Incidence of TB and HIV in prospectively followed household contacts of TB index patients in South Africa.

To report the incidence rates of TB and HIV in household contacts of index patients diagnosed with TB.A prospective cohort study in the Matlosana sub-district of North West Province, South Africa.Contacts of index TB patients received TB and HIV testing after counseling at their first household visi...
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Autor*in:	Cari van Schalkwyk [verfasserIn] Ebrahim Variava [verfasserIn] Adrienne E Shapiro [verfasserIn] Modiehi Rakgokong [verfasserIn] Katlego Masonoke [verfasserIn] Limakatso Lebina [verfasserIn] Alex Welte [verfasserIn] Neil Martinson [verfasserIn]

Format:	E-Artikel
Sprache:	Englisch

Erschienen:	2014

Übergeordnetes Werk:	In: PLoS ONE - Public Library of Science (PLoS), 2007, 9(2014), 4, p e95372
Übergeordnetes Werk:	volume:9 ; year:2014 ; number:4, p e95372

Links:	Link aufrufen Link aufrufen Link aufrufen Journal toc

DOI / URN:	10.1371/journal.pone.0095372

Katalog-ID:	DOAJ045908125

Internformat


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publishDate	2014
allfields	10.1371/journal.pone.0095372 doi (DE-627)DOAJ045908125 (DE-599)DOAJ358eb780373b4023af25aed915b01859 DE-627 ger DE-627 rakwb eng Cari van Schalkwyk verfasserin aut Incidence of TB and HIV in prospectively followed household contacts of TB index patients in South Africa. 2014 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier To report the incidence rates of TB and HIV in household contacts of index patients diagnosed with TB.A prospective cohort study in the Matlosana sub-district of North West Province, South Africa.Contacts of index TB patients received TB and HIV testing after counseling at their first household visit and were then followed up a year later, in 2010. TB or HIV diagnoses that occurred during the period were determined.For 2,377 household contacts, the overall observed TB incidence rate was 1.3 per 100 person years (95% CI 0.9-1.9/100py) and TB incidence for individuals who were HIV-infected and HIV seronegative at baseline was 5.4/100py (95% CI 2.9-9.0/100py) and 0.7/100py (95% CI 0.3-1.4/100py), respectively. The overall HIV incidence rate was 2.2/100py (95% CI 1.3-8.4/100py).In the year following a household case finding visit when household contacts were tested for TB and HIV, the incidence rate of both active TB and HIV infection was found to be extremely high. Clearly, implementing proven strategies to prevent HIV acquisition and preventing TB transmission and progression to disease remains a priority in settings such as South Africa. Medicine R Science Q Ebrahim Variava verfasserin aut Adrienne E Shapiro verfasserin aut Modiehi Rakgokong verfasserin aut Katlego Masonoke verfasserin aut Limakatso Lebina verfasserin aut Alex Welte verfasserin aut Neil Martinson verfasserin aut In PLoS ONE Public Library of Science (PLoS), 2007 9(2014), 4, p e95372 (DE-627)523574592 (DE-600)2267670-3 19326203 nnns volume:9 year:2014 number:4, p e95372 https://doi.org/10.1371/journal.pone.0095372 kostenfrei https://doaj.org/article/358eb780373b4023af25aed915b01859 kostenfrei http://europepmc.org/articles/PMC3997400?pdf=render kostenfrei https://doaj.org/toc/1932-6203 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_34 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_206 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_235 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2031 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2057 GBV_ILN_2061 GBV_ILN_2111 GBV_ILN_2113 GBV_ILN_2190 GBV_ILN_2522 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4335 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 9 2014 4, p e95372
spelling	10.1371/journal.pone.0095372 doi (DE-627)DOAJ045908125 (DE-599)DOAJ358eb780373b4023af25aed915b01859 DE-627 ger DE-627 rakwb eng Cari van Schalkwyk verfasserin aut Incidence of TB and HIV in prospectively followed household contacts of TB index patients in South Africa. 2014 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier To report the incidence rates of TB and HIV in household contacts of index patients diagnosed with TB.A prospective cohort study in the Matlosana sub-district of North West Province, South Africa.Contacts of index TB patients received TB and HIV testing after counseling at their first household visit and were then followed up a year later, in 2010. TB or HIV diagnoses that occurred during the period were determined.For 2,377 household contacts, the overall observed TB incidence rate was 1.3 per 100 person years (95% CI 0.9-1.9/100py) and TB incidence for individuals who were HIV-infected and HIV seronegative at baseline was 5.4/100py (95% CI 2.9-9.0/100py) and 0.7/100py (95% CI 0.3-1.4/100py), respectively. The overall HIV incidence rate was 2.2/100py (95% CI 1.3-8.4/100py).In the year following a household case finding visit when household contacts were tested for TB and