Transcriptomic Profiling of Fibropapillomatosis in Green Sea Turtles (Chelonia mydas) From South Texas
Sea turtle fibropapillomatosis (FP) is a tumor promoting disease that is one of several threats globally to endangered sea turtle populations. The prevalence of FP is highest in green sea turtle (Chelonia mydas) populations, and historically has shown considerable temporal growth. FP tumors can sign...
Ausführliche Beschreibung
Autor*in: |
Nicholas B. Blackburn [verfasserIn] Ana Cristina Leandro [verfasserIn] Nina Nahvi [verfasserIn] Mariana A. Devlin [verfasserIn] Marcelo Leandro [verfasserIn] Ignacio Martinez Escobedo [verfasserIn] Juan M. Peralta [verfasserIn] Jeff George [verfasserIn] Brian A. Stacy [verfasserIn] Thomas W. deMaar [verfasserIn] John Blangero [verfasserIn] Megan Keniry [verfasserIn] Joanne E. Curran [verfasserIn] |
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E-Artikel |
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Sprache: |
Englisch |
Erschienen: |
2021 |
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Übergeordnetes Werk: |
In: Frontiers in Immunology - Frontiers Media S.A., 2011, 12(2021) |
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Übergeordnetes Werk: |
volume:12 ; year:2021 |
Links: |
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DOI / URN: |
10.3389/fimmu.2021.630988 |
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Katalog-ID: |
DOAJ047664517 |
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520 | |a Sea turtle fibropapillomatosis (FP) is a tumor promoting disease that is one of several threats globally to endangered sea turtle populations. The prevalence of FP is highest in green sea turtle (Chelonia mydas) populations, and historically has shown considerable temporal growth. FP tumors can significantly affect the ability of turtles to forage for food and avoid predation and can grow to debilitating sizes. In the current study, based in South Texas, we have applied transcriptome sequencing to FP tumors and healthy control tissue to study the gene expression profiles of FP. By identifying differentially expressed turtle genes in FP, and matching these genes to their closest human ortholog we draw on the wealth of human based knowledge, specifically human cancer, to identify new insights into the biology of sea turtle FP. We show that several genes aberrantly expressed in FP tumors have known tumor promoting biology in humans, including CTHRC1 and NLRC5, and provide support that disruption of the Wnt signaling pathway is a feature of FP. Further, we profiled the expression of current targets of immune checkpoint inhibitors from human oncology in FP tumors and identified potential candidates for future studies. | ||
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10.3389/fimmu.2021.630988 doi (DE-627)DOAJ047664517 (DE-599)DOAJb7c09ce3c24d4b7f8f5899f0be4f626c DE-627 ger DE-627 rakwb eng RC581-607 Nicholas B. Blackburn verfasserin aut Transcriptomic Profiling of Fibropapillomatosis in Green Sea Turtles (Chelonia mydas) From South Texas 2021 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Sea turtle fibropapillomatosis (FP) is a tumor promoting disease that is one of several threats globally to endangered sea turtle populations. The prevalence of FP is highest in green sea turtle (Chelonia mydas) populations, and historically has shown considerable temporal growth. FP tumors can significantly affect the ability of turtles to forage for food and avoid predation and can grow to debilitating sizes. In the current study, based in South Texas, we have applied transcriptome sequencing to FP tumors and healthy control tissue to study the gene expression profiles of FP. By identifying differentially expressed turtle genes in FP, and matching these genes to their closest human ortholog we draw on the wealth of human based knowledge, specifically human cancer, to identify new insights into the biology of sea turtle FP. We show that several genes aberrantly expressed in FP tumors have known tumor promoting biology in humans, including CTHRC1 and NLRC5, and provide support that disruption of the Wnt signaling pathway is a feature of FP. Further, we profiled the expression of current targets of immune checkpoint inhibitors from human oncology in FP tumors and identified potential candidates for future studies. fibropapillomatosis RNA-seq chelonid alphaherpesvirus 5 (ChHV5) precision wildlife medicine conservation medicine Chelonia mydas Immunologic diseases. Allergy Nicholas B. Blackburn verfasserin aut Nicholas B. Blackburn verfasserin aut Ana Cristina Leandro verfasserin aut Ana Cristina Leandro verfasserin aut Nina Nahvi verfasserin aut Mariana A. Devlin verfasserin aut Marcelo Leandro verfasserin aut Marcelo Leandro verfasserin aut Ignacio Martinez Escobedo verfasserin aut Juan M. Peralta verfasserin