Expression Analysis of GRHL3 and PHLDA3 in Head and Neck Squamous Cell Carcinoma

Negin Saffarzadeh,1 Soudeh Ghafouri-Fard,2 Zahra Rezaei,1 Keyvan Aghazadeh,3,4 Farzad Yazdani,4,5 Mehdi Mohebi,2 Mohsen Ahmadi,6,7 Abbas Shakoori,1,8 Javad Tavakkoly-Bazzaz1 1Department of Medical Genetics, School of Medicine, Tehran University of Medical Sciences, Tehran, Iran; 2Department of Medical Genetics, Shahid Beheshti University of Medical Sciences, Tehran, Iran; 3Head and Neck Surgery Research Center, Tehran University of Medical Sciences, Tehran, Iran; 4Otolaryngology Research Center, Amiralam Hospital, Tehran University of Medical Sciences, Tehran, Iran; 5Department of Pathology, School of Medicine, Tehran University of Medical Sciences, Tehran, Iran; 6Booali Medical Research Center, Qom, Iran; 7Booali Office of USERN, Universal Scientific Education and Research Network (USERN), Qom, Iran; 8Department of Medical Genetics, Cancer Institute of Iran, Tehran University of Medical Sciences, Tehran, IranCorrespondence: Abbas Shakoori; Javad Tavakkoly-Bazzaz Tel/Fax +98 2188953005Email shakooriasina.tums.ac.ir; tavakkolybazzazj@tums.ac.irBackground: Head and neck squamous cell carcinoma (HNSCC) includes a group of heterogeneous tumors with generally invasive behavior. The PI3K/AKT pathway plays an important role in the pathogenesis of HNSCC.Methods: In the current study, we investigated the expression of two negative feedback regulators of the PI3K pathway, namely PHLDA3 and GRHL3, in 45 paired samples of HNSCC and adjacent non-cancerous tissues (ANCTs).Results: While expression of GRHL3 was down-regulated in tumoral tissues compared with ANCTs by the factor 4.21, PHLDA3 expression levels were up-regulated by 5.99-times. Gender-based analysis revealed a significant down-regulation of GRHL3 gene expression level in male patients compared with the control samples and significant up-regulation of PHLDA3 gene expression level in both sexes compared with the control samples. Differences in the expressions of both genes were significant in patients aged more than 60 years, but not in the younger patients. Expression of GRHL3 was only down-regulated in patients with positive smoking history. Expression of GRHL3 was decreased in grades 2 and 3 samples compared with controls. There was a significant increase in transcript levels of PHLDA3 in stages II and III HNSCC samples compared with the controls group. ROC curve analysis indicated that the expression level of PHLDA3 could be a promising marker for the diagnosis of HNSCC patients with a sensitivity and specificity of 0.666 and 0.688, respectively. In addition, sensitivity and specificity of GRHL3 were 0.755 and 0.577, respectively.Discussion: The current study indicates dysregulation of regulators of PI3K pathway in HNSCC and their potential application as putative biomarkers for this cancer.Keywords: GRHL3, PHLDA3, head and neck squamous cell carcinoma Ausführliche Beschreibung

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Autor*in:	Saffarzadeh N [verfasserIn] Ghafouri-Fard S [verfasserIn] Rezaei Z [verfasserIn] Aghazadeh K [verfasserIn] Yazdani F [verfasserIn] Mohebi M [verfasserIn] Ahmadi M [verfasserIn] Shakoori A [verfasserIn] Tavakkoly-Bazzaz J [verfasserIn]

Format:	E-Artikel
Sprache:	Englisch

Erschienen:	2020

Schlagwörter:	grhl3 phlda3 head and neck squamous cell carcinoma

Übergeordnetes Werk:	In: Cancer Management and Research - Dove Medical Press, 2009, (2020), Seite 4085-4096
Übergeordnetes Werk:	year:2020 ; pages:4085-4096

Links:	Link aufrufen Link aufrufen Journal toc

Katalog-ID:	DOAJ046499342

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520			\|a Negin Saffarzadeh,1 Soudeh Ghafouri-Fard,2 Zahra Rezaei,1 Keyvan Aghazadeh,3,4 Farzad Yazdani,4,5 Mehdi Mohebi,2 Mohsen Ahmadi,6,7 Abbas Shakoori,1,8 Javad Tavakkoly-Bazzaz1 1Department of Medical Genetics, School of Medicine, Tehran University of Medical Sciences, Tehran, Iran; 2Department of Medical Genetics, Shahid Beheshti University of Medical Sciences, Tehran, Iran; 3Head and Neck Surgery Research Center, Tehran University of Medical Sciences, Tehran, Iran; 4Otolaryngology Research Center, Amiralam Hospital, Tehran University of Medical Sciences, Tehran, Iran; 5Department of Pathology, School of Medicine, Tehran University of Medical Sciences, Tehran, Iran; 6Booali Medical Research Center, Qom, Iran; 7Booali Office of USERN, Universal Scientific Education and Research Network (USERN), Qom, Iran; 8Department of Medical Genetics, Cancer Institute of Iran, Tehran University of Medical Sciences, Tehran, IranCorrespondence: Abbas Shakoori; Javad Tavakkoly-Bazzaz Tel/Fax +98 2188953005Email shakooriasina.tums.ac.ir; tavakkolybazzazj@tums.ac.irBackground: Head and neck squamous cell carcinoma (HNSCC) includes a group of heterogeneous tumors with generally invasive behavior. The PI3K/AKT pathway plays an important role in the pathogenesis of HNSCC.Methods: In the current study, we investigated the expression of two