<i<Mardivirus</i< Infection and Persistence in Feathers of a Chicken Model Harboring a Local Autoimmune Response

Herpesvirus of turkey (HVT) is commonly used as a vaccine to protect chickens against Marek’s disease. Following vaccination, HVT infects feathers where it can be detected in all chicken lines examined. Unlike the parental Brown line (BL), Smyth line (SL) chickens develop vitiligo, due to autoimmune...
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Autor*in:	Gisela F. Erf [verfasserIn] Gilles Le Pape [verfasserIn] Sylvie Rémy [verfasserIn] Caroline Denesvre [verfasserIn]

Format:	E-Artikel
Sprache:	Englisch

Erschienen:	2020

Schlagwörter:	herpesvirus of turkey Marek’s disease vaccine Smyth line vitiligo feathers viral persistence

Übergeordnetes Werk:	In: Microorganisms - MDPI AG, 2013, 8(2020), 10, p 1613
Übergeordnetes Werk:	volume:8 ; year:2020 ; number:10, p 1613

Links:	Link aufrufen Link aufrufen Link aufrufen Journal toc

DOI / URN:	10.3390/microorganisms8101613

Katalog-ID:	DOAJ046300740

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520			\|a Herpesvirus of turkey (HVT) is commonly used as a vaccine to protect chickens against Marek’s disease. Following vaccination, HVT infects feathers where it can be detected in all chicken lines examined. Unlike the parental Brown line (BL), Smyth line (SL) chickens develop vitiligo, due to autoimmune destruction of melanocytes in feathers. Previous reports showed a strong inflammatory response in Smyth chickens’ feathers at vitiligo onset, that subsided once melanocytes were destroyed, and depigmentation was complete. Here, we questioned whether the local autoimmune response in the Smyth model influences HVT infection and persistence in feathers. For this, one-day-old SL and BL chickens were vaccinated with Newcastle disease (rHVT-ND). Vitiligo was scored and HVT loads in pigmented and non-pigmented growing feathers were quantified regularly over 20 weeks. Chickens of both lines showed moderate HVT loads in feathers. At the onset of active vitiligo, the HVT load was significantly higher in SL compared to BL feathers. However, no difference in HVT loads was noticed between pigmented and non-pigmented feathers from SL chickens. Therefore, surprisingly, the inflammatory response in feathers of SL chickens did not inhibit HVT infection and persistence, but on the contrary, temporarily promoted HVT infection in feathers.
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allfields	10.3390/microorganisms8101613 doi (DE-627)DOAJ046300740 (DE-599)DOAJ60f5d14632a4460bbb9ca2e54ef805ea DE-627 ger DE-627 rakwb eng QH301-705.5 Gisela F. Erf verfasserin aut <i<Mardivirus</i< Infection and Persistence in Feathers of a Chicken Model Harboring a Local Autoimmune Response 2020 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Herpesvirus of turkey (HVT) is commonly used as a vaccine to protect chickens against Marek’s disease. Following vaccination, HVT infects feathers where it can be detected in all chicken lines examined. Unlike the parental Brown line (BL), Smyth line (SL) chickens develop vitiligo, due to autoimmune destruction of melanocytes in feathers. Previous reports showed a strong inflammatory response in Smyth chickens’ feathers at vitiligo onset, that subsided once melanocytes were destroyed, and depigmentation was complete. Here, we questioned whether the local autoimmune response in the Smyth model influences HVT infection and persistence in feathers. For this, one-day-old SL and BL chickens were vaccinated with Newcastle disease (rHVT-ND). Vitiligo was scored and HVT loads in pigmented and non-pigmented growing feathers were quantified regularly over 20 weeks. Chickens of both lines showed moderate HVT loads in feathers. At the onset of active vitiligo, the HVT load was significantly higher in SL compared to BL feathers. However, no difference in HVT loads was noticed between pigmented and non-pigmented feathers from SL chickens. Therefore, surprisingly, the inflammatory response in feathers of SL chickens did not inhibit HVT infection and persistence, but on the contrary, temporarily promoted HVT infection in feathers. herpesvirus of turkey Marek’s disease vaccine Smyth line vitiligo feathers viral persistence Biology (General) Gilles Le Pape verfasserin aut Sylvie Rémy verfasserin aut Caroline Denesvre verfasserin aut In Microorganisms MDPI AG, 2013 8(2020), 10, p 1613 (DE-627)750370696 (DE-600)2720891-6 20762607 nnns volume:8 year:2020 number:10, p 1613 https://doi.org/10.3390/microorganisms8101613 kostenfrei https://doaj.org/article/60f5d14632a4460bbb9ca2e54ef805ea kostenfrei https://www.mdpi.com/2076-2607/8/10/1613 kostenfrei https://doaj.org/toc/2076-2607 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 8 2020 10, p 1613