aut Juan M. Peralta verfasserin aut Juan M. Peralta verfasserin aut Jeff George verfasserin aut Brian A. Stacy verfasserin aut Thomas W. deMaar verfasserin aut John Blangero verfasserin aut John Blangero verfasserin aut Megan Keniry verfasserin aut Joanne E. Curran verfasserin aut Joanne E. Curran verfasserin aut In Frontiers in Immunology Frontiers Media S.A., 2011 12(2021) (DE-627)657998354 (DE-600)2606827-8 16643224 nnns volume:12 year:2021 https://doi.org/10.3389/fimmu.2021.630988 kostenfrei https://doaj.org/article/b7c09ce3c24d4b7f8f5899f0be4f626c kostenfrei https://www.frontiersin.org/articles/10.3389/fimmu.2021.630988/full kostenfrei https://doaj.org/toc/1664-3224 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2003 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 12 2021 |
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10.3389/fimmu.2021.630988 doi (DE-627)DOAJ047664517 (DE-599)DOAJb7c09ce3c24d4b7f8f5899f0be4f626c DE-627 ger DE-627 rakwb eng RC581-607 Nicholas B. Blackburn verfasserin aut Transcriptomic Profiling of Fibropapillomatosis in Green Sea Turtles (Chelonia mydas) From South Texas 2021 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Sea turtle fibropapillomatosis (FP) is a tumor promoting disease that is one of several threats globally to endangered sea turtle populations. The prevalence of FP is highest in green sea turtle (Chelonia mydas) populations, and historically has shown considerable temporal growth. FP tumors can significantly affect the ability of turtles to forage for food and avoid predation and can grow to debilitating sizes. In the current study, based in South Texas, we have applied transcriptome sequencing to FP tumors and healthy control tissue to study the gene expression profiles of FP. By identifying differentially expressed turtle genes in FP, and matching these genes to their closest human ortholog we draw on the wealth of human based knowledge, specifically human cancer, to identify new insights into the biology of sea turtle FP. We show that several genes aberrantly expressed in FP tumors have known tumor promoting biology in humans, including CTHRC1 and NLRC5, and provide support that disruption of the Wnt signaling pathway is a feature of FP. Further, we profiled the expression of current targets of immune checkpoint inhibitors from human oncology in FP tumors and identified potential candidates for future studies. fibropapillomatosis RNA-seq chelonid alphaherpesvirus 5 (ChHV5) precision wildlife medicine conservation medicine Chelonia mydas Immunologic diseases. Allergy Nicholas B. Blackburn verfasserin aut Nicholas B. Blackburn verfasserin aut Ana Cristina Leandro verfasserin aut Ana Cristina Leandro verfasserin aut Nina Nahvi verfasserin aut Mariana A. Devlin verfasserin aut Marcelo Leandro verfasserin aut Marcelo Leandro verfasserin aut Ignacio Martinez Escobedo verfasserin aut Juan M. Peralta verfasserin aut Juan M. Peralta verfasserin aut Juan M. Peralta verfasserin aut Jeff George verfasserin aut Brian A. Stacy verfasserin aut Thomas W. deMaar verfasserin aut John Blangero verfasserin aut John Blangero verfasserin aut Megan Keniry verfasserin aut Joanne E. Curran verfasserin aut Joanne E. Curran verfasserin aut In Frontiers in Immunology Frontiers Media S.A., 2011 12(2021) (DE-627)657998354 (DE-600)2606827-8 16643224 nnns volume:12 year:2021 https://doi.org/10.3389/fimmu.2021.630988 kostenfrei https://doaj.org/article/b7c09ce3c24d4b7f8f5899f0be4f626c kostenfrei https://www.frontiersin.org/articles/10.3389/fimmu.2021.630988/full kostenfrei https://doaj.org/toc/1664-3224 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2003 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 12 2021 |
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10.3389/fimmu.2021.630988 doi (DE-627)DOAJ047664517 (DE-599)DOAJb7c09ce3c24d4b7f8f5899f0be4f626c DE-627 ger DE-627 rakwb eng RC581-607 Nicholas B. Blackburn verfasserin aut Transcriptomic Profiling of Fibropapillomatosis in Green Sea Turtles (Chelonia mydas) From South Texas 2021 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Sea turtle fibropapillomatosis (FP) is a tumor promoting disease that is one of several threats globally to endangered sea turtle populations. The prevalence of FP is highest in green sea turtle (Chelonia mydas) populations, and historically has shown considerable temporal growth. FP tumors can significantly affect the ability of turtles to forage for food and avoid predation and can grow to debilitating sizes. In the current study, based in South Texas, we have applied transcriptome sequencing to FP tumors and healthy control tissue to study the gene expression profiles of FP. By identifying differentially expressed turtle genes in FP, and matching these genes to their closest human ortholog we draw on the wealth of human based