negative feedback regulators of the PI3K pathway, namely PHLDA3 and GRHL3, in 45 paired samples of HNSCC and adjacent non-cancerous tissues (ANCTs).Results: While expression of GRHL3 was down-regulated in tumoral tissues compared with ANCTs by the factor 4.21, PHLDA3 expression levels were up-regulated by 5.99-times. Gender-based analysis revealed a significant down-regulation of GRHL3 gene expression level in male patients compared with the control samples and significant up-regulation of PHLDA3 gene expression level in both sexes compared with the control samples. Differences in the expressions of both genes were significant in patients aged more than 60 years, but not in the younger patients. Expression of GRHL3 was only down-regulated in patients with positive smoking history. Expression of GRHL3 was decreased in grades 2 and 3 samples compared with controls. There was a significant increase in transcript levels of PHLDA3 in stages II and III HNSCC samples compared with the controls group. ROC curve analysis indicated that the expression level of PHLDA3 could be a promising marker for the diagnosis of HNSCC patients with a sensitivity and specificity of 0.666 and 0.688, respectively. In addition, sensitivity and specificity of GRHL3 were 0.755 and 0.577, respectively.Discussion: The current study indicates dysregulation of regulators of PI3K pathway in HNSCC and their potential application as putative biomarkers for this cancer.Keywords: GRHL3, PHLDA3, head and neck squamous cell carcinoma
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allfields	(DE-627)DOAJ046499342 (DE-599)DOAJad09547ecd884bddb58ee6d7704154a2 DE-627 ger DE-627 rakwb eng RC254-282 Saffarzadeh N verfasserin aut Expression Analysis of GRHL3 and PHLDA3 in Head and Neck Squamous Cell Carcinoma 2020 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Negin Saffarzadeh,1 Soudeh Ghafouri-Fard,2 Zahra Rezaei,1 Keyvan Aghazadeh,3,4 Farzad Yazdani,4,5 Mehdi Mohebi,2 Mohsen Ahmadi,6,7 Abbas Shakoori,1,8 Javad Tavakkoly-Bazzaz1 1Department of Medical Genetics, School of Medicine, Tehran University of Medical Sciences, Tehran, Iran; 2Department of Medical Genetics, Shahid Beheshti University of Medical Sciences, Tehran, Iran; 3Head and Neck Surgery Research Center, Tehran University of Medical Sciences, Tehran, Iran; 4Otolaryngology Research Center, Amiralam Hospital, Tehran University of Medical Sciences, Tehran, Iran; 5Department of Pathology, School of Medicine, Tehran University of Medical Sciences, Tehran, Iran; 6Booali Medical Research Center, Qom, Iran; 7Booali Office of USERN, Universal Scientific Education and Research Network (USERN), Qom, Iran; 8Department of Medical Genetics, Cancer Institute of Iran, Tehran University of Medical Sciences, Tehran, IranCorrespondence: Abbas Shakoori; Javad Tavakkoly-Bazzaz Tel/Fax +98 2188953005Email shakooriasina.tums.ac.ir; tavakkolybazzazj@tums.ac.irBackground: Head and neck squamous cell carcinoma (HNSCC) includes a group of heterogeneous tumors with generally invasive behavior. The PI3K/AKT pathway plays an important role in the pathogenesis of HNSCC.Methods: In the current study, we investigated the expression of two negative feedback regulators of the PI3K pathway, namely PHLDA3 and GRHL3, in 45 paired samples of HNSCC and adjacent non-cancerous tissues (ANCTs).Results: While expression of GRHL3 was down-regulated in tumoral tissues compared with ANCTs by the factor 4.21, PHLDA3 expression levels were up-regulated by 5.99-times. Gender-based analysis revealed a significant down-regulation of GRHL3 gene expression level in male patients compared with the control samples and significant up-regulation of PHLDA3 gene expression level in both sexes compared with the control samples. Differences in the expressions of both genes were significant in patients aged more than 60 years, but not in the younger patients. Expression of GRHL3 was only down-regulated in patients with positive smoking history. Expression of GRHL3 was decreased in grades 2 and 3 samples compared with controls. There was a significant increase in transcript levels of PHLDA3 in stages II and III HNSCC samples compared with the controls group. ROC curve analysis indicated that the expression level of PHLDA3 could be a promising marker for the diagnosis of HNSCC patients with a sensitivity and specificity of 0.666 and 0.688, respectively. In addition, sensitivity and specificity of GRHL3 were 0.755 and 0.577, respectively.Discussion: The current study indicates dysregulation of regulators of PI3K pathway in HNSCC and their potential application as putative biomarkers for this cancer.Keywords: GRHL3, PHLDA3, head and neck squamous cell carcinoma grhl3 phlda3 head and neck squamous cell carcinoma Neoplasms. Tumors. Oncology. Including cancer and carcinogens Ghafouri-Fard S verfasserin aut Rezaei Z verfasserin aut Aghazadeh K verfasserin aut Yazdani F verfasserin aut Mohebi M verfasserin aut Ahmadi M verfasserin aut Shakoori A verfasserin aut Tavakkoly-Bazzaz J verfasserin aut In Cancer Management and Research Dove Medical Press, 2009 (2020), Seite 4085-4096 (DE-627)606030840 (DE-600)2508013-1 11791322 nnns year:2020 pages:4085-4096 https://doaj.org/article/ad09547ecd884bddb58ee6d7704154a2 kostenfrei https://www.dovepress.com/expression-analysis-of-grhl3-and-phlda3-in-head-and-neck-squamous-cell-peer-reviewed-article-CMAR kostenfrei https://doaj.org/toc/1179-1322 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2003 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 2020 4085-4096
