper and lower extremities may be highest in spring, followed by winter. Seasonal changes should be considered in patients with RA to better understand their symptoms. Rheumatoid arthritis Epidemiology Seasonality Disease activity Diseases of the musculoskeletal system Tetsuji Sawada verfasserin aut Susumu Nishiyama verfasserin aut Kota Shimada verfasserin aut Koichiro Tahara verfasserin aut Haeru Hayashi verfasserin aut Eri Kato verfasserin aut Mayu Tago verfasserin aut Toshihiro Matsui verfasserin aut Shigeto Tohma verfasserin aut In BMC Musculoskeletal Disorders BMC, 2003 20(2019), 1, Seite 8 (DE-627)326643745 (DE-600)2041355-5 14712474 nnns volume:20 year:2019 number:1 pages:8 https://doi.org/10.1186/s12891-019-2418-2 kostenfrei https://doaj.org/article/b62fa40f738c4d6c86b69a4d8f1408e9 kostenfrei http://link.springer.com/article/10.1186/s12891-019-2418-2 kostenfrei https://doaj.org/toc/1471-2474 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2031 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2057 GBV_ILN_2061 GBV_ILN_2111 GBV_ILN_2113 GBV_ILN_2190 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 20 2019 1 8
spelling	10.1186/s12891-019-2418-2 doi (DE-627)DOAJ045723443 (DE-599)DOAJb62fa40f738c4d6c86b69a4d8f1408e9 DE-627 ger DE-627 rakwb eng RC925-935 Hiroaki Mori verfasserin aut Influence of seasonal changes on disease activity and distribution of affected joints in rheumatoid arthritis 2019 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Abstract Background Previous studies suggest that RA activity is sensitive to seasonal changes. This study explored the influence of season on RA activity, particularly the distribution of affected joints, using a nationwide database in Japan. Methods We investigated 12,839 patients whose RA activity was recorded in spring (n = 3250), summer (n = 916), fall (n = 1021), and winter (n = 7652). Disease activity score (DAS) 28-CRP, simplified disease activity index (SDAI), and clinical disease activity index (CDAI) were used as indices of disease activity. Disease activity was also assessed according to DAS28-CRP scores (remission, low, moderate, or high). The affected joint distribution was investigated using novel joint indices (x, y, z), where x and y are indices for the upper and lower joints, respectively, and z is the index for large joint predominance. Results Mean DAS28-CRP and median SDAI and CDAI scores were highest in spring and lowest in fall. There was a significant difference in the DAS28-CRP for fall versus spring and winter. Fall was associated with a higher remission rate, and spring and winter with high and moderate RA activity, respectively. Significant differences in x, y, SDAI, and CDAI scores were found for spring versus summer, fall, and winter, in addition to fall versus winter (except in y). There was no seasonal difference in the z index. Conclusions RA activity in the upper and lower extremities may be highest in spring, followed by winter. Seasonal changes should be considered in patients with RA to better understand their symptoms. Rheumatoid arthritis Epidemiology Seasonality Disease activity Diseases of the musculoskeletal system Tetsuji Sawada verfasserin aut Susumu Nishiyama verfasserin aut Kota Shimada verfasserin aut Koichiro Tahara verfasserin aut Haeru Hayashi verfasserin aut Eri Kato verfasserin aut Mayu Tago verfasserin aut Toshihiro Matsui verfasserin aut Shigeto Tohma verfasserin aut In BMC Musculoskeletal Disorders BMC, 2003 20(2019), 1, Seite 8 (DE-627)326643745 (DE-600)2041355-5 14712474 nnns volume:20 year:2019 number:1 pages:8 https://doi.org/10.1186/s12891-019-2418-2 kostenfrei https://doaj.org/article/b62fa40f738c4d6c86b69a4d8f1408e9 kostenfrei http://link.springer.com/article/10.1186/s12891-019-2418-2 kostenfrei https://doaj.org/toc/1471-2474 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2031 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2057 GBV_ILN_2061 GBV_ILN_2111 GBV_ILN_2113 GBV_ILN_2190 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 20 2019 1 8
