Low T Cell Responsiveness in the Early Phase of COVID-19 Associates with Progression to Severe Pneumonia in Kidney Transplant Recipients

Kidney transplant (KT) recipients are at increased risk of developing severe forms of COVID-19. Little is known about the immunological mechanisms underlying disease severity in these patients receiving T-cell targeting immunosuppressive drugs. We investigated the relationship between T cell respons...
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Autor*in:	Marion Cremoni [verfasserIn] Sébastien Cuozzo [verfasserIn] Emanuela Martinuzzi [verfasserIn] Susana Barbosa [verfasserIn] Nadia Ben Hassen [verfasserIn] Filippo Massa [verfasserIn] Elisa Demonchy [verfasserIn] Matthieu Durand [verfasserIn] Olivier Thaunat [verfasserIn] Vincent Esnault [verfasserIn] Moglie Le Quintrec [verfasserIn] Sophie Caillard [verfasserIn] Nicolas Glaichenhaus [verfasserIn] Antoine Sicard [verfasserIn]

Format:	E-Artikel
Sprache:	Englisch

Erschienen:	2022

Schlagwörter:	kidney transplantation COVID-19 SARS-CoV-2 T lymphocytes immune responsiveness

Übergeordnetes Werk:	In: Viruses - MDPI AG, 2009, 14(2022), 3, p 542
Übergeordnetes Werk:	volume:14 ; year:2022 ; number:3, p 542

