Enhanced apoptosis and inhibition of gastric cancer cell invasion following treatment with LDHAu loaded Doxorubicin

Background: The suppression of cancer cell growth and invasion has become a challenging clinical issue. In this study, we used nanotechnology to create a new drug delivery system to enhance the efficacy of existing drugs. We developed layered double hydroxide by combing Au nanosol (LDHAu) and charac...
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Autor*in:	Hu Zhao [verfasserIn] Xueqin Zhang [verfasserIn]

Format:	E-Artikel
Sprache:	Englisch

Erschienen:	2018

Übergeordnetes Werk:	In: Electronic Journal of Biotechnology - Elsevier, 2016, 32(2018), Seite 13-18
Übergeordnetes Werk:	volume:32 ; year:2018 ; pages:13-18

Links:	Link aufrufen Link aufrufen Link aufrufen Journal toc

DOI / URN:	10.1016/j.ejbt.2017.12.004

Katalog-ID:	DOAJ046475850

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520			\|a Background: The suppression of cancer cell growth and invasion has become a challenging clinical issue. In this study, we used nanotechnology to create a new drug delivery system to enhance the efficacy of existing drugs. We developed layered double hydroxide by combing Au nanosol (LDHAu) and characterized the compound to prove its function as a drug delivery agent. The anti-cancer drug Doxorubicin was loaded into the new drug carrier to assess its quality. We used a combination of apoptosis assays, cell cycle assays, tissue distribution studies, cell endocytosis, transwell invasion assays, and immunoblotting to evaluate the characteristics of LDH@Au as a drug delivery system. Results: Our results show that the LDH@Au-Dox treatment significantly increased cancer cell apoptosis and inhibited cell invasion compared to the control Dox group. Additionally, our data indicate that LDH@Au-Dox has a better target efficiency at the tumor site and improved the following: cellular uptake, anti-angiogenesis action, changes in the cell cycle, and increased caspase pathway activation. Conclusions: Our findings suggest the nano drug is a promising anti-cancer agent and has potential clinical applications. Keywords: Anti-cancer, Doxorubicin, Drug delivery, Layered double hydroxide, LDH@Au, Nanodrug, Nanoparticle, Nanotechnology, Suppression of cancer cell invasion, Suppression of tumor growth, Tumor
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spelling	10.1016/j.ejbt.2017.12.004 doi (DE-627)DOAJ046475850 (DE-599)DOAJ5d6a5f8ed8034812bd743fd122865153 DE-627 ger DE-627 rakwb eng TP248.13-248.65 QH301-705.5 Hu Zhao verfasserin aut Enhanced apoptosis and inhibition of gastric cancer cell invasion following treatment with LDHAu loaded Doxorubicin 2018 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Background: The suppression of cancer cell growth and invasion has become a challenging clinical issue. In this study, we used nanotechnology to create a new drug delivery system to enhance the efficacy of existing drugs. We developed layered double hydroxide by combing Au nanosol (LDHAu) and characterized the compound to prove its function as a drug delivery agent. The anti-cancer drug Doxorubicin was loaded into the new drug carrier to assess its quality. We used a combination of apoptosis assays, cell cycle assays, tissue distribution studies, cell endocytosis, transwell invasion assays, and immunoblotting to evaluate the characteristics of LDH@Au as a drug delivery system. Results: Our results show that the LDH@Au-Dox treatment significantly increased cancer cell apoptosis and inhibited cell invasion compared to the control Dox group. Additionally, our data indicate that LDH@Au-Dox has a better target efficiency at the tumor site and improved the following: cellular uptake, anti-angiogenesis action, changes in the cell cycle, and increased caspase pathway activation. Conclusions: Our findings suggest the nano drug is a promising anti-cancer agent and has potential clinical applications. Keywords: Anti-cancer, Doxorubicin, Drug delivery, Layered double hydroxide, LDH@Au, Nanodrug, Nanoparticle, Nanotechnology, Suppression of cancer cell invasion, Suppression of tumor growth, Tumor Biotechnology Biology (General) Xueqin Zhang verfasserin aut In Electronic Journal of Biotechnology Elsevier, 2016 32(2018), Seite 13-18 (DE-627)320604713 (DE-600)2020598-3 07173458 nnns volume:32 year:2018 pages:13-18 https://doi.org/10.1016/j.ejbt.2017.12.004 kostenfrei https://doaj.org/article/5d6a5f8ed8034812bd743fd122865153 kostenfrei http://www.sciencedirect.com/science/article/pii/S0717345817300830 kostenfrei https://doaj.org/toc/0717-3458 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2005 GBV_ILN_2009 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2055 GBV_ILN_2108 GBV_ILN_2111 GBV_ILN_2119 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 32 2018 13-18
