Relationship between modified homeostasis model assessment/correlative serum factors and diabetic retinopathy among type 2 diabetics with insulin therapy in Guangzhou, China

<b<AIM:</b<To explore the related risk factors for diabetic retinopathy (DR) in type 2 diabetes with insulin therapy.<b<METHODS:</b< We studied the relationships among blood glucose, serum C-peptide, plasma insulin, beta-cell function and the development of DR. Beta-cell func...
Ausführliche Beschreibung

Gespeichert in:

Autor*in:	Li Hu [verfasserIn] Dong-Hao Li [verfasserIn]

Format:	E-Artikel
Sprache:	Englisch

Erschienen:	2014

Schlagwörter:	modified homeostasis model assessment diabetic retinopathy insulin

Übergeordnetes Werk:	In: International Journal of Ophthalmology - Press of International Journal of Ophthalmology (IJO PRESS), 2016, 7(2014), 3, Seite 463-468
Übergeordnetes Werk:	volume:7 ; year:2014 ; number:3 ; pages:463-468

Links:	Link aufrufen Link aufrufen Link aufrufen Journal toc Journal toc

DOI / URN:	10.3980/j.issn.2222-3959.2014.03.14

Katalog-ID:	DOAJ04589017X

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245	1	0	\|a Relationship between modified homeostasis model assessment/correlative serum factors and diabetic retinopathy among type 2 diabetics with insulin therapy in Guangzhou, China
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520			\|a <b<AIM:</b<To explore the related risk factors for diabetic retinopathy (DR) in type 2 diabetes with insulin therapy.<b<METHODS:</b< We studied the relationships among blood glucose, serum C-peptide, plasma insulin, beta-cell function and the development of DR. Beta-cell function was assessed by a modified homeostasis model assessment (modified HOMA) which was gained by using C-peptide to replace insulin in the homeostasis model assessment (HOMA) of beta-cell function. We also studied the relationships between modified HOMA index and serum C-peptide response to 100g tasteless steamed bread to determine the accuracy of modified HOMA.<b<RESULTS:</b<Our study group consisted of 170 type 2 diabetic inpatients with DR (age:58.35±13.87y, mean±SD) and 205 type 2 diabetic inpatients with no DR (NDR) (age:65.52±11.59y). DR patients had higher age, longer diabetic duration, higher hypertension grade, higher postprandial plasma glucose, higher fluctuation level of plasma glucose, lower body mass index (BMI), lower postprandial serum insulin and C-peptide, lower fluctuation level of serum insulin and C-peptide (<i<P</i<＜0.05). In our logistic regression model, duration of diabetes, hypertension grade, fasting plasma insulin and glycosylated hemoglobin (HbA1C) were significantly associated with the presence of DR after adjustment for confounding factors (<i<P</i<＜0.05).<b<CONCLUSION:</b<Our results suggested although modified HOMA showed significant correlation to the occurrence of DR on Spearman’s rank-correlation analysis, logistic regression showed no significant association between these two variables after adjustment for relevant confounding factors (such as age, sex, duration of diabetes, BMI, hypertension grade, HbA1C, plasma insulin). Duration of diabetes, hypertension grade, fasting plasma insulin and HbA1C were independently associated with the development of DR in Chinese type 2 diabetics.
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allfields	10.3980/j.issn.2222-3959.2014.03.14 doi (DE-627)DOAJ04589017X (DE-599)DOAJ424521a4191643f89d5c6c3676e44ab9 DE-627 ger DE-627 rakwb eng RE1-994 Li Hu verfasserin aut Relationship between modified homeostasis model assessment/correlative serum factors and diabetic retinopathy among type 2 diabetics with insulin therapy in Guangzhou, China 2014 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier <b<AIM:</b<To explore the related risk factors for diabetic retinopathy (DR) in type 2 diabetes with insulin therapy.<b<METHODS:</b< We studied the relationships among blood glucose, serum C-peptide, plasma insulin, beta-cell function and the development of DR. Beta-cell function was assessed by a modified homeostasis model assessment (modified HOMA) which was gained by using C-peptide to replace insulin in the homeostasis model assessment (HOMA) of beta-cell function. We also studied the relationships between modified HOMA index and serum C-peptide response to 100g tasteless steamed bread to determine the accuracy of modified HOMA.