Induction of Plasmodium falciparum-specific CD4+ T cells and memory B cells in Gabonese children vaccinated with RTS,S/AS01(E) and RTS,S/AS02(D).

The recombinant circumsporozoite protein (CS) based vaccine, RTS,S, confers protection against Plasmodium falciparum infection in controlled challenge trials and in field studies. The RTS,S recombinant antigen has been formulated with two adjuvant systems, AS01 and AS02, which have both been shown t...
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Autor*in:	Selidji T Agnandji [verfasserIn] Rolf Fendel [verfasserIn] Michaël Mestré [verfasserIn] Michel Janssens [verfasserIn] Johan Vekemans [verfasserIn] Jana Held [verfasserIn] Ferdinand Gnansounou [verfasserIn] Sonja Haertle [verfasserIn] Isabel von Glasenapp [verfasserIn] Sunny Oyakhirome [verfasserIn] Ludovic Mewono [verfasserIn] Philippe Moris [verfasserIn] Marc Lievens [verfasserIn] Marie-Ange Demoitie [verfasserIn] Patrice M Dubois [verfasserIn] Tonya Villafana [verfasserIn] Erik Jongert [verfasserIn] Aurelie Olivier [verfasserIn] Joe Cohen [verfasserIn] Meral Esen [verfasserIn] Peter G Kremsner [verfasserIn] Bertrand Lell [verfasserIn] Benjamin Mordmüller [verfasserIn]

Format:	E-Artikel
Sprache:	Englisch

Erschienen:	2011

Übergeordnetes Werk:	In: PLoS ONE - Public Library of Science (PLoS), 2007, 6(2011), 4, p e18559
Übergeordnetes Werk:	volume:6 ; year:2011 ; number:4, p e18559

Links:	Link aufrufen Link aufrufen Link aufrufen Journal toc

DOI / URN:	10.1371/journal.pone.0018559

Katalog-ID:	DOAJ046838481

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245	1	0	\|a Induction of Plasmodium falciparum-specific CD4+ T cells and memory B cells in Gabonese children vaccinated with RTS,S/AS01(E) and RTS,S/AS02(D).
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520			\|a The recombinant circumsporozoite protein (CS) based vaccine, RTS,S, confers protection against Plasmodium falciparum infection in controlled challenge trials and in field studies. The RTS,S recombinant antigen has been formulated with two adjuvant systems, AS01 and AS02, which have both been shown to induce strong specific antibody responses and CD4 T cell responses in adults. As infants and young children are particularly susceptible to malaria infection and constitute the main target population for a malaria vaccine, we have evaluated the induction of adaptive immune responses in young children living in malaria endemic regions following vaccination with RTS,S/AS01(E) and RTS,S/AS02(D). Our data show that a CS-specific memory B cell response is induced one month after the second and third vaccine dose and that CS-specific antibodies and memory B cells persist up to 12 months after the last vaccine injection. Both formulations also induced low but significant amounts of CS-specific IL-2(+) CD4(+) T cells one month after the second and third vaccine dose, upon short-term in vitro stimulation of whole blood cells with peptides covering the entire CS derived sequence in RTS,S. These results provide evidence that both RTS,S/AS01(E) and RTS,S/AS02(D) induced adaptive immune responses including antibodies, circulating memory B cells and CD4(+) T cells directed against P. falciparum CS protein.ClinicalTrials.gov NCT00307021.
