Inhibitory Effects of <i<Urtica thunbergiana </i<Ethanol Extract on Atopic Dermatitis-Induced NC/Nga Mice

Atopic dermatitis (AD) is a chronic, inflammatory skin disease that persists or repeatedly recurs in both childhood and adulthood. <i<Urtica thunbergiana</i< (UT) is an aroma herb with little-known pharmacological effects and anti-inflammatory activities against AD. This study investigat...
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Autor*in:	Hien T.T. Ngo [verfasserIn] Minzhe Fang [verfasserIn] Eunson Hwang [verfasserIn] Yoosung Kim [verfasserIn] Bom Park [verfasserIn] Seul A Seo [verfasserIn] Nhung Quynh Do [verfasserIn] Quynh T.N. Nguyen [verfasserIn] Tae-Hoo Yi [verfasserIn]

Format:	E-Artikel
Sprache:	Englisch

Erschienen:	2020

Schlagwörter:	atopic dermatitis nc/nga mice keratinocytes biostir tnf-α/ifn-γ

Übergeordnetes Werk:	In: Antioxidants - MDPI AG, 2013, 9(2020), 3, p 197
Übergeordnetes Werk:	volume:9 ; year:2020 ; number:3, p 197

Links:	Link aufrufen Link aufrufen Link aufrufen Journal toc

DOI / URN:	10.3390/antiox9030197

Katalog-ID:	DOAJ047608048

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520			\|a Atopic dermatitis (AD) is a chronic, inflammatory skin disease that persists or repeatedly recurs in both childhood and adulthood. <i<Urtica thunbergiana</i< (UT) is an aroma herb with little-known pharmacological effects and anti-inflammatory activities against AD. This study investigated the immunomodulatory efficacy of 50% ethanol-extracted UT in necrosis factor-alpha/interferon-gamma (TNF-α/IFN-γ)-stimulated HaCaT cells in vitro and AD-Biostir-induced NC/Nga mice in vivo. The results showed that UT exhibits a dose-dependent increase in scavenged free radicals, reaching 76.0% ± 1.4% of scavenged 1,1-diphenyl-2-picrylhydrazyl at a concentration of 250 µg/mL. In addition, UT significantly downregulated the mRNA expression of the following pro-inflammatory cytokines and chemokines in TNF-α/IFN-γ-stimulated HaCaT cells: interleukin (IL)-6, IL-8, thymus- and activation-regulated chemokine, macrophage-derived chemokine, and regulated on activation normal T expressed and secreted. UT-treated HaCaT cells showed inhibition of the overexpression of chemokine-regulated signaling molecules, such as nuclear factor-kappa B, inhibitor of kappa B (IκBα), signal transducer and activator of transcription 1, and mitogen-activated protein kinases (MAPKs). UT dietary administration in AD-Biostir-induced NC/Nga mice treated and improved AD-like symptoms, such as scales, epidermal thickening, the dermatitis severity score, high trans-epidermal water loss, reduced skin hydration, increased mast cells, elevated serum immunoglobulin E levels, and an enlarged spleen. UT treatment inhibited the expression of phosphorylated forms of MAPKs, nuclear factor of activated T-cells 1, and regulator IκBα. It also upregulated filaggrin (FLG) production. Therefore, UT shows high anti-AD activity both in vitro and in vivo<i<,</i< and can be a useful anti-AD agent.