spelling	10.3390/microorganisms8101613 doi (DE-627)DOAJ046300740 (DE-599)DOAJ60f5d14632a4460bbb9ca2e54ef805ea DE-627 ger DE-627 rakwb eng QH301-705.5 Gisela F. Erf verfasserin aut <i<Mardivirus</i< Infection and Persistence in Feathers of a Chicken Model Harboring a Local Autoimmune Response 2020 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Herpesvirus of turkey (HVT) is commonly used as a vaccine to protect chickens against Marek’s disease. Following vaccination, HVT infects feathers where it can be detected in all chicken lines examined. Unlike the parental Brown line (BL), Smyth line (SL) chickens develop vitiligo, due to autoimmune destruction of melanocytes in feathers. Previous reports showed a strong inflammatory response in Smyth chickens’ feathers at vitiligo onset, that subsided once melanocytes were destroyed, and depigmentation was complete. Here, we questioned whether the local autoimmune response in the Smyth model influences HVT infection and persistence in feathers. For this, one-day-old SL and BL chickens were vaccinated with Newcastle disease (rHVT-ND). Vitiligo was scored and HVT loads in pigmented and non-pigmented growing feathers were quantified regularly over 20 weeks. Chickens of both lines showed moderate HVT loads in feathers. At the onset of active vitiligo, the HVT load was significantly higher in SL compared to BL feathers. However, no difference in HVT loads was noticed between pigmented and non-pigmented feathers from SL chickens. Therefore, surprisingly, the inflammatory response in feathers of SL chickens did not inhibit HVT infection and persistence, but on the contrary, temporarily promoted HVT infection in feathers. herpesvirus of turkey Marek’s disease vaccine Smyth line vitiligo feathers viral persistence Biology (General) Gilles Le Pape verfasserin aut Sylvie Rémy verfasserin aut Caroline Denesvre verfasserin aut In Microorganisms MDPI AG, 2013 8(2020), 10, p 1613 (DE-627)750370696 (DE-600)2720891-6 20762607 nnns volume:8 year:2020 number:10, p 1613 https://doi.org/10.3390/microorganisms8101613 kostenfrei https://doaj.org/article/60f5d14632a4460bbb9ca2e54ef805ea kostenfrei https://www.mdpi.com/2076-2607/8/10/1613 kostenfrei https://doaj.org/toc/2076-2607 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 8 2020 10, p 1613
allfields_unstemmed	10.3390/microorganisms8101613 doi (DE-627)DOAJ046300740 (DE-599)DOAJ60f5d14632a4460bbb9ca2e54ef805ea DE-627 ger DE-627 rakwb eng QH301-705.5 Gisela F. Erf verfasserin aut <i<Mardivirus</i< Infection and Persistence in Feathers of a Chicken Model Harboring a Local Autoimmune Response 2020 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Herpesvirus of turkey (HVT) is commonly used as a vaccine to protect chickens against Marek’s disease. Following vaccination, HVT infects feathers where it can be detected in all chicken lines examined. Unlike the parental Brown line (BL), Smyth line (SL) chickens develop vitiligo, due to autoimmune destruction of melanocytes in feathers. Previous reports showed a strong inflammatory response in Smyth chickens’ feathers at vitiligo onset, that subsided once melanocytes were destroyed, and depigmentation was complete. Here, we questioned whether the local autoimmune response in the Smyth model influences HVT infection and persistence in feathers. For this, one-day-old SL and BL chickens were vaccinated with Newcastle disease (rHVT-ND). Vitiligo was scored and HVT loads in pigmented and non-pigmented growing feathers were quantified regularly over 20 weeks. Chickens of both lines showed moderate HVT loads in feathers. At the onset of active vitiligo, the HVT load was significantly higher in SL compared to BL feathers. However, no difference in HVT loads was noticed between pigmented and non-pigmented feathers from SL chickens. Therefore, surprisingly, the inflammatory response in feathers of SL chickens did not inhibit HVT infection and persistence, but on the contrary, temporarily promoted HVT infection in feathers. herpesvirus of turkey Marek’s disease vaccine Smyth line vitiligo feathers viral persistence Biology (General) Gilles Le Pape verfasserin aut Sylvie Rémy verfasserin aut Caroline Denesvre verfasserin aut In Microorganisms MDPI AG, 2013 8(2020), 10, p 1613 (DE-627)750370696 (DE-600)2720891-6 20762607 nnns volume:8 year:2020 number:10, p 1613 https://doi.org/10.3390/microorganisms8101613 kostenfrei https://doaj.org/article/60f5d14632a4460bbb9ca2e54ef805ea kostenfrei https://www.mdpi.com/2076-2607/8/10/1613 kostenfrei https://doaj.org/toc/2076-2607 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 8 2020 10, p 1613