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700	0		\|a Erik Jongert \|e verfasserin \|4 aut
700	0		\|a Aurelie Olivier \|e verfasserin \|4 aut
700	0		\|a Joe Cohen \|e verfasserin \|4 aut
700	0		\|a Meral Esen \|e verfasserin \|4 aut
700	0		\|a Peter G Kremsner \|e verfasserin \|4 aut
700	0		\|a Bertrand Lell \|e verfasserin \|4 aut
700	0		\|a Benjamin Mordmüller \|e verfasserin \|4 aut
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912			\|a GBV_ILN_34
912			\|a GBV_ILN_39
912			\|a GBV_ILN_40
912			\|a GBV_ILN_60
912			\|a GBV_ILN_62
912			\|a GBV_ILN_63
912			\|a GBV_ILN_65
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912			\|a GBV_ILN_70
912			\|a GBV_ILN_73
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912			\|a GBV_ILN_2020
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912			\|a GBV_ILN_2025
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912			\|a GBV_ILN_2038
912			\|a GBV_ILN_2044
912			\|a GBV_ILN_2048
912			\|a GBV_ILN_2050
912			\|a GBV_ILN_2055
912			\|a GBV_ILN_2056
912			\|a GBV_ILN_2057
912			\|a GBV_ILN_2061
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912			\|a GBV_ILN_4125
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912			\|a GBV_ILN_4307
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Indexfelder

author_variant	s t a sta r f rf m m mm m j mj j v jv j h jh f g fg s h sh i v g ivg s o so l m lm p m pm m l ml m a d mad p m d pmd t v tv e j ej a o ao j c jc m e me p g k pgk b l bl b m bm
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publishDate	2011
allfields	10.1371/journal.pone.0018559 doi (DE-627)DOAJ046838481 (DE-599)DOAJ15c7ade9e728478f8dac448f92278a4d DE-627 ger DE-627 rakwb eng Selidji T Agnandji verfasserin aut Induction of Plasmodium falciparum-specific CD4+ T cells and memory B cells in Gabonese children vaccinated with RTS,S/AS01(E) and RTS,S/AS02(D). 2011 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier The recombinant circumsporozoite protein (CS) based vaccine, RTS,S, confers protection against Plasmodium falciparum infection in controlled challenge trials and in field studies. The RTS,S recombinant antigen has been formulated with two adjuvant systems, AS01 and AS02, which have both been shown to induce strong specific antibody responses and CD4 T cell responses in adults. As infants and young children are particularly susceptible to malaria infection and constitute the main target population for a malaria vaccine, we have evaluated the induction of adaptive immune responses in young children living in malaria endemic regions following vaccination with RTS,S/AS01(E) and RTS,S/AS02(D). Our data show that a CS-specific memory B cell response is induced one month after the second and third vaccine dose and that CS-specific antibodies and memory B cells persist up to 12 months after the last vaccine injection. Both formulations also induced low but significant amounts of CS-specific IL-2(+) CD4(+) T cells one month after the second and third vaccine dose, upon short-term in vitro stimulation of whole blood cells with peptides covering the entire CS derived sequence in RTS,S. These results provide evidence that both RTS,S/AS01(E) and RTS,S/AS02(D) induced adaptive immune responses including antibodies, circulating memory B cells and CD4(+) T cells directed against P. falciparum CS protein.ClinicalTrials.gov NCT00307021. Medicine R Science Q Rolf Fendel verfasserin aut Michaël Mestré verfasserin aut Michel Janssens verfasserin aut Johan Vekemans verfasserin aut Jana Held verfasserin aut Ferdinand Gnansounou verfasserin aut Sonja Haertle verfasserin aut Isabel von Glasenapp verfasserin aut Sunny Oyakhirome verfasserin aut Ludovic Mewono verfasserin aut Philippe Moris verfasserin aut Marc Lievens verfasserin aut Marie-Ange Demoitie verfasserin aut Patrice M Dubois verfasserin aut Tonya Villafana verfasserin aut Erik Jongert verfasserin aut Aurelie Olivier verfasserin aut Joe Cohen verfasserin aut Meral Esen verfasserin aut Peter G Kremsner verfasserin aut Bertrand Lell verfasserin aut Benjamin Mordmüller verfasserin aut In PLoS ONE Public Library of Science (PLoS), 2007 6(2011), 4, p e18559 (DE-627)523574592 (DE-600)2267670-3 19326203 nnns volume:6 year:2011 number:4, p e18559 