Risk factors for anastomotic leakage and its impact on long-term survival in left-sided colorectal cancer surgery

Abstract Background Anastomotic leakage (AL) significantly impairs short-term outcomes. The impact on the long-term outcomes remains unclear. This study aimed to identify the risk factors for AL and the impact on long-term survival in patients with left-sided colorectal cancer. Methods Nine-hundred...
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Autor*in:	Marius Kryzauskas [verfasserIn] Augustinas Bausys [verfasserIn] Austeja Elzbieta Degutyte [verfasserIn] Vilius Abeciunas [verfasserIn] Eligijus Poskus [verfasserIn] Rimantas Bausys [verfasserIn] Audrius Dulskas [verfasserIn] Kestutis Strupas [verfasserIn] Tomas Poskus [verfasserIn]

Format:	E-Artikel
Sprache:	Englisch

Erschienen:	2020

Schlagwörter:	Colorectal cancer Anastomotic leakage Risk factors Oncological outcomes Overall survival Disease-free survival

Übergeordnetes Werk:	In: World Journal of Surgical Oncology - BMC, 2003, 18(2020), 1, Seite 9
Übergeordnetes Werk:	volume:18 ; year:2020 ; number:1 ; pages:9

Links:	Link aufrufen Link aufrufen Link aufrufen Journal toc

DOI / URN:	10.1186/s12957-020-01968-8

Katalog-ID:	DOAJ045834946

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520			\|a Abstract Background Anastomotic leakage (AL) significantly impairs short-term outcomes. The impact on the long-term outcomes remains unclear. This study aimed to identify the risk factors for AL and the impact on long-term survival in patients with left-sided colorectal cancer. Methods Nine-hundred patients with left-sided colorectal carcinoma who underwent sigmoid or rectal resection were enrolled in the study. Risk factors for AL after sigmoid or rectal resection were identified, and long-term outcomes of patients with and without AL were compared. Results AL rates following sigmoid and rectal resection were 5.1% and 10.7%, respectively. Higher ASA score (III–IV; OR = 10.54, p = 0.007) was associated with AL in patients undergoing sigmoid surgery on multivariable analysis. Male sex (OR = 2.40, p = 0.004), CCI score < 5 (OR = 1.72, p = 0.025), and T3/T4 stage tumors (OR = 2.25, p = 0.017) were risk factors for AL after rectal resection on multivariable analysis. AL impaired disease-free and overall survival in patients undergoing sigmoid (p = 0.009 and p = 0.001) and rectal (p = 0.003 and p = 0.014) surgery. Conclusion ASA score of III–IV is an independent risk factor for AL after sigmoid surgery, and male sex, higher CCI score, and advanced T stage are risk factors for AL after rectal surgery. AL impairs the long-term survival in patients undergoing left-sided colorectal surgery.
650		4	\|a Colorectal cancer
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650		4	\|a Disease-free survival
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653		0	\|a Neoplasms. Tumors. Oncology. Including cancer and carcinogens
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allfields	10.1186/s12957-020-01968-8 doi (DE-627)DOAJ045834946 (DE-599)DOAJd92275fcc57e46a5a3d3549a75668a4a DE-627 ger DE-627 rakwb eng RD1-811 RC254-282 Marius Kryzauskas verfasserin aut Risk factors for anastomotic leakage and its impact on long-term survival in left-sided colorectal cancer surgery 2020 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Abstract Background Anastomotic leakage (AL) significantly impairs short-term outcomes. The impact on the long-term outcomes remains unclear. This study aimed to identify the risk factors for AL and the impact on long-term survival in patients with left-sided colorectal cancer. Methods Nine-hundred patients with left-sided colorectal carcinoma who underwent sigmoid or rectal resection were enrolled in the study. Risk factors for AL after sigmoid or rectal resection were identified, and long-term outcomes of patients with and without AL were compared. Results AL rates following sigmoid and rectal resection were 5.1% and 10.7%, respectively. Higher ASA score (III–IV; OR = 10.54, p = 0.007) was associated with AL in patients undergoing sigmoid surgery on multivariable analysis. Male sex (OR = 2.40, p = 0.004), CCI score < 5 (OR = 1.72, p = 0.025), and T3/T4 stage tumors (OR = 2.25, p = 0.017) were risk factors for AL after rectal resection on multivariable analysis. AL impaired disease-free and overall survival