The NS Segment of H1N1pdm09 Enhances H5N1 Pathogenicity in a Mouse Model of Influenza Virus Infections

In 2009, the co-circulation of H5N1 and H1N1pdm09 raised concerns that a reassortment event may lead to highly pathogenic influenza strains. H1N1pdm09 and H5N1 are able to infect the same target cells of the lower respiratory tract. To investigate the capacity of the emergence of reassortant viruses...
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Autor*in:	Olivier Ferraris [verfasserIn] Jean-Sébastien Casalegno [verfasserIn] Emilie Frobert [verfasserIn] Maude Bouscambert Duchamp [verfasserIn] Martine Valette [verfasserIn] Frédéric Jacquot [verfasserIn] Hervé Raoul [verfasserIn] Bruno Lina [verfasserIn] Michèle Ottmann [verfasserIn]

Format:	E-Artikel
Sprache:	Englisch

Erschienen:	2018

Schlagwörter:	virus influenza influenza A H5N1 H1N1pdm reassortment pathogenicity mouse model

Übergeordnetes Werk:	In: Viruses - MDPI AG, 2009, 10(2018), 9, p 504
Übergeordnetes Werk:	volume:10 ; year:2018 ; number:9, p 504

Links:	Link aufrufen Link aufrufen Link aufrufen Journal toc

DOI / URN:	10.3390/v10090504

Katalog-ID:	DOAJ047002379

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allfields	10.3390/v10090504 doi (DE-627)DOAJ047002379 (DE-599)DOAJ30ced1804fda4d2b9afad7b8836b3009 DE-627 ger DE-627 rakwb eng QR1-502 Olivier Ferraris verfasserin aut The NS Segment of H1N1pdm09 Enhances H5N1 Pathogenicity in a Mouse Model of Influenza Virus Infections 2018 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier In 2009, the co-circulation of H5N1 and H1N1pdm09 raised concerns that a reassortment event may lead to highly pathogenic influenza strains. H1N1pdm09 and H5N1 are able to infect the same target cells of the lower respiratory tract. To investigate the capacity of the emergence of reassortant viruses, we characterized viruses obtained from the co-infection of cells with H5N1 (A/Turkey/13/2006) and H1N1pdm09 (A/Lyon/969/2009 H1N1). In our analysis, all the screened reassortants possessed the PB2, HA, and NP segments from H5N1 and acquired one or two of the H1N1pdm09 segments. Moreover, the in vivo infections showed that the acquisition of the NS segment from H1N1pdm09 increased the virulence of H5N1 in mice. We conclude, therefore, that reassortment can occur between these two viruses, even if this process has never been detected in nature. virus influenza influenza A H5N1 H1N1pdm reassortment pathogenicity mouse model Microbiology Jean-Sébastien Casalegno verfasserin aut Emilie Frobert verfasserin aut Maude Bouscambert Duchamp verfasserin aut Martine Valette verfasserin aut Frédéric Jacquot verfasserin aut Hervé Raoul verfasserin aut Bruno Lina verfasserin aut Michèle Ottmann verfasserin aut In Viruses MDPI AG, 2009 10(2018), 9, p 504 (DE-627)609775871 (DE-600)2516098-9 19994915 nnns volume:10 year:2018 number:9, p 504 https://doi.org/10.3390/v10090504 kostenfrei https://doaj.org/article/30ced1804fda4d2b9afad7b8836b3009 kostenfrei http://www.mdpi.com/1999-4915/10/9/504 kostenfrei https://doaj.org/toc/1999-4915 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_2005 GBV_ILN_2009 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2055 GBV_ILN_2111 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 10 2018 9, p 504
spelling	10.3390/v10090504 doi (DE-627)DOAJ047002379 (DE-599)DOAJ30ced1804fda4d2b9afad7b8836b3009 DE-627 ger DE-627 rakwb eng QR1-502 Olivier Ferraris verfasserin aut The NS Segment of H1N1pdm09 Enhances H5N1 Pathogenicity in a Mouse Model of Influenza Virus Infections 2018 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier In 2009, the co-circulation of H5N1 and H1N1pdm09 raised concerns that a reassortment event may lead to highly pathogenic influenza strains. H1N1pdm09 and H5N1 are able to infect the same target cells of the lower respiratory tract. To investigate the capacity of the emergence of reassortant viruses, we characterized viruses obtained from the co-infection of cells with H5N1 (A/Turkey/13/2006) and H1N1pdm09 (A/Lyon/969/2009 H1N1). In our analysis, all the screened reassortants possessed the PB2, HA, and NP segments from H5N1 and acquired one or two of the H1N1pdm09 segments. Moreover, the in vivo infections showed that the acquisition of the NS segment from H1N1pdm09 increased the virulence of H5N1 in mice. We conclude, therefore, that reassortment can occur between these two viruses, even