Adaptive Potential of the Heme Oxygenase/Carbon Monoxide Pathway During Hypoxia

Heme oxygenase (HO) enzymes catalyze heme into biliverdin, releasing carbon monoxide (CO) and iron into circulation. These byproducts of heme degradation can have potent cytoprotective effects in the face of stressors such as hypoxia and ischemia-reperfusion events. The potential for exogenous use o...
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Autor*in:	Michael S. Tift [verfasserIn] Rodrigo W. Alves de Souza [verfasserIn] Janick Weber [verfasserIn] Erica C. Heinrich [verfasserIn] Francisco C. Villafuerte [verfasserIn] Atul Malhotra [verfasserIn] Leo E. Otterbein [verfasserIn] Tatum S. Simonson [verfasserIn]

Format:	E-Artikel
Sprache:	Englisch

Erschienen:	2020

Schlagwörter:	carbon monoxide heme oxygenase hypoxia altitude diving evolution

Übergeordnetes Werk:	In: Frontiers in Physiology - Frontiers Media S.A., 2011, 11(2020)
Übergeordnetes Werk:	volume:11 ; year:2020

Links:	Link aufrufen Link aufrufen Link aufrufen Journal toc

DOI / URN:	10.3389/fphys.2020.00886

Katalog-ID:	DOAJ046311394

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520			\|a Heme oxygenase (HO) enzymes catalyze heme into biliverdin, releasing carbon monoxide (CO) and iron into circulation. These byproducts of heme degradation can have potent cytoprotective effects in the face of stressors such as hypoxia and ischemia-reperfusion events. The potential for exogenous use of CO as a therapeutic agent has received increasing attention throughout the past few decades. Further, HO and CO are noted as putatively adaptive in diving mammals and certain high-altitude human populations that are frequently exposed to hypoxia and/or ischemia-reperfusion events, suggesting that HO and endogenous CO afford an evolutionary advantage for hypoxia tolerance and are critical in cell survival and injury avoidance. Our goal is to describe the importance of examining HO and CO in several systems, the physiological links, and the genetic factors that underlie variation in the HO/CO pathway. Finally, we emphasize the ways in which evolutionary perspectives may enhance our understanding of the HO/CO pathway in the context of diverse clinical settings.
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spelling	10.3389/fphys.2020.00886 doi (DE-627)DOAJ046311394 (DE-599)DOAJfaa39b6162fa4b2c9ad35d48e6a632cf DE-627 ger DE-627 rakwb eng QP1-981 Michael S. Tift verfasserin aut Adaptive Potential of the Heme Oxygenase/Carbon Monoxide Pathway During Hypoxia 2020 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Heme oxygenase (HO) enzymes catalyze heme into biliverdin, releasing carbon monoxide (CO) and iron into circulation. These byproducts of heme degradation can have potent cytoprotective effects in the face of stressors such as hypoxia and ischemia-reperfusion events. The potential for exogenous use of CO as a therapeutic agent has received increasing attention throughout the past few decades. Further, HO and CO are noted as putatively adaptive in diving mammals and certain high-altitude human populations that are frequently exposed to hypoxia and/or ischemia-reperfusion events, suggesting that HO and endogenous CO afford an evolutionary advantage for hypoxia tolerance and are critical in cell survival and injury avoidance. Our goal is to describe the importance of examining HO and CO in several systems, the physiological links, and the genetic factors that underlie variation in the HO/CO pathway. Finally, we emphasize the ways in which evolutionary perspectives may enhance our understanding of the HO/CO pathway in the context of diverse clinical settings. carbon monoxide heme oxygenase hypoxia altitude diving evolution Physiology Rodrigo W. Alves de Souza verfasserin aut Janick Weber verfasserin aut Erica C. Heinrich verfasserin aut Francisco C. Villafuerte verfasserin aut Atul Malhotra verfasserin aut Leo E. Otterbein verfasserin aut Tatum S. Simonson verfasserin aut In Frontiers in Physiology Frontiers Media S.A., 2011 11(2020) (DE-627)631498788 (DE-600)2564217-0 1664042X nnns volume:11 year:2020 https://doi.org/10.3389/fphys.2020.00886 kostenfrei https://doaj.org/article/faa39b6162fa4b2c9ad35d48e6a632cf kostenfrei https://www.frontiersin.org/article/10.3389/fphys.2020.00886/full kostenfrei https://doaj.org/toc/1664-042X Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2003 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 11 2020
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allfieldsSound	10.3389/fphys.2020.00886 doi (DE-627)DOAJ046311394 (DE-599)DOAJfaa39b6162fa4b2c9ad35d48e6a632cf DE-627 ger DE-627 rakwb eng QP1-981 Michael S. Tift verfasserin aut Adaptive Potential of the Heme Oxygenase/Carbon Monoxide Pathway During Hypoxia 2020 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Heme oxygenase (HO) enzymes catalyze heme into biliverdin, releasing carbon monoxide (CO) and iron into circulation. These byproducts of heme degradation can have potent cytoprotective effects in the face of stressors such as hypoxia and ischemia-reperfusion events. The potential for exogenous use of CO as a therapeutic agent has received increasing attention throughout the past few decades. Further, HO and CO are noted as putatively adaptive in diving mammals and certain high-altitude human populations that are frequently exposed to hypoxia and/or ischemia-reperfusion events, suggesting that HO and endogenous CO afford an evolutionary advantage for hypoxia tolerance and are critical in cell survival and injury avoidance. Our goal is to describe the importance of examining HO and CO in several systems, the physiological links, and the genetic factors that underlie variation in the HO/CO pathway. Finally, we emphasize the ways in which