in patients undergoing sigmoid (p = 0.009 and p = 0.001) and rectal (p = 0.003 and p = 0.014) surgery. Conclusion ASA score of III–IV is an independent risk factor for AL after sigmoid surgery, and male sex, higher CCI score, and advanced T stage are risk factors for AL after rectal surgery. AL impairs the long-term survival in patients undergoing left-sided colorectal surgery. Colorectal cancer Anastomotic leakage Risk factors Oncological outcomes Overall survival Disease-free survival Surgery Neoplasms. Tumors. Oncology. Including cancer and carcinogens Augustinas Bausys verfasserin aut Austeja Elzbieta Degutyte verfasserin aut Vilius Abeciunas verfasserin aut Eligijus Poskus verfasserin aut Rimantas Bausys verfasserin aut Audrius Dulskas verfasserin aut Kestutis Strupas verfasserin aut Tomas Poskus verfasserin aut In World Journal of Surgical Oncology BMC, 2003 18(2020), 1, Seite 9 (DE-627)369082907 (DE-600)2118383-1 14777819 nnns volume:18 year:2020 number:1 pages:9 https://doi.org/10.1186/s12957-020-01968-8 kostenfrei https://doaj.org/article/d92275fcc57e46a5a3d3549a75668a4a kostenfrei http://link.springer.com/article/10.1186/s12957-020-01968-8 kostenfrei https://doaj.org/toc/1477-7819 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2005 GBV_ILN_2009 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2055 GBV_ILN_2111 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 18 2020 1 9
spelling	10.1186/s12957-020-01968-8 doi (DE-627)DOAJ045834946 (DE-599)DOAJd92275fcc57e46a5a3d3549a75668a4a DE-627 ger DE-627 rakwb eng RD1-811 RC254-282 Marius Kryzauskas verfasserin aut Risk factors for anastomotic leakage and its impact on long-term survival in left-sided colorectal cancer surgery 2020 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Abstract Background Anastomotic leakage (AL) significantly impairs short-term outcomes. The impact on the long-term outcomes remains unclear. This study aimed to identify the risk factors for AL and the impact on long-term survival in patients with left-sided colorectal cancer. Methods Nine-hundred patients with left-sided colorectal carcinoma who underwent sigmoid or rectal resection were enrolled in the study. Risk factors for AL after sigmoid or rectal resection were identified, and long-term outcomes of patients with and without AL were compared. Results AL rates following sigmoid and rectal resection were 5.1% and 10.7%, respectively. Higher ASA score (III–IV; OR = 10.54, p = 0.007) was associated with AL in patients undergoing sigmoid surgery on multivariable analysis. Male sex (OR = 2.40, p = 0.004), CCI score < 5 (OR = 1.72, p = 0.025), and T3/T4 stage tumors (OR = 2.25, p = 0.017) were risk factors for AL after rectal resection on multivariable analysis. AL impaired disease-free and overall survival in patients undergoing sigmoid (p = 0.009 and p = 0.001) and rectal (p = 0.003 and p = 0.014) surgery. Conclusion ASA score of III–IV is an independent risk factor for AL after sigmoid surgery, and male sex, higher CCI score, and advanced T stage are risk factors for AL after rectal surgery. AL impairs the long-term survival in patients undergoing left-sided colorectal surgery. Colorectal cancer Anastomotic leakage Risk factors Oncological outcomes Overall survival Disease-free survival Surgery Neoplasms. Tumors. Oncology. Including cancer and carcinogens Augustinas Bausys verfasserin aut Austeja Elzbieta Degutyte verfasserin aut Vilius Abeciunas verfasserin aut Eligijus Poskus verfasserin aut Rimantas Bausys verfasserin aut Audrius Dulskas verfasserin aut Kestutis Strupas verfasserin aut Tomas Poskus verfasserin aut In World Journal of Surgical Oncology BMC, 2003 18(2020), 1, Seite 9 (DE-627)369082907 (DE-600)2118383-1 14777819 nnns volume:18 year:2020 number:1 pages:9 https://doi.org/10.1186/s12957-020-01968-8 kostenfrei https://doaj.org/article/d92275fcc57e46a5a3d3549a75668a4a kostenfrei http://link.springer.com/article/10.1186/s12957-020-01968-8 kostenfrei https://doaj.org/toc/1477-7819 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2005 GBV_ILN_2009 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2055 GBV_ILN_2111 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 18 2020 1 9
