Enhanced Th17 Responses in Patients with Autoimmune Hepatitis

BACKGROUND T cells are major players in chronic inflammatory diseases such as autoimmune hepatitis (AIH). However, it is not clear which subset of T cells participates in the pathophysiology of the disease. The aim of this study was to assess the expression profile of signature transcription factor...
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Autor*in:	Farinaz Behfarjam [verfasserIn] Siavash Nasseri-Moghaddam [verfasserIn] Zohreh Jadali [verfasserIn]

Format:	E-Artikel
Sprache:	Englisch

Erschienen:	2019

Schlagwörter:	Autoimmune hepatitis Autoimmunity-Gene Expression Profiling

Übergeordnetes Werk:	In: Middle East Journal of Digestive Diseases - Iranian Association of Gastroenterology and Hepatology, Shiraz University of Medical Sciences, 2019, 11(2019), 2, Seite 98-103
Übergeordnetes Werk:	volume:11 ; year:2019 ; number:2 ; pages:98-103

Links:	Link aufrufen Link aufrufen Link aufrufen Journal toc Journal toc

DOI / URN:	10.15171/mejdd.2018.134

Katalog-ID:	DOAJ046596216

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520			\|a BACKGROUND T cells are major players in chronic inflammatory diseases such as autoimmune hepatitis (AIH). However, it is not clear which subset of T cells participates in the pathophysiology of the disease. The aim of this study was to assess the expression profile of signature transcription factor and cytokines of T helper 17 (Th17) cells in patients with AIH. METHODS A total of 24 patients with AIH and 24 normal subjects were recruited in the study. Comparison of gene expression patterns between the patients and normal subjects was done by quantitative real-time reverse transcriptase polymerase chain reaction (qRT-PCR). RESULTS The results showed that retinoic acid receptor-related orphan receptors gamma (RORɣt), interleukin-17A (IL-17A), and interleukin-22 (IL-22) mRNA expression were increased greatly in the patients group compared with the normal controls group (p < 0.05). CONCLUSION Deregulated production of Th17-related molecules may be associated with the pathogenesis of AIH.
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allfields	10.15171/mejdd.2018.134 doi (DE-627)DOAJ046596216 (DE-599)DOAJ8dc4dafbd3b44215a9df8c69129798c7 DE-627 ger DE-627 rakwb eng Farinaz Behfarjam verfasserin aut Enhanced Th17 Responses in Patients with Autoimmune Hepatitis 2019 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier BACKGROUND T cells are major players in chronic inflammatory diseases such as autoimmune hepatitis (AIH). However, it is not clear which subset of T cells participates in the pathophysiology of the disease. The aim of this study was to assess the expression profile of signature transcription factor and cytokines of T helper 17 (Th17) cells in patients with AIH. METHODS A total of 24 patients with AIH and 24 normal subjects were recruited in the study. Comparison of gene expression patterns between the patients and normal subjects was done by quantitative real-time reverse transcriptase polymerase chain reaction (qRT-PCR). RESULTS The results showed that retinoic acid receptor-related orphan receptors gamma (RORɣt), interleukin-17A (IL-17A), and interleukin-22 (IL-22) mRNA expression were increased greatly in the patients group compared with the normal controls group (p < 0.05). CONCLUSION Deregulated production of Th17-related molecules may be associated with the pathogenesis of AIH. Autoimmune hepatitis Autoimmunity-Gene Expression Profiling Medicine R Siavash Nasseri-Moghaddam verfasserin aut Zohreh Jadali verfasserin aut In Middle East Journal of Digestive Diseases Iranian Association of Gastroenterology and Hepatology, Shiraz University of Medical Sciences, 2019 11(2019), 2, Seite 98-103 (DE-627)66684965X (DE-600)2623796-9 20085249 nnns volume:11 year:2019 number:2 pages:98-103 https://doi.org/10.15171/mejdd.2018.134 kostenfrei https://doaj.org/article/8dc4dafbd3b44215a9df8c69129798c7 kostenfrei http://www.mejdd.org/index.php/mejdd/article/view/1984 kostenfrei https://doaj.org/toc/2008-5230 Journal toc kostenfrei https://doaj.org/toc/2008-5249 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ SSG-OLC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_150 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2005 GBV_ILN_2009 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2055 GBV_ILN_2106 GBV_ILN_2111 GBV_ILN_2232 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 11 2019 2 98-103