allfields_unstemmed	10.1186/s12891-019-2418-2 doi (DE-627)DOAJ045723443 (DE-599)DOAJb62fa40f738c4d6c86b69a4d8f1408e9 DE-627 ger DE-627 rakwb eng RC925-935 Hiroaki Mori verfasserin aut Influence of seasonal changes on disease activity and distribution of affected joints in rheumatoid arthritis 2019 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Abstract Background Previous studies suggest that RA activity is sensitive to seasonal changes. This study explored the influence of season on RA activity, particularly the distribution of affected joints, using a nationwide database in Japan. Methods We investigated 12,839 patients whose RA activity was recorded in spring (n = 3250), summer (n = 916), fall (n = 1021), and winter (n = 7652). Disease activity score (DAS) 28-CRP, simplified disease activity index (SDAI), and clinical disease activity index (CDAI) were used as indices of disease activity. Disease activity was also assessed according to DAS28-CRP scores (remission, low, moderate, or high). The affected joint distribution was investigated using novel joint indices (x, y, z), where x and y are indices for the upper and lower joints, respectively, and z is the index for large joint predominance. Results Mean DAS28-CRP and median SDAI and CDAI scores were highest in spring and lowest in fall. There was a significant difference in the DAS28-CRP for fall versus spring and winter. Fall was associated with a higher remission rate, and spring and winter with high and moderate RA activity, respectively. Significant differences in x, y, SDAI, and CDAI scores were found for spring versus summer, fall, and winter, in addition to fall versus winter (except in y). There was no seasonal difference in the z index. Conclusions RA activity in the upper and lower extremities may be highest in spring, followed by winter. Seasonal changes should be considered in patients with RA to better understand their symptoms. Rheumatoid arthritis Epidemiology Seasonality Disease activity Diseases of the musculoskeletal system Tetsuji Sawada verfasserin aut Susumu Nishiyama verfasserin aut Kota Shimada verfasserin aut Koichiro Tahara verfasserin aut Haeru Hayashi verfasserin aut Eri Kato verfasserin aut Mayu Tago verfasserin aut Toshihiro Matsui verfasserin aut Shigeto Tohma verfasserin aut In BMC Musculoskeletal Disorders BMC, 2003 20(2019), 1, Seite 8 (DE-627)326643745 (DE-600)2041355-5 14712474 nnns volume:20 year:2019 number:1 pages:8 https://doi.org/10.1186/s12891-019-2418-2 kostenfrei https://doaj.org/article/b62fa40f738c4d6c86b69a4d8f1408e9 kostenfrei http://link.springer.com/article/10.1186/s12891-019-2418-2 kostenfrei https://doaj.org/toc/1471-2474 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2031 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2057 GBV_ILN_2061 GBV_ILN_2111 GBV_ILN_2113 GBV_ILN_2190 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 20 2019 1 8
allfieldsGer	10.1186/s12891-019-2418-2 doi (DE-627)DOAJ045723443 (DE-599)DOAJb62fa40f738c4d6c86b69a4d8f1408e9 DE-627 ger DE-627 rakwb eng RC925-935 Hiroaki Mori verfasserin aut Influence of seasonal changes on disease activity and distribution of affected joints in rheumatoid arthritis 2019 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Abstract Background Previous studies suggest that RA activity is sensitive to seasonal changes. This study explored the influence of season on RA activity, particularly the distribution of affected joints, using a nationwide database in Japan. Methods We investigated 12,839 patients whose RA activity was recorded in spring (n = 3250), summer (n = 916), fall (n = 1021), and winter (n = 7652). Disease activity score (DAS) 28-CRP, simplified disease activity index (SDAI), and clinical disease activity index (CDAI) were used as indices of disease activity. Disease activity was also assessed according to DAS28-CRP scores (remission, low, moderate, or high). The affected joint distribution was investigated using novel joint indices (x, y, z), where x and y are indices for the upper and lower joints, respectively, and z is the index for large joint predominance. Results Mean DAS28-CRP and median SDAI and CDAI scores were highest in spring and lowest in fall. There was a significant difference in the DAS28-CRP for fall versus spring and winter. Fall was associated with a higher remission rate, and spring and winter with high and moderate RA activity, respectively. Significant differences in x, y, SDAI, and CDAI scores were found for spring versus summer, fall, and winter, in addition to fall versus winter (except in y). There was no seasonal difference in the z index. Conclusions RA activity in the upper and lower extremities may be highest in spring, followed by winter. Seasonal changes should be considered in patients with RA to better understand their symptoms. Rheumatoid arthritis Epidemiology Seasonality Disease activity Diseases of the musculoskeletal system Tetsuji Sawada verfasserin aut Susumu Nishiyama verfasserin aut Kota Shimada verfasserin aut Koichiro Tahara verfasserin aut Haeru Hayashi verfasserin aut Eri Kato verfasserin aut Mayu Tago verfasserin aut Toshihiro Matsui verfasserin aut Shigeto Tohma verfasserin aut In BMC Musculoskeletal Disorders BMC, 2003 20(2019), 1, Seite 8 (DE-627)326643745 (DE-600)2041355-5 14712474 nnns volume:20 year:2019 number:1 pages:8 https://doi.org/10.1186/s12891-019-2418-2 kostenfrei https://doaj.org/article/b62fa40f738c4d6c86b69a4d8f1408e9 kostenfrei http://link.springer.com/article/10.1186/s12891-019-2418-2 kostenfrei https://doaj.org/toc/1471-2474 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2031 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2057 GBV_ILN_2061 GBV_ILN_2111 GBV_ILN_2113 GBV_ILN_2190 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 20 2019 1 8