allfieldsGer	10.3390/microorganisms8101613 doi (DE-627)DOAJ046300740 (DE-599)DOAJ60f5d14632a4460bbb9ca2e54ef805ea DE-627 ger DE-627 rakwb eng QH301-705.5 Gisela F. Erf verfasserin aut <i<Mardivirus</i< Infection and Persistence in Feathers of a Chicken Model Harboring a Local Autoimmune Response 2020 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Herpesvirus of turkey (HVT) is commonly used as a vaccine to protect chickens against Marek’s disease. Following vaccination, HVT infects feathers where it can be detected in all chicken lines examined. Unlike the parental Brown line (BL), Smyth line (SL) chickens develop vitiligo, due to autoimmune destruction of melanocytes in feathers. Previous reports showed a strong inflammatory response in Smyth chickens’ feathers at vitiligo onset, that subsided once melanocytes were destroyed, and depigmentation was complete. Here, we questioned whether the local autoimmune response in the Smyth model influences HVT infection and persistence in feathers. For this, one-day-old SL and BL chickens were vaccinated with Newcastle disease (rHVT-ND). Vitiligo was scored and HVT loads in pigmented and non-pigmented growing feathers were quantified regularly over 20 weeks. Chickens of both lines showed moderate HVT loads in feathers. At the onset of active vitiligo, the HVT load was significantly higher in SL compared to BL feathers. However, no difference in HVT loads was noticed between pigmented and non-pigmented feathers from SL chickens. Therefore, surprisingly, the inflammatory response in feathers of SL chickens did not inhibit HVT infection and persistence, but on the contrary, temporarily promoted HVT infection in feathers. herpesvirus of turkey Marek’s disease vaccine Smyth line vitiligo feathers viral persistence Biology (General) Gilles Le Pape verfasserin aut Sylvie Rémy verfasserin aut Caroline Denesvre verfasserin aut In Microorganisms MDPI AG, 2013 8(2020), 10, p 1613 (DE-627)750370696 (DE-600)2720891-6 20762607 nnns volume:8 year:2020 number:10, p 1613 https://doi.org/10.3390/microorganisms8101613 kostenfrei https://doaj.org/article/60f5d14632a4460bbb9ca2e54ef805ea kostenfrei https://www.mdpi.com/2076-2607/8/10/1613 kostenfrei https://doaj.org/toc/2076-2607 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 8 2020 10, p 1613
allfieldsSound	10.3390/microorganisms8101613 doi (DE-627)DOAJ046300740 (DE-599)DOAJ60f5d14632a4460bbb9ca2e54ef805ea DE-627 ger DE-627 rakwb eng QH301-705.5 Gisela F. Erf verfasserin aut <i<Mardivirus</i< Infection and Persistence in Feathers of a Chicken Model Harboring a Local Autoimmune Response 2020 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Herpesvirus of turkey (HVT) is commonly used as a vaccine to protect chickens against Marek’s disease. Following vaccination, HVT infects feathers where it can be detected in all chicken lines examined. Unlike the parental Brown line (BL), Smyth line (SL) chickens develop vitiligo, due to autoimmune destruction of melanocytes in feathers. Previous reports showed a strong inflammatory response in Smyth chickens’ feathers at vitiligo onset, that subsided once melanocytes were destroyed, and depigmentation was complete. Here, we questioned whether the local autoimmune response in the Smyth model influences HVT infection and persistence in feathers. For this, one-day-old SL and BL chickens were vaccinated with Newcastle disease (rHVT-ND). Vitiligo was scored and HVT loads in pigmented and non-pigmented growing feathers were quantified regularly over 20 weeks. Chickens of both lines showed moderate HVT loads in feathers. At the onset of active vitiligo, the HVT load was significantly higher in SL compared to BL feathers. However, no difference in HVT loads was noticed between pigmented and non-pigmented feathers from SL chickens. Therefore, surprisingly, the inflammatory response in feathers of SL chickens did not inhibit HVT infection and persistence, but on the contrary, temporarily promoted HVT infection in feathers. herpesvirus of turkey Marek’s disease vaccine Smyth line vitiligo feathers viral persistence Biology (General) Gilles Le Pape verfasserin aut Sylvie Rémy verfasserin aut Caroline Denesvre verfasserin aut In Microorganisms MDPI AG, 2013 8(2020), 10, p 1613 (DE-627)750370696 (DE-600)2720891-6 20762607 nnns volume:8 year:2020 number:10, p 1613 https://doi.org/10.3390/microorganisms8101613 kostenfrei https://doaj.org/article/60f5d14632a4460bbb9ca2e54ef805ea kostenfrei https://www.mdpi.com/2076-2607/8/10/1613 kostenfrei https://doaj.org/toc/2076-2607 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 8 2020 10, p 1613