allfields_unstemmed	10.1186/s12957-020-01968-8 doi (DE-627)DOAJ045834946 (DE-599)DOAJd92275fcc57e46a5a3d3549a75668a4a DE-627 ger DE-627 rakwb eng RD1-811 RC254-282 Marius Kryzauskas verfasserin aut Risk factors for anastomotic leakage and its impact on long-term survival in left-sided colorectal cancer surgery 2020 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Abstract Background Anastomotic leakage (AL) significantly impairs short-term outcomes. The impact on the long-term outcomes remains unclear. This study aimed to identify the risk factors for AL and the impact on long-term survival in patients with left-sided colorectal cancer. Methods Nine-hundred patients with left-sided colorectal carcinoma who underwent sigmoid or rectal resection were enrolled in the study. Risk factors for AL after sigmoid or rectal resection were identified, and long-term outcomes of patients with and without AL were compared. Results AL rates following sigmoid and rectal resection were 5.1% and 10.7%, respectively. Higher ASA score (III–IV; OR = 10.54, p = 0.007) was associated with AL in patients undergoing sigmoid surgery on multivariable analysis. Male sex (OR = 2.40, p = 0.004), CCI score < 5 (OR = 1.72, p = 0.025), and T3/T4 stage tumors (OR = 2.25, p = 0.017) were risk factors for AL after rectal resection on multivariable analysis. AL impaired disease-free and overall survival in patients undergoing sigmoid (p = 0.009 and p = 0.001) and rectal (p = 0.003 and p = 0.014) surgery. Conclusion ASA score of III–IV is an independent risk factor for AL after sigmoid surgery, and male sex, higher CCI score, and advanced T stage are risk factors for AL after rectal surgery. AL impairs the long-term survival in patients undergoing left-sided colorectal surgery. Colorectal cancer Anastomotic leakage Risk factors Oncological outcomes Overall survival Disease-free survival Surgery Neoplasms. Tumors. Oncology. Including cancer and carcinogens Augustinas Bausys verfasserin aut Austeja Elzbieta Degutyte verfasserin aut Vilius Abeciunas verfasserin aut Eligijus Poskus verfasserin aut Rimantas Bausys verfasserin aut Audrius Dulskas verfasserin aut Kestutis Strupas verfasserin aut Tomas Poskus verfasserin aut In World Journal of Surgical Oncology BMC, 2003 18(2020), 1, Seite 9 (DE-627)369082907 (DE-600)2118383-1 14777819 nnns volume:18 year:2020 number:1 pages:9 https://doi.org/10.1186/s12957-020-01968-8 kostenfrei https://doaj.org/article/d92275fcc57e46a5a3d3549a75668a4a kostenfrei http://link.springer.com/article/10.1186/s12957-020-01968-8 kostenfrei https://doaj.org/toc/1477-7819 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2005 GBV_ILN_2009 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2055 GBV_ILN_2111 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 18 2020 1 9
allfieldsGer	10.1186/s12957-020-01968-8 doi (DE-627)DOAJ045834946 (DE-599)DOAJd92275fcc57e46a5a3d3549a75668a4a DE-627 ger DE-627 rakwb eng RD1-811 RC254-282 Marius Kryzauskas verfasserin aut Risk factors for anastomotic leakage and its impact on long-term survival in left-sided colorectal cancer surgery 2020 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Abstract Background Anastomotic leakage (AL) significantly impairs short-term outcomes. The impact on the long-term outcomes remains unclear. This study aimed to identify the risk factors for AL and the impact on long-term survival in patients with left-sided colorectal cancer. Methods Nine-hundred patients with left-sided colorectal carcinoma who underwent sigmoid or rectal resection were enrolled in the study. Risk factors for AL after sigmoid or rectal resection were identified, and long-term outcomes of patients with and without AL were compared. Results AL rates following sigmoid and rectal resection were 5.1% and 10.7%, respectively. Higher ASA score (III–IV; OR = 10.54, p = 0.007) was associated with AL in patients undergoing sigmoid surgery on multivariable analysis. Male sex (OR = 2.40, p = 0.004), CCI score < 5 (OR = 1.72, p = 0.025), and T3/T4 stage tumors (OR = 2.25, p = 0.017) were risk factors for AL after rectal resection on multivariable analysis. AL impaired disease-free and overall survival in patients undergoing sigmoid (p = 0.009 and p = 0.001) and rectal (p = 0.003 and p = 0.014) surgery. Conclusion ASA score of III–IV is an independent risk factor for AL after sigmoid surgery, and male sex, higher CCI score, and advanced T stage are risk factors for AL after rectal surgery. AL impairs the long-term survival in patients