Effect of the Albumin Corona on the Toxicity of Combined Graphene Oxide and Cadmium to <i<Daphnia magna</i< and Integration of the Datasets into the NanoCommons Knowledge Base

In this work, we evaluated the effect of protein corona formation on graphene oxide (GO) mixture toxicity testing (i.e., co-exposure) using the <i<Daphnia magna</i< model and assessing acute toxicity determined as immobilisation. Cadmium (Cd<sup<2+</sup<) and bovine serum alb...
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Gespeichert in:

Autor*in:	Diego Stéfani T. Martinez [verfasserIn] Gabriela H. Da Silva [verfasserIn] Aline Maria Z. de Medeiros [verfasserIn] Latif U. Khan [verfasserIn] Anastasios G. Papadiamantis [verfasserIn] Iseult Lynch [verfasserIn]

Format:	E-Artikel
Sprache:	Englisch

Erschienen:	2020

Schlagwörter:	nanoecotoxicity co-exposure nanosafety harmonisation nanoinformatics

Übergeordnetes Werk:	In: Nanomaterials - MDPI AG, 2012, 10(2020), 10, p 1936
Übergeordnetes Werk:	volume:10 ; year:2020 ; number:10, p 1936

Links:	Link aufrufen Link aufrufen Link aufrufen Journal toc

DOI / URN:	10.3390/nano10101936

Katalog-ID:	DOAJ046400656

Internformat


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allfields	10.3390/nano10101936 doi (DE-627)DOAJ046400656 (DE-599)DOAJ9429467d6bdb42c2b0f424a222c47169 DE-627 ger DE-627 rakwb eng QD1-999 Diego Stéfani T. Martinez verfasserin aut Effect of the Albumin Corona on the Toxicity of Combined Graphene Oxide and Cadmium to <i<Daphnia magna</i< and Integration of the Datasets into the NanoCommons Knowledge Base 2020 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier In this work, we evaluated the effect of protein corona formation on graphene oxide (GO) mixture toxicity testing (i.e., co-exposure) using the <i<Daphnia magna</i< model and assessing acute toxicity determined as immobilisation. Cadmium (Cd<sup<2+</sup<) and bovine serum albumin (BSA) were selected as co-pollutant and protein model system, respectively. Albumin corona formation on GO dramatically increased its colloidal stability (ca. 60%) and Cd<sup<2+</sup< adsorption capacity (ca. 4.5 times) in reconstituted water (<i<Daphnia</i< medium). The acute toxicity values (48 h-EC<sub<50</sub<) observed were 0.18 mg L<sup<−1</sup< for Cd<sup<2+</sup<-only and 0.29 and 0.61 mg L<sup<−1</sup< following co-exposure of Cd<sup<2+</sup< with GO and BSAGO materials, respectively, at a fixed non-toxic concentration of 1.0 mg L<sup<−1</sup<. After coronation of GO with BSA, a reduction in cadmium toxicity of 110 % and 238% was achieved when compared to bare GO and Cd<sup<2+</sup<-only, respectively. Integration of datasets associated with graphene-based materials, heavy metals and mixture toxicity is essential to enable re-use of the data and facilitate nanoinformatics approaches for design of safer nanomaterials for water quality monitoring and remediation technologies. Hence, all data from this work were annotated and integrated into the NanoCommons Knowledge Base, connecting the experimental data to nanoinformatics platforms under the FAIR data principles and making them interoperable with similar datasets. nanoecotoxicity co-exposure nanosafety harmonisation nanoinformatics Chemistry Gabriela H. Da Silva verfasserin aut Aline Maria Z. de Medeiros verfasserin aut Latif U. Khan verfasserin aut Anastasios G. Papadiamantis verfasserin aut Iseult Lynch verfasserin aut In Nanomaterials MDPI AG, 2012 10(2020), 10, p 1936 (DE-627)718627199 (DE-600)2662255-5 20794991 nnns volume:10 year:2020 number:10, p 1936 https://doi.org/10.3390/nano10101936 kostenfrei https://doaj.org/article/9429467d6bdb42c2b0f424a222c47169 kostenfrei https://www.mdpi.com/2079-4991/10/10/1936 kostenfrei https://doaj.org/toc/2079-4991 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2014 GBV_ILN_2055 GBV_ILN_2108 GBV_ILN_2119 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4335 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 10 2020 10, p 1936