https://doi.org/10.1371/journal.pone.0018559 kostenfrei https://doaj.org/article/15c7ade9e728478f8dac448f92278a4d kostenfrei http://europepmc.org/articles/PMC3073948?pdf=render kostenfrei https://doaj.org/toc/1932-6203 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_34 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_206 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_235 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2031 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2057 GBV_ILN_2061 GBV_ILN_2111 GBV_ILN_2113 GBV_ILN_2190 GBV_ILN_2522 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4335 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 6 2011 4, p e18559
spelling	10.1371/journal.pone.0018559 doi (DE-627)DOAJ046838481 (DE-599)DOAJ15c7ade9e728478f8dac448f92278a4d DE-627 ger DE-627 rakwb eng Selidji T Agnandji verfasserin aut Induction of Plasmodium falciparum-specific CD4+ T cells and memory B cells in Gabonese children vaccinated with RTS,S/AS01(E) and RTS,S/AS02(D). 2011 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier The recombinant circumsporozoite protein (CS) based vaccine, RTS,S, confers protection against Plasmodium falciparum infection in controlled challenge trials and in field studies. The RTS,S recombinant antigen has been formulated with two adjuvant systems, AS01 and AS02, which have both been shown to induce strong specific antibody responses and CD4 T cell responses in adults. As infants and young children are particularly susceptible to malaria infection and constitute the main target population for a malaria vaccine, we have evaluated the induction of adaptive immune responses in young children living in malaria endemic regions following vaccination with RTS,S/AS01(E) and RTS,S/AS02(D). Our data show that a CS-specific memory B cell response is induced one month after the second and third vaccine dose and that CS-specific antibodies and memory B cells persist up to 12 months after the last vaccine injection. Both formulations also induced low but significant amounts of CS-specific IL-2(+) CD4(+) T cells one month after the second and third vaccine dose, upon short-term in vitro stimulation of whole blood cells with peptides covering the entire CS derived sequence in RTS,S. These results provide evidence that both RTS,S/AS01(E) and RTS,S/AS02(D) induced adaptive immune responses including antibodies, circulating memory B cells and CD4(+) T cells directed against P. falciparum CS protein.ClinicalTrials.gov NCT00307021. Medicine R Science Q Rolf Fendel verfasserin aut Michaël Mestré verfasserin aut Michel Janssens verfasserin aut Johan Vekemans verfasserin aut Jana Held verfasserin aut Ferdinand Gnansounou verfasserin aut Sonja Haertle verfasserin aut Isabel von Glasenapp verfasserin aut Sunny Oyakhirome verfasserin aut Ludovic Mewono verfasserin aut Philippe Moris verfasserin aut Marc Lievens verfasserin aut Marie-Ange Demoitie verfasserin aut Patrice M Dubois verfasserin aut Tonya Villafana verfasserin aut Erik Jongert verfasserin aut Aurelie Olivier verfasserin aut Joe Cohen verfasserin aut Meral Esen verfasserin aut Peter G Kremsner verfasserin aut Bertrand Lell verfasserin aut Benjamin Mordmüller verfasserin aut In PLoS ONE Public Library of Science (PLoS), 2007 6(2011), 4, p e18559 (DE-627)523574592 (DE-600)2267670-3 19326203 nnns volume:6 year:2011 number:4, p e18559 https://doi.org/10.1371/journal.pone.0018559 kostenfrei https://doaj.org/article/15c7ade9e728478f8dac448f92278a4d kostenfrei http://europepmc.org/articles/PMC3073948?pdf=render kostenfrei https://doaj.org/toc/1932-6203 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_34 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_206 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_235 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2031 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2057 GBV_ILN_2061 GBV_ILN_2111 GBV_ILN_2113 GBV_ILN_2190 GBV_ILN_2522 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4335 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 6 2011 4, p e18559