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allfields	10.3390/antiox9030197 doi (DE-627)DOAJ047608048 (DE-599)DOAJ946e6efba7a048778e28d6185244de98 DE-627 ger DE-627 rakwb eng RM1-950 Hien T.T. Ngo verfasserin aut Inhibitory Effects of <i<Urtica thunbergiana </i<Ethanol Extract on Atopic Dermatitis-Induced NC/Nga Mice 2020 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Atopic dermatitis (AD) is a chronic, inflammatory skin disease that persists or repeatedly recurs in both childhood and adulthood. <i<Urtica thunbergiana</i< (UT) is an aroma herb with little-known pharmacological effects and anti-inflammatory activities against AD. This study investigated the immunomodulatory efficacy of 50% ethanol-extracted UT in necrosis factor-alpha/interferon-gamma (TNF-α/IFN-γ)-stimulated HaCaT cells in vitro and AD-Biostir-induced NC/Nga mice in vivo. The results showed that UT exhibits a dose-dependent increase in scavenged free radicals, reaching 76.0% ± 1.4% of scavenged 1,1-diphenyl-2-picrylhydrazyl at a concentration of 250 µg/mL. In addition, UT significantly downregulated the mRNA expression of the following pro-inflammatory cytokines and chemokines in TNF-α/IFN-γ-stimulated HaCaT cells: interleukin (IL)-6, IL-8, thymus- and activation-regulated chemokine, macrophage-derived chemokine, and regulated on activation normal T expressed and secreted. UT-treated HaCaT cells showed inhibition of the overexpression of chemokine-regulated signaling molecules, such as nuclear factor-kappa B, inhibitor of kappa B (IκBα), signal transducer and activator of transcription 1, and mitogen-activated protein kinases (MAPKs). UT dietary administration in AD-Biostir-induced NC/Nga mice treated and improved AD-like symptoms, such as scales, epidermal thickening, the dermatitis severity score, high trans-epidermal water loss, reduced skin hydration, increased mast cells, elevated serum immunoglobulin E levels, and an enlarged spleen. UT treatment inhibited the expression of phosphorylated forms of MAPKs, nuclear factor of activated T-cells 1, and regulator IκBα. It also upregulated filaggrin (FLG) production. Therefore, UT shows high anti-AD activity both in vitro and in vivo<i<,</i< and can be a useful anti-AD agent. <i<urtica thunbergiana</i< atopic dermatitis nc/nga mice keratinocytes biostir tnf-α/ifn-γ Therapeutics. Pharmacology Minzhe Fang verfasserin aut Eunson Hwang verfasserin aut Yoosung Kim verfasserin aut Bom Park verfasserin aut Seul A Seo verfasserin aut Nhung Quynh Do verfasserin aut Quynh T.N. Nguyen verfasserin aut Tae-Hoo Yi verfasserin aut In Antioxidants MDPI AG, 2013 9(2020), 3, p 197 (DE-627)737287578 (DE-600)2704216-9 20763921 nnns volume:9 year:2020 number:3, p 197 https://doi.org/10.3390/antiox9030197 kostenfrei https://doaj.org/article/946e6efba7a048778e28d6185244de98 kostenfrei https://www.mdpi.com/2076-3921/9/3/197 kostenfrei https://doaj.org/toc/2076-3921 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ SSG-OLC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 9 2020 3, p 197
spelling	10.3390/antiox9030197 doi (DE-627)DOAJ047608048 (DE-599)DOAJ946e6efba7a048778e28d6185244de98 DE-627 ger DE-627 rakwb eng RM1-950 Hien T.T. Ngo verfasserin aut Inhibitory Effects of <i<Urtica thunbergiana </i<Ethanol Extract on Atopic Dermatitis-Induced NC/Nga Mice 2020 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Atopic dermatitis (AD) is a chronic, inflammatory skin disease that persists or repeatedly recurs in both childhood and adulthood. <i<Urtica thunbergiana</i< (UT) is an aroma herb with little-known pharmacological effects and anti-inflammatory activities against AD. This study investigated the immunomodulatory efficacy of 50% ethanol-extracted UT in necrosis factor-alpha/interferon-gamma (TNF-α/IFN-γ)-stimulated HaCaT cells in vitro and AD-Biostir-induced NC/Nga mice in vivo. The results showed that UT exhibits a dose-dependent increase in scavenged free radicals, reaching 76.0% ± 1.4% of