spelling	(DE-627)DOAJ046499342 (DE-599)DOAJad09547ecd884bddb58ee6d7704154a2 DE-627 ger DE-627 rakwb eng RC254-282 Saffarzadeh N verfasserin aut Expression Analysis of GRHL3 and PHLDA3 in Head and Neck Squamous Cell Carcinoma 2020 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Negin Saffarzadeh,1 Soudeh Ghafouri-Fard,2 Zahra Rezaei,1 Keyvan Aghazadeh,3,4 Farzad Yazdani,4,5 Mehdi Mohebi,2 Mohsen Ahmadi,6,7 Abbas Shakoori,1,8 Javad Tavakkoly-Bazzaz1 1Department of Medical Genetics, School of Medicine, Tehran University of Medical Sciences, Tehran, Iran; 2Department of Medical Genetics, Shahid Beheshti University of Medical Sciences, Tehran, Iran; 3Head and Neck Surgery Research Center, Tehran University of Medical Sciences, Tehran, Iran; 4Otolaryngology Research Center, Amiralam Hospital, Tehran University of Medical Sciences, Tehran, Iran; 5Department of Pathology, School of Medicine, Tehran University of Medical Sciences, Tehran, Iran; 6Booali Medical Research Center, Qom, Iran; 7Booali Office of USERN, Universal Scientific Education and Research Network (USERN), Qom, Iran; 8Department of Medical Genetics, Cancer Institute of Iran, Tehran University of Medical Sciences, Tehran, IranCorrespondence: Abbas Shakoori; Javad Tavakkoly-Bazzaz Tel/Fax +98 2188953005Email shakooriasina.tums.ac.ir; tavakkolybazzazj@tums.ac.irBackground: Head and neck squamous cell carcinoma (HNSCC) includes a group of heterogeneous tumors with generally invasive behavior. The PI3K/AKT pathway plays an important role in the pathogenesis of HNSCC.Methods: In the current study, we investigated the expression of two negative feedback regulators of the PI3K pathway, namely PHLDA3 and GRHL3, in 45 paired samples of HNSCC and adjacent non-cancerous tissues (ANCTs).Results: While expression of GRHL3 was down-regulated in tumoral tissues compared with ANCTs by the factor 4.21, PHLDA3 expression levels were up-regulated by 5.99-times. Gender-based analysis revealed a significant down-regulation of GRHL3 gene expression level in male patients compared with the control samples and significant up-regulation of PHLDA3 gene expression level in both sexes compared with the control samples. Differences in the expressions of both genes were significant in patients aged more than 60 years, but not in the younger patients. Expression of GRHL3 was only down-regulated in patients with positive smoking history. Expression of GRHL3 was decreased in grades 2 and 3 samples compared with controls. There was a significant increase in transcript levels of PHLDA3 in stages II and III HNSCC samples compared with the controls group. ROC curve analysis indicated that the expression level of PHLDA3 could be a promising marker for the diagnosis of HNSCC patients with a sensitivity and specificity of 0.666 and 0.688, respectively. In addition, sensitivity and specificity of GRHL3 were 0.755 and 0.577, respectively.Discussion: The current study indicates dysregulation of regulators of PI3K pathway in HNSCC and their potential application as putative biomarkers for this cancer.Keywords: GRHL3, PHLDA3, head and neck squamous cell carcinoma grhl3 phlda3 head and neck squamous cell carcinoma Neoplasms. Tumors. Oncology. Including cancer and carcinogens Ghafouri-Fard S verfasserin aut Rezaei Z verfasserin aut Aghazadeh K verfasserin aut Yazdani F verfasserin aut Mohebi M verfasserin aut Ahmadi M verfasserin aut Shakoori A verfasserin aut Tavakkoly-Bazzaz J verfasserin aut In Cancer Management and Research Dove Medical Press, 2009 (2020), Seite 4085-4096 (DE-627)606030840 (DE-600)2508013-1 11791322 nnns year:2020 pages:4085-4096 https://doaj.org/article/ad09547ecd884bddb58ee6d7704154a2 kostenfrei https://www.dovepress.com/expression-analysis-of-grhl3-and-phlda3-in-head-and-neck-squamous-cell-peer-reviewed-article-CMAR kostenfrei https://doaj.org/toc/1179-1322 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2003 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 2020 4085-4096
