Physiology-Enhanced Data Analytics to Evaluate the Effect of Altitude on Intraocular Pressure and Ocular Hemodynamics

Altitude affects intraocular pressure (IOP); however, the underlying mechanisms involved and its relationship with ocular hemodynamics remain unknown. Herein, a validated mathematical modeling approach was used for a physiology-enhanced (<i<pe-</i<) analysis of the Mont Blanc study (MBS)...
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Gespeichert in:

Autor*in:	Alice Verticchio Vercellin [verfasserIn] Alon Harris [verfasserIn] Aditya Belamkar [verfasserIn] Ryan Zukerman [verfasserIn] Lucia Carichino [verfasserIn] Marcela Szopos [verfasserIn] Brent Siesky [verfasserIn] Luciano Quaranta [verfasserIn] Carlo Bruttini [verfasserIn] Francesco Oddone [verfasserIn] Ivano Riva [verfasserIn] Giovanna Guidoboni [verfasserIn]

Format:	E-Artikel
Sprache:	Englisch

Erschienen:	2022

Schlagwörter:	glaucoma altitude intraocular pressure mathematical modeling physiology-enhanced data analytics

Übergeordnetes Werk:	In: Photonics - MDPI AG, 2014, 9(2022), 3, p 158
Übergeordnetes Werk:	volume:9 ; year:2022 ; number:3, p 158