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allfieldsGer	10.1016/j.ejbt.2017.12.004 doi (DE-627)DOAJ046475850 (DE-599)DOAJ5d6a5f8ed8034812bd743fd122865153 DE-627 ger DE-627 rakwb eng TP248.13-248.65 QH301-705.5 Hu Zhao verfasserin aut Enhanced apoptosis and inhibition of gastric cancer cell invasion following treatment with LDHAu loaded Doxorubicin 2018 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Background: The suppression of cancer cell growth and invasion has become a challenging clinical issue. In this study, we used nanotechnology to create a new drug delivery system to enhance the efficacy of existing drugs. We developed layered double hydroxide by combing Au nanosol (LDHAu) and characterized the compound to prove its function as a drug delivery agent. The anti-cancer drug Doxorubicin was loaded into the new drug carrier to assess its quality. We used a combination of apoptosis assays, cell cycle assays, tissue distribution studies, cell endocytosis, transwell invasion assays, and immunoblotting to evaluate the characteristics of LDH@Au as a drug delivery system. Results: Our results show that the LDH@Au-Dox treatment significantly increased cancer cell apoptosis and inhibited cell invasion compared to the control Dox group. Additionally, our data indicate that LDH@Au-Dox has a better target efficiency at the tumor site and improved the following: cellular uptake, anti-angiogenesis action, changes in the cell cycle, and increased caspase pathway activation. Conclusions: Our findings suggest the nano drug is a promising anti-cancer agent and has potential clinical applications. Keywords: Anti-cancer, Doxorubicin, Drug delivery, Layered double hydroxide, LDH@Au, Nanodrug, Nanoparticle, Nanotechnology, Suppression of cancer cell invasion, Suppression of tumor growth, Tumor Biotechnology Biology (General) Xueqin Zhang verfasserin aut In Electronic Journal of Biotechnology Elsevier, 2016 32(2018), Seite 13-18 (DE-627)320604713 (DE-600)2020598-3 07173458 nnns volume:32 year:2018 pages:13-18 https://doi.org/10.1016/j.ejbt.2017.12.004 kostenfrei https://doaj.org/article/5d6a5f8ed8034812bd743fd122865153 kostenfrei http://www.sciencedirect.com/science/article/pii/S0717345817300830 kostenfrei https://doaj.org/toc/0717-3458 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2005 GBV_ILN_2009 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2055 GBV_ILN_2108 GBV_ILN_2111 GBV_ILN_2119 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 32 2018 13-18
allfieldsSound	10.1016/j.ejbt.2017.12.004 doi (DE-627)DOAJ046475850 (DE-599)DOAJ5d6a5f8ed8034812bd743fd122865153 DE-627 ger DE-627 rakwb eng TP248.13-248.65 QH301-705.5 Hu Zhao verfasserin aut Enhanced apoptosis and inhibition of gastric cancer cell invasion following treatment with LDHAu loaded Doxorubicin 2018 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Background: The suppression of cancer cell growth and invasion has become a challenging clinical issue. In this study, we used nanotechnology to create a new drug delivery system to enhance the efficacy of existing drugs. We developed layered double hydroxide by combing Au nanosol (LDHAu) and characterized the compound to prove its function as a drug delivery agent. The anti-cancer drug Doxorubicin was loaded into the new drug carrier to assess its quality. We used a combination of apoptosis assays, cell cycle assays, tissue distribution studies, cell endocytosis, transwell invasion assays, and immunoblotting to evaluate the characteristics of LDH@Au as a drug delivery system. Results: Our results show that the LDH@Au-Dox treatment significantly increased cancer cell apoptosis and inhibited cell invasion compared to the control Dox group. Additionally, our data indicate that LDH@Au-Dox has a better target efficiency at the tumor site and improved the following: cellular uptake, anti-angiogenesis action, changes in the cell cycle, and increased caspase pathway activation. Conclusions: Our findings suggest the nano drug is a promising anti-cancer agent and has potential clinical applications. Keywords: Anti-cancer, Doxorubicin, Drug delivery, Layered double hydroxide, LDH@Au, Nanodrug, Nanoparticle, Nanotechnology, Suppression of cancer cell invasion, Suppression of tumor growth, Tumor Biotechnology Biology (General) Xueqin Zhang verfasserin aut In Electronic Journal of Biotechnology Elsevier, 2016 32(2018), Seite 13-18 (DE-627)320604713 (DE-600)2020598-3 07173458 nnns volume:32 year:2018 pages:13-18 https://doi.org/10.1016/j.ejbt.2017.12.004 kostenfrei https://doaj.org/article/5d6a5f8ed8034812bd743fd122865153 kostenfrei http://www.sciencedirect.com/science/article/pii/S0717345817300830 kostenfrei https://doaj.org/toc/0717-3458 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2005 GBV_ILN_2009 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2055 GBV_ILN_2108 GBV_ILN_2111 GBV_ILN_2119 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 32 2018 13-18
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callnumber-first	T - Technology
author	Hu Zhao
spellingShingle	Hu Zhao misc TP248.13-248.65 misc QH301-705.5 misc Biotechnology misc Biology (General) Enhanced apoptosis and inhibition of gastric cancer cell invasion following treatment with LDHAu loaded Doxorubicin
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topic_title	TP248.13-248.65 QH301-705.5 Enhanced apoptosis and inhibition of gastric cancer cell invasion following treatment with LDHAu loaded Doxorubicin
topic	misc TP248.13-248.65 misc QH301-705.5 misc Biotechnology misc Biology (General)
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title	Enhanced apoptosis and inhibition of gastric cancer cell invasion following treatment with LDHAu loaded Doxorubicin