scavenged 1,1-diphenyl-2-picrylhydrazyl at a concentration of 250 µg/mL. In addition, UT significantly downregulated the mRNA expression of the following pro-inflammatory cytokines and chemokines in TNF-α/IFN-γ-stimulated HaCaT cells: interleukin (IL)-6, IL-8, thymus- and activation-regulated chemokine, macrophage-derived chemokine, and regulated on activation normal T expressed and secreted. UT-treated HaCaT cells showed inhibition of the overexpression of chemokine-regulated signaling molecules, such as nuclear factor-kappa B, inhibitor of kappa B (IκBα), signal transducer and activator of transcription 1, and mitogen-activated protein kinases (MAPKs). UT dietary administration in AD-Biostir-induced NC/Nga mice treated and improved AD-like symptoms, such as scales, epidermal thickening, the dermatitis severity score, high trans-epidermal water loss, reduced skin hydration, increased mast cells, elevated serum immunoglobulin E levels, and an enlarged spleen. UT treatment inhibited the expression of phosphorylated forms of MAPKs, nuclear factor of activated T-cells 1, and regulator IκBα. It also upregulated filaggrin (FLG) production. Therefore, UT shows high anti-AD activity both in vitro and in vivo<i<,</i< and can be a useful anti-AD agent. <i<urtica thunbergiana</i< atopic dermatitis nc/nga mice keratinocytes biostir tnf-α/ifn-γ Therapeutics. Pharmacology Minzhe Fang verfasserin aut Eunson Hwang verfasserin aut Yoosung Kim verfasserin aut Bom Park verfasserin aut Seul A Seo verfasserin aut Nhung Quynh Do verfasserin aut Quynh T.N. Nguyen verfasserin aut Tae-Hoo Yi verfasserin aut In Antioxidants MDPI AG, 2013 9(2020), 3, p 197 (DE-627)737287578 (DE-600)2704216-9 20763921 nnns volume:9 year:2020 number:3, p 197 https://doi.org/10.3390/antiox9030197 kostenfrei https://doaj.org/article/946e6efba7a048778e28d6185244de98 kostenfrei https://www.mdpi.com/2076-3921/9/3/197 kostenfrei https://doaj.org/toc/2076-3921 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ SSG-OLC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 9 2020 3, p 197
allfields_unstemmed	10.3390/antiox9030197 doi (DE-627)DOAJ047608048 (DE-599)DOAJ946e6efba7a048778e28d6185244de98 DE-627 ger DE-627 rakwb eng RM1-950 Hien T.T. Ngo verfasserin aut Inhibitory Effects of <i<Urtica thunbergiana </i<Ethanol Extract on Atopic Dermatitis-Induced NC/Nga Mice 2020 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Atopic dermatitis (AD) is a chronic, inflammatory skin disease that persists or repeatedly recurs in both childhood and adulthood. <i<Urtica thunbergiana</i< (UT) is an aroma herb with little-known pharmacological effects and anti-inflammatory activities against AD. This study investigated the immunomodulatory efficacy of 50% ethanol-extracted UT in necrosis factor-alpha/interferon-gamma (TNF-α/IFN-γ)-stimulated HaCaT cells in vitro and AD-Biostir-induced NC/Nga mice in vivo. The results showed that UT exhibits a dose-dependent increase in scavenged free radicals, reaching 76.0% ± 1.4% of scavenged 1,1-diphenyl-2-picrylhydrazyl at a concentration of 250 µg/mL. In addition, UT significantly downregulated the mRNA expression of the following pro-inflammatory cytokines and chemokines in TNF-α/IFN-γ-stimulated HaCaT cells: interleukin (IL)-6, IL-8, thymus- and activation-regulated chemokine, macrophage-derived chemokine, and regulated on activation normal T expressed and secreted. UT-treated HaCaT cells showed inhibition of the overexpression of chemokine-regulated signaling molecules, such as nuclear factor-kappa B, inhibitor of kappa B (IκBα), signal transducer and activator of transcription 1, and mitogen-activated protein kinases (MAPKs). UT dietary administration in AD-Biostir-induced NC/Nga mice treated and improved AD-like symptoms, such as scales, epidermal thickening, the dermatitis severity score, high trans-epidermal water loss, reduced skin hydration, increased mast cells, elevated serum immunoglobulin E levels, and an enlarged spleen. UT