allfields_unstemmed	10.1371/journal.pone.0018559 doi (DE-627)DOAJ046838481 (DE-599)DOAJ15c7ade9e728478f8dac448f92278a4d DE-627 ger DE-627 rakwb eng Selidji T Agnandji verfasserin aut Induction of Plasmodium falciparum-specific CD4+ T cells and memory B cells in Gabonese children vaccinated with RTS,S/AS01(E) and RTS,S/AS02(D). 2011 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier The recombinant circumsporozoite protein (CS) based vaccine, RTS,S, confers protection against Plasmodium falciparum infection in controlled challenge trials and in field studies. The RTS,S recombinant antigen has been formulated with two adjuvant systems, AS01 and AS02, which have both been shown to induce strong specific antibody responses and CD4 T cell responses in adults. As infants and young children are particularly susceptible to malaria infection and constitute the main target population for a malaria vaccine, we have evaluated the induction of adaptive immune responses in young children living in malaria endemic regions following vaccination with RTS,S/AS01(E) and RTS,S/AS02(D). Our data show that a CS-specific memory B cell response is induced one month after the second and third vaccine dose and that CS-specific antibodies and memory B cells persist up to 12 months after the last vaccine injection. Both formulations also induced low but significant amounts of CS-specific IL-2(+) CD4(+) T cells one month after the second and third vaccine dose, upon short-term in vitro stimulation of whole blood cells with peptides covering the entire CS derived sequence in RTS,S. These results provide evidence that both RTS,S/AS01(E) and RTS,S/AS02(D) induced adaptive immune responses including antibodies, circulating memory B cells and CD4(+) T cells directed against P. falciparum CS protein.ClinicalTrials.gov NCT00307021. Medicine R Science Q Rolf Fendel verfasserin aut Michaël Mestré verfasserin aut Michel Janssens verfasserin aut Johan Vekemans verfasserin aut Jana Held verfasserin aut Ferdinand Gnansounou verfasserin aut Sonja Haertle verfasserin aut Isabel von Glasenapp verfasserin aut Sunny Oyakhirome verfasserin aut Ludovic Mewono verfasserin aut Philippe Moris verfasserin aut Marc Lievens verfasserin aut Marie-Ange Demoitie verfasserin aut Patrice M Dubois verfasserin aut Tonya Villafana verfasserin aut Erik Jongert verfasserin aut Aurelie Olivier verfasserin aut Joe Cohen verfasserin aut Meral Esen verfasserin aut Peter G Kremsner verfasserin aut Bertrand Lell verfasserin aut Benjamin Mordmüller verfasserin aut In PLoS ONE Public Library of Science (PLoS), 2007 6(2011), 4, p e18559 (DE-627)523574592 (DE-600)2267670-3 19326203 nnns volume:6 year:2011 number:4, p e18559 https://doi.org/10.1371/journal.pone.0018559 kostenfrei https://doaj.org/article/15c7ade9e728478f8dac448f92278a4d kostenfrei http://europepmc.org/articles/PMC3073948?pdf=render kostenfrei https://doaj.org/toc/1932-6203 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_34 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_206 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_235 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2031 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2057 GBV_ILN_2061 GBV_ILN_2111 GBV_ILN_2113 GBV_ILN_2190 GBV_ILN_2522 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4335 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 6 2011 4, p e18559
allfieldsGer	10.1371/journal.pone.0018559 doi (DE-627)DOAJ046838481 (DE-599)DOAJ15c7ade9e728478f8dac448f92278a4d DE-627 ger DE-627 rakwb eng Selidji T Agnandji verfasserin aut Induction of Plasmodium falciparum-specific CD4+ T cells and memory B cells in Gabonese children vaccinated with RTS,S/AS01(E) and RTS,S/AS02(D). 2011 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier The recombinant circumsporozoite protein (CS) based vaccine, RTS,S, confers protection against Plasmodium falciparum infection in controlled challenge trials and in field studies. The RTS,S recombinant antigen has been formulated with two adjuvant systems, AS01 and AS02, which have both been shown to induce strong specific antibody responses and CD4 T cell responses in adults. As infants and young children are particularly susceptible to malaria infection and constitute the main target population for a malaria vaccine, we have evaluated the induction of adaptive immune responses in young children living in malaria endemic