Investigation of Biophysical Migration Parameters for Normal Tissue and Metastatic Cancer Cells After Radiotherapy Treatment

A large body of literature has demonstrated that the mechanical properties of microenvironment have a key role in regulating cancer cell adhesion, motility, and invasion. In this work, we have introduced two additional parameters, named cell trajectory extension and area traveled by cell, to describ...
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Autor*in:	Valeria Panzetta [verfasserIn] Giuseppe La Verde [verfasserIn] Mariagabriella Pugliese [verfasserIn] Cecilia Arrichiello [verfasserIn] Paolo Muto [verfasserIn] Marco La Commara [verfasserIn] Vittoria D'Avino [verfasserIn] Paolo A. Netti [verfasserIn] Sabato Fusco [verfasserIn]

Format:	E-Artikel
Sprache:	Englisch

Erschienen:	2020

Schlagwörter:	breast cancer mechanobiology cell motility analysis extracellular matrix stiffness radiotherapy

Übergeordnetes Werk:	In: Frontiers in Physics - Frontiers Media S.A., 2014, 8(2020)
Übergeordnetes Werk:	volume:8 ; year:2020

Links:	Link aufrufen Link aufrufen Link aufrufen Journal toc

DOI / URN:	10.3389/fphy.2020.575906

Katalog-ID:	DOAJ046104496

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spelling	10.3389/fphy.2020.575906 doi (DE-627)DOAJ046104496 (DE-599)DOAJ3e5e5a1cef2343b2b9500f3b603473ee DE-627 ger DE-627 rakwb eng QC1-999 Valeria Panzetta verfasserin aut Investigation of Biophysical Migration Parameters for Normal Tissue and Metastatic Cancer Cells After Radiotherapy Treatment 2020 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier A large body of literature has demonstrated that the mechanical properties of microenvironment have a key role in regulating cancer cell adhesion, motility, and invasion. In this work, we have introduced two additional parameters, named cell trajectory extension and area traveled by cell, to describe the tendency of normal tissue and metastatic cancer cells to move in a directional way when they interact with physio-pathological substrates, characterized by stiffnesses of 1–13 kPa, before and after treatment with 2 doses of X-rays (2 and 10 Gy). We interpreted these data by evaluating also the impact of substrate stiffness on 2 morphological parameters which indicate not only the state of cell adhesion, but also cell polarization, prerequisite to directional movement, and the formation of protrusions over cell perimeters. We believe that a so wide analysis can give an efficient and easily readable overview of effects of radiation therapy on cell-ECM crosstalk when used as therapeutic agent. breast cancer mechanobiology cell motility analysis extracellular matrix stiffness radiotherapy Physics Valeria Panzetta verfasserin aut Giuseppe La Verde verfasserin aut Giuseppe La Verde verfasserin aut Mariagabriella Pugliese verfasserin aut Mariagabriella Pugliese verfasserin aut Cecilia Arrichiello verfasserin aut Paolo Muto verfasserin aut Marco La Commara verfasserin aut Marco La Commara verfasserin aut Vittoria D'Avino verfasserin aut Paolo A. Netti verfasserin aut Paolo A. Netti verfasserin aut Sabato Fusco verfasserin aut Sabato Fusco verfasserin aut In Frontiers in Physics Frontiers Media S.A., 2014 8(2020) (DE-627)750371749 (DE-600)2721033-9 2296424X nnns volume:8 year:2020 https://doi.org/10.3389/fphy.2020.575906 kostenfrei https://doaj.org/article/3e5e5a1cef2343b2b9500f3b603473ee kostenfrei https://www.frontiersin.org/article/10.3389/fphy.2020.575906/full kostenfrei https://doaj.org/toc/2296-424X Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_2003 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4335 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 8 2020
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allfieldsSound	10.3389/fphy.2020.575906 doi (DE-627)DOAJ046104496 (DE-599)DOAJ3e5e5a1cef2343b2b9500f3b603473ee DE-627 ger DE-627 rakwb eng QC1-999 Valeria Panzetta verfasserin aut Investigation of Biophysical Migration Parameters for Normal Tissue and Metastatic Cancer Cells After Radiotherapy Treatment 2020 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier A large body of literature has demonstrated that the mechanical properties of microenvironment have a key role in regulating cancer cell adhesion, motility, and invasion. In this work, we have introduced two additional parameters, named cell trajectory extension and area traveled by cell, to describe the tendency of normal tissue and metastatic cancer cells to move in a directional way when they interact with physio-pathological substrates, characterized by stiffnesses of 1–13 kPa, before and after treatment with 2 doses of X-rays (2 and 10 Gy). We interpreted these data by evaluating also the impact of substrate stiffness on 2 morphological parameters which indicate not only the state of cell adhesion, but also cell polarization, prerequisite to directional movement, and the formation of protrusions over cell perimeters. We believe that a so wide analysis can give an efficient and easily readable overview of effects of radiation therapy on cell-ECM crosstalk when used as therapeutic agent. breast cancer mechanobiology cell motility analysis extracellular matrix stiffness radiotherapy Physics Valeria Panzetta verfasserin aut Giuseppe La Verde verfasserin aut Giuseppe La Verde verfasserin aut Mariagabriella Pugliese verfasserin aut Mariagabriella Pugliese verfasserin aut Cecilia Arrichiello verfasserin aut Paolo Muto verfasserin aut Marco La Commara verfasserin aut Marco La Commara verfasserin aut Vittoria D'Avino verfasserin aut Paolo A. Netti verfasserin aut Paolo A. Netti verfasserin aut Sabato Fusco verfasserin aut Sabato Fusco verfasserin aut In Frontiers in Physics Frontiers Media S.A., 2014 8(2020) (DE-627)750371749 (DE-600)2721033-9 2296424X nnns volume:8 year:2020 https://doi.org/10.3389/fphy.2020.575906 kostenfrei https://doaj.org/article/3e5e5a1cef2343b2b9500f3b603473ee kostenfrei https://www.frontiersin.org/article/10.3389/fphy.2020.575906/full kostenfrei https://doaj.org/toc/2296-424X Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_2003 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4335 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 8 2020