if this process has never been detected in nature. virus influenza influenza A H5N1 H1N1pdm reassortment pathogenicity mouse model Microbiology Jean-Sébastien Casalegno verfasserin aut Emilie Frobert verfasserin aut Maude Bouscambert Duchamp verfasserin aut Martine Valette verfasserin aut Frédéric Jacquot verfasserin aut Hervé Raoul verfasserin aut Bruno Lina verfasserin aut Michèle Ottmann verfasserin aut In Viruses MDPI AG, 2009 10(2018), 9, p 504 (DE-627)609775871 (DE-600)2516098-9 19994915 nnns volume:10 year:2018 number:9, p 504 https://doi.org/10.3390/v10090504 kostenfrei https://doaj.org/article/30ced1804fda4d2b9afad7b8836b3009 kostenfrei http://www.mdpi.com/1999-4915/10/9/504 kostenfrei https://doaj.org/toc/1999-4915 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_2005 GBV_ILN_2009 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2055 GBV_ILN_2111 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 10 2018 9, p 504
allfields_unstemmed	10.3390/v10090504 doi (DE-627)DOAJ047002379 (DE-599)DOAJ30ced1804fda4d2b9afad7b8836b3009 DE-627 ger DE-627 rakwb eng QR1-502 Olivier Ferraris verfasserin aut The NS Segment of H1N1pdm09 Enhances H5N1 Pathogenicity in a Mouse Model of Influenza Virus Infections 2018 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier In 2009, the co-circulation of H5N1 and H1N1pdm09 raised concerns that a reassortment event may lead to highly pathogenic influenza strains. H1N1pdm09 and H5N1 are able to infect the same target cells of the lower respiratory tract. To investigate the capacity of the emergence of reassortant viruses, we characterized viruses obtained from the co-infection of cells with H5N1 (A/Turkey/13/2006) and H1N1pdm09 (A/Lyon/969/2009 H1N1). In our analysis, all the screened reassortants possessed the PB2, HA, and NP segments from H5N1 and acquired one or two of the H1N1pdm09 segments. Moreover, the in vivo infections showed that the acquisition of the NS segment from H1N1pdm09 increased the virulence of H5N1 in mice. We conclude, therefore, that reassortment can occur between these two viruses, even if this process has never been detected in nature. virus influenza influenza A H5N1 H1N1pdm reassortment pathogenicity mouse model Microbiology Jean-Sébastien Casalegno verfasserin aut Emilie Frobert verfasserin aut Maude Bouscambert Duchamp verfasserin aut Martine Valette verfasserin aut Frédéric Jacquot verfasserin aut Hervé Raoul verfasserin aut Bruno Lina verfasserin aut Michèle Ottmann verfasserin aut In Viruses MDPI AG, 2009 10(2018), 9, p 504 (DE-627)609775871 (DE-600)2516098-9 19994915 nnns volume:10 year:2018 number:9, p 504 https://doi.org/10.3390/v10090504 kostenfrei https://doaj.org/article/30ced1804fda4d2b9afad7b8836b3009 kostenfrei http://www.mdpi.com/1999-4915/10/9/504 kostenfrei https://doaj.org/toc/1999-4915 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_2005 GBV_ILN_2009 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2055 GBV_ILN_2111 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 10 2018 9, p 504
allfieldsGer	10.3390/v10090504 doi (DE-627)DOAJ047002379 (DE-599)DOAJ30ced1804fda4d2b9afad7b8836b3009 DE-627 ger DE-627 rakwb eng QR1-502 Olivier Ferraris verfasserin aut The NS Segment of H1N1pdm09 Enhances H5N1 Pathogenicity in a Mouse Model of Influenza Virus Infections 2018 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier In 2009, the co-circulation of H5N1 and H1N1pdm09 raised concerns that a reassortment event may lead to highly pathogenic influenza strains. H1N1pdm09 and H5N1 are able to infect the same target cells of the lower respiratory tract. To investigate the capacity of the emergence of reassortant viruses, we characterized viruses obtained from the co-infection of cells with H5N1 (A/Turkey/13/2006) and H1N1pdm09 (A/Lyon/969/2009 H1N1). In our analysis, all the screened reassortants possessed the PB2, HA, and NP segments from H5N1 and acquired one or two of the H1N1pdm09 segments. Moreover, the in vivo infections showed that the acquisition of the NS segment from H1N1pdm09 increased the virulence of H5N1 in mice. We conclude, therefore, that reassortment can occur between these two viruses, even if this process has never been detected in nature. virus influenza influenza A H5N1 H1N1pdm reassortment pathogenicity mouse model Microbiology Jean-Sébastien Casalegno verfasserin aut Emilie Frobert verfasserin aut Maude Bouscambert Duchamp