Antigenotoxic, Anti-photogenotoxic, and Antioxidant Properties of <i<Polyscias filicifolia</i< Shoots Cultivated In Vitro

Traditional medicinal plants are an important source of active compounds with potential antimutagenic activity. <i<Polyscias filicifolia</i< Bailey (Araliaceae) is a South Asian traditional herb used as an adaptogenic and cardiac drug. Extracts of <i<P. filicifolia</i< contai...
Ausführliche Beschreibung

Gespeichert in:

Autor*in:	Ramona Figat [verfasserIn] Anita Śliwińska [verfasserIn] Anna Stochmal [verfasserIn] Agata Soluch [verfasserIn] Magdalena Sobczak [verfasserIn] Anna Zgadzaj [verfasserIn] Katarzyna Sykłowska-Baranek [verfasserIn] Agnieszka Pietrosiuk [verfasserIn]

Format:	E-Artikel
Sprache:	Englisch

Erschienen:	2020

Schlagwörter:	antigenotoxic agents chlorogenic acid ferulic acid caffeic acid salmonella typhimurium

Übergeordnetes Werk:	In: Molecules - MDPI AG, 2003, 25(2020), 5, p 1090
Übergeordnetes Werk:	volume:25 ; year:2020 ; number:5, p 1090

Links:	Link aufrufen Link aufrufen Link aufrufen Journal toc

DOI / URN:	10.3390/molecules25051090

Katalog-ID:	DOAJ045883637

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allfields_unstemmed	10.3390/molecules25051090 doi (DE-627)DOAJ045883637 (DE-599)DOAJ6e1af388dd9a4faa8e1c0c8c3b26078a DE-627 ger DE-627 rakwb eng QD241-441 Ramona Figat verfasserin aut Antigenotoxic, Anti-photogenotoxic, and Antioxidant Properties of <i<Polyscias filicifolia</i< Shoots Cultivated In Vitro 2020 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Traditional medicinal plants are an important source of active compounds with potential antimutagenic activity. <i<Polyscias filicifolia</i< Bailey (Araliaceae) is a South Asian traditional herb used as an adaptogenic and cardiac drug. Extracts of <i<P. filicifolia</i< contain a wide range of biologically active compounds like phenolic acids and triterpenoid saponins. In the present study. antigenotoxic potential of three naturally occurring phenolic acids and extracts of <i<P. filicifolia</i< growing in vitro with the addition of elicitors was evaluated against direct (4-nitroquinoline-N-oxide (4NQO) and mitomycin C (MMC)) and indirect mutagens (2-aminoanthracene (2AA)). The evaluation was made using a bacterial <i<umu</i<-test. Moreover, the ability to prevent photogenotoxicity induced by chlorpromazine (CPZ) under UVA irradiation was measured. The phytochemical profiling of examined extracts revealed the presence of numerous compounds with the prevelance of chlorogenic, caffeic, and ferulic acid derivatives; however, saponin fractions were also determined. The antioxidant potential of extracts strictly correlated with their composition. The tested extracts exhibited high antigenotoxic activity if the assay was performed with 2AA and metabolic activation. Moreover, the extracts slightly decreased the MMC-induced genotoxicity. However, an increase of the genotoxic effect was observed in the assay performed with 4NQO. In addition, photo-antigenotoxic activity was observed. In our study, phenolic acids exhibited lower activity than the extracts. antigenotoxic agents chlorogenic acid ferulic acid caffeic acid salmonella typhimurium Organic chemistry Anita Śliwińska verfasserin aut Anna Stochmal verfasserin aut Agata Soluch verfasserin aut Magdalena Sobczak verfasserin aut Anna Zgadzaj verfasserin aut Katarzyna Sykłowska-Baranek verfasserin aut Agnieszka Pietrosiuk verfasserin aut In Molecules MDPI AG, 2003 25(2020), 5, p 1090 (DE-627)311313132 (DE-600)2008644-1 14203049 nnns volume:25 year:2020 number:5, p 1090 https://doi.org/10.3390/molecules25051090 kostenfrei https://doaj.org/article/6e1af388dd9a4faa8e1c0c8c3b26078a kostenfrei https://www.mdpi.com/1420-3049/25/5/1090 kostenfrei https://doaj.org/toc/1420-3049 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2005 GBV_ILN_2009 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2055 GBV_ILN_2111 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 25 2020 5, p 1090