undergoing left-sided colorectal surgery. Colorectal cancer Anastomotic leakage Risk factors Oncological outcomes Overall survival Disease-free survival Surgery Neoplasms. Tumors. Oncology. Including cancer and carcinogens Augustinas Bausys verfasserin aut Austeja Elzbieta Degutyte verfasserin aut Vilius Abeciunas verfasserin aut Eligijus Poskus verfasserin aut Rimantas Bausys verfasserin aut Audrius Dulskas verfasserin aut Kestutis Strupas verfasserin aut Tomas Poskus verfasserin aut In World Journal of Surgical Oncology BMC, 2003 18(2020), 1, Seite 9 (DE-627)369082907 (DE-600)2118383-1 14777819 nnns volume:18 year:2020 number:1 pages:9 https://doi.org/10.1186/s12957-020-01968-8 kostenfrei https://doaj.org/article/d92275fcc57e46a5a3d3549a75668a4a kostenfrei http://link.springer.com/article/10.1186/s12957-020-01968-8 kostenfrei https://doaj.org/toc/1477-7819 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2005 GBV_ILN_2009 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2055 GBV_ILN_2111 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 18 2020 1 9
allfieldsSound	10.1186/s12957-020-01968-8 doi (DE-627)DOAJ045834946 (DE-599)DOAJd92275fcc57e46a5a3d3549a75668a4a DE-627 ger DE-627 rakwb eng RD1-811 RC254-282 Marius Kryzauskas verfasserin aut Risk factors for anastomotic leakage and its impact on long-term survival in left-sided colorectal cancer surgery 2020 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Abstract Background Anastomotic leakage (AL) significantly impairs short-term outcomes. The impact on the long-term outcomes remains unclear. This study aimed to identify the risk factors for AL and the impact on long-term survival in patients with left-sided colorectal cancer. Methods Nine-hundred patients with left-sided colorectal carcinoma who underwent sigmoid or rectal resection were enrolled in the study. Risk factors for AL after sigmoid or rectal resection were identified, and long-term outcomes of patients with and without AL were compared. Results AL rates following sigmoid and rectal resection were 5.1% and 10.7%, respectively. Higher ASA score (III–IV; OR = 10.54, p = 0.007) was associated with AL in patients undergoing sigmoid surgery on multivariable analysis. Male sex (OR = 2.40, p = 0.004), CCI score < 5 (OR = 1.72, p = 0.025), and T3/T4 stage tumors (OR = 2.25, p = 0.017) were risk factors for AL after rectal resection on multivariable analysis. AL impaired disease-free and overall survival in patients undergoing sigmoid (p = 0.009 and p = 0.001) and rectal (p = 0.003 and p = 0.014) surgery. Conclusion ASA score of III–IV is an independent risk factor for AL after sigmoid surgery, and male sex, higher CCI score, and advanced T stage are risk factors for AL after rectal surgery. AL impairs the long-term survival in patients undergoing left-sided colorectal surgery. Colorectal cancer Anastomotic leakage Risk factors Oncological outcomes Overall survival Disease-free survival Surgery Neoplasms. Tumors. Oncology. Including cancer and carcinogens Augustinas Bausys verfasserin aut Austeja Elzbieta Degutyte verfasserin aut Vilius Abeciunas verfasserin aut Eligijus Poskus verfasserin aut Rimantas Bausys verfasserin aut Audrius Dulskas verfasserin aut Kestutis Strupas verfasserin aut Tomas Poskus verfasserin aut In World Journal of Surgical Oncology BMC, 2003 18(2020), 1, Seite 9 (DE-627)369082907 (DE-600)2118383-1 14777819 nnns volume:18 year:2020 number:1 pages:9 https://doi.org/10.1186/s12957-020-01968-8 kostenfrei https://doaj.org/article/d92275fcc57e46a5a3d3549a75668a4a kostenfrei http://link.springer.com/article/10.1186/s12957-020-01968-8 kostenfrei https://doaj.org/toc/1477-7819 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2005 GBV_ILN_2009 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2055 GBV_ILN_2111 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 18 2020 1 9
language	English
source	In World Journal of Surgical Oncology 18(2020), 1, Seite 9 volume:18 year:2020 number:1 pages:9
sourceStr	In World Journal of Surgical Oncology 18(2020), 1, Seite 9 volume:18 year:2020 number:1 pages:9
format_phy_str_mv	Article
institution	findex.gbv.de
topic_facet	Colorectal cancer Anastomotic leakage Risk factors Oncological outcomes Overall survival Disease-free survival Surgery Neoplasms. Tumors. Oncology. Including cancer and carcinogens
isfreeaccess_bool	true