verfasserin aut Martine Valette verfasserin aut Frédéric Jacquot verfasserin aut Hervé Raoul verfasserin aut Bruno Lina verfasserin aut Michèle Ottmann verfasserin aut In Viruses MDPI AG, 2009 10(2018), 9, p 504 (DE-627)609775871 (DE-600)2516098-9 19994915 nnns volume:10 year:2018 number:9, p 504 https://doi.org/10.3390/v10090504 kostenfrei https://doaj.org/article/30ced1804fda4d2b9afad7b8836b3009 kostenfrei http://www.mdpi.com/1999-4915/10/9/504 kostenfrei https://doaj.org/toc/1999-4915 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_2005 GBV_ILN_2009 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2055 GBV_ILN_2111 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 10 2018 9, p 504
allfieldsSound	10.3390/v10090504 doi (DE-627)DOAJ047002379 (DE-599)DOAJ30ced1804fda4d2b9afad7b8836b3009 DE-627 ger DE-627 rakwb eng QR1-502 Olivier Ferraris verfasserin aut The NS Segment of H1N1pdm09 Enhances H5N1 Pathogenicity in a Mouse Model of Influenza Virus Infections 2018 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier In 2009, the co-circulation of H5N1 and H1N1pdm09 raised concerns that a reassortment event may lead to highly pathogenic influenza strains. H1N1pdm09 and H5N1 are able to infect the same target cells of the lower respiratory tract. To investigate the capacity of the emergence of reassortant viruses, we characterized viruses obtained from the co-infection of cells with H5N1 (A/Turkey/13/2006) and H1N1pdm09 (A/Lyon/969/2009 H1N1). In our analysis, all the screened reassortants possessed the PB2, HA, and NP segments from H5N1 and acquired one or two of the H1N1pdm09 segments. Moreover, the in vivo infections showed that the acquisition of the NS segment from H1N1pdm09 increased the virulence of H5N1 in mice. We conclude, therefore, that reassortment can occur between these two viruses, even if this process has never been detected in nature. virus influenza influenza A H5N1 H1N1pdm reassortment pathogenicity mouse model Microbiology Jean-Sébastien Casalegno verfasserin aut Emilie Frobert verfasserin aut Maude Bouscambert Duchamp verfasserin aut Martine Valette verfasserin aut Frédéric Jacquot verfasserin aut Hervé Raoul verfasserin aut Bruno Lina verfasserin aut Michèle Ottmann verfasserin aut In Viruses MDPI AG, 2009 10(2018), 9, p 504 (DE-627)609775871 (DE-600)2516098-9 19994915 nnns volume:10 year:2018 number:9, p 504 https://doi.org/10.3390/v10090504 kostenfrei https://doaj.org/article/30ced1804fda4d2b9afad7b8836b3009 kostenfrei http://www.mdpi.com/1999-4915/10/9/504 kostenfrei https://doaj.org/toc/1999-4915 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_2005 GBV_ILN_2009 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2055 GBV_ILN_2111 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 10 2018 9, p 504
language	English
source	In Viruses 10(2018), 9, p 504 volume:10 year:2018 number:9, p 504
sourceStr	In Viruses 10(2018), 9, p 504 volume:10 year:2018 number:9, p 504
format_phy_str_mv	Article
institution	findex.gbv.de
topic_facet	virus influenza influenza A H5N1 H1N1pdm reassortment pathogenicity mouse model Microbiology
isfreeaccess_bool	true
container_title	Viruses
authorswithroles_txt_mv	Olivier Ferraris @@aut@@ Jean-Sébastien Casalegno @@aut@@ Emilie Frobert @@aut@@ Maude Bouscambert Duchamp @@aut@@ Martine Valette @@aut@@ Frédéric Jacquot @@aut@@ Hervé Raoul @@aut@@ Bruno Lina @@aut@@ Michèle Ottmann @@aut@@
publishDateDaySort_date	2018-01-01T00:00:00Z
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callnumber-first	Q - Science
author	Olivier Ferraris
spellingShingle	Olivier Ferraris misc QR1-502 misc virus misc influenza misc influenza A misc H5N1 misc H1N1pdm misc reassortment misc pathogenicity misc mouse model misc Microbiology The NS Segment of H1N1pdm09 Enhances H5N1 Pathogenicity in a Mouse Model of Influenza Virus Infections
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topic_title	QR1-502 The NS Segment of H1N1pdm09 Enhances H5N1 Pathogenicity in a Mouse Model of Influenza Virus Infections virus influenza influenza A H5N1 H1N1pdm reassortment pathogenicity mouse model
topic	misc QR1-502 misc virus misc influenza misc influenza A misc H5N1 misc H1N1pdm misc reassortment misc pathogenicity misc mouse model misc Microbiology
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title	The NS Segment of H1N1pdm09 Enhances H5N1 Pathogenicity in a Mouse Model of Influenza Virus Infections