<b<RESULTS:</b<Our study group consisted of 170 type 2 diabetic inpatients with DR (age:58.35±13.87y, mean±SD) and 205 type 2 diabetic inpatients with no DR (NDR) (age:65.52±11.59y). DR patients had higher age, longer diabetic duration, higher hypertension grade, higher postprandial plasma glucose, higher fluctuation level of plasma glucose, lower body mass index (BMI), lower postprandial serum insulin and C-peptide, lower fluctuation level of serum insulin and C-peptide (<i<P</i<＜0.05). In our logistic regression model, duration of diabetes, hypertension grade, fasting plasma insulin and glycosylated hemoglobin (HbA1C) were significantly associated with the presence of DR after adjustment for confounding factors (<i<P</i<＜0.05).<b<CONCLUSION:</b<Our results suggested although modified HOMA showed significant correlation to the occurrence of DR on Spearman’s rank-correlation analysis, logistic regression showed no significant association between these two variables after adjustment for relevant confounding factors (such as age, sex, duration of diabetes, BMI, hypertension grade, HbA1C, plasma insulin). Duration of diabetes, hypertension grade, fasting plasma insulin and HbA1C were independently associated with the development of DR in Chinese type 2 diabetics. modified homeostasis model assessment diabetic retinopathy insulin Ophthalmology Dong-Hao Li verfasserin aut In International Journal of Ophthalmology Press of International Journal of Ophthalmology (IJO PRESS), 2016 7(2014), 3, Seite 463-468 (DE-627)718635906 (DE-600)2663246-9 22274898 nnns volume:7 year:2014 number:3 pages:463-468 https://doi.org/10.3980/j.issn.2222-3959.2014.03.14 kostenfrei https://doaj.org/article/424521a4191643f89d5c6c3676e44ab9 kostenfrei http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4067660/ kostenfrei https://doaj.org/toc/2222-3959 Journal toc kostenfrei https://doaj.org/toc/2227-4898 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2014 GBV_ILN_2817 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 7 2014 3 463-468
spelling	10.3980/j.issn.2222-3959.2014.03.14 doi (DE-627)DOAJ04589017X (DE-599)DOAJ424521a4191643f89d5c6c3676e44ab9 DE-627 ger DE-627 rakwb eng RE1-994 Li Hu verfasserin aut Relationship between modified homeostasis model assessment/correlative serum factors and diabetic retinopathy among type 2 diabetics with insulin therapy in Guangzhou, China 2014 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier <b<AIM:</b<To explore the related risk factors for diabetic retinopathy (DR) in type 2 diabetes with insulin therapy.<b<METHODS:</b< We studied the relationships among blood glucose, serum C-peptide, plasma insulin, beta-cell function and the development of DR. Beta-cell function was assessed by a modified homeostasis model assessment (modified HOMA) which was gained by using C-peptide to replace insulin in the homeostasis model assessment (HOMA) of beta-cell function. We also studied the relationships between modified HOMA index and serum C-peptide response to 100g tasteless steamed bread to determine the accuracy of modified HOMA.<b<RESULTS:</b<Our study group consisted of 170 type 2 diabetic inpatients with DR (age:58.35±13.87y, mean±SD) and 205 type 2 diabetic inpatients with no DR (NDR) (age:65.52±11.59y). DR patients had higher age, longer diabetic duration, higher hypertension grade, higher postprandial plasma glucose, higher fluctuation level of plasma glucose, lower body mass index (BMI), lower postprandial serum insulin and C-peptide, lower fluctuation level of serum insulin and C-peptide (<i<P</i<＜0.05). In our logistic regression model, duration of diabetes, hypertension grade, fasting plasma insulin and glycosylated hemoglobin (HbA1C) were significantly associated with the presence of DR after adjustment for confounding factors (<i<P</i<＜0.05).<b<CONCLUSION:</b<Our results suggested although modified HOMA showed significant correlation to the occurrence of DR on Spearman’s rank-correlation analysis, logistic regression showed no significant association between these two variables after adjustment for relevant confounding factors (such as age, sex, duration of diabetes, BMI, hypertension grade, HbA1C, plasma insulin). Duration of diabetes, hypertension grade, fasting plasma insulin and HbA1C were independently associated with the development of DR in Chinese type 2 diabetics. modified homeostasis model assessment diabetic retinopathy insulin Ophthalmology Dong-Hao Li verfasserin aut In International Journal of Ophthalmology Press of International Journal of Ophthalmology (IJO PRESS), 2016 7(2014), 3, Seite 463-468 (DE-627)718635906 (DE-600)2663246-9 22274898 nnns volume:7 year:2014 number:3 pages:463-468 https://doi.org/10.3980/j.issn.2222-3959.2014.03.14 kostenfrei https://doaj.org/article/424521a4191643f89d5c6c3676e44ab9 kostenfrei http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4067660/ kostenfrei https://doaj.org/toc/2222-3959 Journal toc kostenfrei https://doaj.org/toc/2227-4898 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2014 GBV_ILN_2817 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 7 2014 3 463-468