allfields_unstemmed	(DE-627)DOAJ046499342 (DE-599)DOAJad09547ecd884bddb58ee6d7704154a2 DE-627 ger DE-627 rakwb eng RC254-282 Saffarzadeh N verfasserin aut Expression Analysis of GRHL3 and PHLDA3 in Head and Neck Squamous Cell Carcinoma 2020 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Negin Saffarzadeh,1 Soudeh Ghafouri-Fard,2 Zahra Rezaei,1 Keyvan Aghazadeh,3,4 Farzad Yazdani,4,5 Mehdi Mohebi,2 Mohsen Ahmadi,6,7 Abbas Shakoori,1,8 Javad Tavakkoly-Bazzaz1 1Department of Medical Genetics, School of Medicine, Tehran University of Medical Sciences, Tehran, Iran; 2Department of Medical Genetics, Shahid Beheshti University of Medical Sciences, Tehran, Iran; 3Head and Neck Surgery Research Center, Tehran University of Medical Sciences, Tehran, Iran; 4Otolaryngology Research Center, Amiralam Hospital, Tehran University of Medical Sciences, Tehran, Iran; 5Department of Pathology, School of Medicine, Tehran University of Medical Sciences, Tehran, Iran; 6Booali Medical Research Center, Qom, Iran; 7Booali Office of USERN, Universal Scientific Education and Research Network (USERN), Qom, Iran; 8Department of Medical Genetics, Cancer Institute of Iran, Tehran University of Medical Sciences, Tehran, IranCorrespondence: Abbas Shakoori; Javad Tavakkoly-Bazzaz Tel/Fax +98 2188953005Email shakooriasina.tums.ac.ir; tavakkolybazzazj@tums.ac.irBackground: Head and neck squamous cell carcinoma (HNSCC) includes a group of heterogeneous tumors with generally invasive behavior. The PI3K/AKT pathway plays an important role in the pathogenesis of HNSCC.Methods: In the current study, we investigated the expression of two negative feedback regulators of the PI3K pathway, namely PHLDA3 and GRHL3, in 45 paired samples of HNSCC and adjacent non-cancerous tissues (ANCTs).Results: While expression of GRHL3 was down-regulated in tumoral tissues compared with ANCTs by the factor 4.21, PHLDA3 expression levels were up-regulated by 5.99-times. Gender-based analysis revealed a significant down-regulation of GRHL3 gene expression level in male patients compared with the control samples and significant up-regulation of PHLDA3 gene expression level in both sexes compared with the control samples. Differences in the expressions of both genes were significant in patients aged more than 60 years, but not in the younger patients. Expression of GRHL3 was only down-regulated in patients with positive smoking history. Expression of GRHL3 was decreased in grades 2 and 3 samples compared with controls. There was a significant increase in transcript levels of PHLDA3 in stages II and III HNSCC samples compared with the controls group. ROC curve analysis indicated that the expression level of PHLDA3 could be a promising marker for the diagnosis of HNSCC patients with a sensitivity and specificity of 0.666 and 0.688, respectively. In addition, sensitivity and specificity of GRHL3 were 0.755 and 0.577, respectively.Discussion: The current study indicates dysregulation of regulators of PI3K pathway in HNSCC and their potential application as putative biomarkers for this cancer.Keywords: GRHL3, PHLDA3, head and neck squamous cell carcinoma grhl3 phlda3 head and neck squamous cell carcinoma Neoplasms. Tumors. Oncology. Including cancer and carcinogens Ghafouri-Fard S verfasserin aut Rezaei Z verfasserin aut Aghazadeh K verfasserin aut Yazdani F verfasserin aut Mohebi M verfasserin aut Ahmadi M verfasserin aut Shakoori A verfasserin aut Tavakkoly-Bazzaz J verfasserin aut In Cancer Management and Research Dove Medical Press, 2009 (2020), Seite 4085-4096 (DE-627)606030840 (DE-600)2508013-1 11791322 nnns year:2020 pages:4085-4096 https://doaj.org/article/ad09547ecd884bddb58ee6d7704154a2 kostenfrei https://www.dovepress.com/expression-analysis-of-grhl3-and-phlda3-in-head-and-neck-squamous-cell-peer-reviewed-article-CMAR kostenfrei https://doaj.org/toc/1179-1322 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2003 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 2020 4085-4096
allfieldsGer	(DE-627)DOAJ046499342 (DE-599)DOAJad09547ecd884bddb58ee6d7704154a2 DE-627 ger DE-627 rakwb eng RC254-282 Saffarzadeh N verfasserin aut Expression Analysis of GRHL3 and PHLDA3 in Head and Neck Squamous Cell Carcinoma 2020 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Negin Saffarzadeh,1 Soudeh Ghafouri-Fard,2 Zahra Rezaei,1 Keyvan Aghazadeh,3,4 Farzad Yazdani,4,5 Mehdi Mohebi,2 Mohsen Ahmadi,6,7 Abbas Shakoori,1,8 Javad Tavakkoly-Bazzaz1 1Department of Medical Genetics, School of Medicine, Tehran University of Medical Sciences, Tehran, Iran; 2Department of Medical Genetics, Shahid Beheshti University of Medical Sciences, Tehran, Iran; 3Head and Neck Surgery Research Center, Tehran University of Medical Sciences, Tehran, Iran; 4Otolaryngology Research Center, Amiralam Hospital, Tehran University of Medical Sciences, Tehran, Iran; 5Department of Pathology, School of Medicine, Tehran University of Medical Sciences, Tehran, Iran; 6Booali Medical Research Center, Qom, Iran; 7Booali Office of USERN, Universal Scientific Education and Research Network (USERN), Qom, Iran; 8Department of Medical Genetics, Cancer Institute of Iran, Tehran University of Medical Sciences, Tehran, IranCorrespondence: Abbas Shakoori; Javad Tavakkoly-Bazzaz Tel/Fax +98 2188953005Email shakooriasina.tums.ac.ir; tavakkolybazzazj@tums.ac.irBackground: Head and neck squamous cell carcinoma (HNSCC) includes a group of heterogeneous tumors with generally invasive behavior. The