spelling	10.3390/nano10101936 doi (DE-627)DOAJ046400656 (DE-599)DOAJ9429467d6bdb42c2b0f424a222c47169 DE-627 ger DE-627 rakwb eng QD1-999 Diego Stéfani T. Martinez verfasserin aut Effect of the Albumin Corona on the Toxicity of Combined Graphene Oxide and Cadmium to <i<Daphnia magna</i< and Integration of the Datasets into the NanoCommons Knowledge Base 2020 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier In this work, we evaluated the effect of protein corona formation on graphene oxide (GO) mixture toxicity testing (i.e., co-exposure) using the <i<Daphnia magna</i< model and assessing acute toxicity determined as immobilisation. Cadmium (Cd<sup<2+</sup<) and bovine serum albumin (BSA) were selected as co-pollutant and protein model system, respectively. Albumin corona formation on GO dramatically increased its colloidal stability (ca. 60%) and Cd<sup<2+</sup< adsorption capacity (ca. 4.5 times) in reconstituted water (<i<Daphnia</i< medium). The acute toxicity values (48 h-EC<sub<50</sub<) observed were 0.18 mg L<sup<−1</sup< for Cd<sup<2+</sup<-only and 0.29 and 0.61 mg L<sup<−1</sup< following co-exposure of Cd<sup<2+</sup< with GO and BSAGO materials, respectively, at a fixed non-toxic concentration of 1.0 mg L<sup<−1</sup<. After coronation of GO with BSA, a reduction in cadmium toxicity of 110 % and 238% was achieved when compared to bare GO and Cd<sup<2+</sup<-only, respectively. Integration of datasets associated with graphene-based materials, heavy metals and mixture toxicity is essential to enable re-use of the data and facilitate nanoinformatics approaches for design of safer nanomaterials for water quality monitoring and remediation technologies. Hence, all data from this work were annotated and integrated into the NanoCommons Knowledge Base, connecting the experimental data to nanoinformatics platforms under the FAIR data principles and making them interoperable with similar datasets. nanoecotoxicity co-exposure nanosafety harmonisation nanoinformatics Chemistry Gabriela H. Da Silva verfasserin aut Aline Maria Z. de Medeiros verfasserin aut Latif U. Khan verfasserin aut Anastasios G. Papadiamantis verfasserin aut Iseult Lynch verfasserin aut In Nanomaterials MDPI AG, 2012 10(2020), 10, p 1936 (DE-627)718627199 (DE-600)2662255-5 20794991 nnns volume:10 year:2020 number:10, p 1936 https://doi.org/10.3390/nano10101936 kostenfrei https://doaj.org/article/9429467d6bdb42c2b0f424a222c47169 kostenfrei https://www.mdpi.com/2079-4991/10/10/1936 kostenfrei https://doaj.org/toc/2079-4991 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2014 GBV_ILN_2055 GBV_ILN_2108 GBV_ILN_2119 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4335 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 10 2020 10, p 1936
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allfieldsGer	10.3390/nano10101936 doi (DE-627)DOAJ046400656 (DE-599)DOAJ9429467d6bdb42c2b0f424a222c47169 DE-627 ger DE-627 rakwb eng QD1-999 Diego Stéfani T. Martinez verfasserin aut Effect of the Albumin Corona on the Toxicity of Combined Graphene Oxide and Cadmium to <i<Daphnia magna</i< and Integration of the Datasets into the NanoCommons Knowledge Base 2020 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier In this work, we evaluated the effect of protein corona formation on graphene oxide (GO) mixture toxicity testing (i.e., co-exposure) using the <i<Daphnia magna</i< model and assessing acute toxicity determined as immobilisation. Cadmium (Cd<sup<2+</sup<) and bovine serum albumin (BSA) were selected as co-pollutant and protein model system, respectively. Albumin corona formation on GO dramatically increased its colloidal stability (ca. 60%) and Cd<sup<2+</sup< adsorption capacity (ca. 4.5 times) in reconstituted water (<i<Daphnia</i< medium). The acute toxicity values (48 h-EC<sub<50</sub<) observed were 0.18 mg L<sup<−1</sup< for Cd<sup<2+</sup<-only and 0.29 and 0.61 mg L<sup<−1</sup< following co-exposure of Cd<sup<2+</sup< with GO and BSAGO materials, respectively, at a fixed non-toxic concentration of 1.0 mg L<sup<−1</sup<. After coronation of GO with BSA, a reduction in cadmium toxicity of 110 % and 238% was achieved when compared to bare GO and Cd<sup<2+</sup<-only, respectively. Integration of datasets associated with graphene-based materials, heavy metals and mixture toxicity