container_title	World Journal of Surgical Oncology
authorswithroles_txt_mv	Marius Kryzauskas @@aut@@ Augustinas Bausys @@aut@@ Austeja Elzbieta Degutyte @@aut@@ Vilius Abeciunas @@aut@@ Eligijus Poskus @@aut@@ Rimantas Bausys @@aut@@ Audrius Dulskas @@aut@@ Kestutis Strupas @@aut@@ Tomas Poskus @@aut@@
publishDateDaySort_date	2020-01-01T00:00:00Z
hierarchy_top_id	369082907
id	DOAJ045834946
language_de	englisch
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callnumber-first	R - Medicine
author	Marius Kryzauskas
spellingShingle	Marius Kryzauskas misc RD1-811 misc RC254-282 misc Colorectal cancer misc Anastomotic leakage misc Risk factors misc Oncological outcomes misc Overall survival misc Disease-free survival misc Surgery misc Neoplasms. Tumors. Oncology. Including cancer and carcinogens Risk factors for anastomotic leakage and its impact on long-term survival in left-sided colorectal cancer surgery
authorStr	Marius Kryzauskas
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topic_title	RD1-811 RC254-282 Risk factors for anastomotic leakage and its impact on long-term survival in left-sided colorectal cancer surgery Colorectal cancer Anastomotic leakage Risk factors Oncological outcomes Overall survival Disease-free survival
topic	misc RD1-811 misc RC254-282 misc Colorectal cancer misc Anastomotic leakage misc Risk factors misc Oncological outcomes misc Overall survival misc Disease-free survival misc Surgery misc Neoplasms. Tumors. Oncology. Including cancer and carcinogens
topic_unstemmed	misc RD1-811 misc RC254-282 misc Colorectal cancer misc Anastomotic leakage misc Risk factors misc Oncological outcomes misc Overall survival misc Disease-free survival misc Surgery misc Neoplasms. Tumors. Oncology. Including cancer and carcinogens
topic_browse	misc RD1-811 misc RC254-282 misc Colorectal cancer misc Anastomotic leakage misc Risk factors misc Oncological outcomes misc Overall survival misc Disease-free survival misc Surgery misc Neoplasms. Tumors. Oncology. Including cancer and carcinogens
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title	Risk factors for anastomotic leakage and its impact on long-term survival in left-sided colorectal cancer surgery
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title_full	Risk factors for anastomotic leakage and its impact on long-term survival in left-sided colorectal cancer surgery
author_sort	Marius Kryzauskas
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author_browse	Marius Kryzauskas Augustinas Bausys Austeja Elzbieta Degutyte Vilius Abeciunas Eligijus Poskus Rimantas Bausys Audrius Dulskas Kestutis Strupas Tomas Poskus
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title_sort	risk factors for anastomotic leakage and its impact on long-term survival in left-sided colorectal cancer surgery
callnumber	RD1-811
title_auth	Risk factors for anastomotic leakage and its impact on long-term survival in left-sided colorectal cancer surgery
abstract	Abstract Background Anastomotic leakage (AL) significantly impairs short-term outcomes. The impact on the long-term outcomes remains unclear. This study aimed to identify the risk factors for AL and the impact on long-term survival in patients with left-sided colorectal cancer. Methods Nine-hundred patients with left-sided colorectal carcinoma who underwent sigmoid or rectal resection were enrolled in the study. Risk factors for AL after sigmoid or rectal resection were identified, and long-term outcomes of patients with and without AL were compared. Results AL rates following sigmoid and rectal resection were 5.1% and 10.7%, respectively. Higher ASA score (III–IV; OR = 10.54, p = 0.007) was associated with AL in patients undergoing sigmoid surgery on multivariable analysis. Male sex (OR = 2.40, p = 0.004), CCI score < 5 (OR = 1.72, p = 0.025), and T3/T4 stage tumors (OR = 2.25, p = 0.017) were risk factors for AL after rectal resection on multivariable analysis. AL impaired disease-free and overall survival in patients undergoing sigmoid (p = 0.009 and p = 0.001) and rectal (p = 0.003 and p = 0.014) surgery. Conclusion ASA score of III–IV is an independent risk factor for AL after sigmoid surgery, and male sex, higher CCI score, and advanced T stage are risk factors for AL after rectal surgery. AL impairs the long-term survival in patients undergoing left-sided colorectal surgery.