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allfieldsSound	10.3390/molecules25051090 doi (DE-627)DOAJ045883637 (DE-599)DOAJ6e1af388dd9a4faa8e1c0c8c3b26078a DE-627 ger DE-627 rakwb eng QD241-441 Ramona Figat verfasserin aut Antigenotoxic, Anti-photogenotoxic, and Antioxidant Properties of <i<Polyscias filicifolia</i< Shoots Cultivated In Vitro 2020 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Traditional medicinal plants are an important source of active compounds with potential antimutagenic activity. <i<Polyscias filicifolia</i< Bailey (Araliaceae) is a South Asian traditional herb used as an adaptogenic and cardiac drug. Extracts of <i<P. filicifolia</i< contain a wide range of biologically active compounds like phenolic acids and triterpenoid saponins. In the present study. antigenotoxic potential of three naturally occurring phenolic acids and extracts of <i<P. filicifolia</i< growing in vitro with the addition of elicitors was evaluated against direct (4-nitroquinoline-N-oxide (4NQO) and mitomycin C (MMC)) and indirect mutagens (2-aminoanthracene (2AA)). The evaluation was made using a bacterial <i<umu</i<-test. Moreover, the ability to prevent photogenotoxicity induced by chlorpromazine (CPZ) under UVA irradiation was measured. The phytochemical profiling of examined extracts revealed the presence of numerous compounds with the prevelance of chlorogenic, caffeic, and ferulic acid derivatives; however, saponin fractions were also determined. The antioxidant potential of extracts strictly correlated with their composition. The tested extracts exhibited high antigenotoxic activity if the assay was performed with 2AA and metabolic activation. Moreover, the extracts slightly decreased the MMC-induced genotoxicity. However, an increase of the genotoxic effect was observed in the assay performed with 4NQO. In addition, photo-antigenotoxic activity was observed. In our study, phenolic acids exhibited lower activity than the extracts. antigenotoxic agents chlorogenic acid ferulic acid caffeic acid salmonella typhimurium Organic chemistry Anita Śliwińska verfasserin aut Anna Stochmal verfasserin aut Agata Soluch verfasserin aut Magdalena Sobczak verfasserin aut Anna Zgadzaj verfasserin aut Katarzyna Sykłowska-Baranek verfasserin aut Agnieszka Pietrosiuk verfasserin aut In Molecules MDPI AG, 2003 25(2020), 5, p 1090 (DE-627)311313132 (DE-600)2008644-1 14203049 nnns volume:25 year:2020 number:5, p 1090 https://doi.org/10.3390/molecules25051090 kostenfrei https://doaj.org/article/6e1af388dd9a4faa8e1c0c8c3b26078a kostenfrei https://www.mdpi.com/1420-3049/25/5/1090 kostenfrei https://doaj.org/toc/1420-3049 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2005 GBV_ILN_2009 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2055 GBV_ILN_2111 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 25 2020 5, p 1090
language	English
source	In Molecules 25(2020), 5, p 1090 volume:25 year:2020 number:5, p 1090
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spellingShingle	Ramona Figat misc QD241-441 misc antigenotoxic agents misc chlorogenic acid misc ferulic acid misc caffeic acid misc salmonella typhimurium misc Organic chemistry Antigenotoxic, Anti-photogenotoxic, and Antioxidant Properties of <i<Polyscias filicifolia</i< Shoots Cultivated In Vitro
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topic_title	QD241-441 Antigenotoxic, Anti-photogenotoxic, and Antioxidant Properties of <i<Polyscias filicifolia</i< Shoots Cultivated In Vitro antigenotoxic agents chlorogenic acid ferulic acid caffeic acid salmonella typhimurium
topic	misc QD241-441 misc antigenotoxic agents misc chlorogenic acid misc ferulic acid misc caffeic acid misc salmonella typhimurium misc Organic chemistry
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title_auth	Antigenotoxic, Anti-photogenotoxic, and Antioxidant Properties of <i<Polyscias filicifolia</i< Shoots Cultivated In Vitro
abstract	Traditional medicinal plants are an important source of active compounds with potential antimutagenic activity. <i<Polyscias filicifolia</i< Bailey (Araliaceae) is a South Asian traditional herb used as an adaptogenic and cardiac drug. Extracts of <i<P. filicifolia</i< contain a wide range of biologically active compounds like phenolic acids and triterpenoid saponins. In the present study. antigenotoxic potential of three naturally occurring phenolic acids and extracts of <i<P. filicifolia</i< growing in vitro with the addition of elicitors was evaluated against direct (4-nitroquinoline-N-oxide (4NQO) and mitomycin C (MMC)) and indirect mutagens (2-aminoanthracene (2AA)). The evaluation was made using a bacterial <i<umu</i<-test. Moreover, the ability to prevent photogenotoxicity induced by chlorpromazine (CPZ) under UVA irradiation was measured. The phytochemical profiling of examined extracts revealed the presence of numerous compounds with the prevelance of chlorogenic, caffeic, and ferulic acid derivatives; however, saponin fractions were also determined. The antioxidant potential of extracts strictly correlated with their composition. The tested extracts exhibited high antigenotoxic activity if the assay was performed with 2AA and metabolic activation. Moreover, the extracts slightly decreased the MMC-induced genotoxicity. However, an increase of the genotoxic effect was observed in the assay performed with 4NQO. In addition, photo-antigenotoxic activity was observed. In our study, phenolic acids exhibited lower activity than the extracts.