language	English
source	In Microorganisms 8(2020), 10, p 1613 volume:8 year:2020 number:10, p 1613
sourceStr	In Microorganisms 8(2020), 10, p 1613 volume:8 year:2020 number:10, p 1613
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institution	findex.gbv.de
topic_facet	herpesvirus of turkey Marek’s disease vaccine Smyth line vitiligo feathers viral persistence Biology (General)
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container_title	Microorganisms
authorswithroles_txt_mv	Gisela F. Erf @@aut@@ Gilles Le Pape @@aut@@ Sylvie Rémy @@aut@@ Caroline Denesvre @@aut@@
publishDateDaySort_date	2020-01-01T00:00:00Z
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Erf</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="245" ind1="1" ind2="0"><subfield code="a"><i<Mardivirus</i< Infection and Persistence in Feathers of a Chicken Model Harboring a Local Autoimmune Response</subfield></datafield><datafield tag="264" ind1=" " ind2="1"><subfield code="c">2020</subfield></datafield><datafield tag="336" ind1=" " ind2=" "><subfield code="a">Text</subfield><subfield code="b">txt</subfield><subfield code="2">rdacontent</subfield></datafield><datafield tag="337" ind1=" " ind2=" "><subfield code="a">Computermedien</subfield><subfield code="b">c</subfield><subfield code="2">rdamedia</subfield></datafield><datafield tag="338" ind1=" " ind2=" "><subfield code="a">Online-Ressource</subfield><subfield code="b">cr</subfield><subfield code="2">rdacarrier</subfield></datafield><datafield tag="520" ind1=" " ind2=" "><subfield code="a">Herpesvirus of turkey (HVT) is commonly used as a vaccine to protect chickens against Marek’s disease. Following vaccination, HVT infects feathers where it can be detected in all chicken lines examined. Unlike the parental Brown line (BL), Smyth line (SL) chickens develop vitiligo, due to autoimmune destruction of melanocytes in feathers. Previous reports showed a strong inflammatory response in Smyth chickens’ feathers at vitiligo onset, that subsided once melanocytes were destroyed, and depigmentation was complete. Here, we questioned whether the local autoimmune response in the Smyth model influences HVT infection and persistence in feathers. For this, one-day-old SL and BL chickens were vaccinated with Newcastle disease (rHVT-ND). Vitiligo was scored and HVT loads in pigmented and non-pigmented growing feathers were quantified regularly over 20 weeks. Chickens of both lines showed moderate HVT loads in feathers. At the onset of active vitiligo, the HVT load was significantly higher in SL compared to BL feathers. 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callnumber-first	Q - Science
author	Gisela F. Erf
spellingShingle	Gisela F. Erf misc QH301-705.5 misc herpesvirus of turkey misc Marek’s disease vaccine misc Smyth line misc vitiligo misc feathers misc viral persistence misc Biology (General) <i<Mardivirus</i< Infection and Persistence in Feathers of a Chicken Model Harboring a Local Autoimmune Response
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topic_title	QH301-705.5 <i<Mardivirus</i< Infection and Persistence in Feathers of a Chicken Model Harboring a Local Autoimmune Response herpesvirus of turkey Marek’s disease vaccine Smyth line vitiligo feathers viral persistence
topic	misc QH301-705.5 misc herpesvirus of turkey misc Marek’s disease vaccine misc Smyth line misc vitiligo misc feathers misc viral persistence misc Biology (General)
topic_unstemmed	misc QH301-705.5 misc herpesvirus of turkey misc Marek’s disease vaccine misc Smyth line misc vitiligo misc feathers misc viral persistence misc Biology (General)
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title	<i<Mardivirus</i< Infection and Persistence in Feathers of a Chicken Model Harboring a Local Autoimmune Response
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title_full	<i<Mardivirus</i< Infection and Persistence in Feathers of a Chicken Model Harboring a Local Autoimmune Response
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author_browse	Gisela F. Erf Gilles Le Pape Sylvie Rémy Caroline Denesvre