PI3K/AKT pathway plays an important role in the pathogenesis of HNSCC.Methods: In the current study, we investigated the expression of two negative feedback regulators of the PI3K pathway, namely PHLDA3 and GRHL3, in 45 paired samples of HNSCC and adjacent non-cancerous tissues (ANCTs).Results: While expression of GRHL3 was down-regulated in tumoral tissues compared with ANCTs by the factor 4.21, PHLDA3 expression levels were up-regulated by 5.99-times. Gender-based analysis revealed a significant down-regulation of GRHL3 gene expression level in male patients compared with the control samples and significant up-regulation of PHLDA3 gene expression level in both sexes compared with the control samples. Differences in the expressions of both genes were significant in patients aged more than 60 years, but not in the younger patients. Expression of GRHL3 was only down-regulated in patients with positive smoking history. Expression of GRHL3 was decreased in grades 2 and 3 samples compared with controls. There was a significant increase in transcript levels of PHLDA3 in stages II and III HNSCC samples compared with the controls group. ROC curve analysis indicated that the expression level of PHLDA3 could be a promising marker for the diagnosis of HNSCC patients with a sensitivity and specificity of 0.666 and 0.688, respectively. In addition, sensitivity and specificity of GRHL3 were 0.755 and 0.577, respectively.Discussion: The current study indicates dysregulation of regulators of PI3K pathway in HNSCC and their potential application as putative biomarkers for this cancer.Keywords: GRHL3, PHLDA3, head and neck squamous cell carcinoma grhl3 phlda3 head and neck squamous cell carcinoma Neoplasms. Tumors. Oncology. Including cancer and carcinogens Ghafouri-Fard S verfasserin aut Rezaei Z verfasserin aut Aghazadeh K verfasserin aut Yazdani F verfasserin aut Mohebi M verfasserin aut Ahmadi M verfasserin aut Shakoori A verfasserin aut Tavakkoly-Bazzaz J verfasserin aut In Cancer Management and Research Dove Medical Press, 2009 (2020), Seite 4085-4096 (DE-627)606030840 (DE-600)2508013-1 11791322 nnns year:2020 pages:4085-4096 https://doaj.org/article/ad09547ecd884bddb58ee6d7704154a2 kostenfrei https://www.dovepress.com/expression-analysis-of-grhl3-and-phlda3-in-head-and-neck-squamous-cell-peer-reviewed-article-CMAR kostenfrei https://doaj.org/toc/1179-1322 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2003 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 2020 4085-4096
allfieldsSound	(DE-627)DOAJ046499342 (DE-599)DOAJad09547ecd884bddb58ee6d7704154a2 DE-627 ger DE-627 rakwb eng RC254-282 Saffarzadeh N verfasserin aut Expression Analysis of GRHL3 and PHLDA3 in Head and Neck Squamous Cell Carcinoma 2020 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Negin Saffarzadeh,1 Soudeh Ghafouri-Fard,2 Zahra Rezaei,1 Keyvan Aghazadeh,3,4 Farzad Yazdani,4,5 Mehdi Mohebi,2 Mohsen Ahmadi,6,7 Abbas Shakoori,1,8 Javad Tavakkoly-Bazzaz1 1Department of Medical Genetics, School of Medicine, Tehran University of Medical Sciences, Tehran, Iran; 2Department of Medical Genetics, Shahid Beheshti University of Medical Sciences, Tehran, Iran; 3Head and Neck Surgery Research Center, Tehran University of Medical Sciences, Tehran, Iran; 4Otolaryngology Research Center, Amiralam Hospital, Tehran University of Medical Sciences, Tehran, Iran; 5Department of Pathology, School of Medicine, Tehran University of Medical Sciences, Tehran, Iran; 6Booali Medical Research Center, Qom, Iran; 7Booali Office of USERN, Universal Scientific Education and Research Network (USERN), Qom, Iran; 8Department of Medical Genetics, Cancer Institute of Iran, Tehran University of Medical Sciences, Tehran, IranCorrespondence: Abbas Shakoori; Javad Tavakkoly-Bazzaz Tel/Fax +98 2188953005Email shakooriasina.tums.ac.ir; tavakkolybazzazj@tums.ac.irBackground: Head and neck squamous cell carcinoma (HNSCC) includes a group of heterogeneous tumors with generally invasive behavior. The PI3K/AKT pathway plays an important role in the pathogenesis of HNSCC.Methods: In the current study, we investigated the expression of two negative feedback regulators of the PI3K pathway, namely PHLDA3 and GRHL3, in 45 paired samples of HNSCC and adjacent non-cancerous tissues (ANCTs).Results: While expression of GRHL3 was down-regulated in tumoral tissues compared with ANCTs by the factor 4.21, PHLDA3 expression levels were up-regulated by 5.99-times. Gender-based analysis revealed a significant down-regulation of GRHL3 gene expression level in male patients compared with the control samples and significant up-regulation of PHLDA3 gene expression level in both sexes compared with the control samples. Differences in the expressions of both genes were significant in patients aged more than 60 years, but not in the younger patients. Expression of GRHL3 was only down-regulated in patients with positive smoking history. Expression of GRHL3 was decreased in grades 2 and 3 samples compared with