HIV, the incidence rate of both active TB and HIV infection was found to be extremely high. Clearly, implementing proven strategies to prevent HIV acquisition and preventing TB transmission and progression to disease remains a priority in settings such as South Africa. Medicine R Science Q Ebrahim Variava verfasserin aut Adrienne E Shapiro verfasserin aut Modiehi Rakgokong verfasserin aut Katlego Masonoke verfasserin aut Limakatso Lebina verfasserin aut Alex Welte verfasserin aut Neil Martinson verfasserin aut In PLoS ONE Public Library of Science (PLoS), 2007 9(2014), 4, p e95372 (DE-627)523574592 (DE-600)2267670-3 19326203 nnns volume:9 year:2014 number:4, p e95372 https://doi.org/10.1371/journal.pone.0095372 kostenfrei https://doaj.org/article/358eb780373b4023af25aed915b01859 kostenfrei http://europepmc.org/articles/PMC3997400?pdf=render kostenfrei https://doaj.org/toc/1932-6203 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_34 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_206 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_235 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2031 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2057 GBV_ILN_2061 GBV_ILN_2111 GBV_ILN_2113 GBV_ILN_2190 GBV_ILN_2522 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4335 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 9 2014 4, p e95372
allfields_unstemmed	10.1371/journal.pone.0095372 doi (DE-627)DOAJ045908125 (DE-599)DOAJ358eb780373b4023af25aed915b01859 DE-627 ger DE-627 rakwb eng Cari van Schalkwyk verfasserin aut Incidence of TB and HIV in prospectively followed household contacts of TB index patients in South Africa. 2014 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier To report the incidence rates of TB and HIV in household contacts of index patients diagnosed with TB.A prospective cohort study in the Matlosana sub-district of North West Province, South Africa.Contacts of index TB patients received TB and HIV testing after counseling at their first household visit and were then followed up a year later, in 2010. TB or HIV diagnoses that occurred during the period were determined.For 2,377 household contacts, the overall observed TB incidence rate was 1.3 per 100 person years (95% CI 0.9-1.9/100py) and TB incidence for individuals who were HIV-infected and HIV seronegative at baseline was 5.4/100py (95% CI 2.9-9.0/100py) and 0.7/100py (95% CI 0.3-1.4/100py), respectively. The overall HIV incidence rate was 2.2/100py (95% CI 1.3-8.4/100py).In the year following a household case finding visit when household contacts were tested for TB and HIV, the incidence rate of both active TB and HIV infection was found to be extremely high. Clearly, implementing proven strategies to prevent HIV acquisition and preventing TB transmission and progression to disease remains a priority in settings such as South Africa. Medicine R Science Q Ebrahim Variava verfasserin aut Adrienne E Shapiro verfasserin aut Modiehi Rakgokong verfasserin aut Katlego Masonoke verfasserin aut Limakatso Lebina verfasserin aut Alex Welte verfasserin aut Neil Martinson verfasserin aut In PLoS ONE Public Library of Science (PLoS), 2007 9(2014), 4, p e95372 (DE-627)523574592 (DE-600)2267670-3 19326203 nnns volume:9 year:2014 number:4, p e95372 https://doi.org/10.1371/journal.pone.0095372 kostenfrei https://doaj.org/article/358eb780373b4023af25aed915b01859 kostenfrei http://europepmc.org/articles/PMC3997400?pdf=render kostenfrei https://doaj.org/toc/1932-6203 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_34 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_206 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_235 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2031 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2057 GBV_ILN_2061 GBV_ILN_2111 GBV_ILN_2113 GBV_ILN_2190 GBV_ILN_2522 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4335 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 9 2014 4, p e95372
allfieldsGer	10.1371/journal.pone.0095372 doi (DE-627)DOAJ045908125 (DE-599)DOAJ358eb780373b4023af25aed915b01859 DE-627 ger DE-627 rakwb eng Cari van Schalkwyk verfasserin aut Incidence of TB and HIV in prospectively followed household contacts of TB index patients in South Africa. 