spelling	10.15171/mejdd.2018.134 doi (DE-627)DOAJ046596216 (DE-599)DOAJ8dc4dafbd3b44215a9df8c69129798c7 DE-627 ger DE-627 rakwb eng Farinaz Behfarjam verfasserin aut Enhanced Th17 Responses in Patients with Autoimmune Hepatitis 2019 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier BACKGROUND T cells are major players in chronic inflammatory diseases such as autoimmune hepatitis (AIH). However, it is not clear which subset of T cells participates in the pathophysiology of the disease. The aim of this study was to assess the expression profile of signature transcription factor and cytokines of T helper 17 (Th17) cells in patients with AIH. METHODS A total of 24 patients with AIH and 24 normal subjects were recruited in the study. Comparison of gene expression patterns between the patients and normal subjects was done by quantitative real-time reverse transcriptase polymerase chain reaction (qRT-PCR). RESULTS The results showed that retinoic acid receptor-related orphan receptors gamma (RORɣt), interleukin-17A (IL-17A), and interleukin-22 (IL-22) mRNA expression were increased greatly in the patients group compared with the normal controls group (p < 0.05). CONCLUSION Deregulated production of Th17-related molecules may be associated with the pathogenesis of AIH. Autoimmune hepatitis Autoimmunity-Gene Expression Profiling Medicine R Siavash Nasseri-Moghaddam verfasserin aut Zohreh Jadali verfasserin aut In Middle East Journal of Digestive Diseases Iranian Association of Gastroenterology and Hepatology, Shiraz University of Medical Sciences, 2019 11(2019), 2, Seite 98-103 (DE-627)66684965X (DE-600)2623796-9 20085249 nnns volume:11 year:2019 number:2 pages:98-103 https://doi.org/10.15171/mejdd.2018.134 kostenfrei https://doaj.org/article/8dc4dafbd3b44215a9df8c69129798c7 kostenfrei http://www.mejdd.org/index.php/mejdd/article/view/1984 kostenfrei https://doaj.org/toc/2008-5230 Journal toc kostenfrei https://doaj.org/toc/2008-5249 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ SSG-OLC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_150 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2005 GBV_ILN_2009 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2055 GBV_ILN_2106 GBV_ILN_2111 GBV_ILN_2232 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 11 2019 2 98-103
allfields_unstemmed	10.15171/mejdd.2018.134 doi (DE-627)DOAJ046596216 (DE-599)DOAJ8dc4dafbd3b44215a9df8c69129798c7 DE-627 ger DE-627 rakwb eng Farinaz Behfarjam verfasserin aut Enhanced Th17 Responses in Patients with Autoimmune Hepatitis 2019 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier BACKGROUND T cells are major players in chronic inflammatory diseases such as autoimmune hepatitis (AIH). However, it is not clear which subset of T cells participates in the pathophysiology of the disease. The aim of this study was to assess the expression profile of signature transcription factor and cytokines of T helper 17 (Th17) cells in patients with AIH. METHODS A total of 24 patients with AIH and 24 normal subjects were recruited in the study. Comparison of gene expression patterns between the patients and normal subjects was done by quantitative real-time reverse transcriptase polymerase chain reaction (qRT-PCR). RESULTS The results showed that retinoic acid receptor-related orphan receptors gamma (RORɣt), interleukin-17A (IL-17A), and interleukin-22 (IL-22) mRNA expression were increased greatly in the patients group compared with the normal controls group (p < 0.05). CONCLUSION Deregulated production of Th17-related molecules may be associated with the pathogenesis of AIH. Autoimmune hepatitis Autoimmunity-Gene Expression Profiling Medicine R Siavash Nasseri-Moghaddam verfasserin aut Zohreh Jadali verfasserin aut In Middle East Journal of Digestive Diseases Iranian Association of Gastroenterology and Hepatology, Shiraz University of Medical Sciences, 2019 11(2019), 2, Seite 98-103 (DE-627)66684965X (DE-600)2623796-9 20085249 nnns volume:11 year:2019 number:2 pages:98-103 https://doi.org/10.15171/mejdd.2018.134 kostenfrei https://doaj.org/article/8dc4dafbd3b44215a9df8c69129798c7 kostenfrei http://www.mejdd.org/index.php/mejdd/article/view/1984 kostenfrei https://doaj.org/toc/2008-5230 Journal toc kostenfrei https://doaj.org/toc/2008-5249 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ SSG-OLC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_150 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2005 GBV_ILN_2009 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2055 GBV_ILN_2106 GBV_ILN_2111 GBV_ILN_2232 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 11 2019 2 98-103