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source	In Frontiers in Physics 8(2020) volume:8 year:2020
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authorswithroles_txt_mv	Valeria Panzetta @@aut@@ Giuseppe La Verde @@aut@@ Mariagabriella Pugliese @@aut@@ Cecilia Arrichiello @@aut@@ Paolo Muto @@aut@@ Marco La Commara @@aut@@ Vittoria D'Avino @@aut@@ Paolo A. Netti @@aut@@ Sabato Fusco @@aut@@
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callnumber-first	Q - Science
author	Valeria Panzetta
spellingShingle	Valeria Panzetta misc QC1-999 misc breast cancer misc mechanobiology misc cell motility analysis misc extracellular matrix stiffness misc radiotherapy misc Physics Investigation of Biophysical Migration Parameters for Normal Tissue and Metastatic Cancer Cells After Radiotherapy Treatment
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topic_title	QC1-999 Investigation of Biophysical Migration Parameters for Normal Tissue and Metastatic Cancer Cells After Radiotherapy Treatment breast cancer mechanobiology cell motility analysis extracellular matrix stiffness radiotherapy
topic	misc QC1-999 misc breast cancer misc mechanobiology misc cell motility analysis misc extracellular matrix stiffness misc radiotherapy misc Physics
topic_unstemmed	misc QC1-999 misc breast cancer misc mechanobiology misc cell motility analysis misc extracellular matrix stiffness misc radiotherapy misc Physics
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title	Investigation of Biophysical Migration Parameters for Normal Tissue and Metastatic Cancer Cells After Radiotherapy Treatment
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title_full	Investigation of Biophysical Migration Parameters for Normal Tissue and Metastatic Cancer Cells After Radiotherapy Treatment
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author_browse	Valeria Panzetta Giuseppe La Verde Mariagabriella Pugliese Cecilia Arrichiello Paolo Muto Marco La Commara Vittoria D'Avino Paolo A. Netti Sabato Fusco
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title_sort	investigation of biophysical migration parameters for normal tissue and metastatic cancer cells after radiotherapy treatment
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title_auth	Investigation of Biophysical Migration Parameters for Normal Tissue and Metastatic Cancer Cells After Radiotherapy Treatment
abstract	A large body of literature has demonstrated that the mechanical properties of microenvironment have a key role in regulating cancer cell adhesion, motility, and invasion. In this work, we have introduced two additional parameters, named cell trajectory extension and area traveled by cell, to describe the tendency of normal tissue and metastatic cancer cells to move in a directional way when they interact with physio-pathological substrates, characterized by stiffnesses of 1–13 kPa, before and after treatment with 2 doses of X-rays (2 and 10 Gy). We interpreted these data by evaluating also the impact of substrate stiffness on 2 morphological parameters which indicate not only the state of cell adhesion, but also cell polarization, prerequisite to directional movement, and the formation of protrusions over cell perimeters. We believe that a so wide analysis can give an efficient and easily readable overview of effects of radiation therapy on cell-ECM crosstalk when used as therapeutic agent.
abstractGer	A large body of literature has demonstrated that the mechanical properties of microenvironment have a key role in regulating cancer cell adhesion, motility, and invasion. In this work, we have introduced two additional parameters, named cell trajectory extension and area traveled by cell, to describe the tendency of normal tissue and metastatic cancer cells to move in a directional way when they interact with physio-pathological substrates, characterized by stiffnesses of 1–13 kPa, before and after treatment with 2 doses of X-rays (2 and 10 Gy). We interpreted these data by evaluating also the impact of substrate stiffness on 2 morphological parameters which indicate not only the state of cell adhesion, but also cell polarization, prerequisite to directional movement, and the formation of protrusions over cell perimeters. We believe that a so wide analysis can give an efficient and easily readable overview of effects of radiation therapy on cell-ECM crosstalk when used as therapeutic agent.
abstract_unstemmed	A large body of literature has demonstrated that the mechanical properties of microenvironment have a key role in regulating cancer cell adhesion, motility, and invasion. In this work, we have introduced two additional parameters, named cell trajectory extension and area traveled by cell, to describe the tendency of normal tissue and metastatic cancer cells to move in a directional way when they interact with physio-pathological substrates, characterized by stiffnesses of 1–13 kPa, before and after treatment with 2 doses of X-rays (2 and 10 Gy). We interpreted these data by evaluating also the impact of substrate stiffness on 2 morphological parameters which indicate not only the state of cell adhesion, but also cell polarization, prerequisite to directional movement, and the formation of protrusions over cell perimeters. We believe that a so wide analysis can give an efficient and easily readable overview of effects of radiation therapy on cell-ECM crosstalk when used as therapeutic agent.
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title_short	Investigation of Biophysical Migration Parameters for Normal Tissue and Metastatic Cancer Cells After Radiotherapy Treatment
url	https://doi.org/10.3389/fphy.2020.575906 https://doaj.org/article/3e5e5a1cef2343b2b9500f3b603473ee https://www.frontiersin.org/article/10.3389/fphy.2020.575906/full https://doaj.org/toc/2296-424X
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up_date	2024-07-03T18:47:56.198Z
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Investigation of Biophysical Migration Parameters for Normal Tissue and Metastatic Cancer Cells After Radiotherapy Treatment

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