2014 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier To report the incidence rates of TB and HIV in household contacts of index patients diagnosed with TB.A prospective cohort study in the Matlosana sub-district of North West Province, South Africa.Contacts of index TB patients received TB and HIV testing after counseling at their first household visit and were then followed up a year later, in 2010. TB or HIV diagnoses that occurred during the period were determined.For 2,377 household contacts, the overall observed TB incidence rate was 1.3 per 100 person years (95% CI 0.9-1.9/100py) and TB incidence for individuals who were HIV-infected and HIV seronegative at baseline was 5.4/100py (95% CI 2.9-9.0/100py) and 0.7/100py (95% CI 0.3-1.4/100py), respectively. The overall HIV incidence rate was 2.2/100py (95% CI 1.3-8.4/100py).In the year following a household case finding visit when household contacts were tested for TB and HIV, the incidence rate of both active TB and HIV infection was found to be extremely high. Clearly, implementing proven strategies to prevent HIV acquisition and preventing TB transmission and progression to disease remains a priority in settings such as South Africa. Medicine R Science Q Ebrahim Variava verfasserin aut Adrienne E Shapiro verfasserin aut Modiehi Rakgokong verfasserin aut Katlego Masonoke verfasserin aut Limakatso Lebina verfasserin aut Alex Welte verfasserin aut Neil Martinson verfasserin aut In PLoS ONE Public Library of Science (PLoS), 2007 9(2014), 4, p e95372 (DE-627)523574592 (DE-600)2267670-3 19326203 nnns volume:9 year:2014 number:4, p e95372 https://doi.org/10.1371/journal.pone.0095372 kostenfrei https://doaj.org/article/358eb780373b4023af25aed915b01859 kostenfrei http://europepmc.org/articles/PMC3997400?pdf=render kostenfrei https://doaj.org/toc/1932-6203 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_34 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_206 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_235 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2031 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2057 GBV_ILN_2061 GBV_ILN_2111 GBV_ILN_2113 GBV_ILN_2190 GBV_ILN_2522 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4335 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 9 2014 4, p e95372
allfieldsSound	10.1371/journal.pone.0095372 doi (DE-627)DOAJ045908125 (DE-599)DOAJ358eb780373b4023af25aed915b01859 DE-627 ger DE-627 rakwb eng Cari van Schalkwyk verfasserin aut Incidence of TB and HIV in prospectively followed household contacts of TB index patients in South Africa. 2014 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier To report the incidence rates of TB and HIV in household contacts of index patients diagnosed with TB.A prospective cohort study in the Matlosana sub-district of North West Province, South Africa.Contacts of index TB patients received TB and HIV testing after counseling at their first household visit and were then followed up a year later, in 2010. TB or HIV diagnoses that occurred during the period were determined.For 2,377 household contacts, the overall observed TB incidence rate was 1.3 per 100 person years (95% CI 0.9-1.9/100py) and TB incidence for individuals who were HIV-infected and HIV seronegative at baseline was 5.4/100py (95% CI 2.9-9.0/100py) and 0.7/100py (95% CI 0.3-1.4/100py), respectively. The overall HIV incidence rate was 2.2/100py (95% CI 1.3-8.4/100py).In the year following a household case finding visit when household contacts were tested for TB and HIV, the incidence rate of both active TB and HIV infection was found to be extremely high. Clearly, implementing proven strategies to prevent HIV acquisition and preventing TB transmission and progression to disease remains a priority in settings such as South Africa. Medicine R Science Q Ebrahim Variava verfasserin aut Adrienne E Shapiro verfasserin aut Modiehi Rakgokong verfasserin aut Katlego Masonoke verfasserin aut Limakatso Lebina verfasserin aut Alex Welte verfasserin aut Neil Martinson verfasserin aut In PLoS ONE Public Library of Science (PLoS), 2007 9(2014), 4, p e95372 (DE-627)523574592 (DE-600)2267670-3 19326203 nnns volume:9 year:2014 number:4, p e95372 https://doi.org/10.1371/journal.pone.0095372 kostenfrei https://doaj.org/article/358eb780373b4023af25aed915b01859 kostenfrei http://europepmc.org/articles/PMC3997400?pdf=render kostenfrei https://doaj.org/toc/1932-6203 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_34 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_206 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_235 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2031 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2057 GBV_ILN_2061 GBV_ILN_2111 GBV_ILN_2113 GBV_ILN_2190 GBV_ILN_2522 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4335 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 9 2014 4, p e95372
language	English
source	In PLoS ONE 9(2014), 4, p e95372 volume:9 year:2014 number:4, p e95372
sourceStr	In PLoS ONE 9(2014), 4, p e95372 volume:9 year:2014 number:4, p e95372
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container_title	PLoS ONE
authorswithroles_txt_mv	Cari van Schalkwyk @@aut@@ Ebrahim Variava @@aut@@ Adrienne E Shapiro @@aut@@ Modiehi Rakgokong @@aut@@ Katlego Masonoke @@aut@@ Limakatso Lebina @@aut@@ Alex Welte @@aut@@ Neil Martinson @@aut@@
publishDateDaySort_date	2014-01-01T00:00:00Z
hierarchy_top_id	523574592
id	DOAJ045908125
language_de	englisch
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author	Cari van Schalkwyk