knowledge, specifically human cancer, to identify new insights into the biology of sea turtle FP. We show that several genes aberrantly expressed in FP tumors have known tumor promoting biology in humans, including CTHRC1 and NLRC5, and provide support that disruption of the Wnt signaling pathway is a feature of FP. Further, we profiled the expression of current targets of immune checkpoint inhibitors from human oncology in FP tumors and identified potential candidates for future studies. fibropapillomatosis RNA-seq chelonid alphaherpesvirus 5 (ChHV5) precision wildlife medicine conservation medicine Chelonia mydas Immunologic diseases. Allergy Nicholas B. Blackburn verfasserin aut Nicholas B. Blackburn verfasserin aut Ana Cristina Leandro verfasserin aut Ana Cristina Leandro verfasserin aut Nina Nahvi verfasserin aut Mariana A. Devlin verfasserin aut Marcelo Leandro verfasserin aut Marcelo Leandro verfasserin aut Ignacio Martinez Escobedo verfasserin aut Juan M. Peralta verfasserin aut Juan M. Peralta verfasserin aut Juan M. Peralta verfasserin aut Jeff George verfasserin aut Brian A. Stacy verfasserin aut Thomas W. deMaar verfasserin aut John Blangero verfasserin aut John Blangero verfasserin aut Megan Keniry verfasserin aut Joanne E. Curran verfasserin aut Joanne E. Curran verfasserin aut In Frontiers in Immunology Frontiers Media S.A., 2011 12(2021) (DE-627)657998354 (DE-600)2606827-8 16643224 nnns volume:12 year:2021 https://doi.org/10.3389/fimmu.2021.630988 kostenfrei https://doaj.org/article/b7c09ce3c24d4b7f8f5899f0be4f626c kostenfrei https://www.frontiersin.org/articles/10.3389/fimmu.2021.630988/full kostenfrei https://doaj.org/toc/1664-3224 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2003 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 12 2021 |
allfieldsGer |
10.3389/fimmu.2021.630988 doi (DE-627)DOAJ047664517 (DE-599)DOAJb7c09ce3c24d4b7f8f5899f0be4f626c DE-627 ger DE-627 rakwb eng RC581-607 Nicholas B. Blackburn verfasserin aut Transcriptomic Profiling of Fibropapillomatosis in Green Sea Turtles (Chelonia mydas) From South Texas 2021 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Sea turtle fibropapillomatosis (FP) is a tumor promoting disease that is one of several threats globally to endangered sea turtle populations. The prevalence of FP is highest in green sea turtle (Chelonia mydas) populations, and historically has shown considerable temporal growth. FP tumors can significantly affect the ability of turtles to forage for food and avoid predation and can grow to debilitating sizes. In the current study, based in South Texas, we have applied transcriptome sequencing to FP tumors and healthy control tissue to study the gene expression profiles of FP. By identifying differentially expressed turtle genes in FP, and matching these genes to their closest human ortholog we draw on the wealth of human based knowledge, specifically human cancer, to identify new insights into the biology of sea turtle FP. We show that several genes aberrantly expressed in FP tumors have known tumor promoting biology in humans, including CTHRC1 and NLRC5, and provide support that disruption of the Wnt signaling pathway is a feature of FP. Further, we profiled the expression of current targets of immune checkpoint inhibitors from human oncology in FP tumors and identified potential candidates for future studies. fibropapillomatosis RNA-seq chelonid alphaherpesvirus 5 (ChHV5) precision wildlife medicine conservation medicine Chelonia mydas Immunologic diseases. Allergy Nicholas B. Blackburn verfasserin aut Nicholas B. Blackburn verfasserin aut Ana Cristina Leandro verfasserin aut Ana Cristina Leandro verfasserin aut Nina Nahvi verfasserin aut Mariana A. Devlin verfasserin aut Marcelo Leandro verfasserin aut Marcelo Leandro verfasserin aut Ignacio Martinez Escobedo verfasserin aut Juan M. Peralta verfasserin aut Juan M. Peralta verfasserin aut Juan M. Peralta verfasserin aut Jeff George verfasserin aut Brian A. Stacy verfasserin aut Thomas W. deMaar verfasserin aut John Blangero verfasserin aut John Blangero verfasserin aut Megan Keniry verfasserin aut Joanne E. Curran verfasserin aut Joanne E. Curran verfasserin aut In Frontiers in Immunology Frontiers Media S.A., 2011 12(2021) (DE-627)657998354 (DE-600)2606827-8 16643224 nnns volume:12 year:2021 https://doi.org/10.3389/fimmu.2021.630988 kostenfrei https://doaj.org/article/b7c09ce3c24d4b7f8f5899f0be4f626c kostenfrei https://www.frontiersin.org/articles/10.3389/fimmu.2021.630988/full kostenfrei https://doaj.org/toc/1664-3224 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2003 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 12 2021 |
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Nicholas B. Blackburn Ana Cristina Leandro Nina Nahvi Mariana A. Devlin Marcelo Leandro Ignacio Martinez Escobedo Juan M. Peralta Jeff George Brian A. Stacy Thomas W. deMaar John Blangero Megan Keniry Joanne E. Curran |