Links:	Link aufrufen Link aufrufen Link aufrufen Journal toc

DOI / URN:	10.3390/photonics9030158

Katalog-ID:	DOAJ046807268

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520			\|a Altitude affects intraocular pressure (IOP); however, the underlying mechanisms involved and its relationship with ocular hemodynamics remain unknown. Herein, a validated mathematical modeling approach was used for a physiology-enhanced (<i<pe-</i<) analysis of the Mont Blanc study (MBS), estimating the effects of altitude on IOP, blood pressure (BP), and retinal hemodynamics. In the MBS, IOP and BP were measured in 33 healthy volunteers at 77 and 3466 m above sea level. <i<Pe-retinal hemodynamics</i< analysis predicted a statistically significant increase (<i<p</i< < 0.001) in the model predicted blood flow and pressure within the retinal vasculature following increases in systemic BP with altitude measured in the MBS. Decreased IOP with altitude led to a non-monotonic behavior of the model predicted retinal vascular resistances, with significant decreases in the resistance of the central retinal artery (<i<p</i< < 0.001) and retinal venules (<i<p</i< = 0.003) and a non-significant increase in the resistance in the central retinal vein (<i<p</i< = 0.253). <i<Pe-aqueous humor</i< analysis showed that a decrease in osmotic pressure difference (OPD) may underlie the difference in IOP measured at different altitudes in the MBS. Our analysis suggests that venules bear the significant portion of the IOP pressure load within the ocular vasculature, and that OPD plays an important role in regulating IOP with changes in altitude.
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spelling	10.3390/photonics9030158 doi (DE-627)DOAJ046807268 (DE-599)DOAJ8c7e70baf1504a10860bf42fc3eb7dc8 DE-627 ger DE-627 rakwb eng TA1501-1820 Alice Verticchio Vercellin verfasserin aut Physiology-Enhanced Data Analytics to Evaluate the Effect of Altitude on Intraocular Pressure and Ocular Hemodynamics 2022 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Altitude affects intraocular pressure (IOP); however, the underlying mechanisms involved and its relationship with ocular hemodynamics remain unknown. Herein, a validated mathematical modeling approach was used for a physiology-enhanced (<i<pe-</i<) analysis of the Mont Blanc study (MBS), estimating the effects of altitude on IOP, blood pressure (BP), and retinal hemodynamics. In the MBS, IOP and BP were measured in 33 healthy volunteers at 77 and 3466 m above sea level. <i<Pe-retinal hemodynamics</i< analysis predicted a statistically significant increase (<i<p</i< < 0.001) in the model predicted blood flow and pressure within the retinal vasculature following increases in systemic BP with altitude measured in the MBS. Decreased IOP with altitude led to a non-monotonic behavior of the model predicted retinal vascular resistances, with significant decreases in the resistance of the central retinal artery (<i<p</i< < 0.001) and retinal venules (<i<p</i< = 0.003) and a non-significant increase in the resistance in the central retinal vein (<i<p</i< = 0.253). <i<Pe-aqueous humor</i< analysis showed that a decrease in osmotic pressure difference (OPD) may underlie the difference in IOP measured at different altitudes in the MBS. Our analysis suggests that venules bear the significant portion of the IOP pressure load within the ocular vasculature, and that OPD plays an important role in regulating IOP with changes in altitude. glaucoma altitude intraocular pressure mathematical modeling physiology-enhanced data analytics Applied optics. Photonics Alon Harris verfasserin aut Aditya Belamkar verfasserin aut Ryan Zukerman verfasserin aut Lucia Carichino verfasserin aut Marcela Szopos verfasserin aut Brent Siesky verfasserin aut Luciano Quaranta verfasserin aut Carlo Bruttini verfasserin aut Francesco Oddone verfasserin aut Ivano Riva verfasserin aut Giovanna Guidoboni verfasserin aut In Photonics MDPI AG, 2014 9(2022), 3, p 158 (DE-627)786192763 (DE-600)2770002-1 23046732 nnns volume:9 year:2022 number:3, p 158 https://doi.org/10.3390/photonics9030158 kostenfrei https://doaj.org/article/8c7e70baf1504a10860bf42fc3eb7dc8 kostenfrei https://www.mdpi.com/2304-6732/9/3/158 kostenfrei https://doaj.org/toc/2304-6732 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_2014 GBV_ILN_2055 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4335 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 9 2022 3, p 158
