Organic Chemistry and Immunochemical Strategies in the Design of Potent Carbohydrate-based Vaccines

A brief overview of carbohydrate antigens processing and uptakes involved in the adaptive immune system is highlighted. To counter balance the poor immunogenicity and T-cell independent characteristics of carbohydrate antigens, chemists have developed original hybrid molecules aimed at targeting spe...
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Gespeichert in:

Autor*in:	René Roy [verfasserIn] Tze Chieh Shiao [verfasserIn]

Format:	E-Artikel
Sprache:	Deutsch ; Englisch ; Französisch

Erschienen:	2011

Schlagwörter:	Bacteria Cancer Carbohydrate Polysaccharides Vaccines

Übergeordnetes Werk:	In: CHIMIA - Swiss Chemical Society, 2020, 65(2011), 1-2
Übergeordnetes Werk:	volume:65 ; year:2011 ; number:1-2

Links:	Link aufrufen Link aufrufen Link aufrufen Journal toc Journal toc

DOI / URN:	10.2533/chimia.2011.24

Katalog-ID:	DOAJ045957169

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callnumber-first	Q - Science
author	René Roy
spellingShingle	René Roy misc QD1-999 misc Bacteria misc Cancer misc Carbohydrate misc Polysaccharides misc Vaccines misc Chemistry Organic Chemistry and Immunochemical Strategies in the Design of Potent Carbohydrate-based Vaccines
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topic_title	QD1-999 Organic Chemistry and Immunochemical Strategies in the Design of Potent Carbohydrate-based Vaccines Bacteria Cancer Carbohydrate Polysaccharides Vaccines
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title	Organic Chemistry and Immunochemical Strategies in the Design of Potent Carbohydrate-based Vaccines
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title_auth	Organic Chemistry and Immunochemical Strategies in the Design of Potent Carbohydrate-based Vaccines
abstract	A brief overview of carbohydrate antigens processing and uptakes involved in the adaptive immune system is highlighted. To counter balance the poor immunogenicity and T-cell independent characteristics of carbohydrate antigens, chemists have developed original hybrid molecules aimed at targeting specific competent immune cell receptors. Amongst several potential vaccine candidates dedicated against diseases, this short report will focused on those most advance and state of the art organic chemistry involved therein. One case has led to the first example of a commercial vaccine entirely prepared from a synthetic carbohydrate antigen against infections caused by the Gram-negative bacteria Haemophilus influenza type b responsible for pneumonia and acute bacterial meningitis in infants. Other commendable examples will illustrate the immunochemical strategies engaged in the development of anticancer carbohydrate-based vaccines.
abstractGer	A brief overview of carbohydrate antigens processing and uptakes involved in the adaptive immune system is highlighted. To counter balance the poor immunogenicity and T-cell independent characteristics of carbohydrate antigens, chemists have developed original hybrid molecules aimed at targeting specific competent immune cell receptors. Amongst several potential vaccine candidates dedicated against diseases, this short report will focused on those most advance and state of the art organic chemistry involved therein. One case has led to the first example of a commercial vaccine entirely prepared from a synthetic carbohydrate antigen against infections caused by the Gram-negative bacteria Haemophilus influenza type b responsible for pneumonia and acute bacterial meningitis in infants. Other commendable examples will illustrate the immunochemical strategies engaged in the development of anticancer carbohydrate-based vaccines.
abstract_unstemmed	A brief overview of carbohydrate antigens processing and uptakes involved in the adaptive immune system is highlighted. To counter balance the poor immunogenicity and T-cell independent characteristics of carbohydrate antigens, chemists have developed original hybrid molecules aimed at targeting specific competent immune cell receptors. Amongst several potential vaccine candidates dedicated against diseases, this short report will focused on those most advance and state of the art organic chemistry involved therein. One case has led to the first example of a commercial vaccine entirely prepared from a synthetic carbohydrate antigen against infections caused by the Gram-negative bacteria Haemophilus influenza type b responsible for pneumonia and acute bacterial meningitis in infants. Other commendable examples will illustrate the immunochemical strategies engaged in the development of anticancer carbohydrate-based vaccines.
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title_short	Organic Chemistry and Immunochemical Strategies in the Design of Potent Carbohydrate-based Vaccines
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