The oncomodulatory role of human cytomegalovirus in colorectal cancer: implications for clinical trials
Increasing evidence suggests that human cytomegalovirus (HCMV), a beta-herpes virus that chronically infects human, is associated with colorectal cancer (CRC). The viral nucleic acids specifically localized to the neoplastic mucosal epithelium of CRC, while tumoral presence of HCMV independently pre...
Ausführliche Beschreibung
Autor*in: |
Hsin-Pai eChen [verfasserIn] Yu-Jiun eChan [verfasserIn] |
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Format: |
E-Artikel |
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Sprache: |
Englisch |
Erschienen: |
2014 |
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Übergeordnetes Werk: |
In: Frontiers in Oncology - Frontiers Media S.A., 2012, 4(2014) |
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Übergeordnetes Werk: |
volume:4 ; year:2014 |
Links: |
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DOI / URN: |
10.3389/fonc.2014.00314 |
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Katalog-ID: |
DOAJ046444904 |
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10.3389/fonc.2014.00314 doi (DE-627)DOAJ046444904 (DE-599)DOAJcd4b38079090456d8680d4a06c0d2da5 DE-627 ger DE-627 rakwb eng RC254-282 Hsin-Pai eChen verfasserin aut The oncomodulatory role of human cytomegalovirus in colorectal cancer: implications for clinical trials 2014 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Increasing evidence suggests that human cytomegalovirus (HCMV), a beta-herpes virus that chronically infects human, is associated with colorectal cancer (CRC). The viral nucleic acids specifically localized to the neoplastic mucosal epithelium of CRC, while tumoral presence of HCMV independently predicted a poor outcome in elderly patients. In the past decade, the concept of oncomodulation of HCMV in human cancers has been formulated. In CRC, changes in the tumor microenvironment are closely related to cancer behavior and prognosis, while the underlying mechanism driving these changes remains unclear. Since HCMV affects multiple cellular functions, including signal pathways that regulate angiogenesis, apoptosis, cell invasiveness and anti-cancer immunity, the virus potentially exerts oncomodulatory effects in the tumor microenvironment of CRC. Here, we summarize the current knowledge about the association between HCMV and CRC and suggest future perspectives on both research and anti-cancer therapy of CRC. colorectal cancer Anti-cancer therapy Human Cytomegalovirus oncomodulation anti-cancer immunity Neoplasms. Tumors. Oncology. Including cancer and carcinogens Hsin-Pai eChen verfasserin aut Hsin-Pai eChen verfasserin aut Yu-Jiun eChan verfasserin aut Yu-Jiun eChan verfasserin aut Yu-Jiun eChan verfasserin aut In Frontiers in Oncology Frontiers Media S.A., 2012 4(2014) (DE-627)684965518 (DE-600)2649216-7 2234943X nnns volume:4 year:2014 https://doi.org/10.3389/fonc.2014.00314 kostenfrei https://doaj.org/article/cd4b38079090456d8680d4a06c0d2da5 kostenfrei http://journal.frontiersin.org/Journal/10.3389/fonc.2014.00314/full kostenfrei https://doaj.org/toc/2234-943X Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ SSG-OLC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 4 2014 |
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RC254-282 The oncomodulatory role of human cytomegalovirus in colorectal cancer: implications for clinical trials colorectal cancer Anti-cancer therapy Human Cytomegalovirus oncomodulation anti-cancer immunity |
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The oncomodulatory role of human cytomegalovirus in colorectal cancer: implications for clinical trials |
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Increasing evidence suggests that human cytomegalovirus (HCMV), a beta-herpes virus that chronically infects human, is associated with colorectal cancer (CRC). The viral nucleic acids specifically localized to the neoplastic mucosal epithelium of CRC, while tumoral presence of HCMV independently predicted a poor outcome in elderly patients. In the past decade, the concept of oncomodulation of HCMV in human cancers has been formulated. In CRC, changes in the tumor microenvironment are closely related to cancer behavior and prognosis, while the underlying mechanism driving these changes remains unclear. Since HCMV affects multiple cellular functions, including signal pathways that regulate angiogenesis, apoptosis, cell invasiveness and anti-cancer immunity, the virus potentially exerts oncomodulatory effects in the tumor microenvironment of CRC. Here, we summarize the current knowledge about the association between HCMV and CRC and suggest future perspectives on both research and anti-cancer therapy of CRC. |
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Increasing evidence suggests that human cytomegalovirus (HCMV), a beta-herpes virus that chronically infects human, is associated with colorectal cancer (CRC). The viral nucleic acids specifically localized to the neoplastic mucosal epithelium of CRC, while tumoral presence of HCMV independently predicted a poor outcome in elderly patients. In the past decade, the concept of oncomodulation of HCMV in human cancers has been formulated. In CRC, changes in the tumor microenvironment are closely related to cancer behavior and prognosis, while the underlying mechanism driving these changes remains unclear. Since HCMV affects multiple cellular functions, including signal pathways that regulate angiogenesis, apoptosis, cell invasiveness and anti-cancer immunity, the virus potentially exerts oncomodulatory effects in the tumor microenvironment of CRC. Here, we summarize the current knowledge about the association between HCMV and CRC and suggest future perspectives on both research and anti-cancer therapy of CRC. |
abstract_unstemmed |
Increasing evidence suggests that human cytomegalovirus (HCMV), a beta-herpes virus that chronically infects human, is associated with colorectal cancer (CRC). The viral nucleic acids specifically localized to the neoplastic mucosal epithelium of CRC, while tumoral presence of HCMV independently predicted a poor outcome in elderly patients. In the past decade, the concept of oncomodulation of HCMV in human cancers has been formulated. In CRC, changes in the tumor microenvironment are closely related to cancer behavior and prognosis, while the underlying mechanism driving these changes remains unclear. Since HCMV affects multiple cellular functions, including signal pathways that regulate angiogenesis, apoptosis, cell invasiveness and anti-cancer immunity, the virus potentially exerts oncomodulatory effects in the tumor microenvironment of CRC. Here, we summarize the current knowledge about the association between HCMV and CRC and suggest future perspectives on both research and anti-cancer therapy of CRC. |
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The oncomodulatory role of human cytomegalovirus in colorectal cancer: implications for clinical trials |
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|
score |
7.398302 |