allfields_unstemmed	10.3980/j.issn.2222-3959.2014.03.14 doi (DE-627)DOAJ04589017X (DE-599)DOAJ424521a4191643f89d5c6c3676e44ab9 DE-627 ger DE-627 rakwb eng RE1-994 Li Hu verfasserin aut Relationship between modified homeostasis model assessment/correlative serum factors and diabetic retinopathy among type 2 diabetics with insulin therapy in Guangzhou, China 2014 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier <b<AIM:</b<To explore the related risk factors for diabetic retinopathy (DR) in type 2 diabetes with insulin therapy.<b<METHODS:</b< We studied the relationships among blood glucose, serum C-peptide, plasma insulin, beta-cell function and the development of DR. Beta-cell function was assessed by a modified homeostasis model assessment (modified HOMA) which was gained by using C-peptide to replace insulin in the homeostasis model assessment (HOMA) of beta-cell function. We also studied the relationships between modified HOMA index and serum C-peptide response to 100g tasteless steamed bread to determine the accuracy of modified HOMA.<b<RESULTS:</b<Our study group consisted of 170 type 2 diabetic inpatients with DR (age:58.35±13.87y, mean±SD) and 205 type 2 diabetic inpatients with no DR (NDR) (age:65.52±11.59y). DR patients had higher age, longer diabetic duration, higher hypertension grade, higher postprandial plasma glucose, higher fluctuation level of plasma glucose, lower body mass index (BMI), lower postprandial serum insulin and C-peptide, lower fluctuation level of serum insulin and C-peptide (<i<P</i<＜0.05). In our logistic regression model, duration of diabetes, hypertension grade, fasting plasma insulin and glycosylated hemoglobin (HbA1C) were significantly associated with the presence of DR after adjustment for confounding factors (<i<P</i<＜0.05).<b<CONCLUSION:</b<Our results suggested although modified HOMA showed significant correlation to the occurrence of DR on Spearman’s rank-correlation analysis, logistic regression showed no significant association between these two variables after adjustment for relevant confounding factors (such as age, sex, duration of diabetes, BMI, hypertension grade, HbA1C, plasma insulin). Duration of diabetes, hypertension grade, fasting plasma insulin and HbA1C were independently associated with the development of DR in Chinese type 2 diabetics. modified homeostasis model assessment diabetic retinopathy insulin Ophthalmology Dong-Hao Li verfasserin aut In International Journal of Ophthalmology Press of International Journal of Ophthalmology (IJO PRESS), 2016 7(2014), 3, Seite 463-468 (DE-627)718635906 (DE-600)2663246-9 22274898 nnns volume:7 year:2014 number:3 pages:463-468 https://doi.org/10.3980/j.issn.2222-3959.2014.03.14 kostenfrei https://doaj.org/article/424521a4191643f89d5c6c3676e44ab9 kostenfrei http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4067660/ kostenfrei https://doaj.org/toc/2222-3959 Journal toc kostenfrei https://doaj.org/toc/2227-4898 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2014 GBV_ILN_2817 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 7 2014 3 463-468
allfieldsGer	10.3980/j.issn.2222-3959.2014.03.14 doi (DE-627)DOAJ04589017X (DE-599)DOAJ424521a4191643f89d5c6c3676e44ab9 DE-627 ger DE-627 rakwb eng RE1-994 Li Hu verfasserin aut Relationship between modified homeostasis model assessment/correlative serum factors and diabetic retinopathy among type 2 diabetics with insulin therapy in Guangzhou, China 2014 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier <b<AIM:</b<To explore the related risk factors for diabetic retinopathy (DR) in type 2 diabetes with insulin therapy.<b<METHODS:</b< We studied the relationships among blood glucose, serum C-peptide, plasma insulin, beta-cell function and the development of DR. Beta-cell function was assessed by a modified homeostasis model assessment (modified HOMA) which was gained by using C-peptide to replace insulin in the homeostasis model assessment (HOMA) of beta-cell function. We also studied the relationships between modified HOMA index and serum C-peptide response to 100g tasteless steamed bread to determine the accuracy of modified HOMA.<b<RESULTS:</b<Our study group consisted of 170 type 2 diabetic inpatients with DR (age:58.35±13.87y, mean±SD) and 205 type 2 diabetic inpatients with no DR (NDR) (age:65.52±11.59y). DR patients had higher age, longer diabetic duration, higher hypertension grade, higher postprandial plasma glucose, higher fluctuation level of plasma glucose, lower body mass index (BMI), lower postprandial serum insulin and C-peptide, lower fluctuation level of serum insulin and C-peptide (<i<P</i<＜0.05). In our logistic regression model, duration of diabetes, hypertension grade, fasting plasma insulin and glycosylated hemoglobin (HbA1C) were significantly associated with the presence of DR after adjustment for confounding factors (<i<P</i<＜0.05).