Mesenchymal Stem Cells and Induced Pluripotent Stem Cells as Therapies for Multiple Sclerosis

Multiple sclerosis (MS) is a chronic, autoimmune, inflammatory demyelinating disorder of the central nervous system that leads to permanent neurological deficits. Current MS treatment regimens are insufficient to treat the irreversible neurological disabilities. Tremendous progress in the experiment...
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Autor*in:	Juan Xiao [verfasserIn] Rongbing Yang [verfasserIn] Sangita Biswas [verfasserIn] Xin Qin [verfasserIn] Min Zhang [verfasserIn] Wenbin Deng [verfasserIn]

Format:	E-Artikel
Sprache:	Englisch

Erschienen:	2015

Schlagwörter:	mesenchymal stem cells induced pluripotent stem cells neural stem cell multiple sclerosis

Übergeordnetes Werk:	In: International Journal of Molecular Sciences - MDPI AG, 2003, 16(2015), 5, Seite 9283-9302
Übergeordnetes Werk:	volume:16 ; year:2015 ; number:5 ; pages:9283-9302

Links:	Link aufrufen Link aufrufen Link aufrufen Journal toc

DOI / URN:	10.3390/ijms16059283

Katalog-ID:	DOAJ046478809

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520			\|a Multiple sclerosis (MS) is a chronic, autoimmune, inflammatory demyelinating disorder of the central nervous system that leads to permanent neurological deficits. Current MS treatment regimens are insufficient to treat the irreversible neurological disabilities. Tremendous progress in the experimental and clinical applications of cell-based therapies has recognized stem cells as potential candidates for regenerative therapy for many neurodegenerative disorders including MS. Mesenchymal stem cells (MSC) and induced pluripotent stem cell (iPSCs) derived precursor cells can modulate the autoimmune response in the central nervous system (CNS) and promote endogenous remyelination and repair process in animal models. This review highlights studies involving the immunomodulatory and regenerative effects of mesenchymal stem cells and iPSCs derived cells in animal models, and their translation into immunomodulatory and neuroregenerative treatment strategies for MS.
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language	English
source	In International Journal of Molecular Sciences 16(2015), 5, Seite 9283-9302 volume:16 year:2015 number:5 pages:9283-9302
sourceStr	In International Journal of Molecular Sciences 16(2015), 5, Seite 9283-9302 volume:16 year:2015 number:5 pages:9283-9302
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topic_facet	mesenchymal stem cells induced pluripotent stem cells neural stem cell multiple sclerosis Biology (General) Chemistry
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container_title	International Journal of Molecular Sciences
authorswithroles_txt_mv	Juan Xiao @@aut@@ Rongbing Yang @@aut@@ Sangita Biswas @@aut@@ Xin Qin @@aut@@ Min Zhang @@aut@@ Wenbin Deng @@aut@@
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callnumber-first	Q - Science
author	Juan Xiao
spellingShingle	Juan Xiao misc QH301-705.5 misc QD1-999 misc mesenchymal stem cells misc induced pluripotent stem cells misc neural stem cell misc multiple sclerosis misc Biology (General) misc Chemistry Mesenchymal Stem Cells and Induced Pluripotent Stem Cells as Therapies for Multiple Sclerosis
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topic_title	QH301-705.5 QD1-999 Mesenchymal Stem Cells and Induced Pluripotent Stem Cells as Therapies for Multiple Sclerosis mesenchymal stem cells induced pluripotent stem cells neural stem cell multiple sclerosis
topic	misc QH301-705.5 misc QD1-999 misc mesenchymal stem cells misc induced pluripotent stem cells misc neural stem cell misc multiple sclerosis misc Biology (General) misc Chemistry
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title	Mesenchymal Stem Cells and Induced Pluripotent Stem Cells as Therapies for Multiple Sclerosis
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title_full	Mesenchymal Stem Cells and Induced Pluripotent Stem Cells as Therapies for Multiple Sclerosis
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title_sort	mesenchymal stem cells and induced pluripotent stem cells as therapies for multiple sclerosis
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title_auth	Mesenchymal Stem Cells and Induced Pluripotent Stem Cells as Therapies for Multiple Sclerosis
abstract	Multiple sclerosis (MS) is a chronic, autoimmune, inflammatory demyelinating disorder of the central nervous system that leads to permanent neurological deficits. Current MS treatment regimens are insufficient to treat the irreversible neurological disabilities. Tremendous progress in the experimental and clinical applications of cell-based therapies has recognized stem cells as potential candidates for regenerative therapy for many neurodegenerative disorders including MS. Mesenchymal stem cells (MSC) and induced pluripotent stem cell (iPSCs) derived precursor cells can modulate the autoimmune response in the central nervous system (CNS) and promote endogenous remyelination and repair process in animal models. This review highlights studies involving the immunomodulatory and regenerative effects of mesenchymal stem cells and iPSCs derived cells in animal models, and their translation into immunomodulatory and neuroregenerative treatment strategies for MS.
abstractGer	Multiple sclerosis (MS) is a chronic, autoimmune, inflammatory demyelinating disorder of the central nervous system that leads to permanent neurological deficits. Current MS treatment regimens are insufficient to treat the irreversible neurological disabilities. Tremendous progress in the experimental and clinical applications of cell-based therapies has recognized stem cells as potential candidates for regenerative therapy for many neurodegenerative disorders including MS. Mesenchymal stem cells (MSC) and induced pluripotent stem cell (iPSCs) derived precursor cells can modulate the autoimmune response in the central nervous system (CNS) and promote endogenous remyelination and repair process in animal models. This review highlights studies involving the immunomodulatory and regenerative effects of mesenchymal stem cells and iPSCs derived cells in animal models, and their translation into immunomodulatory and neuroregenerative treatment strategies for MS.
abstract_unstemmed	Multiple sclerosis (MS) is a chronic, autoimmune, inflammatory demyelinating disorder of the central nervous system that leads to permanent neurological deficits. Current MS treatment regimens are insufficient to treat the irreversible neurological disabilities. Tremendous progress in the experimental and clinical applications of cell-based therapies has recognized stem cells as potential candidates for regenerative therapy for many neurodegenerative disorders including MS. Mesenchymal stem cells (MSC) and induced pluripotent stem cell (iPSCs) derived precursor cells can modulate the autoimmune response in the central nervous system (CNS) and promote endogenous remyelination and repair process in animal models. This review highlights studies involving the immunomodulatory and regenerative effects of mesenchymal stem cells and iPSCs derived cells in animal models, and their translation into immunomodulatory and neuroregenerative treatment strategies for MS.
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title_short	Mesenchymal Stem Cells and Induced Pluripotent Stem Cells as Therapies for Multiple Sclerosis
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