controls. There was a significant increase in transcript levels of PHLDA3 in stages II and III HNSCC samples compared with the controls group. ROC curve analysis indicated that the expression level of PHLDA3 could be a promising marker for the diagnosis of HNSCC patients with a sensitivity and specificity of 0.666 and 0.688, respectively. In addition, sensitivity and specificity of GRHL3 were 0.755 and 0.577, respectively.Discussion: The current study indicates dysregulation of regulators of PI3K pathway in HNSCC and their potential application as putative biomarkers for this cancer.Keywords: GRHL3, PHLDA3, head and neck squamous cell carcinoma grhl3 phlda3 head and neck squamous cell carcinoma Neoplasms. Tumors. Oncology. Including cancer and carcinogens Ghafouri-Fard S verfasserin aut Rezaei Z verfasserin aut Aghazadeh K verfasserin aut Yazdani F verfasserin aut Mohebi M verfasserin aut Ahmadi M verfasserin aut Shakoori A verfasserin aut Tavakkoly-Bazzaz J verfasserin aut In Cancer Management and Research Dove Medical Press, 2009 (2020), Seite 4085-4096 (DE-627)606030840 (DE-600)2508013-1 11791322 nnns year:2020 pages:4085-4096 https://doaj.org/article/ad09547ecd884bddb58ee6d7704154a2 kostenfrei https://www.dovepress.com/expression-analysis-of-grhl3-and-phlda3-in-head-and-neck-squamous-cell-peer-reviewed-article-CMAR kostenfrei https://doaj.org/toc/1179-1322 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2003 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 2020 4085-4096
language	English
source	In Cancer Management and Research (2020), Seite 4085-4096 year:2020 pages:4085-4096
sourceStr	In Cancer Management and Research (2020), Seite 4085-4096 year:2020 pages:4085-4096
format_phy_str_mv	Article
institution	findex.gbv.de
topic_facet	grhl3 phlda3 head and neck squamous cell carcinoma Neoplasms. Tumors. Oncology. Including cancer and carcinogens
isfreeaccess_bool	true
container_title	Cancer Management and Research
authorswithroles_txt_mv	Saffarzadeh N @@aut@@ Ghafouri-Fard S @@aut@@ Rezaei Z @@aut@@ Aghazadeh K @@aut@@ Yazdani F @@aut@@ Mohebi M @@aut@@ Ahmadi M @@aut@@ Shakoori A @@aut@@ Tavakkoly-Bazzaz J @@aut@@
publishDateDaySort_date	2020-01-01T00:00:00Z
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The PI3K/AKT pathway plays an important role in the pathogenesis of HNSCC.Methods: In the current study, we investigated the expression of two negative feedback regulators of the PI3K pathway, namely PHLDA3 and GRHL3, in 45 paired samples of HNSCC and adjacent non-cancerous tissues (ANCTs).Results: While expression of GRHL3 was down-regulated in tumoral tissues compared with ANCTs by the factor 4.21, PHLDA3 expression levels were up-regulated by 5.99-times. Gender-based analysis revealed a significant down-regulation of GRHL3 gene expression level in male patients compared with the control samples and significant up-regulation of PHLDA3 gene expression level in both sexes compared with the control samples. Differences in the expressions of both genes were significant in patients aged more than 60 years, but not in the younger patients. Expression of GRHL3 was only down-regulated in patients with positive smoking history. 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spellingShingle	Saffarzadeh N misc RC254-282 misc grhl3 misc phlda3 misc head and neck squamous cell carcinoma misc Neoplasms. Tumors. Oncology. Including cancer and carcinogens Expression Analysis of GRHL3 and PHLDA3 in Head and Neck Squamous Cell Carcinoma
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topic_title	RC254-282 Expression Analysis of GRHL3 and PHLDA3 in Head and Neck Squamous Cell Carcinoma grhl3 phlda3 head and neck squamous cell carcinoma
topic	misc RC254-282 misc grhl3 misc phlda3 misc head and neck squamous cell carcinoma misc Neoplasms. Tumors. Oncology. Including cancer and carcinogens
topic_unstemmed	misc RC254-282 misc grhl3 misc phlda3 misc head and neck squamous cell carcinoma misc Neoplasms. Tumors. Oncology. Including cancer and carcinogens
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title	Expression Analysis of GRHL3 and PHLDA3 in Head and Neck Squamous Cell Carcinoma
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title_full	Expression Analysis of GRHL3 and PHLDA3 in Head and Neck Squamous Cell Carcinoma
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author_browse	Saffarzadeh N Ghafouri-Fard S Rezaei Z Aghazadeh K Yazdani F Mohebi M Ahmadi M Shakoori A Tavakkoly-Bazzaz J
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title_sort	expression analysis of grhl3 and phlda3 in head and neck squamous cell carcinoma
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title_auth	Expression Analysis of GRHL3 and PHLDA3 in Head and Neck Squamous Cell Carcinoma
