Increased risk of developing lung cancer in Asian patients carrying the TERT rs2736098 G>A polymorphism: evidence from 3,354 cases and 3,518 controls
Zhenhua Yang,1,* Xunlei Zhang,2,* Surong Fang,1 Yan Tan,1 Haijun Yan,1 Wei Gu,1 Jianhong Wang2 1Department of Pneumology, Nanjing First Hospital, Nanjing Medical University, Nanjing, 2Department of Medical Oncology, Nantong University Affiliated Tumor Hospital, Nantong, People’s Republic...
Ausführliche Beschreibung
Gespeichert in:
| Autor*in: |
Yang ZH [verfasserIn] Zhang XL [verfasserIn] Fang SR [verfasserIn] Tan Y [verfasserIn] Yan HJ [verfasserIn] Gu W [verfasserIn] Wang JH [verfasserIn] |
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| Format: |
E-Artikel |
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| Sprache: |
Englisch |
| Erschienen: |
2015 |
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| Übergeordnetes Werk: |
In: OncoTargets and Therapy - Dove Medical Press, 2009, (2015), default, Seite 2757-2765 |
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| Übergeordnetes Werk: |
year:2015 ; number:default ; pages:2757-2765 |
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DOAJ046436995 |
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| 520 | |a Zhenhua Yang,1,* Xunlei Zhang,2,* Surong Fang,1 Yan Tan,1 Haijun Yan,1 Wei Gu,1 Jianhong Wang2 1Department of Pneumology, Nanjing First Hospital, Nanjing Medical University, Nanjing, 2Department of Medical Oncology, Nantong University Affiliated Tumor Hospital, Nantong, People’s Republic of China *These authors contributed equally to this work Background: The association between telomerase reverse transcriptase (TERT) rs2736098 G>A and risk of lung cancer (LC) remains inconclusive. To explore the association more precisely, we performed a comprehensive search and conducted a meta-analysis on all eligible case–control studies involving 3,354 cases and 3,518 controls.Methods: The 95% confidence interval (95% CI) and the pooled odds ratio (OR) were calculated using a random or fixed effect model. Publication bias, heterogeneity, and sensitivity analysis were also explored.Results: All studies were case–control studies on LC in patients of Asian descent, consisting of one Korean study and five Chinese studies. Overall, the variant A allele of TERT rs2736098 G>A was found to significantly increase the risk of LC in all genetic models (GA vs GG: OR =1.13, 95% CI =1.02–1.25, P=0.017; AA vs GG: OR =1.78, 95% CI =1.53–2.07, P<0.001;GA/AA vs GG: OR =1.25, 95% CI =1.14–1.38, P<0.001; AA vs GA/GG: OR =1.66, 95% CI =1.45–1.92, P<0.001). In the subgroup analysis, significant associations were found in Chinese group and hospital-based studies. Different genotype test methods showed no influence on the final results.Conclusion: Our study identified that TERT rs2736098 G>A polymorphism significantly increased the risk of LC in Asian populations. Keywords: genetic polymorphism, TERT, rs2736098 G>A, lung cancer, meta-analysis | ||
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(DE-627)DOAJ046436995 (DE-599)DOAJ82cdf07762af494294c7536885b3c1e5 DE-627 ger DE-627 rakwb eng RC254-282 Yang ZH verfasserin aut Increased risk of developing lung cancer in Asian patients carrying the TERT rs2736098 G>A polymorphism: evidence from 3,354 cases and 3,518 controls 2015 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Zhenhua Yang,1,* Xunlei Zhang,2,* Surong Fang,1 Yan Tan,1 Haijun Yan,1 Wei Gu,1 Jianhong Wang2 1Department of Pneumology, Nanjing First Hospital, Nanjing Medical University, Nanjing, 2Department of Medical Oncology, Nantong University Affiliated Tumor Hospital, Nantong, People’s Republic of China *These authors contributed equally to this work Background: The association between telomerase reverse transcriptase (TERT) rs2736098 G>A and risk of lung cancer (LC) remains inconclusive. To explore the association more precisely, we performed a comprehensive