Common and Unique Transcription Signatures of YAP and TAZ in Gastric Cancer Cells

YAP and its paralog TAZ are the nuclear effectors of the Hippo tumour-suppressor pathway, and function as transcriptional co-activators to control gene expression in response to mechanical cues. To identify both common and unique transcriptional targets of YAP and TAZ in gastric cancer cells, we car...
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Gespeichert in:

Autor*in:	Yaelim Lee [verfasserIn] Megan Finch-Edmondson [verfasserIn] Hamizah Cognart [verfasserIn] Bowen Zhu [verfasserIn] Haiwei Song [verfasserIn] Boon Chuan Low [verfasserIn] Marius Sudol [verfasserIn]

Format:	E-Artikel
Sprache:	Englisch

Erschienen:	2020

Schlagwörter:	YAP (Yes-associated protein 1 also known as YAP1 or YAP65) TAZ (transcriptional co-activator with PDZ-binding motif also known as WWTR1) gastric cancer transcriptome

Übergeordnetes Werk:	In: Cancers - MDPI AG, 2010, 12(2020), 12, p 3667
Übergeordnetes Werk:	volume:12 ; year:2020 ; number:12, p 3667

Links:	Link aufrufen Link aufrufen Link aufrufen Journal toc

DOI / URN:	10.3390/cancers12123667

Katalog-ID:	DOAJ047707615

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allfieldsSound	10.3390/cancers12123667 doi (DE-627)DOAJ047707615 (DE-599)DOAJ4c09132fb0ca4a0eac194e62319ba735 DE-627 ger DE-627 rakwb eng RC254-282 Yaelim Lee verfasserin aut Common and Unique Transcription Signatures of YAP and TAZ in Gastric Cancer Cells 2020 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier YAP and its paralog TAZ are the nuclear effectors of the Hippo tumour-suppressor pathway, and function as transcriptional co-activators to control gene expression in response to mechanical cues. To identify both common and unique transcriptional targets of YAP and TAZ in gastric cancer cells, we carried out RNA-sequencing analysis of overexpressed YAP or TAZ in the corresponding paralogous gene-knockouts (KOs), TAZ KO or YAP KO, respectively. Gene Ontology (GO) analysis of the YAP/TAZ-transcriptional targets revealed activation of genes involved in platelet biology and lipoprotein particle formation as targets that are common for both YAP and TAZ. However, the GO terms for cell-substrate junction were a unique function of YAP. Further, we found that YAP was indispensable for the gastric cancer cells to re-establish cell-substrate junctions on a rigid surface following prolonged culture on a soft substrate. Collectively, our study not only identifies common and unique transcriptional signatures of YAP and TAZ in gastric cancer cells but also reveals a dominant role for YAP over TAZ in the control of cell-substrate adhesion. YAP (Yes-associated protein 1 also known as YAP1 or YAP65) TAZ (transcriptional co-activator with PDZ-binding motif also known as WWTR1) gastric cancer transcriptome Neoplasms. Tumors. Oncology. Including cancer and carcinogens Megan Finch-Edmondson verfasserin aut Hamizah Cognart verfasserin aut Bowen Zhu verfasserin aut Haiwei Song verfasserin aut Boon Chuan Low verfasserin aut Marius Sudol verfasserin aut In Cancers MDPI AG, 2010 12(2020), 12, p 3667 (DE-627)614095670 (DE-600)2527080-1 20726694 nnns volume:12 year:2020 number:12, p 3667 https://doi.org/10.3390/cancers12123667 kostenfrei https://doaj.org/article/4c09132fb0ca4a0eac194e62319ba735 kostenfrei https://www.mdpi.com/2072-6694/12/12/3667 kostenfrei https://doaj.org/toc/2072-6694 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2005 GBV_ILN_2009 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2055 GBV_ILN_2111 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 12 2020 12, p 3667
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topic_facet	YAP (Yes-associated protein 1 also known as YAP1 or YAP65) TAZ (transcriptional co-activator with PDZ-binding motif also known as WWTR1) gastric cancer transcriptome Neoplasms. Tumors. Oncology. Including cancer and carcinogens
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authorswithroles_txt_mv	Yaelim Lee @@aut@@ Megan Finch-Edmondson @@aut@@ Hamizah Cognart @@aut@@ Bowen Zhu @@aut@@ Haiwei Song @@aut@@ Boon Chuan Low @@aut@@ Marius Sudol @@aut@@
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callnumber-first	R - Medicine
author	Yaelim Lee
spellingShingle	Yaelim Lee misc RC254-282 misc YAP (Yes-associated protein 1 misc also known as YAP1 or YAP65) misc TAZ (transcriptional co-activator with PDZ-binding motif misc also known as WWTR1) misc gastric cancer misc transcriptome misc Neoplasms. Tumors. Oncology. Including cancer and carcinogens Common and Unique Transcription Signatures of YAP and TAZ in Gastric Cancer Cells
authorStr	Yaelim Lee
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topic_title	RC254-282 Common and Unique Transcription Signatures of YAP and TAZ in Gastric Cancer Cells YAP (Yes-associated protein 1 also known as YAP1 or YAP65) TAZ (transcriptional co-activator with PDZ-binding motif also known as WWTR1) gastric cancer transcriptome
topic	misc RC254-282 misc YAP (Yes-associated protein 1 misc also known as YAP1 or YAP65) misc TAZ (transcriptional co-activator with PDZ-binding motif misc also known as WWTR1) misc gastric cancer misc transcriptome misc Neoplasms. Tumors. Oncology. Including cancer and carcinogens