regions following vaccination with RTS,S/AS01(E) and RTS,S/AS02(D). Our data show that a CS-specific memory B cell response is induced one month after the second and third vaccine dose and that CS-specific antibodies and memory B cells persist up to 12 months after the last vaccine injection. Both formulations also induced low but significant amounts of CS-specific IL-2(+) CD4(+) T cells one month after the second and third vaccine dose, upon short-term in vitro stimulation of whole blood cells with peptides covering the entire CS derived sequence in RTS,S. These results provide evidence that both RTS,S/AS01(E) and RTS,S/AS02(D) induced adaptive immune responses including antibodies, circulating memory B cells and CD4(+) T cells directed against P. falciparum CS protein.ClinicalTrials.gov NCT00307021. Medicine R Science Q Rolf Fendel verfasserin aut Michaël Mestré verfasserin aut Michel Janssens verfasserin aut Johan Vekemans verfasserin aut Jana Held verfasserin aut Ferdinand Gnansounou verfasserin aut Sonja Haertle verfasserin aut Isabel von Glasenapp verfasserin aut Sunny Oyakhirome verfasserin aut Ludovic Mewono verfasserin aut Philippe Moris verfasserin aut Marc Lievens verfasserin aut Marie-Ange Demoitie verfasserin aut Patrice M Dubois verfasserin aut Tonya Villafana verfasserin aut Erik Jongert verfasserin aut Aurelie Olivier verfasserin aut Joe Cohen verfasserin aut Meral Esen verfasserin aut Peter G Kremsner verfasserin aut Bertrand Lell verfasserin aut Benjamin Mordmüller verfasserin aut In PLoS ONE Public Library of Science (PLoS), 2007 6(2011), 4, p e18559 (DE-627)523574592 (DE-600)2267670-3 19326203 nnns volume:6 year:2011 number:4, p e18559 https://doi.org/10.1371/journal.pone.0018559 kostenfrei https://doaj.org/article/15c7ade9e728478f8dac448f92278a4d kostenfrei http://europepmc.org/articles/PMC3073948?pdf=render kostenfrei https://doaj.org/toc/1932-6203 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_34 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_206 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_235 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2031 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2057 GBV_ILN_2061 GBV_ILN_2111 GBV_ILN_2113 GBV_ILN_2190 GBV_ILN_2522 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4335 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 6 2011 4, p e18559
allfieldsSound	10.1371/journal.pone.0018559 doi (DE-627)DOAJ046838481 (DE-599)DOAJ15c7ade9e728478f8dac448f92278a4d DE-627 ger DE-627 rakwb eng Selidji T Agnandji verfasserin aut Induction of Plasmodium falciparum-specific CD4+ T cells and memory B cells in Gabonese children vaccinated with RTS,S/AS01(E) and RTS,S/AS02(D). 2011 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier The recombinant circumsporozoite protein (CS) based vaccine, RTS,S, confers protection against Plasmodium falciparum infection in controlled challenge trials and in field studies. The RTS,S recombinant antigen has been formulated with two adjuvant systems, AS01 and AS02, which have both been shown to induce strong specific antibody responses and CD4 T cell responses in adults. As infants and young children are particularly susceptible to malaria infection and constitute the main target population for a malaria vaccine, we have evaluated the induction of adaptive immune responses in young children living in malaria endemic regions following vaccination with RTS,S/AS01(E) and RTS,S/AS02(D). Our data show that a CS-specific memory B cell response is induced one month after the second and third vaccine dose and that CS-specific antibodies and memory B cells persist up to 12 months after the last vaccine injection. Both formulations also induced low but significant amounts of CS-specific IL-2(+) CD4(+) T cells one month after the second and third vaccine dose, upon short-term in vitro stimulation of whole blood cells with peptides covering the entire CS derived sequence in RTS,S. These results provide evidence that both RTS,S/AS01(E) and RTS,S/AS02(D) induced adaptive immune responses including antibodies, circulating memory B cells and CD4(+) T cells directed against P. falciparum CS protein.ClinicalTrials.gov NCT00307021. Medicine R Science Q Rolf Fendel verfasserin