search and conducted a meta-analysis on all eligible case–control studies involving 3,354 cases and 3,518 controls.Methods: The 95% confidence interval (95% CI) and the pooled odds ratio (OR) were calculated using a random or fixed effect model. Publication bias, heterogeneity, and sensitivity analysis were also explored.Results: All studies were case–control studies on LC in patients of Asian descent, consisting of one Korean study and five Chinese studies. Overall, the variant A allele of TERT rs2736098 G>A was found to significantly increase the risk of LC in all genetic models (GA vs GG: OR =1.13, 95% CI =1.02–1.25, P=0.017; AA vs GG: OR =1.78, 95% CI =1.53–2.07, P<0.001;GA/AA vs GG: OR =1.25, 95% CI =1.14–1.38, P<0.001; AA vs GA/GG: OR =1.66, 95% CI =1.45–1.92, P<0.001). In the subgroup analysis, significant associations were found in Chinese group and hospital-based studies. Different genotype test methods showed no influence on the final results.Conclusion: Our study identified that TERT rs2736098 G>A polymorphism significantly increased the risk of LC in Asian populations. Keywords: genetic polymorphism, TERT, rs2736098 G>A, lung cancer, meta-analysis Neoplasms. Tumors. Oncology. Including cancer and carcinogens Zhang XL verfasserin aut Fang SR verfasserin aut Tan Y verfasserin aut Yan HJ verfasserin aut Gu W verfasserin aut Wang JH verfasserin aut In OncoTargets and Therapy Dove Medical Press, 2009 (2015), default, Seite 2757-2765 (DE-627)600307654 (DE-600)2495130-4 11786930 nnns year:2015 number:default pages:2757-2765 https://doaj.org/article/82cdf07762af494294c7536885b3c1e5 kostenfrei https://www.dovepress.com/increased-risk-of-developing-lung-cancer-in-asian-patients-carrying-th-peer-reviewed-article-OTT kostenfrei https://doaj.org/toc/1178-6930 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2009 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2055 GBV_ILN_2111 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 2015 default 2757-2765 |
| spelling |
(DE-627)DOAJ046436995 (DE-599)DOAJ82cdf07762af494294c7536885b3c1e5 DE-627 ger DE-627 rakwb eng RC254-282 Yang ZH verfasserin aut Increased risk of developing lung cancer in Asian patients carrying the TERT rs2736098 G>A polymorphism: evidence from 3,354 cases and 3,518 controls 2015 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Zhenhua Yang,1,* Xunlei Zhang,2,* Surong Fang,1 Yan Tan,1 Haijun Yan,1 Wei Gu,1 Jianhong Wang2 1Department of Pneumology, Nanjing First Hospital, Nanjing Medical University, Nanjing, 2Department of Medical Oncology, Nantong University Affiliated Tumor Hospital, Nantong, People’s Republic of China *These authors contributed equally to this work Background: The association between telomerase reverse transcriptase (TERT) rs2736098 G>A and risk of lung cancer (LC) remains inconclusive. To explore the association more precisely, we performed a comprehensive search and conducted a meta-analysis on all eligible case–control studies involving 3,354 cases and 3,518 controls.Methods: The 95% confidence interval (95% CI) and the pooled odds ratio (OR) were calculated using a random or fixed effect model. Publication bias, heterogeneity, and sensitivity analysis were also explored.Results: All studies were case–control studies on LC in patients of Asian descent, consisting of one Korean study and five Chinese studies. Overall, the variant A allele of TERT rs2736098 G>A was found to significantly increase the risk of LC in all genetic models (GA vs GG: OR =1.13, 95% CI =1.02–1.25, P=0.017; AA vs GG: OR =1.78, 95% CI =1.53–2.07, P<0.001;GA/AA vs GG: OR =1.25, 95% CI =1.14–1.38, P<0.001; AA vs GA/GG: OR =1.66, 95% CI =1.45–1.92, P<0.001). In the subgroup analysis, significant associations were found in Chinese group and hospital-based studies. Different genotype test methods showed no influence on the final results.Conclusion: Our study identified that TERT rs2736098 G>A polymorphism significantly