<b<CONCLUSION:</b<Our results suggested although modified HOMA showed significant correlation to the occurrence of DR on Spearman’s rank-correlation analysis, logistic regression showed no significant association between these two variables after adjustment for relevant confounding factors (such as age, sex, duration of diabetes, BMI, hypertension grade, HbA1C, plasma insulin). Duration of diabetes, hypertension grade, fasting plasma insulin and HbA1C were independently associated with the development of DR in Chinese type 2 diabetics. modified homeostasis model assessment diabetic retinopathy insulin Ophthalmology Dong-Hao Li verfasserin aut In International Journal of Ophthalmology Press of International Journal of Ophthalmology (IJO PRESS), 2016 7(2014), 3, Seite 463-468 (DE-627)718635906 (DE-600)2663246-9 22274898 nnns volume:7 year:2014 number:3 pages:463-468 https://doi.org/10.3980/j.issn.2222-3959.2014.03.14 kostenfrei https://doaj.org/article/424521a4191643f89d5c6c3676e44ab9 kostenfrei http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4067660/ kostenfrei https://doaj.org/toc/2222-3959 Journal toc kostenfrei https://doaj.org/toc/2227-4898 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2014 GBV_ILN_2817 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 7 2014 3 463-468
allfieldsSound	10.3980/j.issn.2222-3959.2014.03.14 doi (DE-627)DOAJ04589017X (DE-599)DOAJ424521a4191643f89d5c6c3676e44ab9 DE-627 ger DE-627 rakwb eng RE1-994 Li Hu verfasserin aut Relationship between modified homeostasis model assessment/correlative serum factors and diabetic retinopathy among type 2 diabetics with insulin therapy in Guangzhou, China 2014 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier <b<AIM:</b<To explore the related risk factors for diabetic retinopathy (DR) in type 2 diabetes with insulin therapy.<b<METHODS:</b< We studied the relationships among blood glucose, serum C-peptide, plasma insulin, beta-cell function and the development of DR. Beta-cell function was assessed by a modified homeostasis model assessment (modified HOMA) which was gained by using C-peptide to replace insulin in the homeostasis model assessment (HOMA) of beta-cell function. We also studied the relationships between modified HOMA index and serum C-peptide response to 100g tasteless steamed bread to determine the accuracy of modified HOMA.<b<RESULTS:</b<Our study group consisted of 170 type 2 diabetic inpatients with DR (age:58.35±13.87y, mean±SD) and 205 type 2 diabetic inpatients with no DR (NDR) (age:65.52±11.59y). DR patients had higher age, longer diabetic duration, higher hypertension grade, higher postprandial plasma glucose, higher fluctuation level of plasma glucose, lower body mass index (BMI), lower postprandial serum insulin and C-peptide, lower fluctuation level of serum insulin and C-peptide (<i<P</i<＜0.05). In our logistic regression model, duration of diabetes, hypertension grade, fasting plasma insulin and glycosylated hemoglobin (HbA1C) were significantly associated with the presence of DR after adjustment for confounding factors (<i<P</i<＜0.05).<b<CONCLUSION:</b<Our results suggested although modified HOMA showed significant correlation to the occurrence of DR on Spearman’s rank-correlation analysis, logistic regression showed no significant association between these two variables after adjustment for relevant confounding factors (such as age, sex, duration of diabetes, BMI, hypertension grade, HbA1C, plasma insulin). Duration of diabetes, hypertension grade, fasting plasma insulin and HbA1C were independently associated with the development of DR in Chinese type 2 diabetics. modified homeostasis model assessment diabetic retinopathy insulin Ophthalmology Dong-Hao Li verfasserin aut In International Journal of Ophthalmology Press of International Journal of Ophthalmology (IJO PRESS), 2016 7(2014), 3, Seite 463-468 (DE-627)718635906 (DE-600)2663246-9 22274898 nnns volume:7 year:2014 number:3 pages:463-468 https://doi.org/10.3980/j.issn.2222-3959.2014.03.14 kostenfrei https://doaj.org/article/424521a4191643f89d5c6c3676e44ab9 kostenfrei http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4067660/ kostenfrei https://doaj.org/toc/2222-3959 Journal toc kostenfrei https://doaj.org/toc/2227-4898 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2014 GBV_ILN_2817 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 7 2014 3 463-468
language	English