treatment inhibited the expression of phosphorylated forms of MAPKs, nuclear factor of activated T-cells 1, and regulator IκBα. It also upregulated filaggrin (FLG) production. Therefore, UT shows high anti-AD activity both in vitro and in vivo<i<,</i< and can be a useful anti-AD agent. <i<urtica thunbergiana</i< atopic dermatitis nc/nga mice keratinocytes biostir tnf-α/ifn-γ Therapeutics. Pharmacology Minzhe Fang verfasserin aut Eunson Hwang verfasserin aut Yoosung Kim verfasserin aut Bom Park verfasserin aut Seul A Seo verfasserin aut Nhung Quynh Do verfasserin aut Quynh T.N. Nguyen verfasserin aut Tae-Hoo Yi verfasserin aut In Antioxidants MDPI AG, 2013 9(2020), 3, p 197 (DE-627)737287578 (DE-600)2704216-9 20763921 nnns volume:9 year:2020 number:3, p 197 https://doi.org/10.3390/antiox9030197 kostenfrei https://doaj.org/article/946e6efba7a048778e28d6185244de98 kostenfrei https://www.mdpi.com/2076-3921/9/3/197 kostenfrei https://doaj.org/toc/2076-3921 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ SSG-OLC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 9 2020 3, p 197
allfieldsGer	10.3390/antiox9030197 doi (DE-627)DOAJ047608048 (DE-599)DOAJ946e6efba7a048778e28d6185244de98 DE-627 ger DE-627 rakwb eng RM1-950 Hien T.T. Ngo verfasserin aut Inhibitory Effects of <i<Urtica thunbergiana </i<Ethanol Extract on Atopic Dermatitis-Induced NC/Nga Mice 2020 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Atopic dermatitis (AD) is a chronic, inflammatory skin disease that persists or repeatedly recurs in both childhood and adulthood. <i<Urtica thunbergiana</i< (UT) is an aroma herb with little-known pharmacological effects and anti-inflammatory activities against AD. This study investigated the immunomodulatory efficacy of 50% ethanol-extracted UT in necrosis factor-alpha/interferon-gamma (TNF-α/IFN-γ)-stimulated HaCaT cells in vitro and AD-Biostir-induced NC/Nga mice in vivo. The results showed that UT exhibits a dose-dependent increase in scavenged free radicals, reaching 76.0% ± 1.4% of scavenged 1,1-diphenyl-2-picrylhydrazyl at a concentration of 250 µg/mL. In addition, UT significantly downregulated the mRNA expression of the following pro-inflammatory cytokines and chemokines in TNF-α/IFN-γ-stimulated HaCaT cells: interleukin (IL)-6, IL-8, thymus- and activation-regulated chemokine, macrophage-derived chemokine, and regulated on activation normal T expressed and secreted. UT-treated HaCaT cells showed inhibition of the overexpression of chemokine-regulated signaling molecules, such as nuclear factor-kappa B, inhibitor of kappa B (IκBα), signal transducer and activator of transcription 1, and mitogen-activated protein kinases (MAPKs). UT dietary administration in AD-Biostir-induced NC/Nga mice treated and improved AD-like symptoms, such as scales, epidermal thickening, the dermatitis severity score, high trans-epidermal water loss, reduced skin hydration, increased mast cells, elevated serum immunoglobulin E levels, and an enlarged spleen. UT treatment inhibited the expression of phosphorylated forms of MAPKs, nuclear factor of activated T-cells 1, and regulator IκBα. It also upregulated filaggrin (FLG) production. Therefore, UT shows high anti-AD activity both in vitro and in vivo<i<,</i< and can be a useful anti-AD agent. <i<urtica thunbergiana</i< atopic dermatitis nc/nga mice keratinocytes biostir tnf-α/ifn-γ Therapeutics. Pharmacology Minzhe Fang verfasserin aut Eunson Hwang verfasserin aut Yoosung Kim verfasserin aut Bom Park verfasserin aut Seul A Seo verfasserin aut Nhung Quynh Do verfasserin aut Quynh T.N. Nguyen verfasserin aut Tae-Hoo Yi verfasserin aut In Antioxidants MDPI AG, 2013 9(2020), 3, p 197 (DE-627)737287578 (DE-600)2704216-9 20763921 nnns volume:9 year:2020 number:3, p 197 https://doi.org/10.3390/antiox9030197 kostenfrei https://doaj.org/article/946e6efba7a048778e28d6185244de98 kostenfrei https://www.mdpi.com/2076-3921/9/3/197 kostenfrei https://doaj.org/toc/2076-3921 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ SSG-OLC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 9 2020 3, p 197