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transcriptomic profiling of fibropapillomatosis in green sea turtles (chelonia mydas) from south texas |
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Transcriptomic Profiling of Fibropapillomatosis in Green Sea Turtles (Chelonia mydas) From South Texas |
abstract |
Sea turtle fibropapillomatosis (FP) is a tumor promoting disease that is one of several threats globally to endangered sea turtle populations. The prevalence of FP is highest in green sea turtle (Chelonia mydas) populations, and historically has shown considerable temporal growth. FP tumors can significantly affect the ability of turtles to forage for food and avoid predation and can grow to debilitating sizes. In the current study, based in South Texas, we have applied transcriptome sequencing to FP tumors and healthy control tissue to study the gene expression profiles of FP. By identifying differentially expressed turtle genes in FP, and matching these genes to their closest human ortholog we draw on the wealth of human based knowledge, specifically human cancer, to identify new insights into the biology of sea turtle FP. We show that several genes aberrantly expressed in FP tumors have known tumor promoting biology in humans, including CTHRC1 and NLRC5, and provide support that disruption of the Wnt signaling pathway is a feature of FP. Further, we profiled the expression of current targets of immune checkpoint inhibitors from human oncology in FP tumors and identified potential candidates for future studies. |
abstractGer |
Sea turtle fibropapillomatosis (FP) is a tumor promoting disease that is one of several threats globally to endangered sea turtle populations. The prevalence of FP is highest in green sea turtle (Chelonia mydas) populations, and historically has shown considerable temporal growth. FP tumors can significantly affect the ability of turtles to forage for food and avoid predation and can grow to debilitating sizes. In the current study, based in South Texas, we have applied transcriptome sequencing to FP tumors and healthy control tissue to study the gene expression profiles of FP. By identifying differentially expressed turtle genes in FP, and matching these genes to their closest human ortholog we draw on the wealth of human based knowledge, specifically human cancer, to identify new insights into the biology of sea turtle FP. We show that several genes aberrantly expressed in FP tumors have known tumor promoting biology in humans, including CTHRC1 and NLRC5, and provide support that disruption of the Wnt signaling pathway is a feature of FP. Further, we profiled the expression of current targets of immune checkpoint inhibitors from human oncology in FP tumors and identified potential candidates for future studies. |
abstract_unstemmed |
Sea turtle fibropapillomatosis (FP) is a tumor promoting disease that is one of several threats globally to endangered sea turtle populations. The prevalence of FP is highest in green sea turtle (Chelonia mydas) populations, and historically has shown considerable temporal growth. FP tumors can significantly affect the ability of turtles to forage for food and avoid predation and can grow to debilitating sizes. In the current study, based in South Texas, we have applied transcriptome sequencing to FP tumors and healthy control tissue to study the gene expression profiles of FP. By identifying differentially expressed turtle genes in FP, and matching these genes to their closest human ortholog we draw on the wealth of human based knowledge, specifically human cancer, to identify new insights into the biology of sea turtle FP. We show that several genes aberrantly expressed in FP tumors have known tumor promoting biology in humans, including CTHRC1 and NLRC5, and provide support that disruption of the Wnt signaling pathway is a feature of FP. Further, we profiled the expression of current targets of immune checkpoint inhibitors from human oncology in FP tumors and identified potential candidates for future studies. |
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title_short |
Transcriptomic Profiling of Fibropapillomatosis in Green Sea Turtles (Chelonia mydas) From South Texas |
url |
https://doi.org/10.3389/fimmu.2021.630988 https://doaj.org/article/b7c09ce3c24d4b7f8f5899f0be4f626c https://www.frontiersin.org/articles/10.3389/fimmu.2021.630988/full https://doaj.org/toc/1664-3224 |
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Nicholas B. Blackburn Ana Cristina Leandro Nina Nahvi Mariana A. Devlin Marcelo Leandro Ignacio Martinez Escobedo Juan M. Peralta Jeff George Brian A. Stacy Thomas W. deMaar John Blangero Megan Keniry Joanne E. Curran |
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