Specialized functional diversity and interactions of the Na,K-ATPase

Na,K-ATPase is a protein ubiquitously expressed in the plasma membrane of all animal cells and vitally essential for their functions. A specialized functional diversity of the Na,K-ATPase isozymes is provided by molecular heterogeneity, distinct subcellular localizations and functional interactions...
Ausführliche Beschreibung

Gespeichert in:

Autor*in:	Igor I. Krivoi [verfasserIn] Vladimir V. Matchkov [verfasserIn]

Format:	E-Artikel
Sprache:	Englisch

Erschienen:	2016

Schlagwörter:	Blood Pressure Cell Survival Signaling Pathways Cardiotonic steroids Na/K-ATPase molecular heterogeneity subcellular microdomains

Übergeordnetes Werk:	In: Frontiers in Physiology - Frontiers Media S.A., 2011, 7(2016)
Übergeordnetes Werk:	volume:7 ; year:2016

Links:	Link aufrufen Link aufrufen Link aufrufen Journal toc

DOI / URN:	10.3389/fphys.2016.00179

Katalog-ID:	DOAJ046345337

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topic_facet	Blood Pressure Cell Survival Signaling Pathways Cardiotonic steroids Na/K-ATPase molecular heterogeneity subcellular microdomains Physiology
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container_title	Frontiers in Physiology
authorswithroles_txt_mv	Igor I. Krivoi @@aut@@ Vladimir V. Matchkov @@aut@@
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author	Igor I. Krivoi
spellingShingle	Igor I. Krivoi misc QP1-981 misc Blood Pressure misc Cell Survival misc Signaling Pathways misc Cardiotonic steroids misc Na/K-ATPase molecular heterogeneity misc subcellular microdomains misc Physiology Specialized functional diversity and interactions of the Na,K-ATPase
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topic_title	QP1-981 Specialized functional diversity and interactions of the Na,K-ATPase Blood Pressure Cell Survival Signaling Pathways Cardiotonic steroids Na/K-ATPase molecular heterogeneity subcellular microdomains
topic	misc QP1-981 misc Blood Pressure misc Cell Survival misc Signaling Pathways misc Cardiotonic steroids misc Na/K-ATPase molecular heterogeneity misc subcellular microdomains misc Physiology
topic_unstemmed	misc QP1-981 misc Blood Pressure misc Cell Survival misc Signaling Pathways misc Cardiotonic steroids misc Na/K-ATPase molecular heterogeneity misc subcellular microdomains misc Physiology
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title	Specialized functional diversity and interactions of the Na,K-ATPase
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title_full	Specialized functional diversity and interactions of the Na,K-ATPase
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title_auth	Specialized functional diversity and interactions of the Na,K-ATPase
abstract	Na,K-ATPase is a protein ubiquitously expressed in the plasma membrane of all animal cells and vitally essential for their functions. A specialized functional diversity of the Na,K-ATPase isozymes is provided by molecular heterogeneity, distinct subcellular localizations and functional interactions with molecular environment. Studies over the last decades clearly demonstrated complex and isoform-specific reciprocal functional interactions between the Na,K-ATPase and neighboring proteins and lipids. These interactions are enabled by a spatially restricted ion homeostasis, direct protein-protein/lipid interactions and protein kinase signaling pathways. In addition to its ‘classical’ function in ion translocation, the Na,K-ATPase is now considered as one of the most important signaling molecules in neuronal, epithelial, skeletal, cardiac and vascular tissues. Accordingly, the Na,K-ATPase forms specialized sub-cellular multimolecular microdomains which act as receptors to circulating endogenous cardiotonic steroids triggering a number of signaling pathways. Changes in these endogenous cardiotonic steroid levels and initiated signaling responses have significant adaptive values for tissues and whole organisms under numerous physiological and pathophysiological conditions. This review discusses recent progress in the studies of functional interactions between the Na,K-ATPase and molecular microenvironment, the Na,K-ATPase-dependent signaling pathways and their significance for diversity of cell function.
abstractGer	Na,K-ATPase is a protein ubiquitously expressed in the plasma membrane of all animal cells and vitally essential for their functions. A specialized functional diversity of the Na,K-ATPase isozymes is provided by molecular heterogeneity, distinct subcellular localizations and functional interactions with molecular environment. Studies over the last decades clearly demonstrated complex and isoform-specific reciprocal functional interactions between the Na,K-ATPase and neighboring proteins and lipids. These interactions are enabled by a spatially restricted ion homeostasis, direct protein-protein/lipid interactions and protein kinase signaling pathways. In addition to its ‘classical’ function in ion translocation, the Na,K-ATPase is now considered as one of the most important signaling molecules in neuronal, epithelial, skeletal, cardiac and vascular tissues. Accordingly, the Na,K-ATPase forms specialized sub-cellular multimolecular microdomains which act as receptors to circulating endogenous cardiotonic steroids triggering a number of signaling pathways. Changes in these endogenous cardiotonic steroid levels and initiated signaling responses have significant adaptive values for tissues and whole organisms under numerous physiological and pathophysiological conditions. This review discusses recent progress in the studies of functional interactions between the Na,K-ATPase and molecular microenvironment, the Na,K-ATPase-dependent signaling pathways and their significance for diversity of cell function.
abstract_unstemmed	Na,K-ATPase is a protein ubiquitously expressed in the plasma membrane of all animal cells and vitally essential for their functions. A specialized functional diversity of the Na,K-ATPase isozymes is provided by molecular heterogeneity, distinct subcellular localizations and functional interactions with molecular environment. Studies over the last decades clearly demonstrated complex and isoform-specific reciprocal functional interactions between the Na,K-ATPase and neighboring proteins and lipids. These interactions are enabled by a spatially restricted ion homeostasis, direct protein-protein/lipid interactions and protein kinase signaling pathways. In addition to its ‘classical’ function in ion translocation, the Na,K-ATPase is now considered as one of the most important signaling molecules in neuronal, epithelial, skeletal, cardiac and vascular tissues. Accordingly, the Na,K-ATPase forms specialized sub-cellular multimolecular microdomains which act as receptors to circulating endogenous cardiotonic steroids triggering a number of signaling pathways. Changes in these endogenous cardiotonic steroid levels and initiated signaling responses have significant adaptive values for tissues and whole organisms under numerous physiological and pathophysiological conditions. This review discusses recent progress in the studies of functional interactions between the Na,K-ATPase and molecular microenvironment, the Na,K-ATPase-dependent signaling pathways and their significance for diversity of cell function.
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title_short	Specialized functional diversity and interactions of the Na,K-ATPase
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Specialized functional diversity and interactions of the Na,K-ATPase

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