allfieldsGer	10.15171/mejdd.2018.134 doi (DE-627)DOAJ046596216 (DE-599)DOAJ8dc4dafbd3b44215a9df8c69129798c7 DE-627 ger DE-627 rakwb eng Farinaz Behfarjam verfasserin aut Enhanced Th17 Responses in Patients with Autoimmune Hepatitis 2019 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier BACKGROUND T cells are major players in chronic inflammatory diseases such as autoimmune hepatitis (AIH). However, it is not clear which subset of T cells participates in the pathophysiology of the disease. The aim of this study was to assess the expression profile of signature transcription factor and cytokines of T helper 17 (Th17) cells in patients with AIH. METHODS A total of 24 patients with AIH and 24 normal subjects were recruited in the study. Comparison of gene expression patterns between the patients and normal subjects was done by quantitative real-time reverse transcriptase polymerase chain reaction (qRT-PCR). RESULTS The results showed that retinoic acid receptor-related orphan receptors gamma (RORɣt), interleukin-17A (IL-17A), and interleukin-22 (IL-22) mRNA expression were increased greatly in the patients group compared with the normal controls group (p < 0.05). CONCLUSION Deregulated production of Th17-related molecules may be associated with the pathogenesis of AIH. Autoimmune hepatitis Autoimmunity-Gene Expression Profiling Medicine R Siavash Nasseri-Moghaddam verfasserin aut Zohreh Jadali verfasserin aut In Middle East Journal of Digestive Diseases Iranian Association of Gastroenterology and Hepatology, Shiraz University of Medical Sciences, 2019 11(2019), 2, Seite 98-103 (DE-627)66684965X (DE-600)2623796-9 20085249 nnns volume:11 year:2019 number:2 pages:98-103 https://doi.org/10.15171/mejdd.2018.134 kostenfrei https://doaj.org/article/8dc4dafbd3b44215a9df8c69129798c7 kostenfrei http://www.mejdd.org/index.php/mejdd/article/view/1984 kostenfrei https://doaj.org/toc/2008-5230 Journal toc kostenfrei https://doaj.org/toc/2008-5249 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ SSG-OLC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_150 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2005 GBV_ILN_2009 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2055 GBV_ILN_2106 GBV_ILN_2111 GBV_ILN_2232 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 11 2019 2 98-103
allfieldsSound	10.15171/mejdd.2018.134 doi (DE-627)DOAJ046596216 (DE-599)DOAJ8dc4dafbd3b44215a9df8c69129798c7 DE-627 ger DE-627 rakwb eng Farinaz Behfarjam verfasserin aut Enhanced Th17 Responses in Patients with Autoimmune Hepatitis 2019 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier BACKGROUND T cells are major players in chronic inflammatory diseases such as autoimmune hepatitis (AIH). However, it is not clear which subset of T cells participates in the pathophysiology of the disease. The aim of this study was to assess the expression profile of signature transcription factor and cytokines of T helper 17 (Th17) cells in patients with AIH. METHODS A total of 24 patients with AIH and 24 normal subjects were recruited in the study. Comparison of gene expression patterns between the patients and normal subjects was done by quantitative real-time reverse transcriptase polymerase chain reaction (qRT-PCR). RESULTS The results showed that retinoic acid receptor-related orphan receptors gamma (RORɣt), interleukin-17A (IL-17A), and interleukin-22 (IL-22) mRNA expression were increased greatly in the patients group compared with the normal controls group (p < 0.05). CONCLUSION Deregulated production of Th17-related molecules may be associated with the pathogenesis of AIH. Autoimmune hepatitis Autoimmunity-Gene Expression Profiling Medicine R Siavash Nasseri-Moghaddam verfasserin aut Zohreh Jadali verfasserin aut In Middle East Journal of Digestive Diseases Iranian Association of Gastroenterology and Hepatology, Shiraz University of Medical Sciences, 2019 11(2019), 2, Seite 98-103 (DE-627)66684965X (DE-600)2623796-9 20085249 nnns volume:11 year:2019 number:2 pages:98-103 https://doi.org/10.15171/mejdd.2018.134 kostenfrei https://doaj.org/article/8dc4dafbd3b44215a9df8c69129798c7 kostenfrei http://www.mejdd.org/index.php/mejdd/article/view/1984 kostenfrei https://doaj.org/toc/2008-5230 Journal toc kostenfrei https://doaj.org/toc/2008-5249 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ SSG-OLC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_150 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2005 GBV_ILN_2009 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2055 GBV_ILN_2106 GBV_ILN_2111 GBV_ILN_2232 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 11 2019 2 98-103
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authorswithroles_txt_mv	Farinaz Behfarjam @@aut@@ Siavash Nasseri-Moghaddam @@aut@@ Zohreh Jadali @@aut@@
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However, it is not clear which subset of T cells participates in the pathophysiology of the disease. The aim of this study was to assess the expression profile of signature transcription factor and cytokines of T helper 17 (Th17) cells in patients with AIH. METHODS A total of 24 patients with AIH and 24 normal subjects were recruited in the study. Comparison of gene expression patterns between the patients and normal subjects was done by quantitative real-time reverse transcriptase polymerase chain reaction (qRT-PCR). RESULTS The results showed that retinoic acid receptor-related orphan receptors gamma (RORɣt), interleukin-17A (IL-17A), and interleukin-22 (IL-22) mRNA expression were increased greatly in the patients group compared with the normal controls group (p < 0.05). 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author	Farinaz Behfarjam