increased the risk of LC in Asian populations. Keywords: genetic polymorphism, TERT, rs2736098 G>A, lung cancer, meta-analysis Neoplasms. Tumors. Oncology. Including cancer and carcinogens Zhang XL verfasserin aut Fang SR verfasserin aut Tan Y verfasserin aut Yan HJ verfasserin aut Gu W verfasserin aut Wang JH verfasserin aut In OncoTargets and Therapy Dove Medical Press, 2009 (2015), default, Seite 2757-2765 (DE-627)600307654 (DE-600)2495130-4 11786930 nnns year:2015 number:default pages:2757-2765 https://doaj.org/article/82cdf07762af494294c7536885b3c1e5 kostenfrei https://www.dovepress.com/increased-risk-of-developing-lung-cancer-in-asian-patients-carrying-th-peer-reviewed-article-OTT kostenfrei https://doaj.org/toc/1178-6930 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2009 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2055 GBV_ILN_2111 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 2015 default 2757-2765 |
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(DE-627)DOAJ046436995 (DE-599)DOAJ82cdf07762af494294c7536885b3c1e5 DE-627 ger DE-627 rakwb eng RC254-282 Yang ZH verfasserin aut Increased risk of developing lung cancer in Asian patients carrying the TERT rs2736098 G>A polymorphism: evidence from 3,354 cases and 3,518 controls 2015 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Zhenhua Yang,1,* Xunlei Zhang,2,* Surong Fang,1 Yan Tan,1 Haijun Yan,1 Wei Gu,1 Jianhong Wang2 1Department of Pneumology, Nanjing First Hospital, Nanjing Medical University, Nanjing, 2Department of Medical Oncology, Nantong University Affiliated Tumor Hospital, Nantong, People’s Republic of China *These authors contributed equally to this work Background: The association between telomerase reverse transcriptase (TERT) rs2736098 G>A and risk of lung cancer (LC) remains inconclusive. To explore the association more precisely, we performed a comprehensive search and conducted a meta-analysis on all eligible case–control studies involving 3,354 cases and 3,518 controls.Methods: The 95% confidence interval (95% CI) and the pooled odds ratio (OR) were calculated using a random or fixed effect model. Publication bias, heterogeneity, and sensitivity analysis were also explored.Results: All studies were case–control studies on LC in patients of Asian descent, consisting of one Korean study and five Chinese studies. Overall, the variant A allele of TERT rs2736098 G>A was found to significantly increase the risk of LC in all genetic models (GA vs GG: OR =1.13, 95% CI =1.02–1.25, P=0.017; AA vs GG: OR =1.78, 95% CI =1.53–2.07, P<0.001;GA/AA vs GG: OR =1.25, 95% CI =1.14–1.38, P<0.001; AA vs GA/GG: OR =1.66, 95% CI =1.45–1.92, P<0.001). In the subgroup analysis, significant associations were found in Chinese group and hospital-based studies. Different genotype test methods showed no influence on the final results.Conclusion: Our study identified that TERT rs2736098 G>A polymorphism significantly increased the risk of LC in Asian populations. Keywords: genetic polymorphism, TERT, rs2736098 G>A, lung cancer, meta-analysis Neoplasms. Tumors. Oncology. Including cancer and carcinogens Zhang XL verfasserin aut Fang SR verfasserin aut Tan Y verfasserin aut Yan HJ verfasserin aut Gu W verfasserin aut Wang JH verfasserin aut In OncoTargets and Therapy Dove Medical Press, 2009 (2015), default, Seite 2757-2765 (DE-627)600307654 (DE-600)2495130-4 11786930 nnns year:2015 number:default pages:2757-2765 https://doaj.org/article/82cdf07762af494294c7536885b3c1e5 kostenfrei https://www.dovepress.com/increased-risk-of-developing-lung-cancer-in-asian-patients-carrying-th-peer-reviewed-article-OTT kostenfrei https://doaj.org/toc/1178-6930 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2009 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2055 GBV_ILN_2111 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 2015 default 2757-2765 |
