The role of vitamin D in seasonal acute respiratory viral infections and COVID-19
A link between vitamin D deficiency and susceptibility to infectious diseases was suggested over a hundred years ago. Epidemiological studies show a strong association between seasonal fluctuations in vitamin D levels and the incidence of various infectious diseases, including septic shock, acute re...
Ausführliche Beschreibung
Gespeichert in:
| Autor*in: |
E. A. Pigarova [verfasserIn] A. A. Povalyaeva [verfasserIn] L. K. Dzeranova [verfasserIn] L. Y. Rozhinskaya [verfasserIn] N. G. Mokrysheva [verfasserIn] |
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| Format: |
E-Artikel |
|---|---|
| Sprache: |
Russisch |
| Erschienen: |
2020 |
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| Schlagwörter: |
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| Übergeordnetes Werk: |
In: Терапевтический архив - "Consilium Medicum" Publishing house, 2018, 92(2020), 11, Seite 98-105 |
|---|---|
| Übergeordnetes Werk: |
volume:92 ; year:2020 ; number:11 ; pages:98-105 |
| Links: |
Link aufrufen |
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| DOI / URN: |
10.26442/00403660.2020.11.000785 |
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DOAJ047608803 |
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E. A. Pigarova A. A. Povalyaeva L. K. Dzeranova L. Y. Rozhinskaya N. G. Mokrysheva |
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E. A. Pigarova |
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role of vitamin d in seasonal acute respiratory viral infections and covid-19 |
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The role of vitamin D in seasonal acute respiratory viral infections and COVID-19 |
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A link between vitamin D deficiency and susceptibility to infectious diseases was suggested over a hundred years ago. Epidemiological studies show a strong association between seasonal fluctuations in vitamin D levels and the incidence of various infectious diseases, including septic shock, acute respiratory infections, and influenza. Our understanding of vitamin D metabolism and its extra-skeletal functions has improved significantly over the past three decades, and the discovery that the vitamin D receptor and 1a-hydroxylase, an enzyme needed to convert vitamin D to its active form, is present in the cells of the immune system, revolutionized in this area. Recent studies have shown that vitamin D regulates the expression of specific endogenous antimicrobial peptides in immune cells, modulates the immune response and the course of autoimmune processes; these actions indicate the potential role of vitamin D in modulating the immune response to various infectious diseases. This publication reviews the literature on the effects of vitamin D on immunity, its potential in the prevention and treatment of viral diseases, with a particular focus on COVID-19. |
| abstractGer |
A link between vitamin D deficiency and susceptibility to infectious diseases was suggested over a hundred years ago. Epidemiological studies show a strong association between seasonal fluctuations in vitamin D levels and the incidence of various infectious diseases, including septic shock, acute respiratory infections, and influenza. Our understanding of vitamin D metabolism and its extra-skeletal functions has improved significantly over the past three decades, and the discovery that the vitamin D receptor and 1a-hydroxylase, an enzyme needed to convert vitamin D to its active form, is present in the cells of the immune system, revolutionized in this area. Recent studies have shown that vitamin D regulates the expression of specific endogenous antimicrobial peptides in immune cells, modulates the immune response and the course of autoimmune processes; these actions indicate the potential role of vitamin D in modulating the immune response to various infectious diseases. This publication reviews the literature on the effects of vitamin D on immunity, its potential in the prevention and treatment of viral diseases, with a particular focus on COVID-19. |
| abstract_unstemmed |
A link between vitamin D deficiency and susceptibility to infectious diseases was suggested over a hundred years ago. Epidemiological studies show a strong association between seasonal fluctuations in vitamin D levels and the incidence of various infectious diseases, including septic shock, acute respiratory infections, and influenza. Our understanding of vitamin D metabolism and its extra-skeletal functions has improved significantly over the past three decades, and the discovery that the vitamin D receptor and 1a-hydroxylase, an enzyme needed to convert vitamin D to its active form, is present in the cells of the immune system, revolutionized in this area. Recent studies have shown that vitamin D regulates the expression of specific endogenous antimicrobial peptides in immune cells, modulates the immune response and the course of autoimmune processes; these actions indicate the potential role of vitamin D in modulating the immune response to various infectious diseases. This publication reviews the literature on the effects of vitamin D on immunity, its potential in the prevention and treatment of viral diseases, with a particular focus on COVID-19. |
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The role of vitamin D in seasonal acute respiratory viral infections and COVID-19 |
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https://doi.org/10.26442/00403660.2020.11.000785 https://doaj.org/article/bbcb8f3a1c0a44cdb8d4c8be4ff80811 https://ter-arkhiv.ru/0040-3660/article/viewFile/56945/40135 https://doaj.org/toc/0040-3660 https://doaj.org/toc/2309-5342 |
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