abstractGer	Abstract Background Anastomotic leakage (AL) significantly impairs short-term outcomes. The impact on the long-term outcomes remains unclear. This study aimed to identify the risk factors for AL and the impact on long-term survival in patients with left-sided colorectal cancer. Methods Nine-hundred patients with left-sided colorectal carcinoma who underwent sigmoid or rectal resection were enrolled in the study. Risk factors for AL after sigmoid or rectal resection were identified, and long-term outcomes of patients with and without AL were compared. Results AL rates following sigmoid and rectal resection were 5.1% and 10.7%, respectively. Higher ASA score (III–IV; OR = 10.54, p = 0.007) was associated with AL in patients undergoing sigmoid surgery on multivariable analysis. Male sex (OR = 2.40, p = 0.004), CCI score < 5 (OR = 1.72, p = 0.025), and T3/T4 stage tumors (OR = 2.25, p = 0.017) were risk factors for AL after rectal resection on multivariable analysis. AL impaired disease-free and overall survival in patients undergoing sigmoid (p = 0.009 and p = 0.001) and rectal (p = 0.003 and p = 0.014) surgery. Conclusion ASA score of III–IV is an independent risk factor for AL after sigmoid surgery, and male sex, higher CCI score, and advanced T stage are risk factors for AL after rectal surgery. AL impairs the long-term survival in patients undergoing left-sided colorectal surgery.
abstract_unstemmed	Abstract Background Anastomotic leakage (AL) significantly impairs short-term outcomes. The impact on the long-term outcomes remains unclear. This study aimed to identify the risk factors for AL and the impact on long-term survival in patients with left-sided colorectal cancer. Methods Nine-hundred patients with left-sided colorectal carcinoma who underwent sigmoid or rectal resection were enrolled in the study. Risk factors for AL after sigmoid or rectal resection were identified, and long-term outcomes of patients with and without AL were compared. Results AL rates following sigmoid and rectal resection were 5.1% and 10.7%, respectively. Higher ASA score (III–IV; OR = 10.54, p = 0.007) was associated with AL in patients undergoing sigmoid surgery on multivariable analysis. Male sex (OR = 2.40, p = 0.004), CCI score < 5 (OR = 1.72, p = 0.025), and T3/T4 stage tumors (OR = 2.25, p = 0.017) were risk factors for AL after rectal resection on multivariable analysis. AL impaired disease-free and overall survival in patients undergoing sigmoid (p = 0.009 and p = 0.001) and rectal (p = 0.003 and p = 0.014) surgery. Conclusion ASA score of III–IV is an independent risk factor for AL after sigmoid surgery, and male sex, higher CCI score, and advanced T stage are risk factors for AL after rectal surgery. AL impairs the long-term survival in patients undergoing left-sided colorectal surgery.
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title_short	Risk factors for anastomotic leakage and its impact on long-term survival in left-sided colorectal cancer surgery
url	https://doi.org/10.1186/s12957-020-01968-8 https://doaj.org/article/d92275fcc57e46a5a3d3549a75668a4a http://link.springer.com/article/10.1186/s12957-020-01968-8 https://doaj.org/toc/1477-7819
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