spellingShingle	Cari van Schalkwyk misc Medicine misc R misc Science misc Q Incidence of TB and HIV in prospectively followed household contacts of TB index patients in South Africa.
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topic_title	Incidence of TB and HIV in prospectively followed household contacts of TB index patients in South Africa
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title	Incidence of TB and HIV in prospectively followed household contacts of TB index patients in South Africa.
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title_full	Incidence of TB and HIV in prospectively followed household contacts of TB index patients in South Africa
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author_browse	Cari van Schalkwyk Ebrahim Variava Adrienne E Shapiro Modiehi Rakgokong Katlego Masonoke Limakatso Lebina Alex Welte Neil Martinson
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title_sort	incidence of tb and hiv in prospectively followed household contacts of tb index patients in south africa
title_auth	Incidence of TB and HIV in prospectively followed household contacts of TB index patients in South Africa.
abstract	To report the incidence rates of TB and HIV in household contacts of index patients diagnosed with TB.A prospective cohort study in the Matlosana sub-district of North West Province, South Africa.Contacts of index TB patients received TB and HIV testing after counseling at their first household visit and were then followed up a year later, in 2010. TB or HIV diagnoses that occurred during the period were determined.For 2,377 household contacts, the overall observed TB incidence rate was 1.3 per 100 person years (95% CI 0.9-1.9/100py) and TB incidence for individuals who were HIV-infected and HIV seronegative at baseline was 5.4/100py (95% CI 2.9-9.0/100py) and 0.7/100py (95% CI 0.3-1.4/100py), respectively. The overall HIV incidence rate was 2.2/100py (95% CI 1.3-8.4/100py).In the year following a household case finding visit when household contacts were tested for TB and HIV, the incidence rate of both active TB and HIV infection was found to be extremely high. Clearly, implementing proven strategies to prevent HIV acquisition and preventing TB transmission and progression to disease remains a priority in settings such as South Africa.
abstractGer	To report the incidence rates of TB and HIV in household contacts of index patients diagnosed with TB.A prospective cohort study in the Matlosana sub-district of North West Province, South Africa.Contacts of index TB patients received TB and HIV testing after counseling at their first household visit and were then followed up a year later, in 2010. TB or HIV diagnoses that occurred during the period were determined.For 2,377 household contacts, the overall observed TB incidence rate was 1.3 per 100 person years (95% CI 0.9-1.9/100py) and TB incidence for individuals who were HIV-infected and HIV seronegative at baseline was 5.4/100py (95% CI 2.9-9.0/100py) and 0.7/100py (95% CI 0.3-1.4/100py), respectively. The overall HIV incidence rate was 2.2/100py (95% CI 1.3-8.4/100py).In the year following a household case finding visit when household contacts were tested for TB and HIV, the incidence rate of both active TB and HIV infection was found to be extremely high. Clearly, implementing proven strategies to prevent HIV acquisition and preventing TB transmission and progression to disease remains a priority in settings such as South Africa.
abstract_unstemmed	To report the incidence rates of TB and HIV in household contacts of index patients diagnosed with TB.A prospective cohort study in the Matlosana sub-district of North West Province, South Africa.Contacts of index TB patients received TB and HIV testing after counseling at their first household visit and were then followed up a year later, in 2010. TB or HIV diagnoses that occurred during the period were determined.For 2,377 household contacts, the overall observed TB incidence rate was 1.3 per 100 person years (95% CI 0.9-1.9/100py) and TB incidence for individuals who were HIV-infected and HIV seronegative at baseline was 5.4/100py (95% CI 2.9-9.0/100py) and 0.7/100py (95% CI 0.3-1.4/100py), respectively. The overall HIV incidence rate was 2.2/100py (95% CI 1.3-8.4/100py).In the year following a household case finding visit when household contacts were tested for TB and HIV, the incidence rate of both active TB and HIV infection was found to be extremely high. Clearly, implementing proven strategies to prevent HIV acquisition and preventing TB transmission and progression to disease remains a priority in settings such as South Africa.
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title_short	Incidence of TB and HIV in prospectively followed household contacts of TB index patients in South Africa.
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Incidence of TB and HIV in prospectively followed household contacts of TB index patients in South Africa.

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