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(DE-627)DOAJ046436995 (DE-599)DOAJ82cdf07762af494294c7536885b3c1e5 DE-627 ger DE-627 rakwb eng RC254-282 Yang ZH verfasserin aut Increased risk of developing lung cancer in Asian patients carrying the TERT rs2736098 G>A polymorphism: evidence from 3,354 cases and 3,518 controls 2015 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Zhenhua Yang,1,* Xunlei Zhang,2,* Surong Fang,1 Yan Tan,1 Haijun Yan,1 Wei Gu,1 Jianhong Wang2 1Department of Pneumology, Nanjing First Hospital, Nanjing Medical University, Nanjing, 2Department of Medical Oncology, Nantong University Affiliated Tumor Hospital, Nantong, People’s Republic of China *These authors contributed equally to this work Background: The association between telomerase reverse transcriptase (TERT) rs2736098 G>A and risk of lung cancer (LC) remains inconclusive. To explore the association more precisely, we performed a comprehensive search and conducted a meta-analysis on all eligible case–control studies involving 3,354 cases and 3,518 controls.Methods: The 95% confidence interval (95% CI) and the pooled odds ratio (OR) were calculated using a random or fixed effect model. Publication bias, heterogeneity, and sensitivity analysis were also explored.Results: All studies were case–control studies on LC in patients of Asian descent, consisting of one Korean study and five Chinese studies. Overall, the variant A allele of TERT rs2736098 G>A was found to significantly increase the risk of LC in all genetic models (GA vs GG: OR =1.13, 95% CI =1.02–1.25, P=0.017; AA vs GG: OR =1.78, 95% CI =1.53–2.07, P<0.001;GA/AA vs GG: OR =1.25, 95% CI =1.14–1.38, P<0.001; AA vs GA/GG: OR =1.66, 95% CI =1.45–1.92, P<0.001). In the subgroup analysis, significant associations were found in Chinese group and hospital-based studies. Different genotype test methods showed no influence on the final results.Conclusion: Our study identified that TERT rs2736098 G>A polymorphism significantly increased the risk of LC in Asian populations. Keywords: genetic polymorphism, TERT, rs2736098 G>A, lung cancer, meta-analysis Neoplasms. Tumors. Oncology. Including cancer and carcinogens Zhang XL verfasserin aut Fang SR verfasserin aut Tan Y verfasserin aut Yan HJ verfasserin aut Gu W verfasserin aut Wang JH verfasserin aut In OncoTargets and Therapy Dove Medical Press, 2009 (2015), default, Seite 2757-2765 (DE-627)600307654 (DE-600)2495130-4 11786930 nnns year:2015 number:default pages:2757-2765 https://doaj.org/article/82cdf07762af494294c7536885b3c1e5 kostenfrei https://www.dovepress.com/increased-risk-of-developing-lung-cancer-in-asian-patients-carrying-th-peer-reviewed-article-OTT kostenfrei https://doaj.org/toc/1178-6930 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2009 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2055 GBV_ILN_2111 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 2015 default 2757-2765 |
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(DE-627)DOAJ046436995 (DE-599)DOAJ82cdf07762af494294c7536885b3c1e5 DE-627 ger DE-627 rakwb eng RC254-282 Yang ZH verfasserin aut Increased risk of developing lung cancer in Asian patients carrying the TERT rs2736098 G>A polymorphism: evidence from 3,354 cases and 3,518 controls 2015 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Zhenhua Yang,1,* Xunlei Zhang,2,* Surong Fang,1 Yan Tan,1 Haijun Yan,1 Wei Gu,1 Jianhong Wang2 1Department of Pneumology, Nanjing First Hospital, Nanjing Medical University, Nanjing, 2Department of Medical Oncology, Nantong University Affiliated Tumor Hospital, Nantong, People’s Republic of China *These authors contributed equally to this work Background: The association between telomerase reverse transcriptase (TERT) rs2736098 G>A and risk of lung cancer (LC) remains inconclusive. To explore the association more precisely, we performed a comprehensive search and conducted a meta-analysis on all eligible case–control studies involving 3,354 cases and 