Links:	Link aufrufen Link aufrufen Link aufrufen Journal toc

DOI / URN:	10.3390/v14030542

Katalog-ID:	DOAJ046560203

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spelling	10.3390/v14030542 doi (DE-627)DOAJ046560203 (DE-599)DOAJ37111d438c0a4235b94de3fbe7ea2db4 DE-627 ger DE-627 rakwb eng QR1-502 Marion Cremoni verfasserin aut Low T Cell Responsiveness in the Early Phase of COVID-19 Associates with Progression to Severe Pneumonia in Kidney Transplant Recipients 2022 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Kidney transplant (KT) recipients are at increased risk of developing severe forms of COVID-19. Little is known about the immunological mechanisms underlying disease severity in these patients receiving T-cell targeting immunosuppressive drugs. We investigated the relationship between T cell responsiveness at the beginning of the infection and the risk of subsequent progression to respiratory failure. We performed a multicentric prospective study in KT recipients with a positive RT-PCR COVID-19 test and only mild symptoms at inclusion. Blood samples were collected at baseline in a cell culture system containing T cell stimuli. We assessed T cell responsiveness by computing the ratio between the levels of Th1, Th2, Th17 and Treg cytokines produced after polyclonal stimulation and the number of blood lymphocytes. We then used an unsupervised classification approach to stratify patients into low and high T cell responders and a penalized logistic regression to evaluate the association between T cell responsiveness and progression to severe pneumonia. Forty-five patients were included. All patients who progressed to severe pneumonia (24.4%, n = 11) were low T cell responders at baseline (<i<p</i< = 0.01). In multivariate analysis, low T cell responsiveness at baseline was the main risk factor for subsequent progression to severe pneumonia. This study provides novel insights into the mechanisms underlying COVID-19 severity in organ transplant recipients and data of interest to clinicians managing immunosuppressive drugs in these patients. kidney transplantation COVID-19 SARS-CoV-2 T lymphocytes immune responsiveness Microbiology Sébastien Cuozzo verfasserin aut Emanuela Martinuzzi verfasserin aut Susana Barbosa verfasserin aut Nadia Ben Hassen verfasserin aut Filippo Massa verfasserin aut Elisa Demonchy verfasserin aut Matthieu Durand verfasserin aut Olivier Thaunat verfasserin aut Vincent Esnault verfasserin aut Moglie Le Quintrec verfasserin aut Sophie Caillard verfasserin aut Nicolas Glaichenhaus verfasserin aut Antoine Sicard verfasserin aut In Viruses MDPI AG, 2009 14(2022), 3, p 542 (DE-627)609775871 (DE-600)2516098-9 19994915 nnns volume:14 year:2022 number:3, p 542 https://doi.org/10.3390/v14030542 kostenfrei https://doaj.org/article/37111d438c0a4235b94de3fbe7ea2db4 kostenfrei https://www.mdpi.com/1999-4915/14/3/542 kostenfrei https://doaj.org/toc/1999-4915 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_2005 GBV_ILN_2009 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2055 GBV_ILN_2111 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 14 2022 3, p 542
allfields_unstemmed	10.3390/v14030542 doi (DE-627)DOAJ046560203 (DE-599)DOAJ37111d438c0a4235b94de3fbe7ea2db4 DE-627 ger DE-627 rakwb eng QR1-502 Marion Cremoni verfasserin aut Low T Cell Responsiveness in the Early Phase of COVID-19 Associates with Progression to Severe Pneumonia in Kidney Transplant Recipients 2022 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Kidney transplant (KT) recipients are at increased risk of developing severe forms of COVID-19. Little is known about the immunological mechanisms underlying disease severity in these patients receiving T-cell targeting immunosuppressive drugs. We investigated the relationship between T cell responsiveness at the beginning of the infection and the risk of subsequent progression to respiratory failure. We performed a multicentric prospective study in KT recipients with a positive RT-PCR COVID-19 test and only mild symptoms at inclusion. Blood samples were collected at baseline in a cell culture system containing T cell stimuli. We assessed T cell responsiveness by computing the ratio between the levels of Th1, Th2, Th17 and Treg cytokines produced after polyclonal stimulation and the number of blood lymphocytes. We then used an unsupervised classification approach to stratify patients into low and high T cell responders and a penalized logistic regression to evaluate the association between T cell responsiveness and progression to severe pneumonia. Forty-five patients were included. All patients who progressed to severe pneumonia (24.4%, n = 11) were low T cell responders at baseline (<i<p</i< = 0.01). In multivariate analysis, low T cell responsiveness at baseline was the main risk factor for subsequent progression to severe pneumonia. This study provides novel insights into the mechanisms underlying COVID-19 severity in organ transplant recipients and data of interest to clinicians managing immunosuppressive drugs in these patients. kidney transplantation COVID-19 SARS-CoV-2 T lymphocytes immune responsiveness Microbiology Sébastien Cuozzo verfasserin aut Emanuela Martinuzzi verfasserin aut Susana Barbosa verfasserin aut Nadia Ben Hassen verfasserin aut Filippo Massa verfasserin aut Elisa Demonchy verfasserin aut Matthieu Durand verfasserin aut Olivier Thaunat verfasserin aut Vincent Esnault verfasserin aut Moglie Le Quintrec verfasserin aut Sophie Caillard verfasserin aut Nicolas Glaichenhaus verfasserin aut Antoine Sicard verfasserin aut In Viruses MDPI AG, 2009 14(2022), 3, p 542 (DE-627)609775871 (DE-600)2516098-9 19994915 nnns volume:14 year:2022 number:3, p 542 https://doi.org/10.3390/v14030542 kostenfrei https://doaj.org/article/37111d438c0a4235b94de3fbe7ea2db4 kostenfrei https://www.mdpi.com/1999-4915/14/3/542 kostenfrei https://doaj.org/toc/1999-4915 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_2005 GBV_ILN_2009 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2055 GBV_ILN_2111 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 14 2022 3, p 542