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title_full	Enhanced apoptosis and inhibition of gastric cancer cell invasion following treatment with LDHAu loaded Doxorubicin
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title_sort	apoptosis and inhibition of gastric cancer cell invasion following treatment with ldhau loaded doxorubicin
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title_auth	Enhanced apoptosis and inhibition of gastric cancer cell invasion following treatment with LDHAu loaded Doxorubicin
abstract	Background: The suppression of cancer cell growth and invasion has become a challenging clinical issue. In this study, we used nanotechnology to create a new drug delivery system to enhance the efficacy of existing drugs. We developed layered double hydroxide by combing Au nanosol (LDHAu) and characterized the compound to prove its function as a drug delivery agent. The anti-cancer drug Doxorubicin was loaded into the new drug carrier to assess its quality. We used a combination of apoptosis assays, cell cycle assays, tissue distribution studies, cell endocytosis, transwell invasion assays, and immunoblotting to evaluate the characteristics of LDH@Au as a drug delivery system. Results: Our results show that the LDH@Au-Dox treatment significantly increased cancer cell apoptosis and inhibited cell invasion compared to the control Dox group. Additionally, our data indicate that LDH@Au-Dox has a better target efficiency at the tumor site and improved the following: cellular uptake, anti-angiogenesis action, changes in the cell cycle, and increased caspase pathway activation. Conclusions: Our findings suggest the nano drug is a promising anti-cancer agent and has potential clinical applications. Keywords: Anti-cancer, Doxorubicin, Drug delivery, Layered double hydroxide, LDH@Au, Nanodrug, Nanoparticle, Nanotechnology, Suppression of cancer cell invasion, Suppression of tumor growth, Tumor
abstractGer	Background: The suppression of cancer cell growth and invasion has become a challenging clinical issue. In this study, we used nanotechnology to create a new drug delivery system to enhance the efficacy of existing drugs. We developed layered double hydroxide by combing Au nanosol (LDHAu) and characterized the compound to prove its function as a drug delivery agent. The anti-cancer drug Doxorubicin was loaded into the new drug carrier to assess its quality. We used a combination of apoptosis assays, cell cycle assays, tissue distribution studies, cell endocytosis, transwell invasion assays, and immunoblotting to evaluate the characteristics of LDH@Au as a drug delivery system. Results: Our results show that the LDH@Au-Dox treatment significantly increased cancer cell apoptosis and inhibited cell invasion compared to the control Dox group. Additionally, our data indicate that LDH@Au-Dox has a better target efficiency at the tumor site and improved the following: cellular uptake, anti-angiogenesis action, changes in the cell cycle, and increased caspase pathway activation. Conclusions: Our findings suggest the nano drug is a promising anti-cancer agent and has potential clinical applications. Keywords: Anti-cancer, Doxorubicin, Drug delivery, Layered double hydroxide, LDH@Au, Nanodrug, Nanoparticle, Nanotechnology, Suppression of cancer cell invasion, Suppression of tumor growth, Tumor
abstract_unstemmed	Background: The suppression of cancer cell growth and invasion has become a challenging clinical issue. In this study, we used nanotechnology to create a new drug delivery system to enhance the efficacy of existing drugs. We developed layered double hydroxide by combing Au nanosol (LDHAu) and characterized the compound to prove its function as a drug delivery agent. The anti-cancer drug Doxorubicin was loaded into the new drug carrier to assess its quality. We used a combination of apoptosis assays, cell cycle assays, tissue distribution studies, cell endocytosis, transwell invasion assays, and immunoblotting to evaluate the characteristics of LDH@Au as a drug delivery system. Results: Our results show that the LDH@Au-Dox treatment significantly increased cancer cell apoptosis and inhibited cell invasion compared to the control Dox group. Additionally, our data indicate that LDH@Au-Dox has a better target efficiency at the tumor site and improved the following: cellular uptake, anti-angiogenesis action, changes in the cell cycle, and increased caspase pathway activation. Conclusions: Our findings suggest the nano drug is a promising anti-cancer agent and has potential clinical applications. Keywords: Anti-cancer, Doxorubicin, Drug delivery, Layered double hydroxide, LDH@Au, Nanodrug, Nanoparticle, Nanotechnology, Suppression of cancer cell invasion, Suppression of tumor growth, Tumor
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title_short	Enhanced apoptosis and inhibition of gastric cancer cell invasion following treatment with LDHAu loaded Doxorubicin
url	https://doi.org/10.1016/j.ejbt.2017.12.004 https://doaj.org/article/5d6a5f8ed8034812bd743fd122865153 http://www.sciencedirect.com/science/article/pii/S0717345817300830 https://doaj.org/toc/0717-3458
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up_date	2024-07-03T20:52:56.116Z
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