aut Michaël Mestré verfasserin aut Michel Janssens verfasserin aut Johan Vekemans verfasserin aut Jana Held verfasserin aut Ferdinand Gnansounou verfasserin aut Sonja Haertle verfasserin aut Isabel von Glasenapp verfasserin aut Sunny Oyakhirome verfasserin aut Ludovic Mewono verfasserin aut Philippe Moris verfasserin aut Marc Lievens verfasserin aut Marie-Ange Demoitie verfasserin aut Patrice M Dubois verfasserin aut Tonya Villafana verfasserin aut Erik Jongert verfasserin aut Aurelie Olivier verfasserin aut Joe Cohen verfasserin aut Meral Esen verfasserin aut Peter G Kremsner verfasserin aut Bertrand Lell verfasserin aut Benjamin Mordmüller verfasserin aut In PLoS ONE Public Library of Science (PLoS), 2007 6(2011), 4, p e18559 (DE-627)523574592 (DE-600)2267670-3 19326203 nnns volume:6 year:2011 number:4, p e18559 https://doi.org/10.1371/journal.pone.0018559 kostenfrei https://doaj.org/article/15c7ade9e728478f8dac448f92278a4d kostenfrei http://europepmc.org/articles/PMC3073948?pdf=render kostenfrei https://doaj.org/toc/1932-6203 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_34 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_206 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_235 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2031 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2057 GBV_ILN_2061 GBV_ILN_2111 GBV_ILN_2113 GBV_ILN_2190 GBV_ILN_2522 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4335 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 6 2011 4, p e18559
language	English
source	In PLoS ONE 6(2011), 4, p e18559 volume:6 year:2011 number:4, p e18559
sourceStr	In PLoS ONE 6(2011), 4, p e18559 volume:6 year:2011 number:4, p e18559
format_phy_str_mv	Article
institution	findex.gbv.de
topic_facet	Medicine R Science Q
isfreeaccess_bool	true
container_title	PLoS ONE
authorswithroles_txt_mv	Selidji T Agnandji @@aut@@ Rolf Fendel @@aut@@ Michaël Mestré @@aut@@ Michel Janssens @@aut@@ Johan Vekemans @@aut@@ Jana Held @@aut@@ Ferdinand Gnansounou @@aut@@ Sonja Haertle @@aut@@ Isabel von Glasenapp @@aut@@ Sunny Oyakhirome @@aut@@ Ludovic Mewono @@aut@@ Philippe Moris @@aut@@ Marc Lievens @@aut@@ Marie-Ange Demoitie @@aut@@ Patrice M Dubois @@aut@@ Tonya Villafana @@aut@@ Erik Jongert @@aut@@ Aurelie Olivier @@aut@@ Joe Cohen @@aut@@ Meral Esen @@aut@@ Peter G Kremsner @@aut@@ Bertrand Lell @@aut@@ Benjamin Mordmüller @@aut@@
publishDateDaySort_date	2011-01-01T00:00:00Z
hierarchy_top_id	523574592
id	DOAJ046838481
language_de	englisch
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author	Selidji T Agnandji
spellingShingle	Selidji T Agnandji misc Medicine misc R misc Science misc Q Induction of Plasmodium falciparum-specific CD4+ T cells and memory B cells in Gabonese children vaccinated with RTS,S/AS01(E) and RTS,S/AS02(D).
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topic_title	Induction of Plasmodium falciparum-specific CD4+ T cells and memory B cells in Gabonese children vaccinated with RTS,S/AS01(E) and RTS,S/AS02(D)
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title	Induction of Plasmodium falciparum-specific CD4+ T cells and memory B cells in Gabonese children vaccinated with RTS,S/AS01(E) and RTS,S/AS02(D).
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title_full	Induction of Plasmodium falciparum-specific CD4+ T cells and memory B cells in Gabonese children vaccinated with RTS,S/AS01(E) and RTS,S/AS02(D)
author_sort	Selidji T Agnandji
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author_browse	Selidji T Agnandji Rolf Fendel Michaël Mestré Michel Janssens Johan Vekemans Jana Held Ferdinand Gnansounou Sonja Haertle Isabel von Glasenapp Sunny Oyakhirome Ludovic Mewono Philippe Moris Marc Lievens Marie-Ange Demoitie Patrice M Dubois Tonya Villafana Erik Jongert Aurelie Olivier Joe Cohen Meral Esen Peter G Kremsner Bertrand Lell Benjamin Mordmüller
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title_sort	induction of plasmodium falciparum-specific cd4+ t cells and memory b cells in gabonese children vaccinated with rts,s/as01(e) and rts,s/as02(d)
title_auth	Induction of Plasmodium falciparum-specific CD4+ T cells and memory B cells in Gabonese children vaccinated with RTS,S/AS01(E) and RTS,S/AS02(D).