topic_unstemmed	misc RC254-282 misc YAP (Yes-associated protein 1 misc also known as YAP1 or YAP65) misc TAZ (transcriptional co-activator with PDZ-binding motif misc also known as WWTR1) misc gastric cancer misc transcriptome misc Neoplasms. Tumors. Oncology. Including cancer and carcinogens
topic_browse	misc RC254-282 misc YAP (Yes-associated protein 1 misc also known as YAP1 or YAP65) misc TAZ (transcriptional co-activator with PDZ-binding motif misc also known as WWTR1) misc gastric cancer misc transcriptome misc Neoplasms. Tumors. Oncology. Including cancer and carcinogens
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title	Common and Unique Transcription Signatures of YAP and TAZ in Gastric Cancer Cells
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title_full	Common and Unique Transcription Signatures of YAP and TAZ in Gastric Cancer Cells
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author_browse	Yaelim Lee Megan Finch-Edmondson Hamizah Cognart Bowen Zhu Haiwei Song Boon Chuan Low Marius Sudol
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title_sort	common and unique transcription signatures of yap and taz in gastric cancer cells
callnumber	RC254-282
title_auth	Common and Unique Transcription Signatures of YAP and TAZ in Gastric Cancer Cells
abstract	YAP and its paralog TAZ are the nuclear effectors of the Hippo tumour-suppressor pathway, and function as transcriptional co-activators to control gene expression in response to mechanical cues. To identify both common and unique transcriptional targets of YAP and TAZ in gastric cancer cells, we carried out RNA-sequencing analysis of overexpressed YAP or TAZ in the corresponding paralogous gene-knockouts (KOs), TAZ KO or YAP KO, respectively. Gene Ontology (GO) analysis of the YAP/TAZ-transcriptional targets revealed activation of genes involved in platelet biology and lipoprotein particle formation as targets that are common for both YAP and TAZ. However, the GO terms for cell-substrate junction were a unique function of YAP. Further, we found that YAP was indispensable for the gastric cancer cells to re-establish cell-substrate junctions on a rigid surface following prolonged culture on a soft substrate. Collectively, our study not only identifies common and unique transcriptional signatures of YAP and TAZ in gastric cancer cells but also reveals a dominant role for YAP over TAZ in the control of cell-substrate adhesion.
abstractGer	YAP and its paralog TAZ are the nuclear effectors of the Hippo tumour-suppressor pathway, and function as transcriptional co-activators to control gene expression in response to mechanical cues. To identify both common and unique transcriptional targets of YAP and TAZ in gastric cancer cells, we carried out RNA-sequencing analysis of overexpressed YAP or TAZ in the corresponding paralogous gene-knockouts (KOs), TAZ KO or YAP KO, respectively. Gene Ontology (GO) analysis of the YAP/TAZ-transcriptional targets revealed activation of genes involved in platelet biology and lipoprotein particle formation as targets that are common for both YAP and TAZ. However, the GO terms for cell-substrate junction were a unique function of YAP. Further, we found that YAP was indispensable for the gastric cancer cells to re-establish cell-substrate junctions on a rigid surface following prolonged culture on a soft substrate. Collectively, our study not only identifies common and unique transcriptional signatures of YAP and TAZ in gastric cancer cells but also reveals a dominant role for YAP over TAZ in the control of cell-substrate adhesion.
abstract_unstemmed	YAP and its paralog TAZ are the nuclear effectors of the Hippo tumour-suppressor pathway, and function as transcriptional co-activators to control gene expression in response to mechanical cues. To identify both common and unique transcriptional targets of YAP and TAZ in gastric cancer cells, we carried out RNA-sequencing analysis of overexpressed YAP or TAZ in the corresponding paralogous gene-knockouts (KOs), TAZ KO or YAP KO, respectively. Gene Ontology (GO) analysis of the YAP/TAZ-transcriptional targets revealed activation of genes involved in platelet biology and lipoprotein particle formation as targets that are common for both YAP and TAZ. However, the GO terms for cell-substrate junction were a unique function of YAP. Further, we found that YAP was indispensable for the gastric cancer cells to re-establish cell-substrate junctions on a rigid surface following prolonged culture on a soft substrate. Collectively, our study not only identifies common and unique transcriptional signatures of YAP and TAZ in gastric cancer cells but also reveals a dominant role for YAP over TAZ in the control of cell-substrate adhesion.
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title_short	Common and Unique Transcription Signatures of YAP and TAZ in Gastric Cancer Cells
url	https://doi.org/10.3390/cancers12123667 https://doaj.org/article/4c09132fb0ca4a0eac194e62319ba735 https://www.mdpi.com/2072-6694/12/12/3667 https://doaj.org/toc/2072-6694
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up_date	2024-07-03T13:39:39.353Z
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Common and Unique Transcription Signatures of YAP and TAZ in Gastric Cancer Cells

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