allfieldsSound	10.1186/s12891-019-2418-2 doi (DE-627)DOAJ045723443 (DE-599)DOAJb62fa40f738c4d6c86b69a4d8f1408e9 DE-627 ger DE-627 rakwb eng RC925-935 Hiroaki Mori verfasserin aut Influence of seasonal changes on disease activity and distribution of affected joints in rheumatoid arthritis 2019 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Abstract Background Previous studies suggest that RA activity is sensitive to seasonal changes. This study explored the influence of season on RA activity, particularly the distribution of affected joints, using a nationwide database in Japan. Methods We investigated 12,839 patients whose RA activity was recorded in spring (n = 3250), summer (n = 916), fall (n = 1021), and winter (n = 7652). Disease activity score (DAS) 28-CRP, simplified disease activity index (SDAI), and clinical disease activity index (CDAI) were used as indices of disease activity. Disease activity was also assessed according to DAS28-CRP scores (remission, low, moderate, or high). The affected joint distribution was investigated using novel joint indices (x, y, z), where x and y are indices for the upper and lower joints, respectively, and z is the index for large joint predominance. Results Mean DAS28-CRP and median SDAI and CDAI scores were highest in spring and lowest in fall. There was a significant difference in the DAS28-CRP for fall versus spring and winter. Fall was associated with a higher remission rate, and spring and winter with high and moderate RA activity, respectively. Significant differences in x, y, SDAI, and CDAI scores were found for spring versus summer, fall, and winter, in addition to fall versus winter (except in y). There was no seasonal difference in the z index. Conclusions RA activity in the upper and lower extremities may be highest in spring, followed by winter. Seasonal changes should be considered in patients with RA to better understand their symptoms. Rheumatoid arthritis Epidemiology Seasonality Disease activity Diseases of the musculoskeletal system Tetsuji Sawada verfasserin aut Susumu Nishiyama verfasserin aut Kota Shimada verfasserin aut Koichiro Tahara verfasserin aut Haeru Hayashi verfasserin aut Eri Kato verfasserin aut Mayu Tago verfasserin aut Toshihiro Matsui verfasserin aut Shigeto Tohma verfasserin aut In BMC Musculoskeletal Disorders BMC, 2003 20(2019), 1, Seite 8 (DE-627)326643745 (DE-600)2041355-5 14712474 nnns volume:20 year:2019 number:1 pages:8 https://doi.org/10.1186/s12891-019-2418-2 kostenfrei https://doaj.org/article/b62fa40f738c4d6c86b69a4d8f1408e9 kostenfrei http://link.springer.com/article/10.1186/s12891-019-2418-2 kostenfrei https://doaj.org/toc/1471-2474 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2031 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2057 GBV_ILN_2061 GBV_ILN_2111 GBV_ILN_2113 GBV_ILN_2190 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 20 2019 1 8
language	English
source	In BMC Musculoskeletal Disorders 20(2019), 1, Seite 8 volume:20 year:2019 number:1 pages:8
sourceStr	In BMC Musculoskeletal Disorders 20(2019), 1, Seite 8 volume:20 year:2019 number:1 pages:8
format_phy_str_mv	Article
institution	findex.gbv.de
topic_facet	Rheumatoid arthritis Epidemiology Seasonality Disease activity Diseases of the musculoskeletal system
isfreeaccess_bool	true
container_title	BMC Musculoskeletal Disorders
authorswithroles_txt_mv	Hiroaki Mori @@aut@@ Tetsuji Sawada @@aut@@ Susumu Nishiyama @@aut@@ Kota Shimada @@aut@@ Koichiro Tahara @@aut@@ Haeru Hayashi @@aut@@ Eri Kato @@aut@@ Mayu Tago @@aut@@ Toshihiro Matsui @@aut@@ Shigeto Tohma @@aut@@
publishDateDaySort_date	2019-01-01T00:00:00Z
hierarchy_top_id	326643745
id	DOAJ045723443
language_de	englisch