is essential to enable re-use of the data and facilitate nanoinformatics approaches for design of safer nanomaterials for water quality monitoring and remediation technologies. Hence, all data from this work were annotated and integrated into the NanoCommons Knowledge Base, connecting the experimental data to nanoinformatics platforms under the FAIR data principles and making them interoperable with similar datasets. nanoecotoxicity co-exposure nanosafety harmonisation nanoinformatics Chemistry Gabriela H. Da Silva verfasserin aut Aline Maria Z. de Medeiros verfasserin aut Latif U. Khan verfasserin aut Anastasios G. Papadiamantis verfasserin aut Iseult Lynch verfasserin aut In Nanomaterials MDPI AG, 2012 10(2020), 10, p 1936 (DE-627)718627199 (DE-600)2662255-5 20794991 nnns volume:10 year:2020 number:10, p 1936 https://doi.org/10.3390/nano10101936 kostenfrei https://doaj.org/article/9429467d6bdb42c2b0f424a222c47169 kostenfrei https://www.mdpi.com/2079-4991/10/10/1936 kostenfrei https://doaj.org/toc/2079-4991 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2014 GBV_ILN_2055 GBV_ILN_2108 GBV_ILN_2119 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4335 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 10 2020 10, p 1936
allfieldsSound	10.3390/nano10101936 doi (DE-627)DOAJ046400656 (DE-599)DOAJ9429467d6bdb42c2b0f424a222c47169 DE-627 ger DE-627 rakwb eng QD1-999 Diego Stéfani T. Martinez verfasserin aut Effect of the Albumin Corona on the Toxicity of Combined Graphene Oxide and Cadmium to <i<Daphnia magna</i< and Integration of the Datasets into the NanoCommons Knowledge Base 2020 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier In this work, we evaluated the effect of protein corona formation on graphene oxide (GO) mixture toxicity testing (i.e., co-exposure) using the <i<Daphnia magna</i< model and assessing acute toxicity determined as immobilisation. Cadmium (Cd<sup<2+</sup<) and bovine serum albumin (BSA) were selected as co-pollutant and protein model system, respectively. Albumin corona formation on GO dramatically increased its colloidal stability (ca. 60%) and Cd<sup<2+</sup< adsorption capacity (ca. 4.5 times) in reconstituted water (<i<Daphnia</i< medium). The acute toxicity values (48 h-EC<sub<50</sub<) observed were 0.18 mg L<sup<−1</sup< for Cd<sup<2+</sup<-only and 0.29 and 0.61 mg L<sup<−1</sup< following co-exposure of Cd<sup<2+</sup< with GO and BSAGO materials, respectively, at a fixed non-toxic concentration of 1.0 mg L<sup<−1</sup<. After coronation of GO with BSA, a reduction in cadmium toxicity of 110 % and 238% was achieved when compared to bare GO and Cd<sup<2+</sup<-only, respectively. Integration of datasets associated with graphene-based materials, heavy metals and mixture toxicity is essential to enable re-use of the data and facilitate nanoinformatics approaches for design of safer nanomaterials for water quality monitoring and remediation technologies. Hence, all data from this work were annotated and integrated into the NanoCommons Knowledge Base, connecting the experimental data to nanoinformatics platforms under the FAIR data principles and making them interoperable with similar datasets. nanoecotoxicity co-exposure nanosafety harmonisation nanoinformatics Chemistry Gabriela H. Da Silva verfasserin aut Aline Maria Z. de Medeiros verfasserin aut Latif U. Khan verfasserin aut Anastasios G. Papadiamantis verfasserin aut Iseult Lynch verfasserin aut In Nanomaterials MDPI AG, 2012 10(2020), 10, p 1936 (DE-627)718627199 (DE-600)2662255-5 20794991 nnns volume:10 year:2020 number:10, p 1936 https://doi.org/10.3390/nano10101936 kostenfrei https://doaj.org/article/9429467d6bdb42c2b0f424a222c47169 kostenfrei https://www.mdpi.com/2079-4991/10/10/1936 kostenfrei https://doaj.org/toc/2079-4991 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2014 GBV_ILN_2055 GBV_ILN_2108 GBV_ILN_2119 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4335 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 10 2020 10, p 1936
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callnumber-first	Q - Science
author	Diego Stéfani T. Martinez