evolutionary perspectives may enhance our understanding of the HO/CO pathway in the context of diverse clinical settings. carbon monoxide heme oxygenase hypoxia altitude diving evolution Physiology Rodrigo W. Alves de Souza verfasserin aut Janick Weber verfasserin aut Erica C. Heinrich verfasserin aut Francisco C. Villafuerte verfasserin aut Atul Malhotra verfasserin aut Leo E. Otterbein verfasserin aut Tatum S. Simonson verfasserin aut In Frontiers in Physiology Frontiers Media S.A., 2011 11(2020) (DE-627)631498788 (DE-600)2564217-0 1664042X nnns volume:11 year:2020 https://doi.org/10.3389/fphys.2020.00886 kostenfrei https://doaj.org/article/faa39b6162fa4b2c9ad35d48e6a632cf kostenfrei https://www.frontiersin.org/article/10.3389/fphys.2020.00886/full kostenfrei https://doaj.org/toc/1664-042X Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2003 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 11 2020
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author	Michael S. Tift
spellingShingle	Michael S. Tift misc QP1-981 misc carbon monoxide misc heme oxygenase misc hypoxia misc altitude misc diving misc evolution misc Physiology Adaptive Potential of the Heme Oxygenase/Carbon Monoxide Pathway During Hypoxia
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topic_title	QP1-981 Adaptive Potential of the Heme Oxygenase/Carbon Monoxide Pathway During Hypoxia carbon monoxide heme oxygenase hypoxia altitude diving evolution
topic	misc QP1-981 misc carbon monoxide misc heme oxygenase misc hypoxia misc altitude misc diving misc evolution misc Physiology
topic_unstemmed	misc QP1-981 misc carbon monoxide misc heme oxygenase misc hypoxia misc altitude misc diving misc evolution misc Physiology
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title	Adaptive Potential of the Heme Oxygenase/Carbon Monoxide Pathway During Hypoxia
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title_sort	adaptive potential of the heme oxygenase/carbon monoxide pathway during hypoxia
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title_auth	Adaptive Potential of the Heme Oxygenase/Carbon Monoxide Pathway During Hypoxia
abstract	Heme oxygenase (HO) enzymes catalyze heme into biliverdin, releasing carbon monoxide (CO) and iron into circulation. These byproducts of heme degradation can have potent cytoprotective effects in the face of stressors such as hypoxia and ischemia-reperfusion events. The potential for exogenous use of CO as a therapeutic agent has received increasing attention throughout the past few decades. Further, HO and CO are noted as putatively adaptive in diving mammals and certain high-altitude human populations that are frequently exposed to hypoxia and/or ischemia-reperfusion events, suggesting that HO and endogenous CO afford an evolutionary advantage for hypoxia tolerance and are critical in cell survival and injury avoidance. Our goal is to describe the importance of examining HO and CO in several systems, the physiological links, and the genetic factors that underlie variation in the HO/CO pathway. Finally, we emphasize the ways in which evolutionary perspectives may enhance our understanding of the HO/CO pathway in the context of diverse clinical settings.
abstractGer	Heme oxygenase (HO) enzymes catalyze heme into biliverdin, releasing carbon monoxide (CO) and iron into circulation. These byproducts of heme degradation can have potent cytoprotective effects in the face of stressors such as hypoxia and ischemia-reperfusion events. The potential for exogenous use of CO as a therapeutic agent has received increasing attention throughout the past few decades. Further, HO and CO are noted as putatively adaptive in diving mammals and certain high-altitude human populations that are frequently exposed to hypoxia and/or ischemia-reperfusion events, suggesting that HO and endogenous CO afford an evolutionary advantage for hypoxia tolerance and are critical in cell survival and injury avoidance. Our goal is to describe the importance of examining HO and CO in several systems, the physiological links, and the genetic factors that underlie variation in the HO/CO pathway. Finally, we emphasize the ways in which evolutionary perspectives may enhance our understanding of the HO/CO pathway in the context of diverse clinical settings.
abstract_unstemmed	Heme oxygenase (HO) enzymes catalyze heme into biliverdin, releasing carbon monoxide (CO) and iron into circulation. These byproducts of heme degradation can have potent cytoprotective effects in the face of stressors such as hypoxia and ischemia-reperfusion events. The potential for exogenous use of CO as a therapeutic agent has received increasing attention throughout the past few decades. Further, HO and CO are noted as putatively adaptive in diving mammals and certain high-altitude human populations that are frequently exposed to hypoxia and/or ischemia-reperfusion events, suggesting that HO and endogenous CO afford an evolutionary advantage for hypoxia tolerance and are critical in cell survival and injury avoidance. Our goal is to describe the importance of examining HO and CO in several systems, the physiological links, and the genetic factors that underlie variation in the HO/CO pathway. Finally, we emphasize the ways in which evolutionary perspectives may enhance our understanding of the HO/CO pathway in the context of diverse clinical settings.
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title_short	Adaptive Potential of the Heme Oxygenase/Carbon Monoxide Pathway During Hypoxia
url	https://doi.org/10.3389/fphys.2020.00886 https://doaj.org/article/faa39b6162fa4b2c9ad35d48e6a632cf https://www.frontiersin.org/article/10.3389/fphys.2020.00886/full https://doaj.org/toc/1664-042X
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