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This study explored the influence of season on RA activity, particularly the distribution of affected joints, using a nationwide database in Japan. Methods We investigated 12,839 patients whose RA activity was recorded in spring (n = 3250), summer (n = 916), fall (n = 1021), and winter (n = 7652). Disease activity score (DAS) 28-CRP, simplified disease activity index (SDAI), and clinical disease activity index (CDAI) were used as indices of disease activity. Disease activity was also assessed according to DAS28-CRP scores (remission, low, moderate, or high). The affected joint distribution was investigated using novel joint indices (x, y, z), where x and y are indices for the upper and lower joints, respectively, and z is the index for large joint predominance. Results Mean DAS28-CRP and median SDAI and CDAI scores were highest in spring and lowest in fall. There was a significant difference in the DAS28-CRP for fall versus spring and winter. Fall was associated with a higher remission rate, and spring and winter with high and moderate RA activity, respectively. Significant differences in x, y, SDAI, and CDAI scores were found for spring versus summer, fall, and winter, in addition to fall versus winter (except in y). There was no seasonal difference in the z index. Conclusions RA activity in the upper and lower extremities may be highest in spring, followed by winter. 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callnumber-first	R - Medicine
author	Hiroaki Mori
spellingShingle	Hiroaki Mori misc RC925-935 misc Rheumatoid arthritis misc Epidemiology misc Seasonality misc Disease activity misc Diseases of the musculoskeletal system Influence of seasonal changes on disease activity and distribution of affected joints in rheumatoid arthritis
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topic_title	RC925-935 Influence of seasonal changes on disease activity and distribution of affected joints in rheumatoid arthritis Rheumatoid arthritis Epidemiology Seasonality Disease activity
topic	misc RC925-935 misc Rheumatoid arthritis misc Epidemiology misc Seasonality misc Disease activity misc Diseases of the musculoskeletal system
topic_unstemmed	misc RC925-935 misc Rheumatoid arthritis misc Epidemiology misc Seasonality misc Disease activity misc Diseases of the musculoskeletal system
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title	Influence of seasonal changes on disease activity and distribution of affected joints in rheumatoid arthritis
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title_full	Influence of seasonal changes on disease activity and distribution of affected joints in rheumatoid arthritis
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author_browse	Hiroaki Mori Tetsuji Sawada Susumu Nishiyama Kota Shimada Koichiro Tahara Haeru Hayashi Eri Kato Mayu Tago Toshihiro Matsui Shigeto Tohma
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title_sort	influence of seasonal changes on disease activity and distribution of affected joints in rheumatoid arthritis
callnumber	RC925-935
title_auth	Influence of seasonal changes on disease activity and distribution of affected joints in rheumatoid arthritis
abstract	Abstract Background Previous studies suggest that RA activity is sensitive to seasonal changes. This study explored the influence of season on RA activity, particularly the distribution of affected joints, using a nationwide database in Japan. Methods We investigated 12,839 patients whose RA activity was recorded in spring (n = 3250), summer (n = 916), fall (n = 1021), and winter (n = 7652). Disease activity score (DAS) 28-CRP, simplified disease activity index (SDAI), and clinical disease activity index (CDAI) were used as indices of disease activity. Disease activity was also assessed according to DAS28-CRP scores (remission, low, moderate, or high). The affected joint distribution was investigated using novel joint indices (x, y, z), where x and y are indices for the upper and lower joints, respectively, and z is the index for large joint predominance. Results Mean DAS28-CRP and median SDAI and CDAI scores were highest in spring and lowest in fall. There was a significant difference in the DAS28-CRP for fall versus spring and winter. Fall was associated with a higher remission rate, and spring and winter with high and moderate RA activity, respectively. Significant differences in x, y, SDAI, and CDAI scores were found for spring versus summer, fall, and winter, in addition to fall versus winter (except in y). There was no seasonal difference in the z index. Conclusions RA activity in the upper and lower extremities may be highest in spring, followed by winter. Seasonal changes should be considered in patients with RA to better understand their symptoms.