spellingShingle	Farinaz Behfarjam misc Autoimmune hepatitis misc Autoimmunity-Gene Expression Profiling misc Medicine misc R Enhanced Th17 Responses in Patients with Autoimmune Hepatitis
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topic_title	Enhanced Th17 Responses in Patients with Autoimmune Hepatitis Autoimmune hepatitis Autoimmunity-Gene Expression Profiling
topic	misc Autoimmune hepatitis misc Autoimmunity-Gene Expression Profiling misc Medicine misc R
topic_unstemmed	misc Autoimmune hepatitis misc Autoimmunity-Gene Expression Profiling misc Medicine misc R
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title	Enhanced Th17 Responses in Patients with Autoimmune Hepatitis
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title_full	Enhanced Th17 Responses in Patients with Autoimmune Hepatitis
author_sort	Farinaz Behfarjam
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author_browse	Farinaz Behfarjam Siavash Nasseri-Moghaddam Zohreh Jadali
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author-letter	Farinaz Behfarjam
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title_sort	enhanced th17 responses in patients with autoimmune hepatitis
title_auth	Enhanced Th17 Responses in Patients with Autoimmune Hepatitis
abstract	BACKGROUND T cells are major players in chronic inflammatory diseases such as autoimmune hepatitis (AIH). However, it is not clear which subset of T cells participates in the pathophysiology of the disease. The aim of this study was to assess the expression profile of signature transcription factor and cytokines of T helper 17 (Th17) cells in patients with AIH. METHODS A total of 24 patients with AIH and 24 normal subjects were recruited in the study. Comparison of gene expression patterns between the patients and normal subjects was done by quantitative real-time reverse transcriptase polymerase chain reaction (qRT-PCR). RESULTS The results showed that retinoic acid receptor-related orphan receptors gamma (RORɣt), interleukin-17A (IL-17A), and interleukin-22 (IL-22) mRNA expression were increased greatly in the patients group compared with the normal controls group (p < 0.05). CONCLUSION Deregulated production of Th17-related molecules may be associated with the pathogenesis of AIH.
abstractGer	BACKGROUND T cells are major players in chronic inflammatory diseases such as autoimmune hepatitis (AIH). However, it is not clear which subset of T cells participates in the pathophysiology of the disease. The aim of this study was to assess the expression profile of signature transcription factor and cytokines of T helper 17 (Th17) cells in patients with AIH. METHODS A total of 24 patients with AIH and 24 normal subjects were recruited in the study. Comparison of gene expression patterns between the patients and normal subjects was done by quantitative real-time reverse transcriptase polymerase chain reaction (qRT-PCR). RESULTS The results showed that retinoic acid receptor-related orphan receptors gamma (RORɣt), interleukin-17A (IL-17A), and interleukin-22 (IL-22) mRNA expression were increased greatly in the patients group compared with the normal controls group (p < 0.05). CONCLUSION Deregulated production of Th17-related molecules may be associated with the pathogenesis of AIH.
abstract_unstemmed	BACKGROUND T cells are major players in chronic inflammatory diseases such as autoimmune hepatitis (AIH). However, it is not clear which subset of T cells participates in the pathophysiology of the disease. The aim of this study was to assess the expression profile of signature transcription factor and cytokines of T helper 17 (Th17) cells in patients with AIH. METHODS A total of 24 patients with AIH and 24 normal subjects were recruited in the study. Comparison of gene expression patterns between the patients and normal subjects was done by quantitative real-time reverse transcriptase polymerase chain reaction (qRT-PCR). RESULTS The results showed that retinoic acid receptor-related orphan receptors gamma (RORɣt), interleukin-17A (IL-17A), and interleukin-22 (IL-22) mRNA expression were increased greatly in the patients group compared with the normal controls group (p < 0.05). CONCLUSION Deregulated production of Th17-related molecules may be associated with the pathogenesis of AIH.
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title_short	Enhanced Th17 Responses in Patients with Autoimmune Hepatitis
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up_date	2024-07-03T21:32:30.153Z
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