allfieldsGer	10.3390/v14030542 doi (DE-627)DOAJ046560203 (DE-599)DOAJ37111d438c0a4235b94de3fbe7ea2db4 DE-627 ger DE-627 rakwb eng QR1-502 Marion Cremoni verfasserin aut Low T Cell Responsiveness in the Early Phase of COVID-19 Associates with Progression to Severe Pneumonia in Kidney Transplant Recipients 2022 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Kidney transplant (KT) recipients are at increased risk of developing severe forms of COVID-19. Little is known about the immunological mechanisms underlying disease severity in these patients receiving T-cell targeting immunosuppressive drugs. We investigated the relationship between T cell responsiveness at the beginning of the infection and the risk of subsequent progression to respiratory failure. We performed a multicentric prospective study in KT recipients with a positive RT-PCR COVID-19 test and only mild symptoms at inclusion. Blood samples were collected at baseline in a cell culture system containing T cell stimuli. We assessed T cell responsiveness by computing the ratio between the levels of Th1, Th2, Th17 and Treg cytokines produced after polyclonal stimulation and the number of blood lymphocytes. We then used an unsupervised classification approach to stratify patients into low and high T cell responders and a penalized logistic regression to evaluate the association between T cell responsiveness and progression to severe pneumonia. Forty-five patients were included. All patients who progressed to severe pneumonia (24.4%, n = 11) were low T cell responders at baseline (<i<p</i< = 0.01). In multivariate analysis, low T cell responsiveness at baseline was the main risk factor for subsequent progression to severe pneumonia. This study provides novel insights into the mechanisms underlying COVID-19 severity in organ transplant recipients and data of interest to clinicians managing immunosuppressive drugs in these patients. kidney transplantation COVID-19 SARS-CoV-2 T lymphocytes immune responsiveness Microbiology Sébastien Cuozzo verfasserin aut Emanuela Martinuzzi verfasserin aut Susana Barbosa verfasserin aut Nadia Ben Hassen verfasserin aut Filippo Massa verfasserin aut Elisa Demonchy verfasserin aut Matthieu Durand verfasserin aut Olivier Thaunat verfasserin aut Vincent Esnault verfasserin aut Moglie Le Quintrec verfasserin aut Sophie Caillard verfasserin aut Nicolas Glaichenhaus verfasserin aut Antoine Sicard verfasserin aut In Viruses MDPI AG, 2009 14(2022), 3, p 542 (DE-627)609775871 (DE-600)2516098-9 19994915 nnns volume:14 year:2022 number:3, p 542 https://doi.org/10.3390/v14030542 kostenfrei https://doaj.org/article/37111d438c0a4235b94de3fbe7ea2db4 kostenfrei https://www.mdpi.com/1999-4915/14/3/542 kostenfrei https://doaj.org/toc/1999-4915 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_2005 GBV_ILN_2009 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2055 GBV_ILN_2111 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 14 2022 3, p 542
allfieldsSound	10.3390/v14030542 doi (DE-627)DOAJ046560203 (DE-599)DOAJ37111d438c0a4235b94de3fbe7ea2db4 DE-627 ger DE-627 rakwb eng QR1-502 Marion Cremoni verfasserin aut Low T Cell Responsiveness in the Early Phase of COVID-19 Associates with Progression to Severe Pneumonia in Kidney Transplant Recipients 2022 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Kidney transplant (KT) recipients are at increased risk of developing severe forms of COVID-19. Little is known about the immunological mechanisms underlying disease severity in these patients receiving T-cell targeting immunosuppressive drugs. We investigated the relationship between T cell responsiveness at the beginning of the infection and the risk of subsequent progression to respiratory failure. We performed a multicentric prospective study in KT recipients with a positive RT-PCR COVID-19 test and only mild symptoms at inclusion. Blood samples were collected at baseline in a cell culture system containing T cell stimuli. We assessed T cell responsiveness by computing the ratio between the levels of Th1, Th2, Th17 and Treg cytokines produced after polyclonal stimulation and the number of blood lymphocytes. We then used an unsupervised classification approach to stratify patients into low and high T cell responders and a penalized logistic regression to evaluate the association between T cell responsiveness and progression to severe pneumonia. Forty-five patients were included. All patients who progressed to severe pneumonia (24.4%, n = 11) were low T cell responders at baseline (<i<p</i< = 0.01). In