spellingShingle	Diego Stéfani T. Martinez misc QD1-999 misc nanoecotoxicity misc co-exposure misc nanosafety misc harmonisation misc nanoinformatics misc Chemistry Effect of the Albumin Corona on the Toxicity of Combined Graphene Oxide and Cadmium to <i<Daphnia magna</i< and Integration of the Datasets into the NanoCommons Knowledge Base
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topic_title	QD1-999 Effect of the Albumin Corona on the Toxicity of Combined Graphene Oxide and Cadmium to <i<Daphnia magna</i< and Integration of the Datasets into the NanoCommons Knowledge Base nanoecotoxicity co-exposure nanosafety harmonisation nanoinformatics
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title	Effect of the Albumin Corona on the Toxicity of Combined Graphene Oxide and Cadmium to <i<Daphnia magna</i< and Integration of the Datasets into the NanoCommons Knowledge Base
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title_sort	effect of the albumin corona on the toxicity of combined graphene oxide and cadmium to <i<daphnia magna</i< and integration of the datasets into the nanocommons knowledge base
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title_auth	Effect of the Albumin Corona on the Toxicity of Combined Graphene Oxide and Cadmium to <i<Daphnia magna</i< and Integration of the Datasets into the NanoCommons Knowledge Base
abstract	In this work, we evaluated the effect of protein corona formation on graphene oxide (GO) mixture toxicity testing (i.e., co-exposure) using the <i<Daphnia magna</i< model and assessing acute toxicity determined as immobilisation. Cadmium (Cd<sup<2+</sup<) and bovine serum albumin (BSA) were selected as co-pollutant and protein model system, respectively. Albumin corona formation on GO dramatically increased its colloidal stability (ca. 60%) and Cd<sup<2+</sup< adsorption capacity (ca. 4.5 times) in reconstituted water (<i<Daphnia</i< medium). The acute toxicity values (48 h-EC<sub<50</sub<) observed were 0.18 mg L<sup<−1</sup< for Cd<sup<2+</sup<-only and 0.29 and 0.61 mg L<sup<−1</sup< following co-exposure of Cd<sup<2+</sup< with GO and BSAGO materials, respectively, at a fixed non-toxic concentration of 1.0 mg L<sup<−1</sup<. After coronation of GO with BSA, a reduction in cadmium toxicity of 110 % and 238% was achieved when compared to bare GO and Cd<sup<2+</sup<-only, respectively. Integration of datasets associated with graphene-based materials, heavy metals and mixture toxicity is essential to enable re-use of the data and facilitate nanoinformatics approaches for design of safer nanomaterials for water quality monitoring and remediation technologies. Hence, all data from this work were annotated and integrated into the NanoCommons Knowledge Base, connecting the experimental data to nanoinformatics platforms under the FAIR data principles and making them interoperable with similar datasets.
abstractGer	In this work, we evaluated the effect of protein corona formation on graphene oxide (GO) mixture toxicity testing (i.e., co-exposure) using the <i<Daphnia magna</i< model and assessing acute toxicity determined as immobilisation. Cadmium (Cd<sup<2+</sup<) and bovine serum albumin (BSA) were selected as co-pollutant and protein model system, respectively. Albumin corona formation on GO dramatically increased its colloidal stability (ca. 60%) and Cd<sup<2+</sup< adsorption capacity (ca. 4.5 times) in reconstituted water (<i<Daphnia</i< medium). The acute toxicity values (48 h-EC<sub<50</sub<) observed were 0.18 mg L<sup<−1</sup< for Cd<sup<2+</sup<-only and 0.29 and 0.61 mg L<sup<−1</sup< following co-exposure of Cd<sup<2+</sup< with GO and BSAGO materials, respectively, at a fixed non-toxic concentration of 1.0 mg L<sup<−1</sup<. After coronation of GO with BSA, a reduction in cadmium toxicity of 110 % and 238% was achieved when compared to bare GO and Cd<sup<2+</sup<-only, respectively. Integration of datasets associated with graphene-based materials, heavy metals and mixture toxicity is essential to enable re-use of the data and facilitate nanoinformatics approaches for design of safer nanomaterials for water quality monitoring and remediation technologies. Hence, all data from this work were annotated and integrated into the NanoCommons Knowledge Base, connecting the experimental data to nanoinformatics platforms under the FAIR data principles and making them interoperable with similar datasets.