abstractGer	Abstract Background Previous studies suggest that RA activity is sensitive to seasonal changes. This study explored the influence of season on RA activity, particularly the distribution of affected joints, using a nationwide database in Japan. Methods We investigated 12,839 patients whose RA activity was recorded in spring (n = 3250), summer (n = 916), fall (n = 1021), and winter (n = 7652). Disease activity score (DAS) 28-CRP, simplified disease activity index (SDAI), and clinical disease activity index (CDAI) were used as indices of disease activity. Disease activity was also assessed according to DAS28-CRP scores (remission, low, moderate, or high). The affected joint distribution was investigated using novel joint indices (x, y, z), where x and y are indices for the upper and lower joints, respectively, and z is the index for large joint predominance. Results Mean DAS28-CRP and median SDAI and CDAI scores were highest in spring and lowest in fall. There was a significant difference in the DAS28-CRP for fall versus spring and winter. Fall was associated with a higher remission rate, and spring and winter with high and moderate RA activity, respectively. Significant differences in x, y, SDAI, and CDAI scores were found for spring versus summer, fall, and winter, in addition to fall versus winter (except in y). There was no seasonal difference in the z index. Conclusions RA activity in the upper and lower extremities may be highest in spring, followed by winter. Seasonal changes should be considered in patients with RA to better understand their symptoms.
abstract_unstemmed	Abstract Background Previous studies suggest that RA activity is sensitive to seasonal changes. This study explored the influence of season on RA activity, particularly the distribution of affected joints, using a nationwide database in Japan. Methods We investigated 12,839 patients whose RA activity was recorded in spring (n = 3250), summer (n = 916), fall (n = 1021), and winter (n = 7652). Disease activity score (DAS) 28-CRP, simplified disease activity index (SDAI), and clinical disease activity index (CDAI) were used as indices of disease activity. Disease activity was also assessed according to DAS28-CRP scores (remission, low, moderate, or high). The affected joint distribution was investigated using novel joint indices (x, y, z), where x and y are indices for the upper and lower joints, respectively, and z is the index for large joint predominance. Results Mean DAS28-CRP and median SDAI and CDAI scores were highest in spring and lowest in fall. There was a significant difference in the DAS28-CRP for fall versus spring and winter. Fall was associated with a higher remission rate, and spring and winter with high and moderate RA activity, respectively. Significant differences in x, y, SDAI, and CDAI scores were found for spring versus summer, fall, and winter, in addition to fall versus winter (except in y). There was no seasonal difference in the z index. Conclusions RA activity in the upper and lower extremities may be highest in spring, followed by winter. Seasonal changes should be considered in patients with RA to better understand their symptoms.
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title_short	Influence of seasonal changes on disease activity and distribution of affected joints in rheumatoid arthritis
url	https://doi.org/10.1186/s12891-019-2418-2 https://doaj.org/article/b62fa40f738c4d6c86b69a4d8f1408e9 http://link.springer.com/article/10.1186/s12891-019-2418-2 https://doaj.org/toc/1471-2474
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Influence of seasonal changes on disease activity and distribution of affected joints in rheumatoid arthritis

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