Organic Chemistry and Immunochemical Strategies in the Design of Potent Carbohydrate-based Vaccines
A brief overview of carbohydrate antigens processing and uptakes involved in the adaptive immune system is highlighted. To counter balance the poor immunogenicity and T-cell independent characteristics of carbohydrate antigens, chemists have developed original hybrid molecules aimed at targeting spe...
Ausführliche Beschreibung
Autor*in: |
René Roy [verfasserIn] Tze Chieh Shiao [verfasserIn] |
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Format: |
E-Artikel |
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Sprache: |
Deutsch ; Englisch ; Französisch |
Erschienen: |
2011 |
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Schlagwörter: |
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Übergeordnetes Werk: |
In: CHIMIA - Swiss Chemical Society, 2020, 65(2011), 1-2 |
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Übergeordnetes Werk: |
volume:65 ; year:2011 ; number:1-2 |
Links: |
Link aufrufen |
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DOI / URN: |
10.2533/chimia.2011.24 |
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Katalog-ID: |
DOAJ045957169 |
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10.2533/chimia.2011.24 doi (DE-627)DOAJ045957169 (DE-599)DOAJacaec1f4b7dd467fa0f7c2961dd58661 DE-627 ger DE-627 rakwb ger eng fre QD1-999 René Roy verfasserin aut Organic Chemistry and Immunochemical Strategies in the Design of Potent Carbohydrate-based Vaccines 2011 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier A brief overview of carbohydrate antigens processing and uptakes involved in the adaptive immune system is highlighted. To counter balance the poor immunogenicity and T-cell independent characteristics of carbohydrate antigens, chemists have developed original hybrid molecules aimed at targeting specific competent immune cell receptors. Amongst several potential vaccine candidates dedicated against diseases, this short report will focused on those most advance and state of the art organic chemistry involved therein. One case has led to the first example of a commercial vaccine entirely prepared from a synthetic carbohydrate antigen against infections caused by the Gram-negative bacteria Haemophilus influenza type b responsible for pneumonia and acute bacterial meningitis in infants. Other commendable examples will illustrate the immunochemical strategies engaged in the development of anticancer carbohydrate-based vaccines. Bacteria Cancer Carbohydrate Polysaccharides Vaccines Chemistry Tze Chieh Shiao verfasserin aut In CHIMIA Swiss Chemical Society, 2020 65(2011), 1-2 (DE-627)480660301 (DE-600)2179192-2 26732424 nnns volume:65 year:2011 number:1-2 https://doi.org/10.2533/chimia.2011.24 kostenfrei https://doaj.org/article/acaec1f4b7dd467fa0f7c2961dd58661 kostenfrei https://www.chimia.ch/chimia/article/view/4953 kostenfrei https://doaj.org/toc/0009-4293 Journal toc kostenfrei https://doaj.org/toc/2673-2424 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 65 2011 1-2 |
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Organic Chemistry and Immunochemical Strategies in the Design of Potent Carbohydrate-based Vaccines |
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A brief overview of carbohydrate antigens processing and uptakes involved in the adaptive immune system is highlighted. To counter balance the poor immunogenicity and T-cell independent characteristics of carbohydrate antigens, chemists have developed original hybrid molecules aimed at targeting specific competent immune cell receptors. Amongst several potential vaccine candidates dedicated against diseases, this short report will focused on those most advance and state of the art organic chemistry involved therein. One case has led to the first example of a commercial vaccine entirely prepared from a synthetic carbohydrate antigen against infections caused by the Gram-negative bacteria Haemophilus influenza type b responsible for pneumonia and acute bacterial meningitis in infants. Other commendable examples will illustrate the immunochemical strategies engaged in the development of anticancer carbohydrate-based vaccines. |
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A brief overview of carbohydrate antigens processing and uptakes involved in the adaptive immune system is highlighted. To counter balance the poor immunogenicity and T-cell independent characteristics of carbohydrate antigens, chemists have developed original hybrid molecules aimed at targeting specific competent immune cell receptors. Amongst several potential vaccine candidates dedicated against diseases, this short report will focused on those most advance and state of the art organic chemistry involved therein. One case has led to the first example of a commercial vaccine entirely prepared from a synthetic carbohydrate antigen against infections caused by the Gram-negative bacteria Haemophilus influenza type b responsible for pneumonia and acute bacterial meningitis in infants. Other commendable examples will illustrate the immunochemical strategies engaged in the development of anticancer carbohydrate-based vaccines. |
abstract_unstemmed |
A brief overview of carbohydrate antigens processing and uptakes involved in the adaptive immune system is highlighted. To counter balance the poor immunogenicity and T-cell independent characteristics of carbohydrate antigens, chemists have developed original hybrid molecules aimed at targeting specific competent immune cell receptors. Amongst several potential vaccine candidates dedicated against diseases, this short report will focused on those most advance and state of the art organic chemistry involved therein. One case has led to the first example of a commercial vaccine entirely prepared from a synthetic carbohydrate antigen against infections caused by the Gram-negative bacteria Haemophilus influenza type b responsible for pneumonia and acute bacterial meningitis in infants. Other commendable examples will illustrate the immunochemical strategies engaged in the development of anticancer carbohydrate-based vaccines. |
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