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allfieldsSound	10.3390/photonics9030158 doi (DE-627)DOAJ046807268 (DE-599)DOAJ8c7e70baf1504a10860bf42fc3eb7dc8 DE-627 ger DE-627 rakwb eng TA1501-1820 Alice Verticchio Vercellin verfasserin aut Physiology-Enhanced Data Analytics to Evaluate the Effect of Altitude on Intraocular Pressure and Ocular Hemodynamics 2022 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Altitude affects intraocular pressure (IOP); however, the underlying mechanisms involved and its relationship with ocular hemodynamics remain unknown. Herein, a validated mathematical modeling approach was used for a physiology-enhanced (<i<pe-</i<) analysis of the Mont Blanc study (MBS), estimating the effects of altitude on IOP, blood pressure (BP), and retinal hemodynamics. In the MBS, IOP and BP were measured in 33 healthy volunteers at 77 and 3466 m above sea level. <i<Pe-retinal hemodynamics</i< analysis predicted a statistically significant increase (<i<p</i< < 0.001) in the model predicted blood flow and pressure within the retinal vasculature following increases in systemic BP with altitude measured in the MBS. Decreased IOP with altitude led to a non-monotonic behavior of the model predicted retinal vascular resistances, with significant decreases in the resistance of the central retinal artery (<i<p</i< < 0.001) and retinal venules (<i<p</i< = 0.003) and a non-significant increase in the resistance in the central retinal vein (<i<p</i< = 0.253). <i<Pe-aqueous humor</i< analysis showed that a decrease in osmotic pressure difference (OPD) may underlie the difference in IOP measured at different altitudes in the MBS. Our analysis suggests that venules bear the significant portion of the IOP pressure load within the ocular vasculature, and that OPD plays an important role in regulating IOP with changes in altitude. glaucoma altitude intraocular pressure mathematical modeling physiology-enhanced data analytics Applied optics. Photonics Alon Harris verfasserin aut Aditya Belamkar verfasserin aut Ryan Zukerman verfasserin aut Lucia Carichino verfasserin aut Marcela Szopos verfasserin aut Brent Siesky verfasserin aut Luciano Quaranta verfasserin aut Carlo Bruttini verfasserin aut Francesco Oddone verfasserin aut Ivano Riva verfasserin aut Giovanna Guidoboni verfasserin aut In Photonics MDPI AG, 2014 9(2022), 3, p 158 (DE-627)786192763 (DE-600)2770002-1 23046732 nnns volume:9 year:2022 number:3, p 158 https://doi.org/10.3390/photonics9030158 kostenfrei https://doaj.org/article/8c7e70baf1504a10860bf42fc3eb7dc8 kostenfrei https://www.mdpi.com/2304-6732/9/3/158 kostenfrei https://doaj.org/toc/2304-6732 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_2014 GBV_ILN_2055 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4335 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 9 2022 3, p 158
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source	In Photonics 9(2022), 3, p 158 volume:9 year:2022 number:3, p 158
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callnumber-first	T - Technology
author	Alice Verticchio Vercellin
spellingShingle	Alice Verticchio Vercellin misc TA1501-1820 misc glaucoma misc altitude misc intraocular pressure misc mathematical modeling misc physiology-enhanced data analytics misc Applied optics. Photonics Physiology-Enhanced Data Analytics to Evaluate the Effect of Altitude on Intraocular Pressure and Ocular Hemodynamics
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topic_title	TA1501-1820 Physiology-Enhanced Data Analytics to Evaluate the Effect of Altitude on Intraocular Pressure and Ocular Hemodynamics glaucoma altitude intraocular pressure mathematical modeling physiology-enhanced data analytics
topic	misc TA1501-1820 misc glaucoma misc altitude misc intraocular pressure misc mathematical modeling misc physiology-enhanced data analytics misc Applied optics. Photonics
topic_unstemmed	misc TA1501-1820 misc glaucoma misc altitude misc intraocular pressure misc mathematical modeling misc physiology-enhanced data analytics misc Applied optics. Photonics
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title	Physiology-Enhanced Data Analytics to Evaluate the Effect of Altitude on Intraocular Pressure and Ocular Hemodynamics
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title_sort	physiology-enhanced data analytics to evaluate the effect of altitude on intraocular pressure and ocular hemodynamics
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title_auth	Physiology-Enhanced Data Analytics to Evaluate the Effect of Altitude on Intraocular Pressure and Ocular Hemodynamics
abstract	Altitude affects intraocular pressure (IOP); however, the underlying mechanisms involved and its relationship with ocular hemodynamics remain unknown. Herein, a validated mathematical modeling approach was used for a physiology-enhanced (<i<pe-</i<) analysis of the Mont Blanc study (MBS), estimating the effects of altitude on IOP, blood pressure (BP), and retinal hemodynamics. In the MBS, IOP and BP were measured in 33 healthy volunteers at 77 and 3466 m above sea level. <i<Pe-retinal hemodynamics</i< analysis predicted a statistically significant increase (<i<p</i< < 0.001) in the model predicted blood flow and pressure within the retinal vasculature following increases in systemic BP with altitude measured in the MBS. Decreased IOP with altitude led to a non-monotonic behavior of the model predicted retinal vascular resistances, with significant decreases in the resistance of the central retinal artery (<i<p</i< < 0.001) and retinal venules (<i<p</i< = 0.003) and a non-significant increase in the resistance in the central retinal vein (<i<p</i< = 0.253). <i<Pe-aqueous humor</i< analysis showed that a decrease in osmotic pressure difference (OPD) may underlie the difference in IOP measured at different altitudes in the MBS. Our analysis suggests that venules bear the significant portion of the IOP pressure load within the ocular vasculature, and that OPD plays an important role in regulating IOP with changes in altitude.