source	In International Journal of Ophthalmology 7(2014), 3, Seite 463-468 volume:7 year:2014 number:3 pages:463-468
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topic_facet	modified homeostasis model assessment diabetic retinopathy insulin Ophthalmology
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callnumber-first	R - Medicine
author	Li Hu
spellingShingle	Li Hu misc RE1-994 misc modified homeostasis model assessment misc diabetic retinopathy misc insulin misc Ophthalmology Relationship between modified homeostasis model assessment/correlative serum factors and diabetic retinopathy among type 2 diabetics with insulin therapy in Guangzhou, China
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topic_title	RE1-994 Relationship between modified homeostasis model assessment/correlative serum factors and diabetic retinopathy among type 2 diabetics with insulin therapy in Guangzhou, China modified homeostasis model assessment diabetic retinopathy insulin
topic	misc RE1-994 misc modified homeostasis model assessment misc diabetic retinopathy misc insulin misc Ophthalmology
topic_unstemmed	misc RE1-994 misc modified homeostasis model assessment misc diabetic retinopathy misc insulin misc Ophthalmology
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title	Relationship between modified homeostasis model assessment/correlative serum factors and diabetic retinopathy among type 2 diabetics with insulin therapy in Guangzhou, China
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title_full	Relationship between modified homeostasis model assessment/correlative serum factors and diabetic retinopathy among type 2 diabetics with insulin therapy in Guangzhou, China
author_sort	Li Hu
journal	International Journal of Ophthalmology
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title_sort	relationship between modified homeostasis model assessment/correlative serum factors and diabetic retinopathy among type 2 diabetics with insulin therapy in guangzhou, china
callnumber	RE1-994
title_auth	Relationship between modified homeostasis model assessment/correlative serum factors and diabetic retinopathy among type 2 diabetics with insulin therapy in Guangzhou, China
abstract	<b<AIM:</b<To explore the related risk factors for diabetic retinopathy (DR) in type 2 diabetes with insulin therapy.<b<METHODS:</b< We studied the relationships among blood glucose, serum C-peptide, plasma insulin, beta-cell function and the development of DR. Beta-cell function was assessed by a modified homeostasis model assessment (modified HOMA) which was gained by using C-peptide to replace insulin in the homeostasis model assessment (HOMA) of beta-cell function. We also studied the relationships between modified HOMA index and serum C-peptide response to 100g tasteless steamed bread to determine the accuracy of modified HOMA.<b<RESULTS:</b<Our study group consisted of 170 type 2 diabetic inpatients with DR (age:58.35±13.87y, mean±SD) and 205 type 2 diabetic inpatients with no DR (NDR) (age:65.52±11.59y). DR patients had higher age, longer diabetic duration, higher hypertension grade, higher postprandial plasma glucose, higher fluctuation level of plasma glucose, lower body mass index (BMI), lower postprandial serum insulin and C-peptide, lower fluctuation level of serum insulin and C-peptide (<i<P</i<＜0.05). In our logistic regression model, duration of diabetes, hypertension grade, fasting plasma insulin and glycosylated hemoglobin (HbA1C) were significantly associated with the presence of DR after adjustment for confounding factors (<i<P</i<＜0.05).<b<CONCLUSION:</b<Our results suggested although modified HOMA showed significant correlation to the occurrence of DR on Spearman’s rank-correlation analysis, logistic regression showed no significant association between these two variables after adjustment for relevant confounding factors (such as age, sex, duration of diabetes, BMI, hypertension grade, HbA1C, plasma insulin). Duration of diabetes, hypertension grade, fasting plasma insulin and HbA1C were independently associated with the development of DR in Chinese type 2 diabetics.