allfieldsSound	10.3390/antiox9030197 doi (DE-627)DOAJ047608048 (DE-599)DOAJ946e6efba7a048778e28d6185244de98 DE-627 ger DE-627 rakwb eng RM1-950 Hien T.T. Ngo verfasserin aut Inhibitory Effects of <i<Urtica thunbergiana </i<Ethanol Extract on Atopic Dermatitis-Induced NC/Nga Mice 2020 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Atopic dermatitis (AD) is a chronic, inflammatory skin disease that persists or repeatedly recurs in both childhood and adulthood. <i<Urtica thunbergiana</i< (UT) is an aroma herb with little-known pharmacological effects and anti-inflammatory activities against AD. This study investigated the immunomodulatory efficacy of 50% ethanol-extracted UT in necrosis factor-alpha/interferon-gamma (TNF-α/IFN-γ)-stimulated HaCaT cells in vitro and AD-Biostir-induced NC/Nga mice in vivo. The results showed that UT exhibits a dose-dependent increase in scavenged free radicals, reaching 76.0% ± 1.4% of scavenged 1,1-diphenyl-2-picrylhydrazyl at a concentration of 250 µg/mL. In addition, UT significantly downregulated the mRNA expression of the following pro-inflammatory cytokines and chemokines in TNF-α/IFN-γ-stimulated HaCaT cells: interleukin (IL)-6, IL-8, thymus- and activation-regulated chemokine, macrophage-derived chemokine, and regulated on activation normal T expressed and secreted. UT-treated HaCaT cells showed inhibition of the overexpression of chemokine-regulated signaling molecules, such as nuclear factor-kappa B, inhibitor of kappa B (IκBα), signal transducer and activator of transcription 1, and mitogen-activated protein kinases (MAPKs). UT dietary administration in AD-Biostir-induced NC/Nga mice treated and improved AD-like symptoms, such as scales, epidermal thickening, the dermatitis severity score, high trans-epidermal water loss, reduced skin hydration, increased mast cells, elevated serum immunoglobulin E levels, and an enlarged spleen. UT treatment inhibited the expression of phosphorylated forms of MAPKs, nuclear factor of activated T-cells 1, and regulator IκBα. It also upregulated filaggrin (FLG) production. Therefore, UT shows high anti-AD activity both in vitro and in vivo<i<,</i< and can be a useful anti-AD agent. <i<urtica thunbergiana</i< atopic dermatitis nc/nga mice keratinocytes biostir tnf-α/ifn-γ Therapeutics. Pharmacology Minzhe Fang verfasserin aut Eunson Hwang verfasserin aut Yoosung Kim verfasserin aut Bom Park verfasserin aut Seul A Seo verfasserin aut Nhung Quynh Do verfasserin aut Quynh T.N. Nguyen verfasserin aut Tae-Hoo Yi verfasserin aut In Antioxidants MDPI AG, 2013 9(2020), 3, p 197 (DE-627)737287578 (DE-600)2704216-9 20763921 nnns volume:9 year:2020 number:3, p 197 https://doi.org/10.3390/antiox9030197 kostenfrei https://doaj.org/article/946e6efba7a048778e28d6185244de98 kostenfrei https://www.mdpi.com/2076-3921/9/3/197 kostenfrei https://doaj.org/toc/2076-3921 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ SSG-OLC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 9 2020 3, p 197
language	English
source	In Antioxidants 9(2020), 3, p 197 volume:9 year:2020 number:3, p 197
sourceStr	In Antioxidants 9(2020), 3, p 197 volume:9 year:2020 number:3, p 197
format_phy_str_mv	Article
institution	findex.gbv.de
topic_facet	<i<urtica thunbergiana</i< atopic dermatitis nc/nga mice keratinocytes biostir tnf-α/ifn-γ Therapeutics. Pharmacology
isfreeaccess_bool	true
container_title	Antioxidants
authorswithroles_txt_mv	Hien T.T. Ngo @@aut@@ Minzhe Fang @@aut@@ Eunson Hwang @@aut@@ Yoosung Kim @@aut@@ Bom Park @@aut@@ Seul A Seo @@aut@@ Nhung Quynh Do @@aut@@ Quynh T.N. Nguyen @@aut@@ Tae-Hoo Yi @@aut@@
publishDateDaySort_date	2020-01-01T00:00:00Z
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callnumber-first	R - Medicine
author	Hien T.T. Ngo