abstract_unstemmed	In this work, we evaluated the effect of protein corona formation on graphene oxide (GO) mixture toxicity testing (i.e., co-exposure) using the <i<Daphnia magna</i< model and assessing acute toxicity determined as immobilisation. Cadmium (Cd<sup<2+</sup<) and bovine serum albumin (BSA) were selected as co-pollutant and protein model system, respectively. Albumin corona formation on GO dramatically increased its colloidal stability (ca. 60%) and Cd<sup<2+</sup< adsorption capacity (ca. 4.5 times) in reconstituted water (<i<Daphnia</i< medium). The acute toxicity values (48 h-EC<sub<50</sub<) observed were 0.18 mg L<sup<−1</sup< for Cd<sup<2+</sup<-only and 0.29 and 0.61 mg L<sup<−1</sup< following co-exposure of Cd<sup<2+</sup< with GO and BSAGO materials, respectively, at a fixed non-toxic concentration of 1.0 mg L<sup<−1</sup<. After coronation of GO with BSA, a reduction in cadmium toxicity of 110 % and 238% was achieved when compared to bare GO and Cd<sup<2+</sup<-only, respectively. Integration of datasets associated with graphene-based materials, heavy metals and mixture toxicity is essential to enable re-use of the data and facilitate nanoinformatics approaches for design of safer nanomaterials for water quality monitoring and remediation technologies. Hence, all data from this work were annotated and integrated into the NanoCommons Knowledge Base, connecting the experimental data to nanoinformatics platforms under the FAIR data principles and making them interoperable with similar datasets.
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title_short	Effect of the Albumin Corona on the Toxicity of Combined Graphene Oxide and Cadmium to <i<Daphnia magna</i< and Integration of the Datasets into the NanoCommons Knowledge Base
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Cadmium (Cd<sup<2+</sup<) and bovine serum albumin (BSA) were selected as co-pollutant and protein model system, respectively. Albumin corona formation on GO dramatically increased its colloidal stability (ca. 60%) and Cd<sup<2+</sup< adsorption capacity (ca. 4.5 times) in reconstituted water (<i<Daphnia</i< medium). The acute toxicity values (48 h-EC<sub<50</sub<) observed were 0.18 mg L<sup<−1</sup< for Cd<sup<2+</sup<-only and 0.29 and 0.61 mg L<sup<−1</sup< following co-exposure of Cd<sup<2+</sup< with GO and BSAGO materials, respectively, at a fixed non-toxic concentration of 1.0 mg L<sup<−1</sup<. After coronation of GO with BSA, a reduction in cadmium toxicity of 110 % and 238% was achieved when compared to bare GO and Cd<sup<2+</sup<-only, respectively. Integration of datasets associated with graphene-based materials, heavy metals and mixture toxicity is essential to enable re-use of the data and facilitate nanoinformatics approaches for design of safer nanomaterials for water quality monitoring and remediation technologies. Hence, all data from this work were annotated and integrated into the NanoCommons Knowledge Base, connecting the experimental data to nanoinformatics platforms under the FAIR data principles and making them interoperable with similar datasets.</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a">nanoecotoxicity</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a">co-exposure</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a">nanosafety</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a">harmonisation</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a">nanoinformatics</subfield></datafield><datafield tag="653" ind1=" " ind2="0"><subfield code="a">Chemistry</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Gabriela H. 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Effect of the Albumin Corona on the Toxicity of Combined Graphene Oxide and Cadmium to <i<Daphnia magna</i< and Integration of the Datasets into the NanoCommons Knowledge Base

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