Encapsidation of Different Plasmonic Gold Nanoparticles by the CCMV CP

Different types of gold nanoparticles have been synthesized that show great potential in medical applications such as medical imaging, bio-analytical sensing and photothermal cancer therapy. However, their stability, polydispersity and biocompatibility are major issues of concern. For example, the s...
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Autor*in:	Ana L. Durán-Meza [verfasserIn] Martha I. Escamilla-Ruiz [verfasserIn] Xochitl F. Segovia-González [verfasserIn] Maria V. Villagrana-Escareño [verfasserIn] J. Roger Vega-Acosta [verfasserIn] Jaime Ruiz-Garcia [verfasserIn]

Format:	E-Artikel
Sprache:	Englisch

Erschienen:	2020

Schlagwörter:	plasmonic nanoparticles gold nanoparticles gold nanorods gold nanoshells CCMV virus-like particles

Übergeordnetes Werk:	In: Molecules - MDPI AG, 2003, 25(2020), 11, p 2628
Übergeordnetes Werk:	volume:25 ; year:2020 ; number:11, p 2628

Links:	Link aufrufen Link aufrufen Link aufrufen Journal toc

DOI / URN:	10.3390/molecules25112628

Katalog-ID:	DOAJ04744309X

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allfields	10.3390/molecules25112628 doi (DE-627)DOAJ04744309X (DE-599)DOAJa07f609186ce4304b1c1c0b259e77de6 DE-627 ger DE-627 rakwb eng QD241-441 Ana L. Durán-Meza verfasserin aut Encapsidation of Different Plasmonic Gold Nanoparticles by the CCMV CP 2020 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Different types of gold nanoparticles have been synthesized that show great potential in medical applications such as medical imaging, bio-analytical sensing and photothermal cancer therapy. However, their stability, polydispersity and biocompatibility are major issues of concern. For example, the synthesis of gold nanorods, obtained through the elongated micelle process, produce them with a high positive surface charge that is cytotoxic, while gold nanoshells are unstable and break down in a few weeks due to the Ostwald ripening process. In this work, we report the self-assembly of the capsid protein (CP) of cowpea chlorotic mottle virus (CCMV) around spherical gold nanoparticles, gold nanorods and gold nanoshells to form virus-like particles (VLPs). All gold nanoparticles were synthesized or treated to give them a negative surface charge, so they can interact with the positive N-terminus of the CP leading to the formation of the VLPs. To induce the protein self-assembly around the negative gold nanoparticles, we use different pH and ionic strength conditions determined from a CP phase diagram. The encapsidation with the viral CP will provide the nanoparticles better biocompatibility, stability, monodispersity and a new biological substrate on which can be introduced ligands toward specific cells, broadening the possibilities for medical applications. plasmonic nanoparticles gold nanoparticles gold nanorods gold nanoshells CCMV virus-like particles Organic chemistry Martha I. Escamilla-Ruiz verfasserin aut Xochitl F. Segovia-González verfasserin aut Maria V. Villagrana-Escareño verfasserin aut J. Roger Vega-Acosta verfasserin aut Jaime Ruiz-Garcia verfasserin aut In Molecules MDPI AG, 2003 25(2020), 11, p 2628 (DE-627)311313132 (DE-600)2008644-1 14203049 nnns volume:25 year:2020 number:11, p 2628 https://doi.org/10.3390/molecules25112628 kostenfrei https://doaj.org/article/a07f609186ce4304b1c1c0b259e77de6 kostenfrei https://www.mdpi.com/1420-3049/25/11/2628 kostenfrei https://doaj.org/toc/1420-3049 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2005 GBV_ILN_2009 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2055 GBV_ILN_2111 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 25 2020 11, p 2628
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allfieldsSound	10.3390/molecules25112628 doi (DE-627)DOAJ04744309X (DE-599)DOAJa07f609186ce4304b1c1c0b259e77de6 DE-627 ger DE-627 rakwb eng QD241-441 Ana L. Durán-Meza verfasserin aut Encapsidation of Different Plasmonic Gold Nanoparticles by the CCMV CP 2020 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Different types of gold nanoparticles have been synthesized that show great potential in medical applications such as medical imaging, bio-analytical sensing and photothermal cancer therapy. However, their stability, polydispersity and biocompatibility are major issues of concern. For example, the synthesis of gold nanorods, obtained through the elongated micelle process, produce them with a high positive surface charge that is cytotoxic, while gold nanoshells are unstable and break down in a few weeks due to the Ostwald ripening process. In this work, we report the self-assembly of the capsid protein (CP) of cowpea chlorotic mottle virus (CCMV) around spherical gold nanoparticles, gold nanorods and gold nanoshells to form virus-like particles (VLPs). All gold nanoparticles were synthesized or treated to give them a negative surface charge, so they can interact with the positive N-terminus of the CP leading to the formation of the VLPs. To induce the protein self-assembly around the negative gold nanoparticles, we use different pH and ionic strength conditions determined from a CP phase diagram. The encapsidation with the viral CP will provide the nanoparticles better biocompatibility, stability, monodispersity and a new biological substrate on which can be introduced ligands toward specific cells, broadening the possibilities for medical applications. plasmonic nanoparticles gold nanoparticles gold nanorods gold nanoshells CCMV virus-like particles Organic chemistry Martha I. Escamilla-Ruiz verfasserin aut Xochitl F. Segovia-González verfasserin aut Maria V. Villagrana-Escareño verfasserin aut J. Roger Vega-Acosta verfasserin aut Jaime Ruiz-Garcia verfasserin aut In Molecules MDPI AG, 2003 25(2020), 11, p 2628 (DE-627)311313132 (DE-600)2008644-1 14203049 nnns volume:25 year:2020 number:11, p 2628 https://doi.org/10.3390/molecules25112628 kostenfrei https://doaj.org/article/a07f609186ce4304b1c1c0b259e77de6 kostenfrei https://www.mdpi.com/1420-3049/25/11/2628 kostenfrei https://doaj.org/toc/1420-3049 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2005 GBV_ILN_2009 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2055 GBV_ILN_2111 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 25 2020 11, p 2628
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Durán-Meza</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="245" ind1="1" ind2="0"><subfield code="a">Encapsidation of Different Plasmonic Gold Nanoparticles by the CCMV CP</subfield></datafield><datafield tag="264" ind1=" " ind2="1"><subfield code="c">2020</subfield></datafield><datafield tag="336" ind1=" " ind2=" "><subfield code="a">Text</subfield><subfield code="b">txt</subfield><subfield code="2">rdacontent</subfield></datafield><datafield tag="337" ind1=" " ind2=" "><subfield code="a">Computermedien</subfield><subfield code="b">c</subfield><subfield code="2">rdamedia</subfield></datafield><datafield tag="338" ind1=" " ind2=" "><subfield code="a">Online-Ressource</subfield><subfield code="b">cr</subfield><subfield code="2">rdacarrier</subfield></datafield><datafield tag="520" ind1=" " ind2=" "><subfield code="a">Different types of gold nanoparticles have been synthesized that show great potential in medical applications such as medical imaging, bio-analytical sensing and photothermal cancer therapy. 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callnumber-first	Q - Science
author	Ana L. Durán-Meza
spellingShingle	Ana L. Durán-Meza misc QD241-441 misc plasmonic nanoparticles misc gold nanoparticles misc gold nanorods misc gold nanoshells misc CCMV misc virus-like particles misc Organic chemistry Encapsidation of Different Plasmonic Gold Nanoparticles by the CCMV CP
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topic_title	QD241-441 Encapsidation of Different Plasmonic Gold Nanoparticles by the CCMV CP plasmonic nanoparticles gold nanoparticles gold nanorods gold nanoshells CCMV virus-like particles
topic	misc QD241-441 misc plasmonic nanoparticles misc gold nanoparticles misc gold nanorods misc gold nanoshells misc CCMV misc virus-like particles misc Organic chemistry
topic_unstemmed	misc QD241-441 misc plasmonic nanoparticles misc gold nanoparticles misc gold nanorods misc gold nanoshells misc CCMV misc virus-like particles misc Organic chemistry
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title	Encapsidation of Different Plasmonic Gold Nanoparticles by the CCMV CP
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title_full	Encapsidation of Different Plasmonic Gold Nanoparticles by the CCMV CP
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author_browse	Ana L. Durán-Meza Martha I. Escamilla-Ruiz Xochitl F. Segovia-González Maria V. Villagrana-Escareño J. Roger Vega-Acosta Jaime Ruiz-Garcia
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title_sort	encapsidation of different plasmonic gold nanoparticles by the ccmv cp
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title_auth	Encapsidation of Different Plasmonic Gold Nanoparticles by the CCMV CP