abstract	The recombinant circumsporozoite protein (CS) based vaccine, RTS,S, confers protection against Plasmodium falciparum infection in controlled challenge trials and in field studies. The RTS,S recombinant antigen has been formulated with two adjuvant systems, AS01 and AS02, which have both been shown to induce strong specific antibody responses and CD4 T cell responses in adults. As infants and young children are particularly susceptible to malaria infection and constitute the main target population for a malaria vaccine, we have evaluated the induction of adaptive immune responses in young children living in malaria endemic regions following vaccination with RTS,S/AS01(E) and RTS,S/AS02(D). Our data show that a CS-specific memory B cell response is induced one month after the second and third vaccine dose and that CS-specific antibodies and memory B cells persist up to 12 months after the last vaccine injection. Both formulations also induced low but significant amounts of CS-specific IL-2(+) CD4(+) T cells one month after the second and third vaccine dose, upon short-term in vitro stimulation of whole blood cells with peptides covering the entire CS derived sequence in RTS,S. These results provide evidence that both RTS,S/AS01(E) and RTS,S/AS02(D) induced adaptive immune responses including antibodies, circulating memory B cells and CD4(+) T cells directed against P. falciparum CS protein.ClinicalTrials.gov NCT00307021.
abstractGer	The recombinant circumsporozoite protein (CS) based vaccine, RTS,S, confers protection against Plasmodium falciparum infection in controlled challenge trials and in field studies. The RTS,S recombinant antigen has been formulated with two adjuvant systems, AS01 and AS02, which have both been shown to induce strong specific antibody responses and CD4 T cell responses in adults. As infants and young children are particularly susceptible to malaria infection and constitute the main target population for a malaria vaccine, we have evaluated the induction of adaptive immune responses in young children living in malaria endemic regions following vaccination with RTS,S/AS01(E) and RTS,S/AS02(D). Our data show that a CS-specific memory B cell response is induced one month after the second and third vaccine dose and that CS-specific antibodies and memory B cells persist up to 12 months after the last vaccine injection. Both formulations also induced low but significant amounts of CS-specific IL-2(+) CD4(+) T cells one month after the second and third vaccine dose, upon short-term in vitro stimulation of whole blood cells with peptides covering the entire CS derived sequence in RTS,S. These results provide evidence that both RTS,S/AS01(E) and RTS,S/AS02(D) induced adaptive immune responses including antibodies, circulating memory B cells and CD4(+) T cells directed against P. falciparum CS protein.ClinicalTrials.gov NCT00307021.
abstract_unstemmed	The recombinant circumsporozoite protein (CS) based vaccine, RTS,S, confers protection against Plasmodium falciparum infection in controlled challenge trials and in field studies. The RTS,S recombinant antigen has been formulated with two adjuvant systems, AS01 and AS02, which have both been shown to induce strong specific antibody responses and CD4 T cell responses in adults. As infants and young children are particularly susceptible to malaria infection and constitute the main target population for a malaria vaccine, we have evaluated the induction of adaptive immune responses in young children living in malaria endemic regions following vaccination with RTS,S/AS01(E) and RTS,S/AS02(D). Our data show that a CS-specific memory B cell response is induced one month after the second and third vaccine dose and that CS-specific antibodies and memory B cells persist up to 12 months after the last vaccine injection. Both formulations also induced low but significant amounts of CS-specific IL-2(+) CD4(+) T cells one month after the second and third vaccine dose, upon short-term in vitro stimulation of whole blood cells with peptides covering the entire CS derived sequence in RTS,S. These results provide evidence that both RTS,S/AS01(E) and RTS,S/AS02(D) induced adaptive immune responses including antibodies, circulating memory B cells and CD4(+) T cells directed against P. falciparum CS protein.ClinicalTrials.gov NCT00307021.
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title_short	Induction of Plasmodium falciparum-specific CD4+ T cells and memory B cells in Gabonese children vaccinated with RTS,S/AS01(E) and RTS,S/AS02(D).
url	https://doi.org/10.1371/journal.pone.0018559 https://doaj.org/article/15c7ade9e728478f8dac448f92278a4d http://europepmc.org/articles/PMC3073948?pdf=render https://doaj.org/toc/1932-6203
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up_date	2024-07-03T22:48:56.411Z
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Both formulations also induced low but significant amounts of CS-specific IL-2(+) CD4(+) T cells one month after the second and third vaccine dose, upon short-term in vitro stimulation of whole blood cells with peptides covering the entire CS derived sequence in RTS,S. 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Induction of Plasmodium falciparum-specific CD4+ T cells and memory B cells in Gabonese children vaccinated with RTS,S/AS01(E) and RTS,S/AS02(D).

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