spellingShingle	Hien T.T. Ngo misc RM1-950 misc <i<urtica thunbergiana</i< misc atopic dermatitis misc nc/nga mice misc keratinocytes misc biostir misc tnf-α/ifn-γ misc Therapeutics. Pharmacology Inhibitory Effects of <i<Urtica thunbergiana </i<Ethanol Extract on Atopic Dermatitis-Induced NC/Nga Mice
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topic_title	RM1-950 Inhibitory Effects of <i<Urtica thunbergiana </i<Ethanol Extract on Atopic Dermatitis-Induced NC/Nga Mice <i<urtica thunbergiana</i< atopic dermatitis nc/nga mice keratinocytes biostir tnf-α/ifn-γ
topic	misc RM1-950 misc <i<urtica thunbergiana</i< misc atopic dermatitis misc nc/nga mice misc keratinocytes misc biostir misc tnf-α/ifn-γ misc Therapeutics. Pharmacology
topic_unstemmed	misc RM1-950 misc <i<urtica thunbergiana</i< misc atopic dermatitis misc nc/nga mice misc keratinocytes misc biostir misc tnf-α/ifn-γ misc Therapeutics. Pharmacology
topic_browse	misc RM1-950 misc <i<urtica thunbergiana</i< misc atopic dermatitis misc nc/nga mice misc keratinocytes misc biostir misc tnf-α/ifn-γ misc Therapeutics. Pharmacology
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hierarchy_parent_title	Antioxidants
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title	Inhibitory Effects of <i<Urtica thunbergiana </i<Ethanol Extract on Atopic Dermatitis-Induced NC/Nga Mice
ctrlnum	(DE-627)DOAJ047608048 (DE-599)DOAJ946e6efba7a048778e28d6185244de98
title_full	Inhibitory Effects of <i<Urtica thunbergiana </i<Ethanol Extract on Atopic Dermatitis-Induced NC/Nga Mice
author_sort	Hien T.T. Ngo
journal	Antioxidants
journalStr	Antioxidants
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author_browse	Hien T.T. Ngo Minzhe Fang Eunson Hwang Yoosung Kim Bom Park Seul A Seo Nhung Quynh Do Quynh T.N. Nguyen Tae-Hoo Yi
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author-letter	Hien T.T. Ngo
doi_str_mv	10.3390/antiox9030197
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title_sort	inhibitory effects of <i<urtica thunbergiana </i<ethanol extract on atopic dermatitis-induced nc/nga mice
callnumber	RM1-950
title_auth	Inhibitory Effects of <i<Urtica thunbergiana </i<Ethanol Extract on Atopic Dermatitis-Induced NC/Nga Mice
abstract	Atopic dermatitis (AD) is a chronic, inflammatory skin disease that persists or repeatedly recurs in both childhood and adulthood. <i<Urtica thunbergiana</i< (UT) is an aroma herb with little-known pharmacological effects and anti-inflammatory activities against AD. This study investigated the immunomodulatory efficacy of 50% ethanol-extracted UT in necrosis factor-alpha/interferon-gamma (TNF-α/IFN-γ)-stimulated HaCaT cells in vitro and AD-Biostir-induced NC/Nga mice in vivo. The results showed that UT exhibits a dose-dependent increase in scavenged free radicals, reaching 76.0% ± 1.4% of scavenged 1,1-diphenyl-2-picrylhydrazyl at a concentration of 250 µg/mL. In addition, UT significantly downregulated the mRNA expression of the following pro-inflammatory cytokines and chemokines in TNF-α/IFN-γ-stimulated HaCaT cells: interleukin (IL)-6, IL-8, thymus- and activation-regulated chemokine, macrophage-derived chemokine, and regulated on activation normal T expressed and secreted. UT-treated HaCaT cells showed inhibition of the overexpression of chemokine-regulated signaling molecules, such as nuclear factor-kappa B, inhibitor of kappa B (IκBα), signal transducer and activator of transcription 1, and mitogen-activated protein kinases (MAPKs). UT dietary administration in AD-Biostir-induced NC/Nga mice treated and improved AD-like symptoms, such as scales, epidermal thickening, the dermatitis severity score, high trans-epidermal water loss, reduced skin hydration, increased mast cells, elevated serum immunoglobulin E levels, and an enlarged spleen. UT treatment inhibited the expression of phosphorylated forms of MAPKs, nuclear factor of activated T-cells 1, and regulator IκBα. It also upregulated filaggrin (FLG) production. Therefore, UT shows high anti-AD activity both in vitro and in vivo<i<,</i< and can be a useful anti-AD agent.