abstract	Negin Saffarzadeh,1 Soudeh Ghafouri-Fard,2 Zahra Rezaei,1 Keyvan Aghazadeh,3,4 Farzad Yazdani,4,5 Mehdi Mohebi,2 Mohsen Ahmadi,6,7 Abbas Shakoori,1,8 Javad Tavakkoly-Bazzaz1 1Department of Medical Genetics, School of Medicine, Tehran University of Medical Sciences, Tehran, Iran; 2Department of Medical Genetics, Shahid Beheshti University of Medical Sciences, Tehran, Iran; 3Head and Neck Surgery Research Center, Tehran University of Medical Sciences, Tehran, Iran; 4Otolaryngology Research Center, Amiralam Hospital, Tehran University of Medical Sciences, Tehran, Iran; 5Department of Pathology, School of Medicine, Tehran University of Medical Sciences, Tehran, Iran; 6Booali Medical Research Center, Qom, Iran; 7Booali Office of USERN, Universal Scientific Education and Research Network (USERN), Qom, Iran; 8Department of Medical Genetics, Cancer Institute of Iran, Tehran University of Medical Sciences, Tehran, IranCorrespondence: Abbas Shakoori; Javad Tavakkoly-Bazzaz Tel/Fax +98 2188953005Email shakooriasina.tums.ac.ir; tavakkolybazzazj@tums.ac.irBackground: Head and neck squamous cell carcinoma (HNSCC) includes a group of heterogeneous tumors with generally invasive behavior. The PI3K/AKT pathway plays an important role in the pathogenesis of HNSCC.Methods: In the current study, we investigated the expression of two negative feedback regulators of the PI3K pathway, namely PHLDA3 and GRHL3, in 45 paired samples of HNSCC and adjacent non-cancerous tissues (ANCTs).Results: While expression of GRHL3 was down-regulated in tumoral tissues compared with ANCTs by the factor 4.21, PHLDA3 expression levels were up-regulated by 5.99-times. Gender-based analysis revealed a significant down-regulation of GRHL3 gene expression level in male patients compared with the control samples and significant up-regulation of PHLDA3 gene expression level in both sexes compared with the control samples. Differences in the expressions of both genes were significant in patients aged more than 60 years, but not in the younger patients. Expression of GRHL3 was only down-regulated in patients with positive smoking history. Expression of GRHL3 was decreased in grades 2 and 3 samples compared with controls. There was a significant increase in transcript levels of PHLDA3 in stages II and III HNSCC samples compared with the controls group. ROC curve analysis indicated that the expression level of PHLDA3 could be a promising marker for the diagnosis of HNSCC patients with a sensitivity and specificity of 0.666 and 0.688, respectively. In addition, sensitivity and specificity of GRHL3 were 0.755 and 0.577, respectively.Discussion: The current study indicates dysregulation of regulators of PI3K pathway in HNSCC and their potential application as putative biomarkers for this cancer.Keywords: GRHL3, PHLDA3, head and neck squamous cell carcinoma
abstractGer	Negin Saffarzadeh,1 Soudeh Ghafouri-Fard,2 Zahra Rezaei,1 Keyvan Aghazadeh,3,4 Farzad Yazdani,4,5 Mehdi Mohebi,2 Mohsen Ahmadi,6,7 Abbas Shakoori,1,8 Javad Tavakkoly-Bazzaz1 1Department of Medical Genetics, School of Medicine, Tehran University of Medical Sciences, Tehran, Iran; 2Department of Medical Genetics, Shahid Beheshti University of Medical Sciences, Tehran, Iran; 3Head and Neck Surgery Research Center, Tehran University of Medical Sciences, Tehran, Iran; 4Otolaryngology Research Center, Amiralam Hospital, Tehran University of Medical Sciences, Tehran, Iran; 5Department of Pathology, School of Medicine, Tehran University of Medical Sciences, Tehran, Iran; 6Booali Medical Research Center, Qom, Iran; 7Booali Office of USERN, Universal Scientific Education and Research Network (USERN), Qom, Iran; 8Department of Medical Genetics, Cancer Institute of Iran, Tehran University of Medical Sciences, Tehran, IranCorrespondence: Abbas Shakoori; Javad Tavakkoly-Bazzaz Tel/Fax +98 2188953005Email shakooriasina.tums.ac.ir; tavakkolybazzazj@tums.ac.irBackground: Head and neck squamous cell carcinoma (HNSCC) includes a group of heterogeneous tumors with generally invasive behavior. The PI3K/AKT pathway plays an important role in the pathogenesis of HNSCC.Methods: In the current study, we investigated the expression of two negative feedback regulators of the PI3K pathway, namely PHLDA3 and GRHL3, in 45 paired samples of HNSCC and adjacent non-cancerous tissues (ANCTs).Results: While expression of GRHL3 was down-regulated in tumoral tissues compared with ANCTs by the factor 4.21, PHLDA3 expression levels were up-regulated by 5.99-times. Gender-based analysis revealed a significant down-regulation of GRHL3 gene expression level in male patients compared with the control samples and significant up-regulation of PHLDA3 gene expression level in both sexes compared with the control samples. Differences in the expressions of both genes were significant in patients aged more than 60 years, but not in the younger patients. Expression of GRHL3 was only down-regulated in patients with positive smoking history. Expression of GRHL3 was decreased in grades 2 and 3 samples compared with controls. There was a significant increase in transcript levels of PHLDA3 in stages II and III HNSCC samples compared with the controls group. ROC curve analysis indicated that the expression level of PHLDA3 could be a promising marker for the diagnosis of HNSCC patients with a sensitivity and specificity of 0.666 and 0.688, respectively. In addition, sensitivity and specificity of GRHL3 were 0.755 and 0.577, respectively.Discussion: The current study indicates dysregulation of regulators of PI3K pathway in HNSCC and their potential application as putative biomarkers for this cancer.Keywords: GRHL3, PHLDA3, head and neck squamous cell carcinoma