3,518 controls.Methods: The 95% confidence interval (95% CI) and the pooled odds ratio (OR) were calculated using a random or fixed effect model. Publication bias, heterogeneity, and sensitivity analysis were also explored.Results: All studies were case–control studies on LC in patients of Asian descent, consisting of one Korean study and five Chinese studies. Overall, the variant A allele of TERT rs2736098 G>A was found to significantly increase the risk of LC in all genetic models (GA vs GG: OR =1.13, 95% CI =1.02–1.25, P=0.017; AA vs GG: OR =1.78, 95% CI =1.53–2.07, P<0.001;GA/AA vs GG: OR =1.25, 95% CI =1.14–1.38, P<0.001; AA vs GA/GG: OR =1.66, 95% CI =1.45–1.92, P<0.001). In the subgroup analysis, significant associations were found in Chinese group and hospital-based studies. Different genotype test methods showed no influence on the final results.Conclusion: Our study identified that TERT rs2736098 G>A polymorphism significantly increased the risk of LC in Asian populations. Keywords: genetic polymorphism, TERT, rs2736098 G>A, lung cancer, meta-analysis Neoplasms. Tumors. Oncology. Including cancer and carcinogens Zhang XL verfasserin aut Fang SR verfasserin aut Tan Y verfasserin aut Yan HJ verfasserin aut Gu W verfasserin aut Wang JH verfasserin aut In OncoTargets and Therapy Dove Medical Press, 2009 (2015), default, Seite 2757-2765 (DE-627)600307654 (DE-600)2495130-4 11786930 nnns year:2015 number:default pages:2757-2765 https://doaj.org/article/82cdf07762af494294c7536885b3c1e5 kostenfrei https://www.dovepress.com/increased-risk-of-developing-lung-cancer-in-asian-patients-carrying-th-peer-reviewed-article-OTT kostenfrei https://doaj.org/toc/1178-6930 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2009 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2055 GBV_ILN_2111 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 2015 default 2757-2765 |
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Increased risk of developing lung cancer in Asian patients carrying the TERT rs2736098 G>A polymorphism: evidence from 3,354 cases and 3,518 controls |
| abstract |
Zhenhua Yang,1,* Xunlei Zhang,2,* Surong Fang,1 Yan Tan,1 Haijun Yan,1 Wei Gu,1 Jianhong Wang2 1Department of Pneumology, Nanjing First Hospital, Nanjing Medical University, Nanjing, 2Department of Medical Oncology, Nantong University Affiliated Tumor Hospital, Nantong, People’s Republic of China *These authors contributed equally to this work Background: The association between telomerase reverse transcriptase (TERT) rs2736098 G>A and risk of lung cancer (LC) remains inconclusive. To explore the association more precisely, we performed a comprehensive search and conducted a meta-analysis on all eligible case–control studies involving 3,354 cases and 3,518 controls.Methods: The 95% confidence interval (95% CI) and the pooled odds ratio (OR) were calculated using a random or fixed effect model. Publication bias, heterogeneity, and sensitivity analysis were also explored.Results: All studies were case–control studies on LC in patients of Asian descent, consisting of one Korean study and five Chinese studies. Overall, the variant A allele of TERT rs2736098 G>A was found to significantly increase the risk of LC in all genetic models (GA vs GG: OR =1.13, 95% CI =1.02–1.25, P=0.017; AA vs GG: OR =1.78, 95% CI =1.53–2.07, P<0.001;GA/AA vs GG: OR =1.25, 95% CI =1.14–1.38, P<0.001; AA vs GA/GG: OR =1.66, 95% CI =1.45–1.92, P<0.001). In the subgroup analysis, significant associations were found in Chinese group and hospital-based studies. Different genotype test methods showed no influence on the final results.Conclusion: Our study identified that TERT rs2736098 G>A polymorphism significantly increased the risk of LC in Asian populations. Keywords: genetic polymorphism, TERT, rs2736098 G>A, lung cancer, meta-analysis |
| abstractGer |