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title_sort	<i<mardivirus</i< infection and persistence in feathers of a chicken model harboring a local autoimmune response
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title_auth	<i<Mardivirus</i< Infection and Persistence in Feathers of a Chicken Model Harboring a Local Autoimmune Response
abstract	Herpesvirus of turkey (HVT) is commonly used as a vaccine to protect chickens against Marek’s disease. Following vaccination, HVT infects feathers where it can be detected in all chicken lines examined. Unlike the parental Brown line (BL), Smyth line (SL) chickens develop vitiligo, due to autoimmune destruction of melanocytes in feathers. Previous reports showed a strong inflammatory response in Smyth chickens’ feathers at vitiligo onset, that subsided once melanocytes were destroyed, and depigmentation was complete. Here, we questioned whether the local autoimmune response in the Smyth model influences HVT infection and persistence in feathers. For this, one-day-old SL and BL chickens were vaccinated with Newcastle disease (rHVT-ND). Vitiligo was scored and HVT loads in pigmented and non-pigmented growing feathers were quantified regularly over 20 weeks. Chickens of both lines showed moderate HVT loads in feathers. At the onset of active vitiligo, the HVT load was significantly higher in SL compared to BL feathers. However, no difference in HVT loads was noticed between pigmented and non-pigmented feathers from SL chickens. Therefore, surprisingly, the inflammatory response in feathers of SL chickens did not inhibit HVT infection and persistence, but on the contrary, temporarily promoted HVT infection in feathers.
abstractGer	Herpesvirus of turkey (HVT) is commonly used as a vaccine to protect chickens against Marek’s disease. Following vaccination, HVT infects feathers where it can be detected in all chicken lines examined. Unlike the parental Brown line (BL), Smyth line (SL) chickens develop vitiligo, due to autoimmune destruction of melanocytes in feathers. Previous reports showed a strong inflammatory response in Smyth chickens’ feathers at vitiligo onset, that subsided once melanocytes were destroyed, and depigmentation was complete. Here, we questioned whether the local autoimmune response in the Smyth model influences HVT infection and persistence in feathers. For this, one-day-old SL and BL chickens were vaccinated with Newcastle disease (rHVT-ND). Vitiligo was scored and HVT loads in pigmented and non-pigmented growing feathers were quantified regularly over 20 weeks. Chickens of both lines showed moderate HVT loads in feathers. At the onset of active vitiligo, the HVT load was significantly higher in SL compared to BL feathers. However, no difference in HVT loads was noticed between pigmented and non-pigmented feathers from SL chickens. Therefore, surprisingly, the inflammatory response in feathers of SL chickens did not inhibit HVT infection and persistence, but on the contrary, temporarily promoted HVT infection in feathers.
abstract_unstemmed	Herpesvirus of turkey (HVT) is commonly used as a vaccine to protect chickens against Marek’s disease. Following vaccination, HVT infects feathers where it can be detected in all chicken lines examined. Unlike the parental Brown line (BL), Smyth line (SL) chickens develop vitiligo, due to autoimmune destruction of melanocytes in feathers. Previous reports showed a strong inflammatory response in Smyth chickens’ feathers at vitiligo onset, that subsided once melanocytes were destroyed, and depigmentation was complete. Here, we questioned whether the local autoimmune response in the Smyth model influences HVT infection and persistence in feathers. For this, one-day-old SL and BL chickens were vaccinated with Newcastle disease (rHVT-ND). Vitiligo was scored and HVT loads in pigmented and non-pigmented growing feathers were quantified regularly over 20 weeks. Chickens of both lines showed moderate HVT loads in feathers. At the onset of active vitiligo, the HVT load was significantly higher in SL compared to BL feathers. However, no difference in HVT loads was noticed between pigmented and non-pigmented feathers from SL chickens. Therefore, surprisingly, the inflammatory response in feathers of SL chickens did not inhibit HVT infection and persistence, but on the contrary, temporarily promoted HVT infection in feathers.
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title_short	<i<Mardivirus</i< Infection and Persistence in Feathers of a Chicken Model Harboring a Local Autoimmune Response
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