abstractGer	Altitude affects intraocular pressure (IOP); however, the underlying mechanisms involved and its relationship with ocular hemodynamics remain unknown. Herein, a validated mathematical modeling approach was used for a physiology-enhanced (<i<pe-</i<) analysis of the Mont Blanc study (MBS), estimating the effects of altitude on IOP, blood pressure (BP), and retinal hemodynamics. In the MBS, IOP and BP were measured in 33 healthy volunteers at 77 and 3466 m above sea level. <i<Pe-retinal hemodynamics</i< analysis predicted a statistically significant increase (<i<p</i< < 0.001) in the model predicted blood flow and pressure within the retinal vasculature following increases in systemic BP with altitude measured in the MBS. Decreased IOP with altitude led to a non-monotonic behavior of the model predicted retinal vascular resistances, with significant decreases in the resistance of the central retinal artery (<i<p</i< < 0.001) and retinal venules (<i<p</i< = 0.003) and a non-significant increase in the resistance in the central retinal vein (<i<p</i< = 0.253). <i<Pe-aqueous humor</i< analysis showed that a decrease in osmotic pressure difference (OPD) may underlie the difference in IOP measured at different altitudes in the MBS. Our analysis suggests that venules bear the significant portion of the IOP pressure load within the ocular vasculature, and that OPD plays an important role in regulating IOP with changes in altitude.
abstract_unstemmed	Altitude affects intraocular pressure (IOP); however, the underlying mechanisms involved and its relationship with ocular hemodynamics remain unknown. Herein, a validated mathematical modeling approach was used for a physiology-enhanced (<i<pe-</i<) analysis of the Mont Blanc study (MBS), estimating the effects of altitude on IOP, blood pressure (BP), and retinal hemodynamics. In the MBS, IOP and BP were measured in 33 healthy volunteers at 77 and 3466 m above sea level. <i<Pe-retinal hemodynamics</i< analysis predicted a statistically significant increase (<i<p</i< < 0.001) in the model predicted blood flow and pressure within the retinal vasculature following increases in systemic BP with altitude measured in the MBS. Decreased IOP with altitude led to a non-monotonic behavior of the model predicted retinal vascular resistances, with significant decreases in the resistance of the central retinal artery (<i<p</i< < 0.001) and retinal venules (<i<p</i< = 0.003) and a non-significant increase in the resistance in the central retinal vein (<i<p</i< = 0.253). <i<Pe-aqueous humor</i< analysis showed that a decrease in osmotic pressure difference (OPD) may underlie the difference in IOP measured at different altitudes in the MBS. Our analysis suggests that venules bear the significant portion of the IOP pressure load within the ocular vasculature, and that OPD plays an important role in regulating IOP with changes in altitude.
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Herein, a validated mathematical modeling approach was used for a physiology-enhanced (<i<pe-</i<) analysis of the Mont Blanc study (MBS), estimating the effects of altitude on IOP, blood pressure (BP), and retinal hemodynamics. In the MBS, IOP and BP were measured in 33 healthy volunteers at 77 and 3466 m above sea level. <i<Pe-retinal hemodynamics</i< analysis predicted a statistically significant increase (<i<p</i< < 0.001) in the model predicted blood flow and pressure within the retinal vasculature following increases in systemic BP with altitude measured in the MBS. Decreased IOP with altitude led to a non-monotonic behavior of the model predicted retinal vascular resistances, with significant decreases in the resistance of the central retinal artery (<i<p</i< < 0.001) and retinal venules (<i<p</i< = 0.003) and a non-significant increase in the resistance in the central retinal vein (<i<p</i< = 0.253). <i<Pe-aqueous humor</i< analysis showed that a decrease in osmotic pressure difference (OPD) may underlie the difference in IOP measured at different altitudes in the MBS. Our analysis suggests that venules bear the significant portion of the IOP pressure load within the ocular vasculature, and that OPD plays an important role in regulating IOP with changes in altitude.</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a">glaucoma</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a">altitude</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a">intraocular pressure</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a">mathematical modeling</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a">physiology-enhanced data analytics</subfield></datafield><datafield tag="653" ind1=" " ind2="0"><subfield code="a">Applied optics. 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Physiology-Enhanced Data Analytics to Evaluate the Effect of Altitude on Intraocular Pressure and Ocular Hemodynamics

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