Zhenhua Yang,1,* Xunlei Zhang,2,* Surong Fang,1 Yan Tan,1 Haijun Yan,1 Wei Gu,1 Jianhong Wang2 1Department of Pneumology, Nanjing First Hospital, Nanjing Medical University, Nanjing, 2Department of Medical Oncology, Nantong University Affiliated Tumor Hospital, Nantong, People’s Republic of China *These authors contributed equally to this work Background: The association between telomerase reverse transcriptase (TERT) rs2736098 G>A and risk of lung cancer (LC) remains inconclusive. To explore the association more precisely, we performed a comprehensive search and conducted a meta-analysis on all eligible case–control studies involving 3,354 cases and 3,518 controls.Methods: The 95% confidence interval (95% CI) and the pooled odds ratio (OR) were calculated using a random or fixed effect model. Publication bias, heterogeneity, and sensitivity analysis were also explored.Results: All studies were case–control studies on LC in patients of Asian descent, consisting of one Korean study and five Chinese studies. Overall, the variant A allele of TERT rs2736098 G>A was found to significantly increase the risk of LC in all genetic models (GA vs GG: OR =1.13, 95% CI =1.02–1.25, P=0.017; AA vs GG: OR =1.78, 95% CI =1.53–2.07, P<0.001;GA/AA vs GG: OR =1.25, 95% CI =1.14–1.38, P<0.001; AA vs GA/GG: OR =1.66, 95% CI =1.45–1.92, P<0.001). In the subgroup analysis, significant associations were found in Chinese group and hospital-based studies. Different genotype test methods showed no influence on the final results.Conclusion: Our study identified that TERT rs2736098 G>A polymorphism significantly increased the risk of LC in Asian populations. Keywords: genetic polymorphism, TERT, rs2736098 G>A, lung cancer, meta-analysis |
| abstract_unstemmed |
Zhenhua Yang,1,* Xunlei Zhang,2,* Surong Fang,1 Yan Tan,1 Haijun Yan,1 Wei Gu,1 Jianhong Wang2 1Department of Pneumology, Nanjing First Hospital, Nanjing Medical University, Nanjing, 2Department of Medical Oncology, Nantong University Affiliated Tumor Hospital, Nantong, People’s Republic of China *These authors contributed equally to this work Background: The association between telomerase reverse transcriptase (TERT) rs2736098 G>A and risk of lung cancer (LC) remains inconclusive. To explore the association more precisely, we performed a comprehensive search and conducted a meta-analysis on all eligible case–control studies involving 3,354 cases and 3,518 controls.Methods: The 95% confidence interval (95% CI) and the pooled odds ratio (OR) were calculated using a random or fixed effect model. Publication bias, heterogeneity, and sensitivity analysis were also explored.Results: All studies were case–control studies on LC in patients of Asian descent, consisting of one Korean study and five Chinese studies. Overall, the variant A allele of TERT rs2736098 G>A was found to significantly increase the risk of LC in all genetic models (GA vs GG: OR =1.13, 95% CI =1.02–1.25, P=0.017; AA vs GG: OR =1.78, 95% CI =1.53–2.07, P<0.001;GA/AA vs GG: OR =1.25, 95% CI =1.14–1.38, P<0.001; AA vs GA/GG: OR =1.66, 95% CI =1.45–1.92, P<0.001). In the subgroup analysis, significant associations were found in Chinese group and hospital-based studies. Different genotype test methods showed no influence on the final results.Conclusion: Our study identified that TERT rs2736098 G>A polymorphism significantly increased the risk of LC in Asian populations. Keywords: genetic polymorphism, TERT, rs2736098 G>A, lung cancer, meta-analysis |
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Increased risk of developing lung cancer in Asian patients carrying the TERT rs2736098 G>A polymorphism: evidence from 3,354 cases and 3,518 controls |
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https://doaj.org/article/82cdf07762af494294c7536885b3c1e5 https://www.dovepress.com/increased-risk-of-developing-lung-cancer-in-asian-patients-carrying-th-peer-reviewed-article-OTT https://doaj.org/toc/1178-6930 |
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