multivariate analysis, low T cell responsiveness at baseline was the main risk factor for subsequent progression to severe pneumonia. This study provides novel insights into the mechanisms underlying COVID-19 severity in organ transplant recipients and data of interest to clinicians managing immunosuppressive drugs in these patients. kidney transplantation COVID-19 SARS-CoV-2 T lymphocytes immune responsiveness Microbiology Sébastien Cuozzo verfasserin aut Emanuela Martinuzzi verfasserin aut Susana Barbosa verfasserin aut Nadia Ben Hassen verfasserin aut Filippo Massa verfasserin aut Elisa Demonchy verfasserin aut Matthieu Durand verfasserin aut Olivier Thaunat verfasserin aut Vincent Esnault verfasserin aut Moglie Le Quintrec verfasserin aut Sophie Caillard verfasserin aut Nicolas Glaichenhaus verfasserin aut Antoine Sicard verfasserin aut In Viruses MDPI AG, 2009 14(2022), 3, p 542 (DE-627)609775871 (DE-600)2516098-9 19994915 nnns volume:14 year:2022 number:3, p 542 https://doi.org/10.3390/v14030542 kostenfrei https://doaj.org/article/37111d438c0a4235b94de3fbe7ea2db4 kostenfrei https://www.mdpi.com/1999-4915/14/3/542 kostenfrei https://doaj.org/toc/1999-4915 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_2005 GBV_ILN_2009 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2055 GBV_ILN_2111 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 14 2022 3, p 542
language	English
source	In Viruses 14(2022), 3, p 542 volume:14 year:2022 number:3, p 542
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authorswithroles_txt_mv	Marion Cremoni @@aut@@ Sébastien Cuozzo @@aut@@ Emanuela Martinuzzi @@aut@@ Susana Barbosa @@aut@@ Nadia Ben Hassen @@aut@@ Filippo Massa @@aut@@ Elisa Demonchy @@aut@@ Matthieu Durand @@aut@@ Olivier Thaunat @@aut@@ Vincent Esnault @@aut@@ Moglie Le Quintrec @@aut@@ Sophie Caillard @@aut@@ Nicolas Glaichenhaus @@aut@@ Antoine Sicard @@aut@@
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callnumber-first	Q - Science
author	Marion Cremoni
spellingShingle	Marion Cremoni misc QR1-502 misc kidney transplantation misc COVID-19 misc SARS-CoV-2 misc T lymphocytes misc immune responsiveness misc Microbiology Low T Cell Responsiveness in the Early Phase of COVID-19 Associates with Progression to Severe Pneumonia in Kidney Transplant Recipients
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topic_title	QR1-502 Low T Cell Responsiveness in the Early Phase of COVID-19 Associates with Progression to Severe Pneumonia in Kidney Transplant Recipients kidney transplantation COVID-19 SARS-CoV-2 T lymphocytes immune responsiveness
topic	misc QR1-502 misc kidney transplantation misc COVID-19 misc SARS-CoV-2 misc T lymphocytes misc immune responsiveness misc Microbiology
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title	Low T Cell Responsiveness in the Early Phase of COVID-19 Associates with Progression to Severe Pneumonia in Kidney Transplant Recipients
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author_browse	Marion Cremoni Sébastien Cuozzo Emanuela Martinuzzi Susana Barbosa Nadia Ben Hassen Filippo Massa Elisa Demonchy Matthieu Durand Olivier Thaunat Vincent Esnault Moglie Le Quintrec Sophie Caillard Nicolas Glaichenhaus Antoine Sicard
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title_sort	low t cell responsiveness in the early phase of covid-19 associates with progression to severe pneumonia in kidney transplant recipients
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title_auth	Low T Cell Responsiveness in the Early Phase of COVID-19 Associates with Progression to Severe Pneumonia in Kidney Transplant Recipients
abstract	Kidney transplant (KT) recipients are at increased risk of developing severe forms of COVID-19. Little is known about the immunological mechanisms underlying disease severity in these patients receiving T-cell targeting immunosuppressive drugs. We investigated the relationship between T cell responsiveness at the beginning of the infection and the risk of subsequent progression to respiratory failure. We performed a multicentric prospective study in KT recipients with a positive RT-PCR COVID-19 test and only mild symptoms at inclusion. Blood samples were collected at baseline in a cell culture system containing T cell stimuli. We assessed T cell responsiveness by computing the ratio between the levels of Th1, Th2, Th17 and Treg cytokines produced after polyclonal stimulation and the number of blood lymphocytes. We then used an unsupervised classification approach to stratify patients into low and high T cell responders and a penalized logistic regression to evaluate the association between T cell responsiveness and progression to severe pneumonia. Forty-five patients were included. All patients who progressed to severe pneumonia (24.4%, n = 11) were low T cell responders at baseline (<i<p</i< = 0.01). In multivariate analysis, low T cell responsiveness at baseline was the main risk factor for subsequent progression to severe pneumonia. This study provides novel insights into the mechanisms underlying COVID-19 severity in organ transplant recipients and data of interest to clinicians managing immunosuppressive drugs in these patients.