abstract	Different types of gold nanoparticles have been synthesized that show great potential in medical applications such as medical imaging, bio-analytical sensing and photothermal cancer therapy. However, their stability, polydispersity and biocompatibility are major issues of concern. For example, the synthesis of gold nanorods, obtained through the elongated micelle process, produce them with a high positive surface charge that is cytotoxic, while gold nanoshells are unstable and break down in a few weeks due to the Ostwald ripening process. In this work, we report the self-assembly of the capsid protein (CP) of cowpea chlorotic mottle virus (CCMV) around spherical gold nanoparticles, gold nanorods and gold nanoshells to form virus-like particles (VLPs). All gold nanoparticles were synthesized or treated to give them a negative surface charge, so they can interact with the positive N-terminus of the CP leading to the formation of the VLPs. To induce the protein self-assembly around the negative gold nanoparticles, we use different pH and ionic strength conditions determined from a CP phase diagram. The encapsidation with the viral CP will provide the nanoparticles better biocompatibility, stability, monodispersity and a new biological substrate on which can be introduced ligands toward specific cells, broadening the possibilities for medical applications.
abstractGer	Different types of gold nanoparticles have been synthesized that show great potential in medical applications such as medical imaging, bio-analytical sensing and photothermal cancer therapy. However, their stability, polydispersity and biocompatibility are major issues of concern. For example, the synthesis of gold nanorods, obtained through the elongated micelle process, produce them with a high positive surface charge that is cytotoxic, while gold nanoshells are unstable and break down in a few weeks due to the Ostwald ripening process. In this work, we report the self-assembly of the capsid protein (CP) of cowpea chlorotic mottle virus (CCMV) around spherical gold nanoparticles, gold nanorods and gold nanoshells to form virus-like particles (VLPs). All gold nanoparticles were synthesized or treated to give them a negative surface charge, so they can interact with the positive N-terminus of the CP leading to the formation of the VLPs. To induce the protein self-assembly around the negative gold nanoparticles, we use different pH and ionic strength conditions determined from a CP phase diagram. The encapsidation with the viral CP will provide the nanoparticles better biocompatibility, stability, monodispersity and a new biological substrate on which can be introduced ligands toward specific cells, broadening the possibilities for medical applications.
abstract_unstemmed	Different types of gold nanoparticles have been synthesized that show great potential in medical applications such as medical imaging, bio-analytical sensing and photothermal cancer therapy. However, their stability, polydispersity and biocompatibility are major issues of concern. For example, the synthesis of gold nanorods, obtained through the elongated micelle process, produce them with a high positive surface charge that is cytotoxic, while gold nanoshells are unstable and break down in a few weeks due to the Ostwald ripening process. In this work, we report the self-assembly of the capsid protein (CP) of cowpea chlorotic mottle virus (CCMV) around spherical gold nanoparticles, gold nanorods and gold nanoshells to form virus-like particles (VLPs). All gold nanoparticles were synthesized or treated to give them a negative surface charge, so they can interact with the positive N-terminus of the CP leading to the formation of the VLPs. To induce the protein self-assembly around the negative gold nanoparticles, we use different pH and ionic strength conditions determined from a CP phase diagram. The encapsidation with the viral CP will provide the nanoparticles better biocompatibility, stability, monodispersity and a new biological substrate on which can be introduced ligands toward specific cells, broadening the possibilities for medical applications.
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title_short	Encapsidation of Different Plasmonic Gold Nanoparticles by the CCMV CP
url	https://doi.org/10.3390/molecules25112628 https://doaj.org/article/a07f609186ce4304b1c1c0b259e77de6 https://www.mdpi.com/1420-3049/25/11/2628 https://doaj.org/toc/1420-3049
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author2	Martha I. Escamilla-Ruiz Xochitl F. Segovia-González Maria V. Villagrana-Escareño J. Roger Vega-Acosta Jaime Ruiz-Garcia
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up_date	2024-07-04T01:20:23.815Z
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Encapsidation of Different Plasmonic Gold Nanoparticles by the CCMV CP

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