abstractGer	Traditional medicinal plants are an important source of active compounds with potential antimutagenic activity. <i<Polyscias filicifolia</i< Bailey (Araliaceae) is a South Asian traditional herb used as an adaptogenic and cardiac drug. Extracts of <i<P. filicifolia</i< contain a wide range of biologically active compounds like phenolic acids and triterpenoid saponins. In the present study. antigenotoxic potential of three naturally occurring phenolic acids and extracts of <i<P. filicifolia</i< growing in vitro with the addition of elicitors was evaluated against direct (4-nitroquinoline-N-oxide (4NQO) and mitomycin C (MMC)) and indirect mutagens (2-aminoanthracene (2AA)). The evaluation was made using a bacterial <i<umu</i<-test. Moreover, the ability to prevent photogenotoxicity induced by chlorpromazine (CPZ) under UVA irradiation was measured. The phytochemical profiling of examined extracts revealed the presence of numerous compounds with the prevelance of chlorogenic, caffeic, and ferulic acid derivatives; however, saponin fractions were also determined. The antioxidant potential of extracts strictly correlated with their composition. The tested extracts exhibited high antigenotoxic activity if the assay was performed with 2AA and metabolic activation. Moreover, the extracts slightly decreased the MMC-induced genotoxicity. However, an increase of the genotoxic effect was observed in the assay performed with 4NQO. In addition, photo-antigenotoxic activity was observed. In our study, phenolic acids exhibited lower activity than the extracts.
abstract_unstemmed	Traditional medicinal plants are an important source of active compounds with potential antimutagenic activity. <i<Polyscias filicifolia</i< Bailey (Araliaceae) is a South Asian traditional herb used as an adaptogenic and cardiac drug. Extracts of <i<P. filicifolia</i< contain a wide range of biologically active compounds like phenolic acids and triterpenoid saponins. In the present study. antigenotoxic potential of three naturally occurring phenolic acids and extracts of <i<P. filicifolia</i< growing in vitro with the addition of elicitors was evaluated against direct (4-nitroquinoline-N-oxide (4NQO) and mitomycin C (MMC)) and indirect mutagens (2-aminoanthracene (2AA)). The evaluation was made using a bacterial <i<umu</i<-test. Moreover, the ability to prevent photogenotoxicity induced by chlorpromazine (CPZ) under UVA irradiation was measured. The phytochemical profiling of examined extracts revealed the presence of numerous compounds with the prevelance of chlorogenic, caffeic, and ferulic acid derivatives; however, saponin fractions were also determined. The antioxidant potential of extracts strictly correlated with their composition. The tested extracts exhibited high antigenotoxic activity if the assay was performed with 2AA and metabolic activation. Moreover, the extracts slightly decreased the MMC-induced genotoxicity. However, an increase of the genotoxic effect was observed in the assay performed with 4NQO. In addition, photo-antigenotoxic activity was observed. In our study, phenolic acids exhibited lower activity than the extracts.
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author2Str	Anita Śliwińska Anna Stochmal Agata Soluch Magdalena Sobczak Anna Zgadzaj Katarzyna Sykłowska-Baranek Agnieszka Pietrosiuk
ppnlink	311313132
callnumber-subject	QD - Chemistry
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isOA_txt	true
hochschulschrift_bool	false
doi_str	10.3390/molecules25051090
callnumber-a	QD241-441
up_date	2024-07-03T17:36:41.693Z
_version_	1803580291674013698
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Antigenotoxic, Anti-photogenotoxic, and Antioxidant Properties of <i<Polyscias filicifolia</i< Shoots Cultivated In Vitro

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