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title_full	The NS Segment of H1N1pdm09 Enhances H5N1 Pathogenicity in a Mouse Model of Influenza Virus Infections
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author_browse	Olivier Ferraris Jean-Sébastien Casalegno Emilie Frobert Maude Bouscambert Duchamp Martine Valette Frédéric Jacquot Hervé Raoul Bruno Lina Michèle Ottmann
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title_sort	ns segment of h1n1pdm09 enhances h5n1 pathogenicity in a mouse model of influenza virus infections
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title_auth	The NS Segment of H1N1pdm09 Enhances H5N1 Pathogenicity in a Mouse Model of Influenza Virus Infections
abstract	In 2009, the co-circulation of H5N1 and H1N1pdm09 raised concerns that a reassortment event may lead to highly pathogenic influenza strains. H1N1pdm09 and H5N1 are able to infect the same target cells of the lower respiratory tract. To investigate the capacity of the emergence of reassortant viruses, we characterized viruses obtained from the co-infection of cells with H5N1 (A/Turkey/13/2006) and H1N1pdm09 (A/Lyon/969/2009 H1N1). In our analysis, all the screened reassortants possessed the PB2, HA, and NP segments from H5N1 and acquired one or two of the H1N1pdm09 segments. Moreover, the in vivo infections showed that the acquisition of the NS segment from H1N1pdm09 increased the virulence of H5N1 in mice. We conclude, therefore, that reassortment can occur between these two viruses, even if this process has never been detected in nature.
abstractGer	In 2009, the co-circulation of H5N1 and H1N1pdm09 raised concerns that a reassortment event may lead to highly pathogenic influenza strains. H1N1pdm09 and H5N1 are able to infect the same target cells of the lower respiratory tract. To investigate the capacity of the emergence of reassortant viruses, we characterized viruses obtained from the co-infection of cells with H5N1 (A/Turkey/13/2006) and H1N1pdm09 (A/Lyon/969/2009 H1N1). In our analysis, all the screened reassortants possessed the PB2, HA, and NP segments from H5N1 and acquired one or two of the H1N1pdm09 segments. Moreover, the in vivo infections showed that the acquisition of the NS segment from H1N1pdm09 increased the virulence of H5N1 in mice. We conclude, therefore, that reassortment can occur between these two viruses, even if this process has never been detected in nature.
abstract_unstemmed	In 2009, the co-circulation of H5N1 and H1N1pdm09 raised concerns that a reassortment event may lead to highly pathogenic influenza strains. H1N1pdm09 and H5N1 are able to infect the same target cells of the lower respiratory tract. To investigate the capacity of the emergence of reassortant viruses, we characterized viruses obtained from the co-infection of cells with H5N1 (A/Turkey/13/2006) and H1N1pdm09 (A/Lyon/969/2009 H1N1). In our analysis, all the screened reassortants possessed the PB2, HA, and NP segments from H5N1 and acquired one or two of the H1N1pdm09 segments. Moreover, the in vivo infections showed that the acquisition of the NS segment from H1N1pdm09 increased the virulence of H5N1 in mice. We conclude, therefore, that reassortment can occur between these two viruses, even if this process has never been detected in nature.
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title_short	The NS Segment of H1N1pdm09 Enhances H5N1 Pathogenicity in a Mouse Model of Influenza Virus Infections
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up_date	2024-07-03T23:36:43.057Z
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H1N1pdm09 and H5N1 are able to infect the same target cells of the lower respiratory tract. To investigate the capacity of the emergence of reassortant viruses, we characterized viruses obtained from the co-infection of cells with H5N1 (A/Turkey/13/2006) and H1N1pdm09 (A/Lyon/969/2009 H1N1). In our analysis, all the screened reassortants possessed the PB2, HA, and NP segments from H5N1 and acquired one or two of the H1N1pdm09 segments. Moreover, the in vivo infections showed that the acquisition of the NS segment from H1N1pdm09 increased the virulence of H5N1 in mice. 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The NS Segment of H1N1pdm09 Enhances H5N1 Pathogenicity in a Mouse Model of Influenza Virus Infections

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