abstract_unstemmed	Negin Saffarzadeh,1 Soudeh Ghafouri-Fard,2 Zahra Rezaei,1 Keyvan Aghazadeh,3,4 Farzad Yazdani,4,5 Mehdi Mohebi,2 Mohsen Ahmadi,6,7 Abbas Shakoori,1,8 Javad Tavakkoly-Bazzaz1 1Department of Medical Genetics, School of Medicine, Tehran University of Medical Sciences, Tehran, Iran; 2Department of Medical Genetics, Shahid Beheshti University of Medical Sciences, Tehran, Iran; 3Head and Neck Surgery Research Center, Tehran University of Medical Sciences, Tehran, Iran; 4Otolaryngology Research Center, Amiralam Hospital, Tehran University of Medical Sciences, Tehran, Iran; 5Department of Pathology, School of Medicine, Tehran University of Medical Sciences, Tehran, Iran; 6Booali Medical Research Center, Qom, Iran; 7Booali Office of USERN, Universal Scientific Education and Research Network (USERN), Qom, Iran; 8Department of Medical Genetics, Cancer Institute of Iran, Tehran University of Medical Sciences, Tehran, IranCorrespondence: Abbas Shakoori; Javad Tavakkoly-Bazzaz Tel/Fax +98 2188953005Email shakooriasina.tums.ac.ir; tavakkolybazzazj@tums.ac.irBackground: Head and neck squamous cell carcinoma (HNSCC) includes a group of heterogeneous tumors with generally invasive behavior. The PI3K/AKT pathway plays an important role in the pathogenesis of HNSCC.Methods: In the current study, we investigated the expression of two negative feedback regulators of the PI3K pathway, namely PHLDA3 and GRHL3, in 45 paired samples of HNSCC and adjacent non-cancerous tissues (ANCTs).Results: While expression of GRHL3 was down-regulated in tumoral tissues compared with ANCTs by the factor 4.21, PHLDA3 expression levels were up-regulated by 5.99-times. Gender-based analysis revealed a significant down-regulation of GRHL3 gene expression level in male patients compared with the control samples and significant up-regulation of PHLDA3 gene expression level in both sexes compared with the control samples. Differences in the expressions of both genes were significant in patients aged more than 60 years, but not in the younger patients. Expression of GRHL3 was only down-regulated in patients with positive smoking history. Expression of GRHL3 was decreased in grades 2 and 3 samples compared with controls. There was a significant increase in transcript levels of PHLDA3 in stages II and III HNSCC samples compared with the controls group. ROC curve analysis indicated that the expression level of PHLDA3 could be a promising marker for the diagnosis of HNSCC patients with a sensitivity and specificity of 0.666 and 0.688, respectively. In addition, sensitivity and specificity of GRHL3 were 0.755 and 0.577, respectively.Discussion: The current study indicates dysregulation of regulators of PI3K pathway in HNSCC and their potential application as putative biomarkers for this cancer.Keywords: GRHL3, PHLDA3, head and neck squamous cell carcinoma
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title_short	Expression Analysis of GRHL3 and PHLDA3 in Head and Neck Squamous Cell Carcinoma
url	https://doaj.org/article/ad09547ecd884bddb58ee6d7704154a2 https://www.dovepress.com/expression-analysis-of-grhl3-and-phlda3-in-head-and-neck-squamous-cell-peer-reviewed-article-CMAR https://doaj.org/toc/1179-1322
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Expression of GRHL3 was decreased in grades 2 and 3 samples compared with controls. There was a significant increase in transcript levels of PHLDA3 in stages II and III HNSCC samples compared with the controls group. ROC curve analysis indicated that the expression level of PHLDA3 could be a promising marker for the diagnosis of HNSCC patients with a sensitivity and specificity of 0.666 and 0.688, respectively. In addition, sensitivity and specificity of GRHL3 were 0.755 and 0.577, respectively.Discussion: The current study indicates dysregulation of regulators of PI3K pathway in HNSCC and their potential application as putative biomarkers for this cancer.Keywords: GRHL3, PHLDA3, head and neck squamous cell carcinoma</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a">grhl3</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a">phlda3</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a">head and neck squamous cell carcinoma</subfield></datafield><datafield tag="653" ind1=" " ind2="0"><subfield code="a">Neoplasms. Tumors. Oncology. 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Expression Analysis of GRHL3 and PHLDA3 in Head and Neck Squamous Cell Carcinoma

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