abstractGer	Kidney transplant (KT) recipients are at increased risk of developing severe forms of COVID-19. Little is known about the immunological mechanisms underlying disease severity in these patients receiving T-cell targeting immunosuppressive drugs. We investigated the relationship between T cell responsiveness at the beginning of the infection and the risk of subsequent progression to respiratory failure. We performed a multicentric prospective study in KT recipients with a positive RT-PCR COVID-19 test and only mild symptoms at inclusion. Blood samples were collected at baseline in a cell culture system containing T cell stimuli. We assessed T cell responsiveness by computing the ratio between the levels of Th1, Th2, Th17 and Treg cytokines produced after polyclonal stimulation and the number of blood lymphocytes. We then used an unsupervised classification approach to stratify patients into low and high T cell responders and a penalized logistic regression to evaluate the association between T cell responsiveness and progression to severe pneumonia. Forty-five patients were included. All patients who progressed to severe pneumonia (24.4%, n = 11) were low T cell responders at baseline (<i<p</i< = 0.01). In multivariate analysis, low T cell responsiveness at baseline was the main risk factor for subsequent progression to severe pneumonia. This study provides novel insights into the mechanisms underlying COVID-19 severity in organ transplant recipients and data of interest to clinicians managing immunosuppressive drugs in these patients.
abstract_unstemmed	Kidney transplant (KT) recipients are at increased risk of developing severe forms of COVID-19. Little is known about the immunological mechanisms underlying disease severity in these patients receiving T-cell targeting immunosuppressive drugs. We investigated the relationship between T cell responsiveness at the beginning of the infection and the risk of subsequent progression to respiratory failure. We performed a multicentric prospective study in KT recipients with a positive RT-PCR COVID-19 test and only mild symptoms at inclusion. Blood samples were collected at baseline in a cell culture system containing T cell stimuli. We assessed T cell responsiveness by computing the ratio between the levels of Th1, Th2, Th17 and Treg cytokines produced after polyclonal stimulation and the number of blood lymphocytes. We then used an unsupervised classification approach to stratify patients into low and high T cell responders and a penalized logistic regression to evaluate the association between T cell responsiveness and progression to severe pneumonia. Forty-five patients were included. All patients who progressed to severe pneumonia (24.4%, n = 11) were low T cell responders at baseline (<i<p</i< = 0.01). In multivariate analysis, low T cell responsiveness at baseline was the main risk factor for subsequent progression to severe pneumonia. This study provides novel insights into the mechanisms underlying COVID-19 severity in organ transplant recipients and data of interest to clinicians managing immunosuppressive drugs in these patients.
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container_issue	3, p 542
title_short	Low T Cell Responsiveness in the Early Phase of COVID-19 Associates with Progression to Severe Pneumonia in Kidney Transplant Recipients
url	https://doi.org/10.3390/v14030542 https://doaj.org/article/37111d438c0a4235b94de3fbe7ea2db4 https://www.mdpi.com/1999-4915/14/3/542 https://doaj.org/toc/1999-4915
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author2	Sébastien Cuozzo Emanuela Martinuzzi Susana Barbosa Nadia Ben Hassen Filippo Massa Elisa Demonchy Matthieu Durand Olivier Thaunat Vincent Esnault Moglie Le Quintrec Sophie Caillard Nicolas Glaichenhaus Antoine Sicard
author2Str	Sébastien Cuozzo Emanuela Martinuzzi Susana Barbosa Nadia Ben Hassen Filippo Massa Elisa Demonchy Matthieu Durand Olivier Thaunat Vincent Esnault Moglie Le Quintrec Sophie Caillard Nicolas Glaichenhaus Antoine Sicard
ppnlink	609775871
callnumber-subject	QR - Microbiology
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doi_str	10.3390/v14030542
callnumber-a	QR1-502
up_date	2024-07-03T21:20:12.976Z
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Little is known about the immunological mechanisms underlying disease severity in these patients receiving T-cell targeting immunosuppressive drugs. We investigated the relationship between T cell responsiveness at the beginning of the infection and the risk of subsequent progression to respiratory failure. We performed a multicentric prospective study in KT recipients with a positive RT-PCR COVID-19 test and only mild symptoms at inclusion. Blood samples were collected at baseline in a cell culture system containing T cell stimuli. We assessed T cell responsiveness by computing the ratio between the levels of Th1, Th2, Th17 and Treg cytokines produced after polyclonal stimulation and the number of blood lymphocytes. We then used an unsupervised classification approach to stratify patients into low and high T cell responders and a penalized logistic regression to evaluate the association between T cell responsiveness and progression to severe pneumonia. 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Low T Cell Responsiveness in the Early Phase of COVID-19 Associates with Progression to Severe Pneumonia in Kidney Transplant Recipients

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