abstractGer	<b<AIM:</b<To explore the related risk factors for diabetic retinopathy (DR) in type 2 diabetes with insulin therapy.<b<METHODS:</b< We studied the relationships among blood glucose, serum C-peptide, plasma insulin, beta-cell function and the development of DR. Beta-cell function was assessed by a modified homeostasis model assessment (modified HOMA) which was gained by using C-peptide to replace insulin in the homeostasis model assessment (HOMA) of beta-cell function. We also studied the relationships between modified HOMA index and serum C-peptide response to 100g tasteless steamed bread to determine the accuracy of modified HOMA.<b<RESULTS:</b<Our study group consisted of 170 type 2 diabetic inpatients with DR (age:58.35±13.87y, mean±SD) and 205 type 2 diabetic inpatients with no DR (NDR) (age:65.52±11.59y). DR patients had higher age, longer diabetic duration, higher hypertension grade, higher postprandial plasma glucose, higher fluctuation level of plasma glucose, lower body mass index (BMI), lower postprandial serum insulin and C-peptide, lower fluctuation level of serum insulin and C-peptide (<i<P</i<＜0.05). In our logistic regression model, duration of diabetes, hypertension grade, fasting plasma insulin and glycosylated hemoglobin (HbA1C) were significantly associated with the presence of DR after adjustment for confounding factors (<i<P</i<＜0.05).<b<CONCLUSION:</b<Our results suggested although modified HOMA showed significant correlation to the occurrence of DR on Spearman’s rank-correlation analysis, logistic regression showed no significant association between these two variables after adjustment for relevant confounding factors (such as age, sex, duration of diabetes, BMI, hypertension grade, HbA1C, plasma insulin). Duration of diabetes, hypertension grade, fasting plasma insulin and HbA1C were independently associated with the development of DR in Chinese type 2 diabetics.
abstract_unstemmed	<b<AIM:</b<To explore the related risk factors for diabetic retinopathy (DR) in type 2 diabetes with insulin therapy.<b<METHODS:</b< We studied the relationships among blood glucose, serum C-peptide, plasma insulin, beta-cell function and the development of DR. Beta-cell function was assessed by a modified homeostasis model assessment (modified HOMA) which was gained by using C-peptide to replace insulin in the homeostasis model assessment (HOMA) of beta-cell function. We also studied the relationships between modified HOMA index and serum C-peptide response to 100g tasteless steamed bread to determine the accuracy of modified HOMA.<b<RESULTS:</b<Our study group consisted of 170 type 2 diabetic inpatients with DR (age:58.35±13.87y, mean±SD) and 205 type 2 diabetic inpatients with no DR (NDR) (age:65.52±11.59y). DR patients had higher age, longer diabetic duration, higher hypertension grade, higher postprandial plasma glucose, higher fluctuation level of plasma glucose, lower body mass index (BMI), lower postprandial serum insulin and C-peptide, lower fluctuation level of serum insulin and C-peptide (<i<P</i<＜0.05). In our logistic regression model, duration of diabetes, hypertension grade, fasting plasma insulin and glycosylated hemoglobin (HbA1C) were significantly associated with the presence of DR after adjustment for confounding factors (<i<P</i<＜0.05).<b<CONCLUSION:</b<Our results suggested although modified HOMA showed significant correlation to the occurrence of DR on Spearman’s rank-correlation analysis, logistic regression showed no significant association between these two variables after adjustment for relevant confounding factors (such as age, sex, duration of diabetes, BMI, hypertension grade, HbA1C, plasma insulin). Duration of diabetes, hypertension grade, fasting plasma insulin and HbA1C were independently associated with the development of DR in Chinese type 2 diabetics.
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title_short	Relationship between modified homeostasis model assessment/correlative serum factors and diabetic retinopathy among type 2 diabetics with insulin therapy in Guangzhou, China
url	https://doi.org/10.3980/j.issn.2222-3959.2014.03.14 https://doaj.org/article/424521a4191643f89d5c6c3676e44ab9 http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4067660/ https://doaj.org/toc/2222-3959 https://doaj.org/toc/2227-4898
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In our logistic regression model, duration of diabetes, hypertension grade, fasting plasma insulin and glycosylated hemoglobin (HbA1C) were significantly associated with the presence of DR after adjustment for confounding factors (<i<P</i<＜0.05).<b<CONCLUSION:</b<Our results suggested although modified HOMA showed significant correlation to the occurrence of DR on Spearman’s rank-correlation analysis, logistic regression showed no significant association between these two variables after adjustment for relevant confounding factors (such as age, sex, duration of diabetes, BMI, hypertension grade, HbA1C, plasma insulin). 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Relationship between modified homeostasis model assessment/correlative serum factors and diabetic retinopathy among type 2 diabetics with insulin therapy in Guangzhou, China

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