abstractGer	Atopic dermatitis (AD) is a chronic, inflammatory skin disease that persists or repeatedly recurs in both childhood and adulthood. <i<Urtica thunbergiana</i< (UT) is an aroma herb with little-known pharmacological effects and anti-inflammatory activities against AD. This study investigated the immunomodulatory efficacy of 50% ethanol-extracted UT in necrosis factor-alpha/interferon-gamma (TNF-α/IFN-γ)-stimulated HaCaT cells in vitro and AD-Biostir-induced NC/Nga mice in vivo. The results showed that UT exhibits a dose-dependent increase in scavenged free radicals, reaching 76.0% ± 1.4% of scavenged 1,1-diphenyl-2-picrylhydrazyl at a concentration of 250 µg/mL. In addition, UT significantly downregulated the mRNA expression of the following pro-inflammatory cytokines and chemokines in TNF-α/IFN-γ-stimulated HaCaT cells: interleukin (IL)-6, IL-8, thymus- and activation-regulated chemokine, macrophage-derived chemokine, and regulated on activation normal T expressed and secreted. UT-treated HaCaT cells showed inhibition of the overexpression of chemokine-regulated signaling molecules, such as nuclear factor-kappa B, inhibitor of kappa B (IκBα), signal transducer and activator of transcription 1, and mitogen-activated protein kinases (MAPKs). UT dietary administration in AD-Biostir-induced NC/Nga mice treated and improved AD-like symptoms, such as scales, epidermal thickening, the dermatitis severity score, high trans-epidermal water loss, reduced skin hydration, increased mast cells, elevated serum immunoglobulin E levels, and an enlarged spleen. UT treatment inhibited the expression of phosphorylated forms of MAPKs, nuclear factor of activated T-cells 1, and regulator IκBα. It also upregulated filaggrin (FLG) production. Therefore, UT shows high anti-AD activity both in vitro and in vivo<i<,</i< and can be a useful anti-AD agent.
abstract_unstemmed	Atopic dermatitis (AD) is a chronic, inflammatory skin disease that persists or repeatedly recurs in both childhood and adulthood. <i<Urtica thunbergiana</i< (UT) is an aroma herb with little-known pharmacological effects and anti-inflammatory activities against AD. This study investigated the immunomodulatory efficacy of 50% ethanol-extracted UT in necrosis factor-alpha/interferon-gamma (TNF-α/IFN-γ)-stimulated HaCaT cells in vitro and AD-Biostir-induced NC/Nga mice in vivo. The results showed that UT exhibits a dose-dependent increase in scavenged free radicals, reaching 76.0% ± 1.4% of scavenged 1,1-diphenyl-2-picrylhydrazyl at a concentration of 250 µg/mL. In addition, UT significantly downregulated the mRNA expression of the following pro-inflammatory cytokines and chemokines in TNF-α/IFN-γ-stimulated HaCaT cells: interleukin (IL)-6, IL-8, thymus- and activation-regulated chemokine, macrophage-derived chemokine, and regulated on activation normal T expressed and secreted. UT-treated HaCaT cells showed inhibition of the overexpression of chemokine-regulated signaling molecules, such as nuclear factor-kappa B, inhibitor of kappa B (IκBα), signal transducer and activator of transcription 1, and mitogen-activated protein kinases (MAPKs). UT dietary administration in AD-Biostir-induced NC/Nga mice treated and improved AD-like symptoms, such as scales, epidermal thickening, the dermatitis severity score, high trans-epidermal water loss, reduced skin hydration, increased mast cells, elevated serum immunoglobulin E levels, and an enlarged spleen. UT treatment inhibited the expression of phosphorylated forms of MAPKs, nuclear factor of activated T-cells 1, and regulator IκBα. It also upregulated filaggrin (FLG) production. Therefore, UT shows high anti-AD activity both in vitro and in vivo<i<,</i< and can be a useful anti-AD agent.
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container_issue	3, p 197
title_short	Inhibitory Effects of <i<Urtica thunbergiana </i<Ethanol Extract on Atopic Dermatitis-Induced NC/Nga Mice
url	https://doi.org/10.3390/antiox9030197 https://doaj.org/article/946e6efba7a048778e28d6185244de98 https://www.mdpi.com/2076-3921/9/3/197 https://doaj.org/toc/2076-3921
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